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Complement Ther Med ; 82: 103047, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38697487

RESUMEN

OBJECTIVE: The object of this study was to determine the effect of EAS (Equine-Assisted Services) on arthritis conditions, as measured by the sTnT (Skeletal troponin) and COMP (cartilage oligomeric matrix proteins) biomarkers, compared to an exercise attention control intervention. DESIGN: This was a secondary analysis of a randomized clinical trial comparing equine-assisted therapy to exercise education attention-control on cartilage and skeletal biomarkers in adults with arthritis. Twenty-one adults (Mage = 64 years) with arthritis who attended rheumatology clinics in the midwestern United States participated. RESULTS: No changes were found in sTnT from baseline to week six within either intervention nor were there differences in changes between the two groups (p = 0.91). COMP increased from baseline to week six for both conditions, suggesting increased deterioration of cartilage and joints. Although the attention-control condition demonstrated larger increases in cartilage oligomeric matrix proteins level, compared to the EAS condition, these differences were not statistically (p = 0.58) or clinically significant (i.e., trivial effect, d = -0.16). When 3 outliers were removed, the differences in changes between EAT and attention-control group could be arguably of clinical significance (d = - 0.33), suggesting that the attention-control group demonstrated larger increases in levels of COMP than those in the EAS condition, though this difference was not statistically significant (p = 0.28). CONCLUSION: Although equine-assisted therapy may reduce pain and improve quality of life for adults with arthritis, findings here are not fully corroborated with biomarkers.


Asunto(s)
Biomarcadores , Proteína de la Matriz Oligomérica del Cartílago , Terapía Asistida por Caballos , Humanos , Persona de Mediana Edad , Proyectos Piloto , Biomarcadores/sangre , Femenino , Masculino , Anciano , Proteína de la Matriz Oligomérica del Cartílago/sangre , Terapía Asistida por Caballos/métodos , Caballos , Artritis/terapia , Animales , Cartílago/metabolismo
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