RESUMEN
The challenges and difficulties associated with conventional drug delivery systems have led to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug delivery of proteins and peptides to the lungs is complicated owing to the large size and polar characteristics of the latter. Nevertheless, the pulmonary route has attracted great interest today among formulation scientists, as it has evolved into one of the important targeted drug delivery platforms for the delivery of peptides, and related compounds effectively to the lungs, primarily for the management and treatment of chronic lung diseases. In this review, we have discussed and summarized the current scenario and recent developments in targeted delivery of proteins and peptide-based drugs to the lungs. Moreover, we have also highlighted the advantages of pulmonary drug delivery over conventional drug delivery approaches for peptide-based drugs, in terms of efficacy, retention time and other important pharmacokinetic parameters. The review also highlights the future perspectives and the impact of targeted drug delivery on peptide-based drugs in the coming decade.
Asunto(s)
Portadores de Fármacos/química , Pulmón/metabolismo , Péptidos/administración & dosificación , Proteínas/administración & dosificación , Administración por Inhalación , Animales , Portadores de Fármacos/administración & dosificación , Humanos , Pulmón/efectos de los fármacos , Enfermedades Pulmonares/tratamiento farmacológico , Nanopartículas/administración & dosificación , Nanopartículas/química , Péptidos/uso terapéutico , Proteínas/uso terapéuticoRESUMEN
A GA-based privacy preserving utility mining method is proposed to find appropriate transactions to be inserted into the database for hiding sensitive high utility itemsets. It maintains the low information loss while providing information to the data demanders and protects the high-risk information in the database. A flexible evaluation function with three factors is designed in the proposed approach to evaluate whether the processed transactions are required to be inserted. Three different weights are, respectively, assigned to the three factors according to users. Moreover, the downward closure property and the prelarge concept are adopted in the proposed approach to reduce the cost of rescanning database, thus speeding up the evaluation process of chromosomes.
