[Image analysis system for detection facial paralysis]. / Bildanalysesystem zur Erkennung einer Fazialisparese.

BACKGROUND: Evaluation of facial nerve paresis depends on visual assessment and naturally differs from examiner to examiner. An objective measurement instrument is presented. PATIENTS AND METHOD: Facial features are automatically localized by a parametric face model in videos of a face during relaxation and exercises. Gray-level information is analyzed by a special steerable filter and used to identify symmetries. The computer system was tested in 19 individuals. RESULTS: Automatic localization of facial features such as the upper arc of the head and ears was correct in 95%, the eyes in 82%, and the mouth in 73%. Lid paresis was correctly recognized in seven of ten (70%) and oral paresis in 10 of 12 (83%) cases. Unaffected eyelid movements were identified in eight of nine (89%) and healthy oral regions in all seven (100%) cases. CONCLUSION: The computer system presented is able to automatically localize facial features and to identify facial nerve paresis. It is a considerable step toward automatic and objective grading of facial nerve paresis.

A threshold-like measure for the assessment of olfactory sensitivity: the "random" procedure.

Many tests of olfactory dysfunction are either too complex, too expensive, or too time-consuming to be of use in routine clinical testing. Thus, the present multicenter study was undertaken to investigate a new approach, the so-called "random" test. In this test different concentrations of citronellal and phenyl ethyl alcohol are applied according to a pre-established order; patients are asked to identify the odor if possible. The test score is the sum of correctly identified odors. Test administration takes about 10 min. Two studies were performed. Basic characteristics of the test were explored in experiment 1 in 176 healthy subjects (76 male, 100 female; age 12-85 years, mean age 30 years), namely test-retest reliability, correlation with other measures of olfactory sensitivity, and sensitivity of the test to differences in age and gender. In the second experiment the test was tried in 97 patients (45 male, 52 female; age 19-78 years, mean age 47 years) in a clinical environment to investigate its usefulness in diagnosing olfactory loss. The "random"-test was found (1) to exhibit a test-retest reliability similar to that reported for established measures of olfactory function (r = 0.71; P < 0.001), (2) to correlate with other measures of olfactory sensitivity (0.82 > r > 0.60; P < 0.001), (3) to differentiate between expected differences in olfactory sensitivity in relation to gender (t > 2.602, P < 0.011), and (4) to discriminate between different degrees of olfactory loss (F > 36.6, P < 0.001). Based on these data, and the fact that the new test requires little time and is easy to use, this approach can be expected to suit clinical needs.

Enlarged middle fossa vestibular schwannoma surgery: experience with 735 cases.

OBJECTIVE: To show the clinical outcome in patients with sporadic vestibular schwannoma (VS) operated on by the enlarged middle cranial fossa approach (EMFA). STUDY DESIGN: Retrospective case review. SETTING: A tertiary referral center with four neurotologists experienced in EMFA surgery. PATIENTS: There were 376 women and 359 men, with a mean age of 51.1 years (range, 12-77). INTERVENTION: Enlarged middle cranial fossa approach surgery. MAIN OUTCOME MEASURES: Magnetic resonance imaging and computed tomography scans were used for follow-up and re-evaluation of the operative sites. Facial nerve function and hearing were tested. RESULTS: Overall complete VS removal was achieved in 97.1% of patients. There were two recurrences (0.3%) after microscopically complete tumor removal. Depending on the tumor size, postoperative normal and near-normal facial outcome ranged from 83% to 99% (average, 92%), and hearing at or near the preoperative level (+/-15 dB pure-tone average or +/-15% speech discrimination) was preserved in 60.2%, 48.2%, 23.9%, and 17.6%, respectively. CONCLUSIONS: The EMFA is an excellent low-morbidity approach for VS removal with limited cerebellopontine angle extension (2 cm). Specific advantages of the EMFA are the superior internal auditory canal exposure, resulting in an extremely low tumor recurrence rate; best capability for hearing preservation; and minimal incidence of cerebrospinal fluid leaks. Postoperative facial function outcome compares with that of other surgical approaches. The best results are achieved in subjects with small tumors and good hearing, advocating early diagnosis and treatment.

Surface vs intramuscular laryngeal electromyography.

PURPOSE: To compare surface and intramuscular laryngeal electromyography (EMG) with adductor pollicis muscle EMG after 0.1 mgxkg(-1) cisatracurium. METHODS: This prospective study included ten patients undergoing surgery with risk of damage to the recurrent laryngeal nerve (RLN). The tracheas were intubated after fentanyl/propofol without the aid of muscle relaxation. A surface laryngeal electrode was attached to the tube and placed amidst the vocal cords; two straight needles were inserted endoscopically into the left lateral cricoarytenoid muscle. Single twitch stimulation of the left RLN (0.1 Hz) was performed transcutaneously; skin EMG of the left adductor pollicis muscle was performed at 0.1 Hz. After supramaximal stimulation for 10 min, 0.1 mgxkg(-1) cisatracurium was injected. Lag, onset time and peak effect were measured and compared. RESULTS: Good correlation (r = 0.9, 0.8, P < 0.005) and good comparability of the two methods of laryngeal EMG (mean difference and limits of agreement: 0 +/- 28 sec for lag time, -2 +/- 84 sec for onset time) was shown. The mean surface laryngeal lag and onset times were 67 +/- 22 sec and 198 +/- 72 sec, compared with the adductor pollicis muscle (98 +/- 30 sec and 242 +/- 59 sec) at P < 0.01. Peak effects at larynx (92 +/- 9%) and adductor pollicis muscle (95 +/- 3%) were similar. CONCLUSION: Surface laryngeal EMG is comparable to intramuscular laryngeal EMG to determine degree and onset of the neuromuscular blockade. Increasing muscle relaxation does not cause the surface electrode to lose contact with the vocal cords and therefore underestimate onset time and peak effect.

Bilateral mucosa-associated lymphoid tissue lymphoma of the parotid gland.

Mucosa-associated lymphoid tissue (MALT) tumors of the parotid gland are extranodal non-Hodgkin lymphomas. Stage I and II MALT tumors are usually treated with surgery or radiotherapy. Bilateral MALT-derived non-Hodgkin lymphoma of the parotid glands is rare, and optimal treatment is debatable. Two patients presented at the otorhinolaryngology department of the Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany. The treatment strategy that was used in case 1 was also successfully used in case 2. A precise diagnosis could not be made by either fine-needle biopsy or intraoperative frozen section biopsy; it was achieved with open biopsy. Surgery and/or radiotherapy proved to be effective. There was no recurrence of disease in either case. The advantages of surgery are complete resection of the tumor and absence of xerostomia and mucositis, which are caused by irradiation. Radiotherapy does not produce a scar or an indentation at the parotid region, however, and results in a better cosmetic appearance. Therefore, we recommend open biopsy with facial nerve monitoring and subsequent irradiation in cases in which bilateral prominence of the parotid glands and suspicion of a MALT lymphoma are both present.

[Electrophysiological diagnosis of the caudal cranial nerves]. / Elektrophysiologische Diagnostik der kaudalen Hirnnerven.

The lower cranial nerves (CN. IX-XII) are responsible for the nerve supply of the pharyngolaryngeal region. Loss of innervation is manifested by dysphagia, aspiration, altered speech production, dyspnea and/or stridor, and visible loss of movement. In general electrophysiological testing should be applied in every kind of paresis. Beside standard equipment for electromyography limited special equipment is necessary. Examination under local anaesthesia is possible and can serve as a basis for therapeutic consequences. In this article general aspects as seen from an oto-rhino-laryngological standpoint are presented.

[Idiopathic facial paralysis]. / Die idiopathische Fazialisparese.

Although acute idiopathic facial paresis is often labelled "Bell's palsy", historical studies show that Nicolaus Anton Friedreich (1761-1836) from Würzburg was the first physician to describe the typical symptoms of the disorder in 1797, approximately 24 years prior to the paper published by Sir Charles Bell. Diagnostics has now improved to the extent that acute idiopathic facial palsy can more frequently be assigned to etiologies caused by inflammatory disorders. Herpes simplex virus type I and Borrelia burgdorferi are particularly relevant. Underestimation of the degree of paresis is, particularly in children, a drawback of the clinical examination. "Incomplete eyelid closure" is not a reliable indicator of remaining nerve function. For this reason complete electromyography (EMG) is recommended in all cases of severe facial paresis. Since electroneurography does not reliably reflect the degree of denervation present, needle EMG is preferred. The therapy of the facial palsy of unclear etiology is still not well defined. Nevertheless, we recommend that a combined treatment should be used early, at least in patients with disfiguring pareses. Combinations may consist of cortisone, virostatic agents and hemorrheologic substances and possibly antibiotics. Surgical decompression of the facial nerve remains controversial, since positive surgical results lack statistical support. Individual instructions for facial exercises, massage and muscle relaxation can support rehabilitation and possibly reduce the production of pathological synkinesia. Electrical stimulation should not be used. There are a number of possibilities available to reduce the effects of misdirected reinnervation, especially the use of botulinum-A-toxin. However, intensive diagnosis and therapy in the early phase of paresis are decisive in obtaining a favorable outcome. Further refinements in rehabilitation and comparative multicenter controlled studies are still required for future improvements in affected patients.

The value of methylprednisolone in the treatment of an experimental sensorineural hearing loss following drill-induced ossicular chain injury: a randomized, blinded study in guinea-pigs.

In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.

[Electromyography study and follow-up of bilateral recurrent laryngeal nerve paralysis after thyroid gland operations]. / Elektromyographische Untersuchung und Verlaufsbeobachtung von beidseitigen Rekurrensparesen nach Schilddrüsenoperationen.

Bilateral recurrent laryngeal nerve (RLN) palsies result in dyspnea and often require further surgery to secure an adequate airway for safe respiration. The present study was devised to determine a predictive value of laryngeal electromyography (LEMG) and if it has therapeutic consequences. In a retrospective study of 63 patients with bilateral recurrent laryngeal nerve palsies after thyroid gland surgery we compared the results of LEMG from the thyroarytenoid muscles with the spontaneous recovery rate of vocal cord mobility. A tracheostomy had to be performed in 18 patients because of unsafe dyspnea, while a unilateral lateral cord fixation had to be carried out in 20 patients. Primary thyroidectomies as treatment for benign goiters showed spontaneous normalization of unilateral or bilateral vocal cord mobility in 75% of cases versus 36% after revision thyroidectomies. Single LEMG correctly predicted prognosis in 78% of patients. In all, LEMG was found to be of value in the assessment of bilateral recurrent laryngeal nerve palsies. Findings also showed that a lateral cord fixation should be planned after a 9-month waiting period. When a patient refuses a tracheostomy lateral cord fixation can be performed at an earlier time, with the use of repeated LEMGs to predict whether or not a corrective surgery.

Experimental sensorineural hearing loss following drill-induced ossicular chain injury.

In a guinea pig model, a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. Drilling resulted in a threshold shift within seconds, and after 15 min it averaged 35.7 dB for clicks, 35 dB nHL for 4 kHz bursts, 36.7 dB nHL for 6 kHz bursts and 39 dB nHL for 8 kHz bursts. The deterioration of the threshold shift remained stable throughout the 5-week post-operative observation period. In five animals a disarticulation of the incudostapedial joint was performed prior to drilling, but this did not reduce the threshold shift. Caution is mandatory during drilling around an intact ossicular chain to avoid a permanent sensorineural hearing loss, and disarticulation of the incudostapedial joint prior to drilling has no protective value.

'Sniffin' sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold.

'Sniffin' Sticks' is a new test of nasal chemosensory performance based on pen-like odor dispensing devices. It comprises three tests of olfactory function, namely tests for odor threshold (n-butanol, testing by means of a single staircase), odor discrimination (16 pairs of odorants, triple forced choice) and odor identification (16 common odorants, multiple forced choice from four verbal items per test odorant). After extensive preliminary investigations the tests were applied to a group of 104 healthy volunteers (52 female, 52 male, mean age 49.5 years, range 18-84 years) in order to establish test-retest reliability and to compare them with an established measure of olfactory performance (the Connecticut Chemosensory Clinical Research Center Test, CCCRC). Performance decreased with increasing age of the subjects (P < 0.001). Coefficients of correlation between sessions 1 and 2 were 0.61 for thresholds, 0.54 for discrimination and 0.73 for identification. Butanol thresholds as obtained with the CCCRC increased as a function of age; this relation to the subjects' age was not found for the CCCRC odor identification task. The test-retest reliability for CCCRC thresholds was 0.36, for odor identification it was 0.60. It is concluded that 'Sniffin' Sticks' may be suited for the routine clinical assessment of olfactory performance.

Prognostic Factors Including Proliferation Markers Ki-67, bax, and bcl-2 in Temporal Bone Paraganglioma.

Valuable criteria with which to predict the clinical behavior of the temporal bone paraganglioma or the response to treatment are lacking. The analysis of markers of cell proliferation is a possibility to estimate the prognosis. Extensive patient data on 40 temporal bone paragangliomas were gathered over the years and correlated with the data obtained by staining histologic sections with bcl-2, bax, and MIB I markers of cellular proliferation. The immunohistochemistry was in all cases negative for bcl-2, positive for bax, and for Ki-67 positive in 20% of tumors. The scores for Ki-67 did not correlate with the majority of clinical parameters, except for treatment modality, preoperative hearing loss, and cranial nerve involvement. The tendency toward poorer hearing and a higher incidence of preoperative lower cranial nerve palsies was demonstrated in patients with higher Ki-67 scores. Furthermore, the higher rate of subtotal tumor removals in these patients reveals technical difficulties in accomplishing a radical removal, although the incidence of residual tumors was thus not affected. In view of the present information obtained with proliferation markers, the site of tumor origin still remains the most predictive variable for the course of the disease.

[Function preserving surgery of glomus jugulare tumors. An achievable goal?]. / Funktionserhaltende Chirurgie von Glomus-jugulare-Tumoren. Ein realisierbares Ziel?

In this retrospective study, oncologic and functional results of 24 patients treated for glomus jugulare tumor stages C and D are reported. The surgical approach used was a combined transmastoid-transcervical approach, which was modified according to individual tumor growth. As needed, this was combined with a transtemporal or retrosigmoid approach. Complete tumor removal resulted in a cure rate of 100%. Surgically induced cranial nerve palsies developed in 38% of the patients. In 54% of cases it was possible to retain middle ear function. Seven patients had incomplete tumor removal requiring postoperative irradiation, with tumor progression occurring in 2 patients. Radical tumor removal was modified by efforts to reduce mutilating resections. These results show that individually tailored and combined multidirectional surgical approaches can allow total tumor removal to be performed with lower morbidity.

Endonasal endoscopic surgery for rhinogen intraorbital abscess: a report of six cases.

Intraorbital abscess is a serious complication of sinusitis with the danger of permanent loss of vision and even the danger of life-threatening progress. The recommended surgical procedure in the literature for drainage of an intraorbital abscess is the external approach. We report on successful functional endonasal endoscopic surgery in a series of six sequential cases with intraorbital abscesses following sinusitis. The main advantages of this approach are the simultaneous treatment of causative disorders with surgery following the pathogenic route of the abscess formation and lack of trauma to further structures. The endoscope with 25- or 70-degree angled axis of vision enables the surgeon to explore and drain the abscess cavity, which often is located behind the bulbus, with minimal trauma. For the trained surgeon the field of vision is favorable as compared with the external approach when the abscess is located right in the axis of vision and one has to cut through healthy tissue and the intact skin, which, especially in children, can lead to long-lasting visible scars.

[Pneumolabyrinth. Radiologic sign of perilymph fistula]. / Pneumolabyrinth. Radiologisches Indiz einer Perilymphfistel.

Post-traumatic cochleo-vestibular symptoms can be caused by peri-lymph fistulas, although these cannot be proven preoperatively in most cases by direct clinical examination. A rare case of a traumatic burst fracture of the promotory wall with a consequent perilymph fistula is presented. A preoperative computed tomographic finding of air in the basal turn of the cochlea and superior semicircular canal (pneumolabyrinth) is a reliable sign of perilymph fistula and justifies operative exploration for closure of the fistula. High-resolution computer tomographic imaging of the petrous bones in patients with post-traumatic cochleo-vestibular disturbances is mandatory.

[Electrode applicator for endolaryngeal electromyography of the larynx with local anesthesia]. / Elektrodenapplikator für die endolaryngeale Kehlkopfmyographie in Lokalanästhesie.

Electromyography of the internal laryngeal muscles is not yet a routine examination. To improve the technique, we developed a new applicator for easy and safe endolaryngeal placement of electrodes, which is now routinely used. Application of the electrodes is successful in a higher percentage of patients than with applicator forceps used previously. Additionally, the danger of displacement of needles within the pharynx or larynx and of injury of the mucosa has been completely eliminated. This application technique can be recommended for endolaryngeal placement of wire electrodes for laryngeal electromyography.