1.
Antimicrob Agents Chemother
; 60(8): 4956-60, 2016 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27270287
RESUMEN
For the past decades, an acidic pH has been used to render Mycobacterium tuberculosis susceptible to pyrazinamide for in vitro testing. Here, we show that at the standard breakpoint concentration and reduced culture temperatures, pyrazinamide (PZA) is active against tuberculosis (TB) at neutral pH. This finding should help unravel the mechanism of action of PZA and allow drug susceptibility testing (DST) methods to be optimized.