1.
J Org Chem
; 89(2): 1127-1139, 2024 Jan 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38166204
RESUMEN
Cycloheptenones are widespread in natural products and bioactive molecules. An efficient and convenient NaH-mediated Cope Rearrangement of doubly activated vinylcyclopropanes is reported for the synthesis of cyclohepten-4-ones. These flexible intramolecular reactions were applicable to a wide range of substrates and could be performed on gram scale. The derivatization of the product leads to short and highly efficient synthesis of some useful functional molecules.