Integrable Atomtronic Interferometry.

High sensitivity quantum interferometry requires more than just access to entangled states. It is achieved through the deep understanding of quantum correlations in a system. Integrable models offer the framework to develop this understanding. We communicate the design of interferometric protocols for an integrable model that describes the interaction of bosons in a four-site configuration. Analytic formulas for the quantum dynamics of certain observables are computed. These expose the system's functionality as both an interferometric identifier, and producer, of NOON states. Being equivalent to a controlled-phase gate acting on 2 hybrid qudits, this system also highlights an equivalence between Heisenberg-limited interferometry and quantum information. These results are expected to open new avenues for integrability-enhanced atomtronic technologies.

Interacting bosons in a triple well: Preface of many-body quantum chaos.

Systems of interacting bosons in triple-well potentials are of significant theoretical and experimental interest. They are explored in contexts that range from quantum phase transitions and quantum dynamics to semiclassical analysis. Here, we systematically investigate the onset of quantum chaos in a triple-well model that moves away from integrability as its potential gets tilted. Even in its deepest chaotic regime, the system presents features reminiscent of integrability. Our studies are based on level spacing distribution and spectral form factor, structure of the eigenstates, and diagonal and off-diagonal elements of observables in relationship to the eigenstate thermalization hypothesis. With only three sites, the system's eigenstates are at the brink of becoming fully chaotic, so they do not yet exhibit Gaussian distributions, which resonates with the results for the observables.

[The first clinical use of an Dynamic Registration Tool for Navigation in FESS]. / Der erste klinische Einsatz einer dynamischen (Nach-) Registrierung für die Navigation in der FESS.

BACKGROUND: The effective register accuracy in an situs issues a challenge to the employment of instrument navigation in the ENT Surgery. The idea of the initially determined process Dynamic Registration Supply (DRS) is to improve the register accuracy by the automatic, and interoperability of the register. MATERIALS AND METHODS: The aim was to determine clinical use of DRS. Opto-electrical system Navigation Panel Unit, vs. 4.0.0 with the functionality DRS was used. Experiments were carried out on 95 patients who had so called FESS. The data of a control group were available to researchers. The measuring log includes among other things following parameters: retooling time, cutting-suture time, frequency of use of the navigated pointer, frequency of additional registration. RESULTS: At least once during the procedure DRS has been activated in 85 of 95 interventions (89.5). The time required increased by 15% accumulated 189 s per intervention. The most frequently used additional registration was in the region of sphenoid sinus. The surgeons underlined that out of 95 surveys in 75 cases the DRS rendered the instrument navigation more precise, while 1% of 93 cases considered this function as unwanted. CONCLUSION: The first clinical study for use of an automatic algorithm for recognition and reduction of faulty registration of a CT, navigation was successful. The findings suggest that by using automatic intraoperative registration DRS consisting inaccuracy can be reduced. In practice this means an efficient quality improvement of the Navigation.

The male bias in the number of Purkinje cells and the size of the murine cerebellum may require Müllerian inhibiting substance/anti-Müllerian hormone.

There is a male bias in the size of the cerebellum, with males, on average, having more Purkinje cells than females. The critical periods in cerebellum development occur when the immature testes secrete Müllerian inhibiting substance (MIS; synonym anti-Müllerian hormone) but only trace levels of testosterone. This suggests that the male bias in the cerebellum is generated by a different mechanism to the testosterone-sensitive reproductive nuclei. Consistent with this, in the present study, we report that Purkinje cells and other cerebella neurones express receptors for MIS, and that MIS(-/-) male mice have female-like numbers of Purkinje cells and a female-like size to other parts of their cerebellum. The size of the cell bodies of Purkinje cells was also dimorphic, although only a minority of this was a result of MIS. This suggests that MIS induces the initial male bias in the cerebellum, which is then refined by pubescent testosterone and/or other sex-specific factors.

Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas.

Y-receptor-knockout mice have become an important tool to elucidate specific physiological roles of individual Y-receptors. However, their phenotypes are not always confirmatory to results obtained by pharmacological investigations in vivo or in vitro. These discrepancies may, at least in part, be due to compensatory changes in the expression of remaining Y-receptor types. To determine whether deletion of individual Y-receptors results in altered mRNA expression and/or binding toward other Y-receptor types, we applied in-situ hybridization and radioligand-binding studies on brain slices of Npy1r-, Npy2r- or Npy5r-knockout mice. Significant changes were seen in Y1-receptor-deficient mice. Thus, Y2-receptor mRNA and (125)I-peptide YY(3-36) binding in the hippocampus proper were increased by up to 55% and 89%, respectively. Similar increases in (125)I-peptide YY(3-36) binding were observed in the caudo-dorsal extension of the lateral septum, an area heavily targeted by hippocampal projections and involved in Y1-receptor-regulated anxiety. Increased (125)I-peptide YY(3-36) binding and Y2-receptor mRNA levels were also observed in the medial amygdaloid nucleus. In contrast, (125)I-peptide YY(3-36) binding was reduced in the central amygdaloid nucleus. Y2-receptor mRNA in the intermediate part of the lateral septum was reduced by 42%. Only minimal changes were observed in Y2- or Y5-receptor-deficient mice. Our results demonstrate that compensatory changes in the expression of Y2-receptors occur in Y1-receptor-deficient mice. These adaptations are likely to contribute to changed physiological function. Thus, alterations in Y2-receptors have to be taken in account upon discussion of Y1-receptor function, especially in emotional aspects like anxiety and aggression, but also alcoholism.

[Outcome quality of psychosomatic rehabilitation: goal attainment scaling on the basis of a structured catalogue of therapy goals]. / Ergebnisqualität psychosomatischer Rehabilitation: Zielerreichungsskalierung auf der Basis einer strukturierten Therapiezielliste.

Within the scope of a multicenter study regarding the outcome quality of inpatient psychosomatic rehabilitation a structured catalogue of therapy goals (SZK, strukturierter Therapiezielkatalog) was developed. The catalogue contains 89 predetermined therapy goals as well as the option to formulate further goals in own words. The SZK is available both as a patient and as a therapist version. At the beginning of treatment up to five primary objectives are chosen from the list. At the end of treatment and at the 1-year follow-up the level of achievement of objectives is assessed. Moreover the SZK contains the option to mark goals as not relevant any more and to add goals which came up during the treatment and to evaluate them regarding the level of achievement. The study on hand asks for empirical identification of the target structure. Furthermore, reliability and validity of the calculated measures of goal attainment are analysed. As the most important finding the SZK turns out to be a practical and economical assessment instrument for goal-oriented evaluation.

[Severe hypoglycemia in diabetics with impaired renal function]. / Schwere Hypoglykämien bei Diabetikern mit eingeschränkter Nierenfunktion.

BACKGROUND AND OBJECTIVE: Reduction of renal function in patients with type 1 or type 2 diabetes is associated with a clearly increased risk of hypoglycemia. Main causes are an altered pharmacokinetics of insulin and oral antidiabetics and/or impaired renal glucose production. A knowledge of renal function is, therefore, essential for preventing hypoglycemia caused by antidiabetic treatment. But serum creatinine, most commonly used in general practice, is an imprecise indication of renal function. This investigation assessed the significance of a false estimation of renal function as a partial cause of severe hypoglycemia. PATIENTS AND METHODS: The study group consisted of 35 diabetics (21 females, 14 males; average age 61 years) who had been hospitalized because of an episode of severe hypoglycemia accompanied by loss of consciousness. Renal function was measured by serum creatinine and by creatinine clearance as calculated by the formula of Cockcroft and Gault. Also taken into account were HBA1c the antidiabetic treatment before and after discharge, and any additional medication. RESULTS: Impaired renal function was established by the serum creatinine level in 9 patients and by calculated creatine clearance in 24. Compared with patients with normal renal function, those with renal failure were older (74.3 vs. 32.8 years), had more rarely undergone intensive insulin treatment (5 of 24 vs. 9 of 11) and had more commonly received ACE inhibitors (10/24 vs. 1/11). The insulin dosage at discharge had been reduced in 16 off 22 insulin-dependent patients in renal failure, and long-acting sulfonylurea preparation were discontinued or changed to gliquidone in the others. CONCLUSION: This investigation indicates that false estimation of renal function from the level of serum creatinine is an important partial cause of hypoglycemia requiring treatment, especially in elderly persons with reduced muscle mass in whom renal function should be determined by calculating or measuring creatinine clearance.

[Individualized outcome measurement -- a comparison between prospective and retrospective problem marking in psychosomatic rehabilitation]. / Individuelle Ergebnismessung -- Vergleich zwischen prospektiven und retrospektiven Problemangaben in der psychosomatischen Rehabilitation.

This article reports on a questionnaire concerning individual problems in psychosomatic rehabilitation. A sample of 858 patients answered the questions at the beginning and on a one year catamnestic measurement. First, the frequency of occurrence of several symptoms was asked. Second, the rehabilitants were asked to indicate for each symptom if it was an important problem before treatment. This procedure of identifying problems was done at the beginning (prospective marking) and also at the one year follow up (retrospective marking). The questionnaire allows to compute eight subscales and one global scale regarding all items (classical approach). Frequency of occurrence decreased with an average effect size (ES) of 0.56 on the global scale. In the next step, measurement was individualized by regarding only items which were marked as relevant problem. By prospective marking, effect size was 1.32. By retrospective marking, no growth of effect size in comparison to the classical approach was found (ES = 0.56). The results indicate that the prospective approach of identifying problems is the better way of individualizing measurements. Moreover, the impact of individual problem definition on outcome was demonstrated.

Evidence for impaired glucose effectiveness in cirrhotic patients after liver transplantation.

To evaluate the impact of acute and chronic liver disease and single immunosuppression (cyclosporine A [CSA] or FK506) on insulin sensitivity and glucose effectiveness in liver-grafted patients, we performed a frequently sampled intravenous glucose tolerance test (FSIGTT) in nondiabetic patients after orthotopic liver transplantation (OLT) with acute liver failure ([ALF] group, n = 9, with CSA therapy), in patients after OLT with chronic liver disease (CSA group, n = 8; FK506 group, n = 8), and in 9 healthy control subjects. Insulin sensitivity and glucose effectiveness were determined by analyzing glucose and insulin data from the FSIGTT with Bergman's minimal model technique for glucose. The intravenous glucose tolerance index ([KG] ie, the slope of the regression of the logarithm of blood glucose concentration) was not different between the ALF group (2.17 +/- 0.16 min(-1)) and controls (2.29 +/- 0.13 min(-1)), but was lower (P < .05) in both groups with chronic liver disease (CSA group, 1.46 +/- 0.1; FK506 group, 1.61 +/- 0.11 min(-1)) compared with the ALF group (P < .05). A positive relation for the KG and glucose effectiveness was found in all liver-grafted patients and controls. Insulin sensitivity was not different between all liver-grafted patients and controls. The body mass index (BMI) was the overall determinant of insulin sensitivity in all groups. Single immunosuppressive therapy does not impair insulin sensitivity in liver-grafted patients. The lower glucose effectiveness in liver-grafted patients with chronic liver disease but not in patients after ALF points to a defect in the regulation of glucose-mediated glucose uptake in peripheral tissue.

[Long-term outcomes of psychosomatic rehabilitation]. / Langfristige Ergebnisse Psychosomatischer Rehabilitation.

According to the latest state of research psychosomatic rehabilitation can be considered as effective and efficient. Several program-evaluation studies document process and outcomes of over 4000 psychosomatic patients in rehabilitation clinics so far. The majority of patients in all studies show positive therapy outcomes, which also can be demonstrated in follow-up investigations. Those positive results cover disease and disorder related aspects as well as cost relevant facets. This paper presents one of those program-evaluation studies which reports the outcomes of a one year and a five year follow-up respectively. It focuses on the outcomes of those subjects which participated in both inquiries. In addition to single criteria the construction of a multiple outcome criterion is discussed.

The legacy of Friedrich Loeffler--the Institute on the Isle of Riems.

When starting the experiments on foot and mouth disease on the Isle of Riems in October 1910, Friedrich Loeffler could continue investigations that had been interrupted in 1907 by ministerial order. Loeffler's appointment to Berlin in 1913 and his sudden death in 1915 lead to the temporary cessation of work on the Riems. With high personal creativity and many years of seminal influence, Otto Waldmann carried Loeffler's ideas further, in the selection of themes and research strategy, making the Riems a world famous place of research. Some essential elements have determined life and research on the island for decades: the development of measures against epidemics, the conception of their application, the extension of research to new diseases of economic significance, the close contacts with the veterinary practice at all times, the presentation of results to experts and the stimulating discussions in the laboratory. I will try to briefly draw a bow covering the decades of different social conditions to the present and to suggest that Loeffler's ideas, which have been improved with the years, can affect many a current decision, even though differentiated individually.

[Evaluation of psychosomatic treatment--results of a catamnestic study]. / Evaluation psychosomatischer Heilverfahren--Ergebnisse einer Katamnesestudie.

The authors report first results of a program evaluation (n = 560) in a psychoanalytically oriented psychosomatic clinic. Based on a naturalistic design, the study includes three points of measurement (beginning and end of treatment, 1-year follow-up) at which data were collected from patients and therapists. The article gives an overview of the general issues involved as well as of the methodological procedure and presents some catamnestic subjective and cost-relevant singular outcome criteria.

[Evaluation of change by patients and staff and specialist physicians in psychosomatic rehabilitation--a catamnestic comparison]. / Veränderungsbeurteilungen von Patienten und von Haus- und Fachärzten nach psychosomatischer Rehabilitation--Ein katamnestischer Vergleich.

Considering three single outcome criteria reflecting the change of a) physical state, b) general condition and c) ability to work catamnestic ratings of patients and of external doctors are compared. The ratings were assessed by questionnaires 12 months after the end of inpatient psychosomatic treatments ("direct measurement of change"). Mayor findings are: a) the judgements of both data sources indicated positive change or improvement for a majority of patients, b) the ratings of the external doctors were more favourable than the patients' self-ratings, c) moderate but statistically significant correlations between the ratings of the two groups of judges were to be observed. From a more methodological point of view it will be attempted to analyze the meaning of these correlations somewhat more in detail.

Application of microbiological cancer test to cattle infected with bovine leucosis virus.

A microbiological cancer test, previously verified in men and dogs using a clostridium strain (Clostridium butyricum CNRZ 528), was applied to cattle infected with bovine leucosis virus (BLV). An extended period of time was allowed to pass after infection with BLV, which had been checked up through specific serological and virological examinations. The cattle belonged to different age groups and stages of infection (with and without haematological alterations [preleukosis], with incipient tumour development [swelling of externally visible and palpable lymph nodes]). Controls included BLV-infected cows as well as test animals to which isotonic saline had been applied or healthy BLV-free cattle in which the clostridium strain had been used. The serological investigation was carried out in a blind test. 3 of 6 BLV-infected spore-treated heads of cattle responded positively to the cancer test, while the other 3 were negative. The 3 cows with positive cancer test were haematologically and serologically leucosis-positive animals with clinically detectable enlargement of lymph nodes. The 3 negative ones of this group, also serologically and haematologically leucosis-positive, were younger animals without signs of tumorous process. 3 spore-treated BLV-free cows and 2 BLV-infected animals, treated with isotonic saline, were cancer test-negative, as well. Finally, 4 BLV-infected and 2 BLV-free cattle, all of them without spore injection, were completely cancer test-negative. 1 cow of the BLV-infected group did not produce spore antibodies after spore treatment, while 1 cow of the BLV-free untreated control group developed spore antibodies.

[Cost-benefit analysis of the control and cure of enzootic bovine leukosis, described in the example of a selected territory]. / Kosten-Nutzen-Analyse zur Bekämpfung und Sanierung der enzootischen Rinderleukose, dargestellt am Beispiel eines ausgewählten Territoriums.

Severe economic damage had been inflicted upon numerous industrialised dairy farms by enzootic bovine leucosis in a selected region with predominance of stepwise production. Initial contamination at the beginning of control action and sanitation had been as high as 98 percent. The annual damage, in monetary terms, had been 3,205,041. - Marks, according to calculations. Now, after eleven years of control and sanitation, eradication of enzootic bovine leucosis has come into sight. Even during these eleven years, control action yielded a benefit of 19,005,451. - Marks, that is 1,727,768.20 Marks per annum or 69. - Marks per cow and annum. It will be possible in forthcoming years to bring the cost factor down and, consequently, to further increase the benefit.

[Immunization of young cattle with gp51 of the bovine leukosis virus and the subsequent experimental infection]. / Immunisierung von Jungrindern mit gp51 des bovinen Leukosevirus und nachfolgender Testinfektion.

Calves were immunised by means of a native Al(OH)3-absorbed gp51-preparation which had been obtained from a foetal lamb kidney cell line, following bovine leucosis virus (BLV) infection. 9 animals were immunised 3 times, using 300 micrograms gp51. 7 animals underwent test infection, using 2.5 x 10(3) or 2.5 x 10(4) BLV-infected lymphocytes. Serological and virological reactions of all animals, including 3 calves which had received only test infections, were followed up through 40 weeks by means of immunodiffusion test, enzyme-immuno-assay, gp51 antibody radio-immuno-assay, reverse transcriptase test, syncytial test, competitive p24 radio-immuno-assay, and by transmission of whole blood in animal experiments. The results obtained from virological testing showed that 1 animal had been protected by preceding immunisation. 4 in 7 immunised and test-infected animals exhibited transient BLV values, between the 7th and 16th weeks from infection. Typical leucosis infection had been induced to 2 animals. The above findings are discussed and are compared to similar results recorded by other working groups.

[Satisfaction with inpatient management. Development of a questionnaire and initial validity studies]. / Zufriedenheit mit der stationären Versorgung. Entwicklung eines Fragebogens und erste Validitätsuntersuchungen.

In Germany methodologically reliable procedures to assess patients satisfaction with inpatient health care are almost totally missing. With reference to the well known American CSQ-Questionnaire (Attkisson et al.) a 17-items questionnaire (to assess satisfaction) was developed and presented to a sample of 300 patients undergoing inpatient treatment within a psychosomatic clinic (the rate of responding was about 80%). With a concise form of the questionnaire (Zuf-8, 8 items) an economical and reliable test-instrument is presented in this paper to measure general satisfaction, which also was investigated in regard to item- and factor analysis. This method seems suitable for measuring patient satisfaction with inpatient psychosomatic treatment. The investigated scales of satisfaction show a statistically significant correlation with additionally obtained patient characteristics. This inquiry also suggests that it might be rewarding to pursue the often neglected phenomenon of questionnaires filled out incomplete as an indicator of latent dissatisfaction.

[The reasons for the occurrence of non-specific reactions in the immunodiffusion test for enzootic bovine leukosis]. / Zu Ursachen für das Auftreten unspezifischer Reaktionen im Immundiffusionstest bei enzootischer Rinderleukose.

A batch of enzootic bovine leucosis antigen earmarked for immunodiffusion testing exhibited unspecific responses to cattle sera, which prompted an investigation of the underlying causes. Evidence was produced, for the first time ever, that such reactions were attributable to an antigen-antibody reaction caused by Mycoplasma arginini.

[Retroviruses. Problems in electron microscopic diagnosis]. / Retroviren. Probleme bei der elektronenmikroskopischen Diagnostik.

A department of electron microscopy with specialisation in virus diagnosis evaluates the results concerning retrovirus findings. In the course of research work already classified retroviruses were observed, numerous unexpected retrovirus diagnoses being of special interest. This concerned exclusively to ultra-thin sections of permanent and immune cells. Expounded in this paper are principles by which examiners should abide in any case. Reference is also made to the importance of individual findings.