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1.
Sci Rep ; 14(1): 14024, 2024 Jun 18.
Artículo en Inglés | MEDLINE | ID: mdl-38890344

RESUMEN

In the construction of tunnels under existing stations, it is necessary to control their settlement. When there is a pile foundation in the existing station, the pile cutting has a significant impact on the settlement of the existing station. To determine the influence of existing piles on the settlement of subway stations, a reasonable pile-cutting time is proposed. Based on the Chengdu Metro Line 9 underpassing the existing Line 1 hatchery station, the settlement law of the tunnel underpassing the existing Line 1 station is analysed via a numerical simulation. Furthermore, the deformation and stress characteristics of the existing piles, pipe roofs, and tunnel linings and the supporting effect on the existing station are discussed. It is concluded that the cutting of existing piles causes a change in the tunnel bearing system, thus resulting in a certain deformation of the station. The influence of different pile cutting times on the settlement of the existing station is then analysed, and it is clarified that the tunnel support stiffness is significantly enhanced after the construction of the secondary lining. At this time, the settlement of the existing pile station is significantly reduced. Finally, through a field investigation, the effect of surface grouting, pipe shed, and multilayer lining on the settlement control of the existing station while the existing pile foundation exists is determined. This research can provide a reference for the settlement control and foundation underpinning of existing stations at ultra-small distances in underground excavation tunnels.

2.
Eur J Nutr ; 63(5): 1759-1769, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38622294

RESUMEN

PURPOSE: The available evidence regarding the role of fruit and vegetable consumption in the development of colorectal polyps remains inconclusive, and there is a lack of data on different histopathologic features of polyps. We aimed to evaluate the associations of fruit and vegetable consumption with the prevalence of colorectal polyps and its subtypes in a high-risk population in China. METHODS: We included 6783 Chinese participants aged 40-80 years who were at high risk of colorectal cancer (CRC) in the Lanxi Pre-colorectal Cancer Cohort (LP3C). Dietary information was obtained through a validated food-frequency questionnaire (FFQ), and colonoscopy screening was used to detect colorectal polyps. Dose-response associations of fruit and vegetable intake with the prevalence of polyps were calculated using multivariate-adjusted regression models, which was reported as odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: 2064 cases of colorectal polyps were ascertained in the LP3C during 2018-2019. Upon multivariable adjustments, including the diet quality, fruit consumption was inversely associated with the prevalence of polyps (P trend = 0.02). Participants in the highest tertile of fruit intake had a 25% lower risk (OR: 0.75; 95% CI 0.62‒0.92) compared to non-consumers, while vegetable consumption had no significant association with polyp prevalence (P trend = 0.86). In terms of colorectal histopathology and multiplicity, higher fruit intake was correlated with 24, 23, and 33% lower prevalence of small polyps (OR: 0.76; 95% CI 0.62‒0.94; P trend = 0.05), single polyp (OR: 0.77; 95% CI 0.62‒0.96; P trend = 0.04), and distal colon polyps (OR: 0.67; 95% CI 0.51‒0.87; P trend = 0.003), respectively. CONCLUSIONS: Fresh fruit is suggested as a protective factor to prevent colorectal polyps in individuals at high risk of CRC, and should be underscored in dietary recommendations, particularly for high-risk populations.


Asunto(s)
Pólipos del Colon , Neoplasias Colorrectales , Dieta , Frutas , Verduras , Humanos , Persona de Mediana Edad , Femenino , Masculino , China/epidemiología , Anciano , Prevalencia , Dieta/métodos , Dieta/estadística & datos numéricos , Estudios de Cohortes , Adulto , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/prevención & control , Pólipos del Colon/epidemiología , Factores de Riesgo , Anciano de 80 o más Años , Pueblos del Este de Asia
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