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1.
Chem Commun (Camb) ; 56(43): 5751-5754, 2020 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-32319979

RESUMEN

Dual C-H sulfenylation was used to obtain 3-vulcanized imidazoheterocycles using odorless elemental sulfur under catalyst- and additive-free conditions. C-H activation of both imidazoheterocycles and arylamines/arenols/indoles was realized by a practical protocol in which DMSO served as both a solvent and an internal oxidant.

2.
Org Biomol Chem ; 15(44): 9455-9464, 2017 Nov 15.
Artículo en Inglés | MEDLINE | ID: mdl-29098222

RESUMEN

An efficient and convenient copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates has been described. This procedure provides a wide range of structurally diverse coumarinylthio-/coumarinylseleno-substituted imidazoheterocycles in good yields and with good functional group tolerance. Biological evaluation showed that the newly synthesized compound 6d possesses significant in vitro antiproliferative activities against human-derived esophageal, breast, stomach, and prostate cancer cell lines compared with the positive control, 5-fluorouracil.


Asunto(s)
Cobre/química , Cumarinas/química , Imidazoles/química , Selenio/química , Azufre/química , Catálisis
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