Comment on Costa et al. The Effectiveness of Different Concepts of Bracing in Adolescent Idiopathic Scoliosis (AIS): A Systematic Review and Meta-Analysis. J. Clin. Med. 2021, 10, 2145.

I read the above-mentioned work with great interest, and I would like to thank the authors for considering two papers from our working group [...].

Conservative treatment of a scoliosis patient after two heart surgeries in early childhood - A case report.

INTRODUCTION: This is a case report of a juvenile female patient with scoliosis following two heart surgeries for congenital heart disease (CHD). PATIENT PRESENTATION MANAGEMENT AND OUTCOME: Initially, the premenarchial female was 9 years old and had a Tanner stage 2-3 with a single thoracic curve of 65° Cobb. Because of the high risk for progression, immediate brace treatment was proposed as the father declined surgery. The patient received intensive treatment according to the Schroth Best Practice® programme and a Gensingen Brace® designed for large thoracic curves. Over the 18 months following the initial visit, she received two additional braces. As a result, the progression of the main curve was prevented. The patient continues to maintain an improved cosmetic result and is currently at a Risser 2. CONCLUSION: Surgery performed for CHD in rare cases may lead to stiff spinal deformity as a consequence of that surgery. Progression of a severe and stiff curve was prevented during the most vulnerable phase of the pubertal growth spurt with an improved clinical result. Therefore, we assume that the patient may have a normal life in adulthood with minor restrictions only. Supported by pattern-specific high correction exercises and braces, these typical single thoracic curves can be re-compensated to a more balanced appearance, less prone to progression in adulthood. CLINICAL IMPLICATIONS: Because of the relative high risks of spinal fusion and the long-term unknowns of such an intervention, high-impact conservative treatment should be implemented first before surgical correction is considered.

Is there an indication for surgery in patients with spinal deformities? - A critical appraisal.

BACKGROUND: High-quality evidence exists to support physiotherapy and brace treatment for scoliosis and other spinal deformities. However, according to previous systematic reviews, it seems that no evidence exists for surgery. Nevertheless, the number of research articles focussing on spinal surgery highly exceeds the number of articles focussing on conservative treatment. OBJECTIVE: The purpose of this study is to conduct an updated search for systematic reviews providing high-quality evidence for spinal surgery in patients with spinal deformities. METHOD: A narrative review including PubMed and the Cochrane database was conducted on April 12, 2020, with the following search terms: (1) spinal deformities, surgery, systematic review and outcome; (2) kyphosis, surgery, systematic review and outcome; (3) Scheuermann's disease, surgery, systematic review and outcome, and (4) scoliosis, surgery, systematic review and outcome. RESULTS: No reviews containing prospective controlled or randomised controlled studies were found providing evidence for surgery. CONCLUSIONS: A general indication for spine surgery just based on the Cobb angle is not given. In view of the long-term unknown variables and the possible long-term complications of such treatment, a surgical indication for patients with spinal deformities must be reviewed on an individual basis and considered carefully. A current systematic review appears necessary in order to be able to draw final conclusions on the indication for surgery in patients with spinal deformities. CLINICAL IMPLICATIONS: In view of the increasing number of surgeons with an affiliation to industry, the indication for surgery needs to be given by independent conservative specialists for spinal deformities in order to provide an objective recommendation.

Brace treatment for patients with scoliosis: State of the art.

BACKGROUND: Physiotherapy, brace applications or surgery are the treatment options utilised to manage patients with scoliosis. Many different brace applications are used, and the success rates of orthoses vary. OBJECTIVES: Brace applications can have detrimental impacts on the patient leading to physical discomfort, psychological discomfort, and in some instance the use of braces may even be painful. Therefore, future developments in this field should be aimed at improving the success rate and reducing physical distress experienced by the patient while using brace applications. The purpose of this article is to provide recommendations with respect to the most appropriate bracing approach in general. METHOD: A narrative review of the scientific literature was carried out to substantiate the statements made in this article. RESULTS: The most important braces provided for the treatment of patients with scoliosis and the treatment results that can be achieved are presented and discussed, taking into account the most recent systematic reviews. A wide range of success rates have been found for the different brace applications. CONCLUSION: Given that brace application may impact the patient leading to physical discomfort and psychological distress, good quality management in brace application for patients with scoliosis is needed to ensure the best possible outcome and the least stressful management. CLINICAL IMPLICATIONS: Safety in brace application for patients with scoliosis needs improvement. The use of standardised and reliable computer aided design (CAD) libraries and appropriate patient information based on published guidelines is suggested.

[Is it possible to improve treatment safety in the brace treatment of scoliosis patients by using standardized CAD algorithms?] / Ist eine Verbesserung der Behandlungssicherheit in der Korsettversorgung von Skoliosepatienten durch Anwendung standardisierter CAD-Algorithmen möglich?

BACKGROUND: The treatment of scoliosis patients with corrective braces today still leads to quite different results. The published success rates between 50 and 90% inevitably lead to the question of how the success rates of brace treatment can be increased and standardized. The results of a computer aided design (CAD) Chêneau application, developed with this objective, are presented. MATERIALS AND METHODS: On the reporting date (December 8, 2019), the prospectively created database of our department was evaluated retrospectively. Only immature girls with adolescent idiopathic scoliosis (AIS), aged 10-14 years, Risser signs 0-2, were included in the database. RESULTS: Both the entire group with an observation period of at least 18 months and the patient groups with completed treatment had success rates between 86 and 88%. Overall, the results were significantly better than the 72% success rate of the Boston Brace Control Group (BRAIST). In comparison with the results of other Chêneau derivatives, the success rate of our series was distinctly better. CONCLUSIONS: Treatment safety in brace treatment for patients with scoliosis should be improved. One approach may be the use of standardized CAD libraries. Further investigations with study designs of higher evidence are necessary to support the results found in our investigation.

Reliability of the original Lehnert-Schroth (LS) scoliosis classification in physiotherapy practice.

[Purpose] The foundations of the scoliosis specific and evidence-based physiotherapy program according to Schroth is the original the Lehnert-Schroth (LS) classification which is still in use today. The purpose of this paper is to test the reliability of the LS classification system, using clinical and radiological images of scoliosis patients as classified by specialist experienced clinicians. [Participants and Methods] A list of 40 pictures of X-Rays and a list of 40 clinical pictures (all posterior trunk images) of patients with idiopathic scoliosis were provided by the second author. Three specialist professional physiotherapists or orthotists rated all clinical and radiological pictures according to these two patterns of the LS classification. [Results] The intra-observer Kappa value was 0.90 (clinical) and 1.00 (x-rays). The inter-observer Kappa values at average was 0.65 (clinical) and 0.71 (x-rays). [Conclusion] For the application of classifying the patients when prescribing postural advice and exercises from the Schroth program the LS-classification seems an easy to use and highly reliable tool. This test demonstrated sufficient reliability with respect to the x-rays, but the tests of the clinical pictures alone, demonstrated fair levels of reliability, which indicates that it is an appropriate tool for physiotherapists when an x-ray is not available.

Clinical classification of scoliosis patients using machine learning and markerless 3D surface trunk data.

Markerless 3D surface topography for scoliosis diagnosis and brace treatment can avoid repeated radiation known from standard X-ray analysis and possible side effects. Combined with the method of torso asymmetry analysis, curve severity and progression can be evaluated with high reliability. In the current study, a machine learning approach was utilised to classify scoliosis patients based on their trunk surface asymmetry pattern. Frontal X-ray and 3D scanning analysis with a clinical classification based on Cobb angle and spinal curve pattern were performed with 50 patients. Similar as in a previous study, each patient's trunk 3D reconstruction was used for an elastic registration of a reference surface mesh with fixed number of vertices. Subsequently, an asymmetry distance map between original and reflected torso was calculated. A fully connected neural network was then utilised to classify patients regarding their Cobb angle (mild, moderate, severe) and an Augmented Lehnert-Schroth (ALS) classification based on their full torso asymmetry distance map. The results reveal a classification success rate of 90% (SE: 80%, SP: 100%) regarding the curve severity (mild vs moderate-severe) and 50-72% regarding the ALS group. Identifying patient curve severity and treatment group was reasonably possible allowing for a decision support during diagnosis and treatment planning. Graphical abstract.

Innovative decision support for scoliosis brace therapy based on statistical modelling of markerless 3D trunk surface data.

Recently markerless 3D scanning methods receive an increased interest for therapy planning and brace treatment of patients with scoliosis. This avoids repeated radiation known from standard X-Ray analysis. Several authors introduced the method of asymmetry distance maps in order to classify curve severity and progression. The current work extends this approach by statistical mean shape 3D models of the human trunk in order to classify patients. 50 patients were included in this study performing frontal X-ray and 3D scanning analysis. All patients were classified by a clinician according to their Cobb angle and spinal curve pattern (Augmented-Lehnert-Schroth ALS). 3D reconstructions of each patient trunk were processed in a way to elastically register a reference surface mesh with fixed number of data points. Mean 3D shape models were generated for each curve pattern. An asymmetry distance map was then calculated for each patient and mean shape model. Single patient 3D reconstructions were classified according to severity and ALS treatment group. Optimal sensitivity and specificity was 97%/39% thoracic and 87%/42% lumbar respectively for detecting mild and moderate-severe patients. Identifying a treatment group was possible for three combined groups allowing to support decisions during diagnosis and therapy planning.

Non-specific chronic low back pain in patients with scoliosis-an overview of the literature on patients undergoing brace treatment.

[Purpose] Although there is evidence that non-specific chronic pain can be influenced by physical therapy, some patients with scoliosis and chronic pain may benefit from additional brace treatment. The purpose of this review is to answer the question whether there are studies on the use of brace treatment in patients with scoliosis and pain and to investigate whether brace treatment does positively influence chronic pain. [Methods] A PubMed review has been undertaken using the key words (1) scoliosis and pain and brace treatment and (2) scoliosis and pain and orthotics. From both searches the studies were extracted that included a patient group with the diagnosis of a scoliosis and with additional chronic non-specific low back pain, treated with a brace. [Results] One hundred forty two items have been found for search (1) and 111 for search (2). The total number of relevant items found in both searches was 10. According to the studies found, bracing seems an effective treatment for this condition. [Conclusion] Brace treatment in patients with scoliosis and chronic non-specific low back pain has demonstrated to be effective. It should be used when exercise treatment is not effective. A clinical test is demonstrated to predict the most beneficial approach in brace treatment.

First end-result of a prospective cohort with AIS treated with a CAD Chêneau style brace.

[Purpose] Specific exercises and brace treatment are the two evidence-based modes of treatment for patients with scoliosis. The purpose of this paper is to present the first end-results from a prospective cohort that commenced treatment in 2011 with a CAD based Chêneau derivate and is then compared to the published results achieved with the Boston Brace. [Participants and Methods] Inclusion criteria for the study, refers to the SRS inclusion criteria on bracing, except the range of Cobb angles which was extended to curvatures of up to 45°. Twenty-eight patients were weaned from their CAD Chêneau style brace. The results of this cohort have been compared with the BRAIST study by Weinstein et al. with the help of the Z-test. [Results] A success rate of 92.9% has been achieved. This was compared to the success rate of 72% in the BRAIST study. The differences were highly significant in the Z-test. [Conclusion] The results achieved with the GBW are significantly and better than the results achieved with the Boston brace. Therefore, the standards for bracing should be reviewed with the results that symmetric compression with Boston bracing is not as successful, when compared to asymmetric high correction bracing results, which allow a standardized classification-based corrective approach.

Hemidystrophic Thorax Mimicking Scoliosis.

BACKGROUND: We regularly use Angle of Trunk Rotation (ATR) measurements for scoliosis screening and also for clinical follow-up of our scoliosis patients under treatment. In some patients, when ATR measurements exceed the screening threshold but without a significant degree of curvature on the X-ray (Cobb angle), a Hemidystrophic Thorax (HDT) is diagnosed. The purpose of this paper was to present a case series of patients with this kind of thoracic deformity because this may be mimicking scoliosis to a significant degree. MATERIALS AND METHODS: This case series is a consecutive series of patients where the first author detected a hemidystrophic thorax instead of or in combination with scoliosis. A 3D scan of the trunk was made and adjusted to the coordinates in order to achieve an upright orientation of the upper trunk. The scan was scaled in order to determine certain anatomic landmarks, as performed in preparation for bracing. The scan was cut horizontally at the xiphoid level and the plane at this level was analysed visually in order to detect deformations that were different to the typical scoliotic deformations in the horizontal plane. RESULTS: Seven cases were analysed and described in more detail. CONCLUSION: The condition of HDT may lead to significant rib humps that mimic scoliosis. According to our case series, mild scoliosis can also be associated with HDT. HDT, according to the cases presented in this study, seems to be a relatively benign deformity. Long-term observations are necessary before a final conclusion can be drawn with respect to prognosis.

Workflow of CAD / CAM Scoliosis Brace Adjustment in Preparation Using 3D Printing.

BACKGROUND: High correction bracing is the most effective conservative treatment for patients with scoliosis during growth. Still today braces for the treatment of scoliosis are made by casting patients while computer aided design (CAD) and computer aided manufacturing (CAM) is available with all possibilities to standardize pattern specific brace treatment and improve wearing comfort. OBJECTIVE: CAD / CAM brace production mainly relies on carving a polyurethane foam model which is the basis for vacuuming a polyethylene (PE) or polypropylene (PP) brace. Purpose of this short communication is to describe the workflow currently used and to outline future requirements with respect to 3D printing technology. METHOD: Description of the steps of virtual brace adjustment as available today are content of this paper as well as an outline of the great potential there is for the future 3D printing technology. RESULTS: For 3D printing of scoliosis braces it is necessary to establish easy to use software plug-ins in order to allow adding 3D printing technology to the current workflow of virtual CAD / CAM brace adjustment. Textures and structures can be added to the brace models at certain well defined locations offering the potential of more wearing comfort without losing in-brace correction. CONCLUSIONS: Advances have to be made in the field of CAD / CAM software tools with respect to design and generation of individually structured brace models based on currently well established and standardized scoliosis brace libraries.

Application of extracorporeal shockwaves in the treatment of scoliosis: a case report.

[Purpose] In a pilot investigation, extracorporeal shockwave therapy was applied to patients with idiopathic scoliosis. This case report aimed to describe the effects of repeated extracorporeal shockwave therapy on the clinical signs of a patient with scoliosis due to a functional tethered cord syndrome. [Subject and Methods] In June 2016, a 13-year-old girl presented with a left thoracic curvature. Radiograph showed a left thoracic curve of 24°. An angle of trunk rotation of 21° was measured using a scoliometer. Extracorporeal shockwave therapy was proposed to support conservative treatment. Five sessions of extracorporeal shockwave therapy were applied. Finger-floor distance and the angle of trunk rotation before and after each application of extracorporeal shockwave therapy were measured. [Results] The average finger-floor distances before and after extracorporeal shockwave therapy were 22.6 cm and 15.6 cm, respectively. The average angles of trunk rotation before and after the therapy were 13° and 10.2°, respectively. [Conclusion] The short-term effect of extracorporeal shockwave therapy was revealed in this study. The neural structures that inhibited free mobility of the spine were mobilized. Furthermore, deformity was reduced by applying extracorporeal shockwave therapy.

A Prospective Cohort Study of AIS Patients with 40° and More Treated with a Gensingen Brace (GBW): Preliminary Results.

INTRODUCTION: There is a growing resistance from patients and their families to spinal fusion surgery for scoliosis. Due to inconclusive evidence that surgery has a long-term effect on scoliosis and/or improves the quality of life for patients with scoliosis, there is a need to extend the conservative perspective of treatment to patients with curvatures greater than 40 degrees. For that reason, a prospective cohort study was initiated to determine the effectiveness of the Gensingen brace (a Cheneau-style TLSO) in preventing progression in skeletally immature patients. MATERIALS AND METHODS: Since 2011, fifty-five patients have been enrolled in this prospective cohort study. This report includes the mid-term results of twenty-five of these patients, who have a minimum follow-up of 18 months and an average follow-up of 30.4 months (SD 9.2). The twenty-five patients had the following characteristics at the start of treatment: Cobb angle: 49° (SD 8.4; 40º-71º); 12.4 years old (SD 0.82); Risser: 0.84 (SD 0.94; 0-2). A z-test was used to compare the success rate in this cohort to the success rate in the prospective braced cohort from BrAIST. RESULTS: After follow-up, the average Cobb angle was 44.2° (SD 12.9). Two patients progressed, 12 patients were able to achieve halted progression, and eleven patients improved. Angle of trunk rotation (ATR) decreased from 12.2 to 10.1 degrees in the thoracic spine (p = 0.11) while the ATR decreased from 4.7 to 3.6 degrees in the lumbar spine (p = 0.0074). When comparing the success rate of the BrAIST cohort with the success rate of patients in this cohort, the difference was statistically significant (z = -3.041; p = 0.01). CONCLUSION: Conservative brace treatment using the Gensingen brace was successful in 92% of cases of patients with AIS of 40 degrees and higher. This is a significant improvement compared to the results attained in the BrAIST study (72%). Reduction of the ATR shows that postural improvement is also possible.