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1.
JMIR Aging ; 7: e53025, 2024 Feb 08.
Artículo en Inglés | MEDLINE | ID: mdl-38329793

RESUMEN

BACKGROUND: Social media platforms have been effective in raising awareness of the underassessment and undertreatment of pain in dementia. OBJECTIVE: After a successful pilot campaign, we aimed to scale our pain-in-dementia knowledge mobilization pilot initiative (ie, #SeePainMoreClearly) to several social media platforms with the aid of a digital media partner. The goal of the initiative was to increase awareness of the challenges in the assessment and management of pain among people with dementia. A variety of metrics were implemented to evaluate the effort. Through this work, we endeavored to highlight key differences between our pilot initiative (which was a grassroots initiative), focusing largely on Twitter and YouTube, and the current science-media partnership. We also aimed to generate recommendations suitable for other social media campaigns related to health or aging. METHODS: Evidence-based information about pain in dementia was summarized into engaging content (eg, videos) tailored to the needs of various knowledge users (eg, health professionals, families, and policy makers). We disseminated information using Facebook (Meta Platforms), Twitter (X Corp), YouTube (Alphabet Inc), Instagram (Meta Platforms), and LinkedIn (LinkedIn Corp) and measured the success of the initiative over a 12-month period (2020 to 2021). The evaluation methods focused on web analytics and questionnaires related to social media content. Knowledge users' web responses about the initiative and semistructured interviews were analyzed using thematic analysis. RESULTS: During the course of the campaign, >700 posts were shared across all platforms. Web analytics showed that we drew >60,000 users from 82 countries to our resource website. Of the social media platforms used, Facebook was the most effective in reaching knowledge users (ie, over 1,300,000 users). Questionnaire responses from users were favorable; interview responses indicated that the information shared throughout the initiative increased awareness of the problem of pain in dementia and influenced respondent behavior. CONCLUSIONS: In this investigation, we demonstrated success in directing knowledge users to a resource website with practical information that health professionals could use in patient care along with pain assessment and management information for caregivers and people living with dementia. The evaluation metrics suggested no considerable differences between our pilot campaign and broader initiative when accounting for the length of time of each initiative. The limitations of large-scale health campaigns were noted, and recommendations were outlined for other researchers aiming to leverage social media as a knowledge mobilization tool.


Asunto(s)
Demencia , Dolor , Medios de Comunicación Sociales , Humanos , Internet , Dolor/etiología
2.
Int J Nurs Stud ; 143: 104508, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37209531

RESUMEN

BACKGROUND: Monitoring body temperature is essential for safe perioperative care. Without patient monitoring during each surgical phase, alterations in core body temperature will not be recognised, prevented, or treated. Safe use of warming interventions also depends on monitoring. Yet there has been limited evaluation of temperature monitoring practices as the primary endpoint. OBJECTIVE: To investigate temperature monitoring practices during all stages of perioperative care. We examined what patient characteristics are associated with the rate of temperature monitoring, along with clinical variables such as warming intervention or exposure to hypothermia. DESIGN: An observational period-prevalence study over seven days across five Australian hospitals. SETTINGS: Four metropolitan, tertiary hospitals and one regional hospital. PARTICIPANTS: We selected all adult patients (N = 1690) undergoing any surgical procedure and any mode of anaesthesia during the study period. METHODS: Patient characteristics, perioperative temperature data, warming interventions and exposure to hypothermia were retrospectively collected from patient charts. We describe the frequencies and distribution of temperature data at each perioperative stage, including adherence to minimum temperature monitoring based on clinical guidelines. To examine associations with clinical variables, we also modelled the rate of temperature monitoring using each patient's count of recorded temperature measurements within their calculated time interval from anaesthetic induction to postanaesthetic care unit discharge. All analyses adjusted 95% confidence intervals (CI) for patient clustering by hospital. RESULTS: There were low levels of temperature monitoring, with most temperature data clustered around admission to postanaesthetic care. Over half of patients (51.8%) had two or less temperatures recorded during perioperative care and one-third (32.7%) had no temperature data at all prior to admission to postanaesthetic care. Of all patients that received active warming intervention during surgery, over two-thirds (68.5%) had no temperature monitoring recorded. In our adjusted model, associations between clinical variables and the rate of temperature monitoring often did not reflect clinical risk or need: rates were decreased for those with greatest operative risk (American Society of Anesthesiologists Classification IV: rate ratio (RR) 0.78, 95% CI 0.68-0.89; emergency surgery: RR 0.89, 0.80-0.98), and neither warming interventions (intraoperative warming: RR 1.01, 0.93-1.10; postanaesthetic care unit warming: RR 1.02, 0.98-1.07) nor hypothermia at postanaesthetic care unit admission (RR 1.12, 0.98-1.28) were associated with monitoring rate. CONCLUSIONS: Our findings point to the need for systems-level change to enable proactive temperature monitoring over all phases of perioperative care to enhance patient safety outcomes. REGISTRATION: Not a clinical trial.


Asunto(s)
Hipotermia , Adulto , Femenino , Humanos , Hipotermia/epidemiología , Hipotermia/prevención & control , Prevalencia , Estudios Retrospectivos , Estudios Transversales , Australia , Hospitales , Temperatura Corporal
3.
Clin Obes ; 11(5): e12468, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34101372

RESUMEN

Non-Hispanic Black women have the highest rates of overweight/obesity of any group in the United States. To date, few interventions have worked to reduce overweight/obesity in this population. This study investigated the views of Black women with overweight and obesity treated in a primary care setting regarding desired and undesired verbal and non-verbal behaviours by providers in provider-patient clinical encounters focused on losing weight, maintaining weight loss, and/or obesity. Two focus groups and an individual interview (n = 15) were conducted. Qualitative data analysis yielded five distinct themes, with 11 codes (listed in parenthesis): (a) desired weight-focused discussions (codes: Discussing weight loss with patients and discussing weight-loss maintenance with patients), (b) desired weight-focused support (codes: Supporting patients experiencing weight loss and supporting patients experiencing weight gain), (c) undesired weight-focused discussions (codes: Things to avoid during weight loss discussions and things to avoid during weight gain discussions), (d) desired attitudes and behaviours during weight-focused discussions (codes: Show caring and understanding and encourage behaviour change for weight loss), and (e) building physician-patient rapport (codes: Enable patients to feel respected by doctors, enable patients to feel comfortable with doctors and enable patients to trust their doctors). The qualitative approach employed in this study generates a deep understanding not only of the experiences of Black women patients but also of potential strategies that physicians could employ to succeed in their discussions with patients regarding healthy weight achievement and maintenance.


Asunto(s)
Obesidad , Sobrepeso , Femenino , Grupos Focales , Humanos , Obesidad/terapia , Estados Unidos , Aumento de Peso , Pérdida de Peso
4.
J Prim Care Community Health ; 11: 2150132720949412, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32783582

RESUMEN

Since the release of Healthy People 2020, there has been extensive research understanding factors associated with health-related quality of life (HRQoL) among specific populations. Despite this growing body of research, little has been conducted to understand the factors associated with HRQoL among uninsured/underinsured Americans. The purposes of the present study were to assess clinic staff to determine: (1) whether there is a need to examine HRQoL among uninsured/underinsured individuals, (2) whether there is a need for tailored HRQoL-promoting interventions among uninsured/underinsured individuals, and (3) the factors associated with HRQoL among uninsured/underinsured individuals. A survey was sent to an association of 41 clinics that provides free medical services to uninsured/underinsured individuals. The majority of participants indicated that uninsured/underinsured individuals experience unique factors associated with HRQoL and that there was a need to implement tailored HRQoL-improving interventions among uninsured/underinsured individuals. The results also present the personal/contextual factors associated with HRQoL of uninsured/underinsured individuals.


Asunto(s)
Pacientes no Asegurados , Calidad de Vida , Instituciones de Atención Ambulatoria , Humanos , Encuestas y Cuestionarios , Estados Unidos
5.
Pain Med ; 21(12): 3366-3376, 2020 12 25.
Artículo en Inglés | MEDLINE | ID: mdl-32488250

RESUMEN

OBJECTIVE: To investigate the relationship of emotion regulation strategies (i.e., emotional suppression and reappraisal) with pain catastrophizing, fear of pain, pain intensity, worry, and depression as function of age in samples of older and younger adults. DESIGN: Cross-sectional design using validated questionnaires. SETTING: Participants resided in the community. They completed validated measures using online questionnaires. SUBJECTS: Two-hundred fifty-seven older adults and 254 younger adults with chronic pain participated. METHODS: Participants completed validated questionnaires of emotion regulation strategies, pain-related functioning and mental health. RESULTS: Emotion regulation varied as a function of age and gender. Among our chronic pain sample, older adult males reported lower use of reappraisal and suppression than younger adult males, while older adult females reported higher use of reappraisal than younger adult females. Emotional suppression was positively related to pain catastrophizing, pain intensity, worry, and depression. Reappraisal was negatively related to depression and worry. Interestingly, age showed a positive relationship with fear of pain, pain catastrophizing, worry, depression, and pain intensity, while gender was related to fear of pain and worry. Finally, emotional reappraisal partially mediated the relationship between the affective dimensions of pain intensity and pain catastrophizing among older adults. CONCLUSIONS: Our results indicate that reappraisal strategies are important for older and younger adults with chronic pain, pointing to the necessity of considering these strategies when working clinically with such populations. However, given our findings as well as those in the literature, gender should also be considered.


Asunto(s)
Regulación Emocional , Anciano , Ansiedad , Catastrofización , Estudios Transversales , Emociones , Femenino , Humanos , Masculino
6.
Internet Interv ; 20: 100309, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32071887

RESUMEN

With the growing use of ICBT in routine care clinics there is a need for literature on how to monitor and improve the quality of therapist behaviours in clinical practice. In this paper, we first provide background literature on Audit and Feedback (A&F), a common quality improvement technique, and then present a case study regarding the use of A&F to improve quality of therapist behaviours in emails sent to patients provided with ICBT in routine care. The A&F measure used was derived from previous research on therapist's email behaviours in ICBT. Fifteen undesirable therapist behaviours (e.g., Did Not Message, Unresponsive to Symptom Increase, Does Not Address Patient Concern) were audited in 1840 emails sent from eight therapists to 198 randomly selected patients, representing 18% of 1114 patients who started between one and five lessons of ICBT in the previous year and did not formally withdraw from treatment (n = 31 patients). The therapists who were audited were provided feedback four times over a one-year period from October 2018 to September 2019. Overall, in all audit periods, we found a low percentage of undesirable therapist behaviours (i.e., therapists displayed the behaviour in 12% or less of the total emails sent). For most therapist behaviours, we saw a trend towards improvement across the four audit cycles. Three therapist behaviours (i.e., Failure to Ask One Question to the Patient, Poor Instructions, Not Linking Email to Course Content) did not follow this pattern and were flagged for clinical discussion to determine why behaviours were elevated and whether these behaviours represented unrealistic expectations. The process was valuable for monitoring and improving therapist behaviours and highlights the need for future research on standards for therapist behaviours (e.g., which behaviours to focus on, setting acceptable levels of undesirable behaviour).

7.
J Clin Psychol Med Settings ; 25(1): 104, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29270917

RESUMEN

The original version of this article unfortunately contains a mistake. In page 229, first paragraph, line 5, the value 0.353 should read as 0.347. In page 230, first paragraph, line 10, the value 0.121 should read as - 0.121.

8.
J Clin Psychol Med Settings ; 24(3-4): 223-233, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28861690

RESUMEN

Sexual minorities experience higher rates of several physical health problems compared to their heterosexual counterparts. The present study uses Meyer's Minority Stress Model (Psychological Bulletin, 129(5): 674-697, 2003) to examine physical health indicators among 250 adults who identified as sexual minorities. Study hypotheses include that sexual minority stress is predictive of two physical health indicators (i.e., engagement in a health-promoting lifestyle and number of physical health problems) and that planning (i.e., problem-focused) and social support coping will partially mediate the relationship between sexual minority stress and each physical health indicator. Results showed that as level of sexual minority stress increased, engagement in a health-promoting lifestyle decreased and the number of physical health problems increased. Planning and social support coping did not mediate these relationships; however, as levels of coping increased, engagement in a health-promoting lifestyle increased. These findings have implications for researchers and healthcare professionals in their efforts to promote the physical health of sexual minorities.


Asunto(s)
Adaptación Psicológica , Indicadores de Salud , Minorías Sexuales y de Género/psicología , Estrés Psicológico/psicología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Lista de Verificación , Femenino , Promoción de la Salud , Humanos , Estilo de Vida , Masculino , Persona de Mediana Edad , Modelos Psicológicos , Prejuicio , Solución de Problemas , Apoyo Social , Estrés Psicológico/complicaciones , Adulto Joven
9.
Am J Lifestyle Med ; 11(6): 479-488, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-30202374

RESUMEN

Objective. To examine the impact of a community-informed and community-based Health-Smart Church (HSC) Program on engagement in health promoting behaviors (healthy eating and physical activity) and health outcomes (body mass index, weight, and systolic and diastolic blood pressure). Design. A total of 70 overweight/obese Hispanic adults participated in an intervention group (n = 37) or a waitlist control group (n = 33) in 2 Hispanic churches in Bronx, New York. Results. Post-intervention the intervention group significantly increased in frequency of healthy eating and physical activity compared to the waitlist control group. Although no significant changes in body mass index or systolic blood pressure were found for either group, the intervention group decreased significantly in weight from pre-intervention to post-intervention. Conclusions. The results of the present study add to the growing body of literature evidencing the successful use of community-engaged and community-based participatory health promotion interventions with racial/ethnic minority populations and highlight important practices and considerations for similar health promotion interventions with these communities.

10.
J Racial Ethn Health Disparities ; 4(1): 70-78, 2017 02.
Artículo en Inglés | MEDLINE | ID: mdl-26830631

RESUMEN

Black adults in the United States are disproportionately affected by health disparities, such as overweight and obesity. Research suggests that Black adults engage in fewer health-promoting behaviors (e.g., physical activity and healthy eating) than their non-Hispanic White counterparts. These health-promoting behaviors are known protective factors against overweight/obesity and related health concerns. This community-based participatory research study employed a waitlist control design and a university-church partnership approach to test the impact of a church-based health-empowerment program designed to increase health-promoting behaviors (called health-smart behaviors) and improve health indicators (e.g., reduce weight) among overweight/obese Black adult churchgoers. Results indicate that the intervention group (n = 37) experienced a significant increase in levels of healthy eating and physical activity and a significant decrease in weight compared to the waitlist control group (n = 33). Results from this study have implications for the design of church-based, culturally sensitive health promotion interventions to increase health-smart behaviors and ultimately prevent and reduce obesity and related diseases in Black communities.


Asunto(s)
Negro o Afroamericano/psicología , Conductas Relacionadas con la Salud/etnología , Promoción de la Salud/métodos , Poder Psicológico , Religión , Adolescente , Adulto , Negro o Afroamericano/estadística & datos numéricos , Investigación Participativa Basada en la Comunidad , Femenino , Disparidades en el Estado de Salud , Humanos , Masculino , Persona de Mediana Edad , Obesidad/etnología , Obesidad/prevención & control , Sobrepeso/etnología , Sobrepeso/prevención & control , Evaluación de Programas y Proyectos de Salud , Estados Unidos/epidemiología , Adulto Joven
11.
Pain Med ; 18(10): 1895-1907, 2017 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-27837033

RESUMEN

OBJECTIVE: Pain is prevalent among older adults but is often underestimated and undertreated, especially in people with severe dementia who have limited ability to self-report pain. Pain in patients with moderate to severe dementia can be assessed using observational tools. Informal caregivers (relatives of seniors with dementia) are an untapped assessor group who often bear the responsibility of care for their loved ones. Our objective was to evaluate the ability of laypeople to assess pain using observational measures originally developed for use by health care professionals. DESIGN: We employed a quasi-experimental design and presented videos depicting patients with dementia (portrayed by actors) displaying pain behaviors or during a calm relaxed state (no pain) to long-term care nurses and laypeople. Participants rated the pain behaviors observed in each video by completing two standardized observational measures that had been previously developed for use by long-term care staff. RESULTS: As expected, both laypeople and nurses were able to effectively differentiate painful from nonpainful situations using the standardized tools. Both groups were also able to discriminate among gradations of pain (i.e., no pain, mild, moderate, severe) and required comparable amounts of time to complete the assessments. CONCLUSIONS: We conclude that, as hypothesized, the instruments under study can be used for the assessment of pain by laypeople. This is the first study to validate these instruments for use by laypeople. The use of these tools by laypeople (under the guidance of health professionals) has the potential of facilitating earlier detection and treatment of pain in older adults with dementia who live in community settings.


Asunto(s)
Cuidadores/educación , Demencia , Evaluación Geriátrica/métodos , Dimensión del Dolor/métodos , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Psicometría/instrumentación
12.
Pain Res Manag ; 2016: 6493463, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27445619

RESUMEN

Background. Although feasible protocols for pain assessment and management in long-term care (LTC) have been developed, these have not been implemented on a large-scale basis. Objective. To implement a program of regular pain assessment in two LTC facilities, using implementation science principles, and to evaluate the process and success of doing so. Methods. The implementation protocol included a pain assessment workshop and the establishment of a nurse Pain Champion. Quality indicators were tracked before and after implementation. Focus groups and interviews with staff were also conducted. Results. The implementation effort was successful in increasing and regularizing pain assessments. This was sustained during the follow-up period. Staff members reported enthusiasm about the protocol at baseline and positive results following its implementation. Despite the success in increasing assessments, we did not identify changes in the percentages of patients reported as having moderate-to-severe pain. Discussion. It is our hope that our feasibility demonstration will encourage more facilities to improve their pain assessment/management practices. Conclusions. It is feasible to implement regular and systematic pain assessment in LTC. Future research should focus on ensuring effective clinical practices in response to assessment results, and determination of longer-term sustainability.


Asunto(s)
Manejo del Dolor , Dimensión del Dolor , Dolor/diagnóstico , Indicadores de Calidad de la Atención de Salud , Transferencia de Experiencia en Psicología , Femenino , Grupos Focales , Humanos , Cuidados a Largo Plazo , Masculino , Enfermeras y Enfermeros
13.
Disabil Rehabil ; 38(11): 1041-52, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26474116

RESUMEN

PURPOSE: The purpose of this study was to determine whether providing fall risk information to long-term care (LTC) nurses affects restraint use, activities of daily living (ADL), falls, and nurse fears about patient falls. METHODS: One-hundred and fifty LTC residents were randomized to a fall risk assessment intervention or care-as-usual group. Hypotheses were tested using analyses of variance and path analyses. RESULTS: Restraint use was associated with lower ADL scores. In the intervention group, there ceased to be significant relationships between nurse fears about falls and patient falls (after controlling for actual patient risk; post-intervention, nurse fears about falls were based on realistic appraisals), and between fears and restraints (i.e. unjustified nurse fears became less likely to lead to unjustified restraint use). No group differences in falls were identified. CONCLUSION: Despite a lack of group differences in falls, results show initial promise in potentially impacting resident care. Increasing intervention intensity may lead to fall reductions in future research. IMPLICATIONS FOR REHABILITATION: Given the high prevalence rates of falls in LTC and associated injuries, prevention programs are important. Nurse fears about patient falls may impact upon restraint use which, when excessive, can interfere with the patient's ability to perform ADL. Excessive restraint use, due to unjustified nurse fears, could also lead to falls. Providing accurate, concise information to nursing staff about patient fall risk may aid in reducing the association between unjustified nurse fears and the resulting restraint use that can have potential negative consequences.


Asunto(s)
Accidentes por Caídas/prevención & control , Hogares para Ancianos , Enfermeras y Enfermeros/psicología , Casas de Salud , Restricción Física , Anciano , Anciano de 80 o más Años , Actitud del Personal de Salud , Femenino , Evaluación Geriátrica/métodos , Enfermería Geriátrica/métodos , Humanos , Cuidados a Largo Plazo/métodos , Masculino , Evaluación en Enfermería/métodos , Evaluación de Procesos y Resultados en Atención de Salud , Restricción Física/métodos , Restricción Física/estadística & datos numéricos , Medición de Riesgo/métodos , Factores de Riesgo
14.
J Nurs Manag ; 24(3): 300-8, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26044745

RESUMEN

AIM: To study resilience among long-term care (LTC) nurses and its relationship to organisational empowerment, self-reported quality of care, perceptions of resident personhood (i.e. viewing another person as a person, implying respect) and absenteeism. BACKGROUND: Although resilience has been examined among nurses, it has not been studied in LTC nurses where resident rates of dementia are high, and nurses may experience stress affecting care and the way residents are perceived. METHOD: A sample of one hundred and thirty LTC nurses from across North America completed a series of questionnaires. RESULTS: Resilient nurses were more likely to report higher quality of care and to view residents as having higher personhood status (despite deteriorating cognitive function). Resilience was not predictive of absenteeism. Organisational empowerment did not add to the predictive power of resilience. CONCLUSIONS: Resilience is of importance in LTC nursing research and future studies could examine this construct in relation to objectively measured resident outcomes. IMPLICATIONS FOR NURSING MANAGEMENT: Our findings suggest that interventions to improve LTC staff resilience would be important to pursue and that consideration should be given to resilience in optimizing the match between potential staff members and LTC positions.


Asunto(s)
Absentismo , Cuidados a Largo Plazo , Enfermeras y Enfermeros/psicología , Atención de Enfermería/normas , Poder Psicológico , Resiliencia Psicológica , Adulto , Actitud del Personal de Salud , Femenino , Humanos , Masculino , Persona de Mediana Edad , América del Norte , Relaciones Enfermero-Paciente , Atención de Enfermería/psicología , Pruebas Psicológicas , Calidad de la Atención de Salud , Autoinforme , Encuestas y Cuestionarios
15.
Pain ; 156(5): 868-879, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25734999

RESUMEN

Although emotion regulation modulates the pain experience, inconsistencies have been identified regarding the impact of specific regulation strategies on pain. Our goal was to examine the effects of emotion suppression and cognitive reappraisal on automatic (ie, nonverbal) and cognitively mediated (ie, verbal) pain expressions. Nonclinical participants were randomized into either a suppression (n = 58), reappraisal (n = 51), or monitoring control (n = 42) condition. Upon arrival to the laboratory, participants completed the Emotion Regulation Questionnaire, to quantify self-reported suppression and reappraisal tendencies. Subsequently, they completed a thermal pain threshold and tolerance task. They were then provided with instructions to use, depending on their experimental condition, suppression, reappraisal, or monitoring strategies. Afterward, they were exposed to experimentally induced pain. Self-report measures of pain, anxiety, and tension were administered, and facial expressions, heart rate, and galvanic skin response were recorded. The Facial Action Coding System was used to quantify general and pain-related facial activity (ie, we defined facial actions that occurred during at least 5% of pain stimulation periods as "pain-related actions"). Reappraisal and suppression induction led to reductions in nonverbal and verbal indices of pain. Moreover, self-reported tendencies to use suppression and reappraisal (as measured by the Emotion Regulation Questionnaire) did not interact with experimental condition in the determination of participants' responses. Results suggest that consciously applying emotion regulation strategies during a painful task can moderate both cognitively mediated (e.g., verbal) and automatic (e.g., facial activity) expressions of pain.


Asunto(s)
Cognición , Emociones , Umbral del Dolor/psicología , Dolor/psicología , Adolescente , Adulto , Ansiedad/fisiopatología , Ansiedad/psicología , Expresión Facial , Femenino , Respuesta Galvánica de la Piel , Frecuencia Cardíaca , Humanos , Inhibición Psicológica , Masculino , Dolor/fisiopatología , Dimensión del Dolor/métodos , Umbral del Dolor/fisiología , Distribución Aleatoria , Autoinforme , Encuestas y Cuestionarios , Adulto Joven
16.
Arch Womens Ment Health ; 18(2): 209-219, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25109484

RESUMEN

Postpartum depression (PPD) afflicts up to 15 % of women following childbirth and negatively impacts both mother and child. Therapist-assisted internet cognitive behavior therapy (TAICBT) is a promising intervention for the treatment of PPD; however, women's perceptions of TAICBT have not been examined. Responses to 10 open-ended questions from 24 women who received TAICBT for PPD were thematically analyzed. The majority of women expressed that the TAICBT program afforded flexibility, accessibility, and convenience, as well as anonymity and privacy. Some participants described the program as helping them take a step in the right direction and enhance their self-awareness and parenting skills. Participants also described having the internet therapist individualize their treatment. Challenges related to the TAICBT program were also identified by a minority of participants including managing time to log onto the program, the fast pace, completion of homework around childcare duties, and challenges of not having a face-to-face therapist. Participants also made suggestions for future programming. The large majority of participants consistently described their internet therapist favorably; however, challenges related to the internet therapy were also identified. Results should be integrated in the development of future programming.


Asunto(s)
Terapia Cognitivo-Conductual/métodos , Depresión Posparto/terapia , Internet , Servicios de Salud Mental/organización & administración , Madres/psicología , Satisfacción del Paciente , Adulto , Depresión Posparto/diagnóstico , Depresión Posparto/psicología , Femenino , Humanos , Evaluación de Programas y Proyectos de Salud , Investigación Cualitativa , Autocuidado , Resultado del Tratamiento
17.
Genetics ; 197(4): 1123-36, 2014 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-24879463

RESUMEN

Telomere length is tightly regulated in cells that express telomerase. The Saccharomyces cerevisiae Ku heterodimer, a DNA end-binding complex, positively regulates telomere length in a telomerase-dependent manner. Ku associates with the telomerase RNA subunit TLC1, and this association is required for TLC1 nuclear retention. Ku-TLC1 interaction also impacts the cell-cycle-regulated association of the telomerase catalytic subunit Est2 to telomeres. The promotion of TLC1 nuclear localization and Est2 recruitment have been proposed to be the principal role of Ku in telomere length maintenance, but neither model has been directly tested. Here we study the impact of forced recruitment of Est2 to telomeres on telomere length in the absence of Ku's ability to bind TLC1 or DNA ends. We show that tethering Est2 to telomeres does not promote efficient telomere elongation in the absence of Ku-TLC1 interaction or DNA end binding. Moreover, restoration of TLC1 nuclear localization, even when combined with Est2 recruitment, does not bypass the role of Ku. In contrast, forced recruitment of Est1, which has roles in telomerase recruitment and activation, to telomeres promotes efficient and progressive telomere elongation in the absence of Ku-TLC1 interaction, Ku DNA end binding, or Ku altogether. Ku associates with Est1 and Est2 in a TLC1-dependent manner and enhances Est1 recruitment to telomeres independently of Est2. Together, our results unexpectedly demonstrate that the principal role of Ku in telomere length maintenance is to promote the association of Est1 with telomeres, which may in turn allow for efficient recruitment and activation of the telomerase holoenzyme.


Asunto(s)
Proteínas de Unión al ADN/metabolismo , Proteínas de Saccharomyces cerevisiae/metabolismo , Saccharomyces cerevisiae/genética , Telomerasa/metabolismo , Homeostasis del Telómero/genética , Telómero/metabolismo , ADN de Hongos/genética , Proteínas de Unión al ADN/genética , Procesamiento de Imagen Asistido por Computador , Hibridación Fluorescente in Situ , Regiones Promotoras Genéticas , Proteínas de Saccharomyces cerevisiae/genética , Telomerasa/genética
18.
J Biol Chem ; 289(15): 10308-10317, 2014 Apr 11.
Artículo en Inglés | MEDLINE | ID: mdl-24567323

RESUMEN

The Ku70-Ku80 ring complex encloses DNA ends to facilitate telomere maintenance and DNA break repair. Many studies focus on the ring-forming regions of subunits Ku70 and Ku80. Less is known about the Ku70 C-terminal tail, which lies outside the ring. Our results suggest that this region is responsible for dynamic sumoylation of Yku70 upon DNA association in budding yeast. Mutating a cluster of five lysines in this region largely eliminates Yku70 sumoylation. Chromatin immunoprecipitation analyses show that yku70 mutants with these lysines replaced by arginines exhibit reduced Ku-DNA association at both telomeres and internal DNA breaks. Consistent with this physical evidence, Yku70 sumoylation deficiency is associated with impaired ability to block DNA end resection and suppression of multiple defects caused by inefficient resection. Correlating with these, yku70 mutants with reduced sumoylation levels exhibit shorter telomeres, increased G overhang levels, and altered levels of non-homologous end joining. We also show that diminution of sumoylation does not affect Yku70 protein levels or its interactions with protein and RNA partners. These results suggest a model whereby Yku70 sumoylation upon DNA association strengthens Ku-DNA interaction to promote multiple functions of Ku.


Asunto(s)
Proteínas de Unión al ADN/genética , Proteínas de Unión al ADN/metabolismo , ADN/química , Proteínas de Saccharomyces cerevisiae/genética , Proteínas de Saccharomyces cerevisiae/metabolismo , Saccharomyces cerevisiae/genética , Reparación del ADN por Unión de Extremidades , Reparación del ADN , Regulación Fúngica de la Expresión Génica , Lisina/química , Mutación , Proteínas Nucleares/genética , Proteínas Nucleares/metabolismo , Fenotipo , Plásmidos/metabolismo , Unión Proteica , Estructura Terciaria de Proteína , Saccharomyces cerevisiae/metabolismo , Sumoilación , Telómero/ultraestructura
19.
Clin J Pain ; 30(9): 816-24, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-24281294

RESUMEN

OBJECTIVES: Our goal was to develop and validate, based on theoretical and empirical knowledge, the Pain Assessment Checklist for Seniors with Limited Ability to Communicate (PACSLAC-II), a shorter tool that would improve on the PACSLAC, while addressing limitations of the original version. METHODS: The PACSLAC was revised based on the relevant clinical and theoretical literature. Psychometric properties and clinical utility of the resulting 31-item PACSLAC-II were examined. Specifically, the PACSLAC-II was used to assess pain based on video footage of long-term care (LTC) residents with dementia undergoing painful procedures as part of routine care. Its ability to discriminate pain from non-pain-related states was compared with that of preexisting pain assessment tools using archival data. A second phase involved the use of the PACSLAC and PACSLAC-II by LTC staff to solicit feedback from health care providers. Mixed-methods analysis of this feedback was conducted. RESULTS: The PACSLAC-II demonstrated satisfactory reliability, excellent validity, and ability to differentiate between pain and nonpain states. The PACSLAC-II also accounted for unique variance in differentiating between pain and nonpain states, even after controlling for the preexisting tools combined, including the PACSLAC. The PACSLAC-II was also preferred by many LTC nurses and care aides, because of its length and condensed nature, which was thought to facilitate documentation and greater efficiency in pain management. DISCUSSION: Findings indicate that the empirical and theoretically driven revisions to the PACSLAC led to improved ability to differentiate between pain and nonpain states, while retaining its clinical utility.


Asunto(s)
Trastornos de la Comunicación/complicaciones , Dimensión del Dolor/métodos , Dolor/complicaciones , Dolor/diagnóstico , Anciano , Anciano de 80 o más Años , Demencia/complicaciones , Femenino , Personal de Salud , Humanos , Inyecciones/efectos adversos , Cuidados a Largo Plazo , Masculino , Persona de Mediana Edad , Movimiento , Pruebas Neuropsicológicas , Escalas de Valoración Psiquiátrica , Psicometría , Reproducibilidad de los Resultados , Grabación en Video
20.
Pain Manag Nurs ; 15(4): 748-59, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24157227

RESUMEN

An ongoing concern in long-term care (LTC) is that pain problems are often not identified correctly. There is also evidence that behavioral disturbance due to pain is misattributed to psychiatric conditions and consequently frequently treated with psychotropic rather than analgesic medication. This can result in unnecessary polypharmacy and ineffective pain management. In a previous study, implementation of a pain assessment protocol resulted in changes in administration of pro re nata (PRN) medications and positive outcomes. However, there were no changes in regularly scheduled medications suggesting that assessment results were either not communicated to the prescribing physicians or not taken into account. The goal of this study was to determine whether a pain assessment protocol, augmented with communication of the assessment results to the residents' physicians, affects prescriptions of analgesic and psychotropic medication. Psychotropic medication reduction would help address the problem of polypharmacy frequently seen in LTC facilities. PRN medications were also examined. This investigation involved a two group design (control vs. assessment). A mixed methods analysis included both quantitative and qualitative procedures. At the end of the study, residents in the pain assessment group were administered fewer psychotropic medications than patients in the control group, helping address the problem of polypharmacy. Pain levels were comparable between the groups. Health care staff indicated that the protocol resulted in more careful evaluation of residents' pain and greater appropriateness of prescriptions including reductions in polypharmacy.


Asunto(s)
Cuidados a Largo Plazo , Dolor/tratamiento farmacológico , Dolor/enfermería , Esquema de Medicación , Humanos , Investigación en Evaluación de Enfermería , Manejo del Dolor/enfermería
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