Correction: Development of a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells.

Correction for 'Development of a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells' by Yan Zhang et al., Chem. Commun., 2020, 56, 8952-8955, DOI: 10.1039/D0CC03134H.

Development of a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells.

We developed a new strategy to sensitively detect transcription factors (TFs) based on the integration of a bidirectional isothermal exponential amplification reaction (EXPAR) with endonuclease IV (endo IV)-assisted cycle digestion of signal probes. This assay exhibits ultrahigh sensitivity with a detection limit of 1.29 × 10-14 M, and it can measure endogenous NF-κB p50 in HeLa cell extracts. Moreover, this strategy can be applied to screen TF inhibitors and detect other TFs by simply changing the TF-binding sequence.