Validating the AI-assisted second language (L2) learning attitude scale for Chinese college students and its correlation with L2 proficiency.

The positive impact of Artificial Intelligence (AI) on second language (L2) learning is well-documented. An individual's attitude toward AI significantly influences its adoption. Despite this, no specific scale has been designed to measure this attitude, particularly in the Chinese context. To address this gap, our study aims to construct the AI-Assisted L2 Learning Attitude Scale for Chinese College Students (AL2AS-CCS) and evaluate its reliability, validity, and relationship with L2 proficiency. Our research comprises two phases, each involving separate samples. In Phase One (Sample 1: n = 379), we conducted exploratory factor analysis (EFA) to determine the factor structure of the AL2AS-CCS. The resulting two-factor structure consists of 12 items, categorized into cognitive and behavioral components. In Phase Two (Sample 2: n = 429), we performed confirmatory factor analysis (CFA) to validate the factor structure and assess model fit. CFA in Sample 2 confirmed the factor structure and demonstrated a good model fit. Additionally, the AL2AS-CCS exhibited high criterion validity, internal consistency, and cross-gender invariance. Our findings suggest that the AL2AS-CCS is a valid measurement tool for assessing Chinese college students' attitude toward AI-assisted L2 learning. Moreover, Chinese college students were discovered to maintain a moderately positive attitude toward AI-assisted L2 learning. Additionally, a positive correlation was identified between this attitude and their L2 proficiency.

Genome-wide identification, characterization and expression profiling of TLR family genes in Chromileptes altivelis.

Toll-like receptors (TLRs) represent a prominent category of pattern recognition receptors that have been extensively investigated for their pivotal role in combating pathogen incursions. Despite this, there has been a notable absence of comprehensive identification and exploration of the immune response associated with the TLR family genes in C. altivelis. This study successfully identified and named fourteen genes as Catlr1-1, Catlr1-2, Catlr2-1, Catlr2-2, Catlr3, Catlr5, Catlr7, Catlr8, Catlr9, Catlr13-1, Catlr13-2, Catlr18, Catlr21, and Catlr22. A series of bioinformatic analysis were performed, encompassing analysis of protein properties, examination of gene structures, evolutionary assessments, and prediction of protein tertiary structures. The expression patterns of Catlr genes were analyzed in five immune tissues: liver, spleen, kidney, gill, and intestine, in both healthy and bacterial stimulated-fish. The results showed that different tissue and different genes showed differed expression patterns after V. harveyi infection, indicating the involvement of all Catlr members in mounting immune responses following infection in various tissues. Additionally, histological evaluations of immune tissues unveiled varying levels of damage. In conclusion, this investigation into the TLR gene family offers novel information that contribute to a more profound comprehension of the immune response mechanisms in C. altivelis.

Exploring the Impact of a Supportive Work Environment on Chinese L2 Teachers' Emotions: A Partial Least Squares-SEM Approach.

Second language (L2) teachers' emotions can influence their well-being and students' performance. However, most of the existing studies have focused on the role of individual factors in affecting L2 teachers' emotions, while leaving environmental factors underexplored. To fill this gap, this study aimed to examine how the four dimensions of a supportive work environment (SWE) (perceived climate, PC; supervisory relationship, SR; peer group interaction, PGI; and perceived organization support, POS) relate to L2 teachers' emotions (enjoyment, anxiety, pride, and anger). A sample of 406 Chinese L2 teachers completed two valid scales to measure their SWE and emotions. The data were analyzed by Partial Least Squares-Structural Equation Modeling (SEM) using Smart PLS 3 software. The results showed that (1) PC, PGI, and POS had a positive and significant effect on enjoyment, while SR had no significant effect; (2) PGI and POS had a negative and significant effect on anxiety, while PC and SR had no significant effect; (3) PGI had a positive and significant effect on pride, while the other three dimensions had no significant effect; and (4) POS had a negative and significant effect on anger, while the other three dimensions had no significant effect. The study concludes with some implications for L2 teachers' education.

The Chinese Adaptation and Validation of the Adolescents' Ageism Toward Older Adults Scale.

Objectives: The purpose of this study was to translate and validate the adolescents' ageism toward older adults scale (AGES) in the Chinese cultural context and examine its psychometric properties among Chinese adolescents. Methods: The study consists of two phases with two separate samples. In phase one (sample 1: n = 407), exploratory factor analysis (EFA) is conducted to determine the factor structure of the C-AGES. In phase two (sample 2: n = 379), confirmatory factor analysis (CFA) is performed to confirm the factor structure and assess the model fit of the C-AGES. Results: EFA reveals a two-factor structure consisting of 17 items for the C-AGES. CFA in sample 2 confirms the factor structure and demonstrates good model fit. The C-AGES also exhibits high criterion validity, internal consistency, and cross-gender invariance. Discussion: The results suggest that the C-AGES is a valid measurement tool for assessing agism among Chinese adolescents.

Unveiling Chinese senior high school EFL students' burnout and engagement: Profiles and antecedents.

Burnout impairs English as a foreign language (EFL) learning, while engagement enhances it. However, most relevant studies have focused on college students, neglecting senior high school students. To address this gap, this mixed-methods study used two scales to assess the levels of burnout and engagement among 1234 Chinese senior high school EFL students. We also applied a person-centered approach with a statistical software (Mplus 8.7) to identify their latent profiles. Then, we conducted semi-structured interviews with 30 students and analyzed the data using thematic analysis with a qualitative software (MAXQDA 2022) to investigate the antecedents of their burnout and engagement. The statistical analysis revealed three profiles: high burnout-low engagement (16.0 %), moderate burnout-moderate engagement (61.8 %), and low burnout-high engagement (22.2 %). The profiles were associated with demographic characteristics such as gender, age, and grade. The thematic analysis identified four major antecedents: high academic stress and low academic support for burnout, and high external support and high internal support for engagement. Each major antecedent consisted of several categories and subcategories. This study could inform the design of effective interventions to reduce Chinese EFL students' burnout and increase their engagement.

Positive emotions, self-regulatory capacity, and EFL performance in the Chinese senior high school context.

Previous research on English as a foreign language (EFL) learning has predominantly focused on negative emotions such as anxiety and boredom, neglecting positive emotions. Self-regulation, a cognitive factor, has emerged as a key construct of positive psychology in recent years. However, few studies have examined the mechanisms by which positive emotions influence EFL performance, especially through cognitive factors. Given the high-stakes nature of Chinese college entrance examination and Chinese culture's value on effort, Chinese senior high school students may experience distinct EFL emotions. Therefore, this study, based on the control-value theory (CVT), explored the potential mediating role of self-regulatory capacity (boredom, awareness, goal, and emotion controls) in the relationship between the three focal positive emotions (enjoyment, hope, and pride) and EFL performance among Chinese senior high school students. A paper-and-pencil questionnaire survey was administered to 330 Chinese third-year senior high school students (male: n = 159; female: n = 171). The data were analyzed using descriptive statistics, correlation analysis, and mediation analysis with SPSS 26 and PROCESS V3.3. The results indicated that the students reported low levels of enjoyment and pride, moderate levels of hope, low levels of awareness, goal, and emotion controls, and moderate levels of boredom control. The results also revealed significant and large associations among the three positive emotions, the four components of self-regulatory capacity, and EFL performance. Furthermore, the results suggested that self-regulatory capacity partially mediated the effect of positive emotions on EFL performance, supporting the CVT framework. The study concluded with implications for educators and suggestions for future research.

The Chinese adaptation and validation of the Fear of Being Single Scale for college students.

The Fear of Being Single Scale (FOBS) is a widely used measure of the fear of being single, but its applicability to Chinese populations has not been established. This study aimed to translate the FOBS into Chinese and examine its psychometric properties among Chinese college students. The study consisted of three phases with three samples (total n = 1768). In the first phase (Sample 1: n = 571), an exploratory factor analysis (EFA) supported a unidimensional structure with 6 items for the Chinese version of the FOBS (C-FOBS). In the second phase (Sample 2: n = 692), a confirmatory factor analysis (CFA) validated the factor structure and indicated good model fit. The C-FOBS also demonstrated good internal consistency, split-half reliability, criterion validity, and cross-gender invariance. In the third phase (Sample 3: n = 505), the C-FOBS showed acceptable test-retest reliability over a two-week interval. The results suggest that the C-FOBS is a reliable and valid instrument for assessing the fear of being single among Chinese college students.

Exploring the Relationship Between Intolerance of Uncertainty and Trust in Physicians from Spousal and Parent-Child Perspectives.

Objective: The present study aimed to probe the intergenerational transmission of intolerance of uncertainty (IU) and trust in physicians. Besides, through the actor-partner interdependence model (APIM), the predictive effect of parents' IU on their own and their spouses' trust in physicians was examined. A mediation model was further constructed to probe the mechanisms by which parents' IU affects children's trust in physicians. Methods: The Intolerance of Uncertainty Scale-12 (IUS-12) and the Wake Forest Physician Trust Scale (WFPTS) were employed to conduct the questionnaire survey among 384 families (each family with a father, mother, and one child). Results: IU and trust in physicians were found to be intergenerationally transmitted. The results of the APIM analyses showed that fathers' total IUS-12 scores negatively predicted their own (ß = -0.419, p < 0.01) and mothers' (ß = -0.235, p < 0.01) total WFPTS scores. Mothers' total IUS-12 scores negatively predicted their own (ß = -0.353, p < 0.01) and fathers' (ß = -0.138, p = 0.017) total WFPTS scores. The results of mediation analyses indicated that parents' total WFPTS scores and children's total IUS-12 scores mediated the effect of parents' total IUS-12 scores on children's total WFPTS scores. Conclusion: The public's IU is a crucial influencing factor of their trust in physicians. Besides, the IU between couples and between parents and children could be mutually affected. On the one hand, husbands' IU could affect their own and their wives' trust in physicians, and vice versa. On the other hand, parents' IU and trust in physicians could affect their children's IU and trust in physicians, respectively.

Evaluation of Glutamine Utilization in Patients With Sickle Cell Disease.

Glutamine (Gln) was FDA-approved in 2017 to reduce acute sickle cell disease (SCD) pain and acute chest syndrome. However, typical pediatric patients with SCD exhibit moderate adherence, measured by a medication possession ratio <80%. This study examined Gln utilization in a "real-world" clinical setting to determine factors influencing medication adherence and to characterize the impact of an interdisciplinary team approach at an institution with specialty pharmacy services. A retrospective chart review identified 40 patients prescribed Gln by sickle cell specialists over a 2-year period and met selection criteria. Gln medication possession ratio for pediatric (72%) and adult (76%) patients were higher than other SCD medications. Pediatric patients (74%) demonstrated significantly lower first-attempt insurance approval rate compared with adult patients (95%) ( P =0.0026), suggesting an initial access barrier for pediatric patients. Pediatric patients demonstrated significantly higher number of medication fills (9.11 fills) compared with adult patients (3.86 fills) ( P =0.007), which suggests interdisciplinary collaboration may facilitate sustainable management of a new therapy. The majority of pediatric (89%) and adult (90%) patients reported high satisfaction with Gln ("excellent") with minor or no side effects. Multidisciplinary health care provider collaborations and tracking medication adherence metrics can help address barriers to care for SCD patients.

A comparative study of self-praise on English and Chinese social media: strategies, themes, and motivations.

The act of self-praise, a novel and prevalent discourse pattern on social media across different cultures, is still understudied. As such, this study delves into self-praise from linguistic and psychological perspectives by examining and comparing the strategies, themes, and motivations of self-praise on English and Chinese social media. A discourse-based analysis of the data comprising 200 posts from Twitter (English) users and 200 posts from Weibo (Chinese) users revealed that Twitter users favored more unmodified explicit self-praise strategies, while Weibo users opted for more implicit self-praise strategies. Both groups employed explicit self-praise equally, but with different sub-strategies. The most prevalent themes were appearance, competence/performance, skills, virtues, and self-encouragement. Appearance was more dominant among Twitter users, whereas skills and self-encouragement were more popular among Weibo users. Both groups valued competence/performance and virtues, but with different virtues. Twitter users valued cherishing friendship, bravery, and maturity, whereas Weibo users stressed kindness, cherishing kinship, and thoughtfulness. Two semi-structured interviews conducted with six Twitter participants and six Weibo participants indicated that the motivations for online self-praise in both groups were psychological needs such as self-flattery, self-presentation, and self-encouragement, while commercial profit was a motivation only for Weibo participants. This study also discusses the social and cultural factors that may account for these differences and provides implications for future research on online self-praise.

Relationship between Chinese middle-aged and old couples' Confucian coping thinking and marital quality.

Objective: Drawing on the actor-partner interdependence model (APIM), the present study investigated the relationship between Chinese middle-aged and old couples' Confucian coping thinking and their marital quality in the hope to provide a theoretical basis for ameliorating marital quality. Methods: With 744 middle-aged and old couples as participants, the Confucian Coping Questionnaire (CCQ) and the Quality of Marriage Index (QMI) were employed to probe the relationship between responsibility thinking (RT), pro-setback thinking (PT), fate thinking (FT), and marital quality. Results: Husbands' and wives' scores in responsibility thinking and pro-setback thinking had significantly positive correlations with their own and their spouses' scores in marital quality, respectively, and husbands' and wives' scores in fate thinking had significantly negative correlations with their own and their spouses' marital quality, respectively. Husbands' responsibility thinking, pro-setback thinking, and fate thinking had a significant actor effect. Husbands' responsibility thinking and fate thinking had a significant partner effect. Wives' responsibility thinking, pro-setback thinking, and fate thinking had a significant actor effect. Wives' responsibility thinking and pro-setback thinking had a significant partner effect. Conclusion: From the perspective of dyadic relationships, the present study found that responsibility thinking and pro-setback thinking could positively predict marital quality, while pro-setback thinking could negatively predict marital quality.

A qualitative analysis of control-value appraisals, positive achievement emotions, and EFL performance in a Chinese senior high school context.

Based on the control-value theory (CVT), this study qualitatively investigated the relationship between control-value appraisals, achievement emotions (mainly enjoyment, pride, and hope), and English-as-a-foreign-language (EFL) performance, and explored other antecedents of achievement emotions in addition to control-value appraisals. Data were collected from six Chinese high school students through two semi-structured interviews and one focus group discussion. With thematic analysis, data were analyzed under the framework of the CVT using NVivo 11.0. Results indicate that high perceived control, high perceived extrinsic, and intrinsic values were interactively associated with enjoyment, pride, and hope. Low perceived control, high perceived extrinsic value, and low perceived intrinsic value were interactively associated with fewer positive achievement emotions (only hope) and more negative achievement emotions like fear. High perceived control, high perceived extrinsic value, and low perceived intrinsic value were interactively associated with fewer positive achievement emotions (only pride), and more negative achievement emotions like anguish. Besides, positive achievement emotions were positively associated with EFL performance, while negative achievement emotions were negatively associated with EFL performance. Moreover, factors inside the classroom, factors outside the classroom, and personal factors were found to be the antecedents of achievement emotions in EFL learning.

Patient Toward Physician Occupational Stigma Scale: Development of the Chinese Version.

Background/Objective: Physicians' occupational stigma could eradicate physician-patient trust, threatening physicians' social status and occupational reputation. Hitherto, there has been no scale obtaining good psychometric properties to assess patients' stigma toward physicians. The present study aimed to develop the Patient toward Physician Occupational Stigma Scale (PPOSS) and examine its reliability and validity. Methods: The questionnaire comprising sociodemographic information and the PPOSS were employed to survey 645 Chinese patients in two phases. In Sample 2, the Wake Forest Physician Trust Scale (WFOTS), the Intolerance of Uncertainty Scale-12 (IUS-12), and the Brief Illness Perception Questionnaire (BIPQ) were tested. Results: The PPOSS includes 19 items subsumed into three dimensions of stereotype, discrimination, and prejudice. According to the results of confirmatory factor analysis (CFA), the three-factor model fitted well (χ2/df=2.065, RMSEA=0.057, SRMR=0.045, RFI=0.904, CFI=0.956, IFI=0.956, PNFI=0.779, PCFI=0.811). The PPOSS was significantly negatively correlated with the WFOTS, and significantly positively correlated with the IUS-12 and the BIPQ. The Cronbach's alpha coefficients for the total scale and each dimension were between 0.87 and 0.94, and the split-half reliability coefficients were between 0.84 and 0.93. Besides, the PPOSS had the measurement invariance across gender. Conclusion: With its satisfactory psychometric properties, the PPOSS can be used as an effective instrument to assess patients' stigma toward physicians.

Facile Synthesis of Monodispersed Titanium Nitride Quantum Dots for Harmonic Mode-Locking Generation in an Ultrafast Fiber Laser.

As a member of the transition metal nitride material family, titanium nitride (TiN) quantum dots (QDs) have attracted great attention in optical and electronic fields because of their excellent optoelectronic properties and favorable stability. Herein, TiN QDs were synthesized and served as a saturable absorber (SA) for an ultrafast fiber laser. Due to the strong nonlinear optical absorption characteristics with a modulation depth of ~33%, the typical fundamental mode-locked pulses and harmonics mode-locked pulses can be easily obtained in an ultrafast erbium-doped fiber laser with a TiN-QD SA. In addition, at the maximum pump power, harmonic mode-locked pulses with a repetition rate of ~1 GHz (164th order) and a pulse duration of ~1.45 ps are achieved. As far as we know, the repetition rate is the highest in the ultrafast fiber laser using TiN QDs as an SA. Thus, these experimental results indicate that TiN QDs can be considered a promising material, showing more potential in the category of ultrafast laser and nonlinear optics.

Long-term effects of a community-based positive youth development program for Black youth: health, education, and financial well-being in adulthood.

BACKGROUND: Childhood poverty is known to be associated with poor health. For youth living in extreme poverty, community-based programs focused on youth development are one strategy to improve health and well-being outcomes. However, very few evaluations of the long-term effectiveness of youth development programs have been conducted. The aim of this study was to assess the long-term effectiveness of a positive youth development program (PYD), serving a segregated housing project with a history of community violence, to improve the health, education, and financial well-being of its alumni. METHODS: A quasi-experimental causal comparative study design was used to study the effectiveness of the Cabrini-Green Youth Program (CGYP). CGYP alumni (mean: 16.8 +/- 7.4 years after program participation) were surveyed. For comparison, participants from the same housing project who were eligible to participate in the CGYP but did not, were identified. RESULTS: In total, 246/417 (59%) eligible alumni were located. 221 alumni were available to be interviewed; 191/221 (86%) completed the interview survey along with 143 in the comparison group. Both groups self-identified as being Black, African American, and of Other race. Alumni were younger (34.6 vs. 38.1 years, p < .001), less likely to be female (62% vs. 74%, p =.03), and more likely to have been abused as a child (26% vs. 11%, p = .001). The majority in both groups reported to be in good to excellent health (83% of alumni vs. 74% of comparison group). After adjusting for comparison group differences, alumni were more likely to have completed college, 24% vs. 12% (adjusted odds ratio (aOR) 2.47, 95% CI, 1.25-4.86), and to end up with some money at the end of the month, 35% vs. 19% (aOR 2.16, 95% CI, 1.17, 3.97). CONCLUSIONS: Participation in a PYD program starting at a young age may be associated with reduced poverty in adulthood, possibly aided by higher educational attainment and resultant increased income. PYD may be an effective strategy to supplement evidenced-based poverty reducing policies. This study of a voluntary, community-based PYD program is unique in its up to 33-year follow-up and an outcome assessment that measures more than knowledge change.

Vaso-occlusive Pain Crisis Mimicking Mandibular Abscess in an Adolescent with Sickle Cell Disease.

In people with sickle cell disease (SCD), oral abscesses are concerning clinical conditions and carry a high risk of postoperative sickle cell complications. We present an unusual case of a 14-year-old girl with SCD whose initial presentation of facial swelling, headaches, jaw pain, and paresthesia mimicked an odontogenic abscess. She was diagnosed with vaso-occlusive crisis in the mandibular bone and successfully managed noninvasively. This is among the youngest cases of paresthesia in the lower lip in SCD, which provided a clue that postponing invasive aspiration or biopsy was possible under empiric antibiotics and close observation.

YBX3 Mediates the Metastasis of Nasopharyngeal Carcinoma via PI3K/AKT Signaling.

The metastasis of nasopharyngeal carcinoma (NPC) is a complex process associated with oncogenic dysfunction, the deciphering of which remains a challenge and requires more in-depth studies. Y-box protein 3 (YBX3) is a DNA/RNA binding protein associated with gene transcription, DNA repair, and the progression of various diseases. However, whether and how YBX3 affects the metastasis of NPC remains unknown. Thus, in this study, we aimed to investigate the role of YBX3 in the metastasis of NPC and determine its underlying mechanism. Interestingly, it was found that the expression of YBX3, which was associated with NPC metastasis, was upregulated in the clinical NPC tissues and cell lines. Moreover, we found that knockdown of YBX3 expression by lentivirus shRNA significantly suppressed NPC cells migration in vitro and metastasis in vivo. Mechanistically, RNA sequencing results suggested that the genes regulated by YBX3 were significantly enriched in cell adhesion molecules, cAMP signaling pathway, calcium signaling pathway, focal adhesion, PI3K/AKT signaling pathway, Ras signaling pathway, Rap1 signaling pathway, NF-κB signaling pathway, and Chemokine signaling pathway. Of these, PI3K/AKT signaling pathway contained the most genes. Accordingly, YBX3 knockdown decreased the activation of PI3K/AKT signaling pathway, thereby inhibit epithelial-to-mesenchymal transition (EMT) and MMP1. These results have demonstrated that YBX3 are involved in the metastasis of NPC through regulating PI3K/AKT signaling pathway, and serve as a potential therapeutic target for patients with NPC.

Identification of differentially expressed circular RNAs in human nasopharyngeal carcinoma.

BACKGROUND: Circular RNAs (circRNAs) are endogenous RNAs that have a covalent closed cycle configuration. circRNAs have been found to be differentially expressed in many human cancers. Therefore, circRNAs may be ideal biomarkers for the diagnosis and treatment of cancer. However, we know very little about the function of circRNAs in nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the circRNA expression profiles in NPC. METHODS: We utilized high-throughput RNA sequencing (RNA-Seq) to evaluate the circRNA expression profile in NPC A total of 13,561 unique circRNA candidates were detected. Selection of aberrantly expressed circRNAs was carried out using a q-value of < 0.001 with a fold change of > 2.0 or < 0.5. We carried out Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses to identify the biological functions of differentially expressed circRNAs. Moreover, bioinformatics analyses were implemented to predict the effects between circRNAs and cancer-related microRNAs (miRNAs), and we used Cytoscape to build a cancer-related circRNA-miRNA target gene map. Finally, to verify dysregulated circRNAs, quantitative real-time PCR was utilized. RESULTS: In NPC tissues, we found that 73 circRNAs were downregulated and 59 were upregulated. The top 12 candidate circRNAs were selected from several vital NPC pathways such as the human papillomavirus and Epstein-Barr virus infection signaling pathways (hsa05165 and hsa05169, respectively), Hepatitis B (hsa05161), and the Ras signaling pathway (hsa04014). A network map of circRNA-miRNA interactions of 12 differentially expressed circRNAs was built. Hsa_circ_0007637 expression distinguished NPC tissues from paired healthy tissues and NPC cell lines (HNE1 6-10B, 5-8F, CNE-2, and so on) from a normal epithelial (NP460) cell line. CONCLUSIONS: In this study, we investigated the profiles of differentially expressed circRNAs in NPC, and our results show that hsa_circ_0007637 may be a biomarker for NPC and play a role in its development. This observation-based research identified dysregulated circRNAs in NPC, which may assist in the development of biomarkers for this disease. Further studies on the mechanisms and functions of these circRNAs may promote our understanding of NPC tumorigenesis.