RESUMEN
BACKGROUND: Oral squamous cell carcinoma in minors is considered to be a distinct entity from OSCC in older patients, with an uncertain etiology. Human papillomavirus (HPV) infection may trigger the initiation and promote the progression of OSCC, but these roles have not been firmly established.We aimed to explore the correlation between HPV infection and the development of oral squamous cell carcinoma in minors and know the characteristics of OSCC in young patients more thoroughly. METHOD: From January 2013 to December 2022,6 cases of OSCC aged < 15 years were selected from the Department of Oral Pathology, Peking University School of Stomatology, Beijing, China. All cases underwent testing for high-risk HPV mRNA infection using the RNA scope technique, and immunohistochemical staining was performed to investigate the expression of p16, pan-cytokeratin (CK), CK5/6, CK7, CK8/18, epidermal growth factor receptor (EGFR), p53, and Ki-67. Furthermore, we reviewed the literature on OSCC in patients aged < 21 years. CONCLUSIONS: Minors OSCC is associated with HPV infection, and that p16 can serve as an immunohistochemical marker of HPV positivity.
Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Infecciones por Papillomavirus , Humanos , Anciano , Carcinoma de Células Escamosas de Cabeza y Cuello , Carcinoma de Células Escamosas/patología , Neoplasias de la Boca/patología , Infecciones por Papillomavirus/complicaciones , Infecciones por Papillomavirus/epidemiología , Incidencia , Papillomaviridae/genética , ADN Viral/genética , Inhibidor p16 de la Quinasa Dependiente de Ciclina/genéticaRESUMEN
With the development of flexible devices, the demand for wearable power sources has increased and gradually become imperative. Zinc-air batteries (ZABs) have attracted lots of research interest due to their high theoretical energy density and excellent safety properties, which can meet the wearable energy supply requirements. Here, the flexibility of energy storage devices is discussed first, followed by the chemistries and development of flexible ZABs. The design of flexible electrodes, the properties of solid-state electrolytes (SSEs), and the construction of deformable structures are discussed in depth. The researchers working on flexible energy storage devices will benefit from the work.
RESUMEN
High-speed trains have a large amount of ancillary equipment, which is suspended from the underside of the train by means of a suspension structure. Due to the large mass of the ancillary equipment, the suspension structure is subjected to various loads during train operation and there is a risk of fatigue failure. In this paper, the stress distribution at the suspension point and the lo-cation of the maximum stress point under load are investigated in detail based on actual test loads at the suspension point and finite element simulation analysis. In order to further investigate the fracture failure of the suspension points, experimental studies were carried out. Firstly, static strength tests were carried out to obtain the load-displacement curves of the structural members and to determine the fracture strength of the structure based on the displacement sensors, and secondly, fatigue tests at different stress levels were carried out to obtain the load-life curves of the structural members and to investigate the probabilistic load-life curves at different reliability levels. The test results show that the structural component has a high fracture strength of 65kN, while the conditional fatigue strength is relatively low, corresponding to a load level of 12.5kN at a median life of 106 cycles. The above research work provides the necessary basis for the design, optimization and reliability assessment of the suspension structures of high-speed trains.