Integrating mental health literacy into Chinese college student mental health education in the post-COVID-19 era.

This study investigates the influence of COVID-19 on the mental health of Chinese college students and evaluates the current status of mental health literacy (MHL) education. With mental health issues among students becoming increasingly prominent due to the pandemic and rapid social changes, enhancing MHL is critical. The research highlights the necessity of integrating mental health education with MHL to foster resilience and effective coping strategies. It proposes a model combining online and offline education to maximize accessibility and engagement. By examining both domestic and international perspectives, the study underscores the importance of comprehensive mental health education reform in the post-pandemic era. This integrated approach aims to improve students' mental well-being, reduce stigma, and encourage help-seeking behaviors, ultimately contributing to a healthier and more supportive campus environment.

A network meta-analysis for safety of endothelin receptor antagonists in pulmonary arterial hypertension.

BACKGROUND: Currently, direct comparative safety between endothelin receptor antagonists (ERAs) in pulmonary arterial hypertension (PAH) is limited. Thus, a systematic review with network analysis was conducted. METHODS: An electronic search was performed for randomized controlled trials (RCTs) that reported the interested safety data (abnormal liver function, peripheral edema, and anemia) of ERAs in PAH. Risk ratios (RRs) with their confidence intervals (CIs) and the surface under the cumulative ranking curve (SUCRA) were calculated using a network analysis. RESULTS: Ten RCTs involving 2,288 patients were included. Compared with placebo, bosentan (RR, 2.93; 95% CI, 1.78-4.84) significantly increased the risk of abnormal liver function, ambrisentan (RR, 1.62; 95% CI, 1.23-2.13) significantly increased the risk of peripheral edema, and macitentan (RR, 3.42; 95% CI, 1.65-7.07) significantly increased the risk of anemia. SUCRA analysis suggested that bosentan 125 mg twice daily had the highest risk of abnormal liver function; ambrisentan 10 mg once daily had the highest risk of peripheral edema; macitentan 10 mg once daily had the highest risk of anemia. CONCLUSIONS: Abnormal liver function (bosentan), peripheral edema (ambrisentan), and anemia (macitentan) were the safety indicators of ERAs in patients with PAH. Different monitoring parameters should be considered for individual ERA.

Salient Object Detection with Recurrent Fully Convolutional Networks.

Deep networks have been proved to encode high-level features with semantic meaning and delivered superior performance in salient object detection. In this paper, we take one step further by developing a new saliency detection method based on recurrent fully convolutional networks (RFCNs). Compared with existing deep network based methods, the proposed network is able to incorpor- ate saliency prior knowledge for more accurate inference. In addition, the recurrent architecture enables our method to automatically learn to refine the saliency map by iteratively correcting its previous errors, yielding more reliable final predictions. To train such a netw- ork with numerous parameters, we propose a pre-training strategy using semantic segmentation data, which simultaneously leverages the strong supervision of segmentation tasks for effective training and enables the network to capture generic representations to chara- cterize category-agnostic objects for saliency detection. Extensive experimental evaluations demonstrate that the proposed method compares favorably against state-of-the-art saliency detection approaches. Additional validations are also performed to study the impact of the recurrent architecture and pre-training strategy on both saliency detection and semantic segmentation, which provides important knowledge for network design and training in the future research.

Immunotoxicity assessment of ordered mesoporous carbon nanoparticles modified with PVP/PEG.

With large surface area and three-dimensional pore structure, mesoporous carbon nanoparticles (MCN) have attracted enormous interests as potential drug carriers. However, MCN immunotoxicity has not been clarified clearly up to now. Herein we reported the effect of MCN with and without PVP or DSPE mPEG2000 (PEG) modification on immune cells including dendritic cells (DCs), T lymphocytes and RAW264.7 macrophages in vitro. Furthermore, blood biochemical tests, alexin C3 assay and histological analysis were used to investigate the toxicity of MCN in vivo. The synthesized MCN with average particle size about 90 nm was naturally insoluble in water. Surface modification with PVP (MCN-PVP) or PEG (MCN-PEG) slightly increased the particle size and Zeta potential, and effectively improved the dispersion of mesoporous carbon. MCN, MCN-PVP and MCN-PEG promoted the differentiation and maturation of the DCs, while the levels of secreted TNF-α and IL-6 were significantly suppressed by MCN-PVP and MCN-PEG. These materials significantly induced apoptosis of T lymphocytes. The histopathologic results showed that there was no significant difference between nanoparticles with or without modification. Importantly, the materials deposition was observed in the lung, which could potentially inhibit lung metastasis. In conclusion, the ordered mesoporous carbon nanoparticles superficially modified by PVP or PEG perform well in immunological biocompatibility, and are likely to be a promising candidate as medicine carrier in pharmaceutics and clinic.

Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy.

In this study, a highly effective transmembrane delivery vehicle based on PEGylated oxidized mesoporous carbon nanosphere (oMCN@PEG) was successfully fabricated in a facile strategy. oMCN@PEG exhibited a narrow size distribution of 90 nm, excellent hydrophilicity, good biocompatibility, and a very high loading efficiency for doxorubicin (DOX). The drug system (oMCN@DOX@PEG) exhibited excellent stability under neutral pH conditions, but with dramatic releases of DOX at reduced pH conditions. Pharmacokinetics study revealed that oMCN@DOX@PEG could prolong the circulation of DOX in the blood stream. The endocytosis, cytotoxicity, and anticancer effect in vitro and in vivo of the drug-loaded nanoparticles were also evaluated. Our results showed that the nanoparticles efficiently penetrated the membrane of tumor cells, subsequently released drugs, and efficiently inhibited the growth of cancer cells both in vitro and in vivo. Especially, oMCN@DOX@PEG also exhibited significant antimetastasis effect in advanced stage of malignant cancer, improving the survival time of tumor-bearing mice. The results suggested that oMCN@PEG might be a promising anticancer drug delivery vehicle for cancer therapy.