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BACKGROUND: Migraine, a widespread neurological condition, substantially affects the quality of life, particularly for adolescents and young adults. While its impact is significant, there remains a paucity of comprehensive global research on the burden of migraine in younger demographics. Our study sought to elucidate the global prevalence, incidence, and disability-adjusted life-years (DALYs) associated with migraine in the 15-39 age group from 1990 to 2021, utilizing data from the Global Burden of Disease (GBD) 2021 study. METHODS: Our comprehensive study analyzed migraine data from the GBD 2021 report, examining the prevalence, incidence, and DALYs across 204 countries and territories over a 32-year span. We stratified the information by age, sex, year, geographical region, and Socio-demographic Index (SDI). To evaluate temporal trends in these metrics, we employed the estimated annual percentage change (EAPC) calculation. RESULTS: Between 1990 and 2021, the worldwide prevalence of migraine among 15-39 year-olds increased substantially. By 2021, an estimated 593.8 million cases were reported, representing a 39.52% rise from 425.6 million cases in 1990. Global trends showed increases in age-standardized prevalence rate, incidence rate, and DALY rate for migraine during this period. The EAPC were positive for all three metrics: 0.09 for ASPR, 0.03 for ASIR, and 0.09 for DALY rate. Regions with medium SDI reported the highest absolute numbers of prevalent cases, incident cases, and DALYs in 2021. However, high SDI regions demonstrated the most elevated rates overall. Across the globe, migraine prevalence peaked in the 35-39 age group. Notably, female rates consistently exceeded male rates across all age categories. CONCLUSION: The global impact of migraine on youths and young adults has grown considerably from 1990 to 2021, revealing notable variations across SDI regions, countries, age groups, and sexes. This escalating burden necessitates targeted interventions and public health initiatives, especially in areas and populations disproportionately affected by migraine.
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Carga Global de Enfermedades , Salud Global , Trastornos Migrañosos , Humanos , Trastornos Migrañosos/epidemiología , Adolescente , Adulto Joven , Adulto , Masculino , Femenino , Carga Global de Enfermedades/tendencias , Prevalencia , Salud Global/estadística & datos numéricos , Incidencia , Años de Vida Ajustados por Calidad de Vida , Años de Vida Ajustados por Discapacidad/tendenciasRESUMEN
A nonlinear Tomlinson-Harashima precoding (NTHP) scheme has been verified for its capability to effectively address both the linear and nonlinear inter-symbol interferences (ISIs) arising in the intensity-modulation direct-detection (IM-DD) fiber optics transmission. Nevertheless, the application of the NTHP scheme may significantly increase the number of levels for the intensity modulated signals, resulting in the reduction of both eye width and receiver sensitivity. Here, we propose a fractionally spaced NTHP with a weight clustering (FS-NTHP-WC) scheme. Consequently, an accurate ISI feedback can be obtained to enlarge the eye width; meanwhile a hardware-efficient implementation without the equalization penalty can be achieved by weight clustering and pruning. When the C-band 100â Gbaud/λ PAM-4 signals are transmitted, our proposed FS-NTHP-WC scheme not only can achieve 0.25â dB and 0.5â dB gains of receiver sensitivity under back-to-back (B2B) and 2-km standard single-mode fiber (SSMF) transmission conditions, respectively, but can also cut down the computational complexity by 90% and 76% in terms of the number of multiplications and additions, respectively, in comparison with the NTHP scheme.
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We propose a high-speed multimode fiber short-reach optical interconnect system based on a Kramers-Kronig (KK) field reconstruction with the mode division multiplexing (MDM) and polarization division multiplexing (PDM) technology. In this work, the LP01, LP21a, LP21b, and LP02 modes are selected as independent channels to carry information. The demonstration achieved the 800â Gb/s net data rate per wavelength with a bit-rate-distance-product (BDP) of 8â Tb/s·km. To the best of our knowledge, this is the highest experimental record of a single wavelength BDP over the SMMF with KK detection. In addition, we discuss the system performance after all multiple-input multiple-output (MIMO) and partial MIMO processing and give guidance on the trade-off between system performance and computational resource.
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The performance of high-speed intensity modulation direct detection (IM-DD) transmissions is severely degraded due to the occurrence of multipath interference (MPI), especially when a higher-order modulation format is utilized. Here, we propose and demonstrate, for the first time to the best of our knowledge, that a Nyquist subcarrier modulation (Nyquist-SCM) format inherently exhibits resistance to the MPI. We experimentally evaluate the MPI tolerance by transmitting 56â Gbit/s PAM-4 signals and Nyquist-SCM 16QAM signals over the 2â km standard single-mode fiber (SSMF) when the C-band semiconductor laser with a linewidth of 1.7â MHz is utilized. In comparison with the PAM-4 format, the Nyquist-SCM 16QAM format can lead to an enhanced MPI tolerance of 4â dB at the KP4-FEC threshold of BER = 2 × 10-4. In addition, even with the help of MPI mitigation for the PAM-4 signals based on two newly reported methods, the utilization of Nyquist-SCM 16QAM signal can still guarantee an improved MPI tolerance of 1â dB.
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BACKGROUND: Accumulating evidence suggests a pivotal role of vitamin B2 in the pathogenesis and progression of prostate cancer (PCa). Vitamin B2 intake has been postulated to modulate the screening rate for PCa by altering the concentration of prostate-specific antigen(PSA). However, the relationship between vitamin B2 and PSA remains indeterminate. Hence, we conducted a comprehensive evaluation of the association between vitamin B2 intake and PSA levels, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database. METHODS: From a pool of 20,371 participants in the NHANES survey conducted between 2003 and 2010, a cohort of 2,323 participants was selected for the present study. The male participants were classified into four distinct groups based on their levels of vitamin B2 intake. We employed a multiple linear regression model and a non-parametric regression method to investigate the relationship between vitamin B2 and PSA levels. RESULTS: The study cohort comprised of 2,323 participants with a mean age of 54.95 years (± 11.73). Our findings revealed a statistically significant inverse correlation between vitamin B2 intake (mg) and PSA levels, with a reduction of 0.13 ng/ml PSA concentration for every unit increase in vitamin B2 intake. Furthermore, we employed a fully adjusted model to construct a smooth curve to explore the possible linear relationship between vitamin B2 intake and PSA concentration. CONCLUSIONS: Our study in American men has unveiled a notable inverse association between vitamin B2 intake and PSA levels, potentially posing a challenge for the identification of asymptomatic prostate cancer. Specifically, our findings suggest that individuals with higher vitamin B2 intake may be at a greater risk of being diagnosed with advanced prostate cancer in the future, possibly indicating a detection bias. These results may offer a novel explanation for the observed positive correlation between vitamin B2 intake and prostate cancer.
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Encuestas Nutricionales , Antígeno Prostático Específico , Neoplasias de la Próstata , Riboflavina , Humanos , Masculino , Antígeno Prostático Específico/sangre , Persona de Mediana Edad , Estados Unidos/epidemiología , Anciano , Neoplasias de la Próstata/sangre , Neoplasias de la Próstata/epidemiología , Riboflavina/administración & dosificación , AdultoRESUMEN
We propose a rapid and precise scheme for characterizing the full-field frequency response of a thin-film lithium niobate-based intensity modulator (TFLN-IM) via a specially designed multi-tone microwave signal. Our proposed scheme remains insensitive to the bias-drift of IM. Experimental verification is implemented with a self-packaged TFLN-IM with a 3â dB bandwidth of 30â GHz. In comparison with the vector network analyzer (VNA) characterization results, the deviation values of the amplitude-frequency response (AFR) and phase-frequency response (PFR) within the 50â GHz bandwidth are below 0.3â dB and 0.15â rad, respectively. When the bias is drifted within 90% of the Vπ range, the deviation fluctuation values of AFR and PFR are less than 0.3â dB and 0.05â rad, respectively. With the help of the full-field response results, we can pre-compensate the TFLN-IM for the 64â Gbaud PAM-4 signals under the back-to-back (B2B) transmission, achieving a received optical power (ROP) gain of 2.3â dB. The versatility of our proposed full-field response characterization scheme can extend to various optical transceivers, offering the advantage of low cost, robust operation, and flexible implementation.
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The fulfilment of the adiabatic criterion is indispensable for the realization of a low-loss photonic lantern (PL), concurrently imposing a stringent restriction on the taper transition length of the PL. Here, by relaxing the adiabatic criterion, a low-loss and compact PL based on a step-index double cladding fiber (SI-DCF) is theoretically proposed and experimentally demonstrated. The use of SI-DCF can reduce the mode field diameter (MFD) expansion ratio during the tapering processing and greatly decrease the taper transition length required for adiabatic tapering. We initially evaluate the variation of both MFD and effective refractive index (RI) along the fiber tapering based on three types of fiber structures, including the modified standard single-mode fiber (SSMF), the graded-index fiber (GIF), and the proposed SI-DCF. In comparison with the commonly used fiber geometry, the SI-DCF can reduce the MFD expansion ratio from 77.73% to 38.81%, leading to more than half reduction of the tapering length for both 3-mode and 6-mode PLs. Then, two kinds of SI-DCF with different core diameters are fabricated to realize a 3-mode PL. The fabricated PL possesses a 1.5â cm tapering length and less than 0.2â dB insertion loss (IL). After splicing with the commercial few-mode fiber, the PL has an average IL of 0.6â dB and more than 13â dB LP11 mode purity over the C-band. Finally, a transfer matrix measurement indicates that the fabricated PLs have a mode coupling of less than -10â dB at 1550â nm.
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OBJECTIVE: This modelling study aimed to estimate the burden for allergic diseases in children during a period of 30 years. DESIGN: Population-based observational study. MAIN OUTCOMES AND MEASURES: The data on the incidence, mortality and disability-adjusted life years (DALYs) for childhood allergic diseases, such as atopic dermatitis (AD) and asthma, were retrieved from the Global Burden of Disease study 2019 online database. This data set spans various groups, including different regions, ages, genders and Socio-Demographic Indices (SDI), covering the period from 1990 to 2019. RESULTS: In 2019, there were approximately 81 million children with asthma and 5.6 million children with AD worldwide. The global incidence of asthma in children was 20 million. Age-standardised incidence rates showed a decrease of 4.17% for asthma, from 1075.14 (95% uncertainty intervals (UI), 724.63 to 1504.93) per 100 000 population in 1990 to 1030.33 (95% UI, 683.66 to 1449.53) in 2019. Similarly, the rates for AD decreased by 5.46%, from 594.05 (95% UI, 547.98 to 642.88) per 100 000 population in 1990 to 561.61 (95% UI, 519.03 to 608.29) in 2019. The incidence of both asthma and AD was highest in children under 5 years of age, gradually decreasing with age. Interestingly, an increase in SDI was associated with a rise in the incidence of both conditions. However, the mortality rate and DALYs for asthma showed a contrasting trend. CONCLUSIONS: Over the past three decades, there has been a worldwide increase in new asthma and AD cases, even though mortality rates have significantly declined. However, the prevalence of these allergic diseases among children varies considerably across regions, countries and age groups. This variation highlights the need for precise prevalence assessments. These assessments are vital in formulating effective strategies for prevention and treatment.
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Asma , Dermatitis Atópica , Niño , Humanos , Masculino , Femenino , Preescolar , Carga Global de Enfermedades , Años de Vida Ajustados por Calidad de Vida , Prevalencia , Incidencia , Asma/epidemiología , Dermatitis Atópica/epidemiología , Salud Global , Factores de RiesgoRESUMEN
AIM: To propose an algorithm for automatic detection of diabetic retinopathy (DR) lesions based on ultra-widefield scanning laser ophthalmoscopy (SLO). METHODS: The algorithm utilized the FasterRCNN (Faster Regions with CNN features)+ResNet50 (Residua Network 50)+FPN (Feature Pyramid Networks) method for detecting hemorrhagic spots, cotton wool spots, exudates, and microaneurysms in DR ultra-widefield SLO. Subimage segmentation combined with a deeper residual network FasterRCNN+ResNet50 was employed for feature extraction to enhance intelligent learning rate. Feature fusion was carried out by the feature pyramid network FPN, which significantly improved lesion detection rates in SLO fundus images. RESULTS: By analyzing 1076 ultra-widefield SLO images provided by our hospital, with a resolution of 2600×2048 dpi, the accuracy rates for hemorrhagic spots, cotton wool spots, exudates, and microaneurysms were found to be 87.23%, 83.57%, 86.75%, and 54.94%, respectively. CONCLUSION: The proposed algorithm demonstrates intelligent detection of DR lesions in ultra-widefield SLO, providing significant advantages over traditional fundus color imaging intelligent diagnosis algorithms.
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As for the photonic interconnection based on the multiple-lane intensity modulation direct detection (IM-DD) transmission, both intra-channel inter-symbol-interference (ISI) originating from bandwidth constraint, and inter-channel performance discrepancy emerging from inter-channel component differences are the major bottleneck for the throughput enhancement. Here, we propose a pairwise Tomlinson-Harshima precoding (P-THP) scheme, in order to simultaneously deal with both intra-channel ISI and inter-channel performance discrepancy. The effective function of the proposed P-THP scheme is experimentally evaluated by transmitting 4-channel 81-GBaud PAM4 signals over 2â km standard single-mode fiber (SSMF). Compared with the conventional scheme with only applying THP on individual wavelength channel, the required optical received power (ROP) under the back-to-back (B2B) transmission can be reduced by 0.75â¼1â dB with the help of proposed P-THP in different experimental component configurations, at the 7% hard decision forward error correction (HD-FEC) threshold of BER = 3.8 × 10-3. After the 2â km SSMF transmission, only the use of proposed P-THP can guarantee to reach the designated HD-FEC threshold, leading to a net rate of >600 Gbit/s.
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With the rapid urbanization and industrialization, heavy metal contamination in urban soil and surface dust has received particular attention due to its negative effects on the eco-environment and human health. Contamination and spatio-temporal characteristics, contamination sources, and source apportionment methods, as well as the ecological and health risks of heavy metals in urban soil and surface dust were reviewed. The knowledge gaps in current research and prospects of future works were proposed. Four key points were presented, including improving the research on the interaction mechanism of heavy metals in urban soil and surface dust under complex conditions, enriching verification methods to improve the source apportionment reliability of anthropogenic metals by receptor models, strengthening the research on chemical forms of heavy metals from different sources and their short-term accumulation processes in surface dust, and raising the credibility of ecological and health risk forecast of heavy metals by integrating the improved exposure parameters and chemical forms.
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BACKGROUND: Depression is a significant mental health concern affecting the overall well-being of adolescents and young adults. Recently, the prevalence of depression has increased among young people. Nonetheless, there is little research delving into the longitudinal epidemiology of adolescent depression over time. AIMS: To investigate the longitudinal epidemiology of depression among adolescents and young adults aged 10-24 years. METHOD: Our research focused on young people (aged 10-24 years) with depression, using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. We explored the age-standardised prevalence, incidence and disability-adjusted life-years (DALYs) of depression in different groups, including various regions, ages, genders and sociodemographic indices, from 1990 to 2019. RESULTS: The prevalence, incidence and DALYs of depression in young people increased globally between 1990 and 2019. Regionally, higher-income regions like High-Income North America and Australasia recorded rising age-standardised prevalence and incidence rates, whereas low- or middle-income regions mostly saw reductions. Nationally, countries such as Greenland, the USA and Palestine reported the highest age-standardised prevalence and incidence rates in 2019, whereas Qatar witnessed the largest growth over time. The burden disproportionately affected females across age groups and world regions. The most prominent age effect on incidence and prevalence rates was in those aged 20-24 years. The depression burden showed an unfavourable trend in younger cohorts born after 1980, with females reporting a higher cohort risk than males. CONCLUSIONS: Between 1990 and 2019, the general pattern of depression among adolescents varied according to age, gender, time period and generational cohort, across regions and nations.
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The synthesis of heterojunction materials is regarded as an efficient way to enhance catalytic activities in various catalytic reactions. However, the existing fabrication approaches often rely on complex multi-step synthesis process. In this work, we fabricate sweater-ball shaped nanostructured MOF/TMS (Ni-MOF/NiS1.03) heterojunction by one-pot, one-step solvothermal method. According to the results of discrete Fourier transform (DFT) calculations and experiments, the formation of Ni-MOF/NiS1.03 heterojunction interfaces improves electron transfer and charge redistribution, and increases the adsorption energy of glucose molecules as well, which is conducive to enhance electrochemical activity of electrode materials. The as-prepared Ni-MOF/NiS1.03 heterojunction exhibit enhanced glucose sensitivity, wide detection range and low detection limit. This study paves the way towards the development of MOF-based heterojunctions for electrochemical applications.
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The Kramers-Kronig (KK) receiver has attracted much attention in short-range optical interconnection because of its ability to recover the phase of the signal from the intensity information through KK algorithm. In high-speed KK systems, such as virtual-carrier (VC) assisted ones, an alternating current (AC) coupled photo-detector (PD) is preferred due to relaxing the requirements of analog-to-digital converter (ADC) and electronic amplifier by filtering direct current (DC) component. However, the loss of the DC component will cause the KK algorithm to break down, so it is necessary to accurately recover DC value in the digital domain with multiple-sweep. In this paper, we propose what we believe is a novel non-sweep DC component estimation scheme based on optimized digital carrier-to-signal power ratio (OD-CSPR) method, which can accurately estimate the DC component with only 3-4 iterations in the scenario of VC-assisted KK receiver optical transmission. The scheme utilizes the one-dimensional search optimization algorithm based on golden section search and parabolic interpolation without sweeping. The simulation and experimental results of the proposed non-sweep OD-CSPR method show that the DC component can be estimated accurately in a large CSPR range, and the system performance is close to that of the conventional DC-sweep method. Compared with the typical defined digital CSPR (DD-CSPR) based optimization method, the proposed one can realize optical signal-to-noise ratio (OSNR) gains of 0.9â dB in the back-to-back (B2B) and 0.7â dB under 80â km fiber transmission scenarios respectively with a total bit rate of 160Gb/s.
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Background: In the contemporary academic milieu, an array of erudite investigations has meticulously delved into the ramifications of social media paradigms on the nuances of modern societal interactions. Predominantly, these scholarly endeavors have harnessed quantitative methodologies to discern both the advantageous and detrimental implications of social media. Notwithstanding these extensive analyses, there appears to be a conspicuous lacuna in the literature about the subjective repercussions of social media on the well-being and contentment of tertiary education students. In light of this gap, the present qualitative exploration seeks to elucidate the perceptions of Chinese collegiate individuals vis-à-vis the influence of social media platforms on their experiential happiness. Method: Guided by interpretative phenomenological analysis (Jonathan et al., 2022) [1], we conducted 3 semi-structured interviews with 5 university students. Result: Using an interpretive phenomenology analysis approach four themes. They are (1) The Paradox of Temperance and Indulgence, (2) Identity Construction and Presentation, (3) Social Support and Connection, and (4) Social Comparison and Self-Evaluation. Discussion: Findings suggest that the individual well-being of college students may be affected by ambivalence between moderate and indulgent use of social media, social media interactions to maintain and enhance personal identity, and comparisons between individuals and certain online groups. Therefore, the government, higher education institutions, and college students should work together to build a safe and happy university life.
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BACKGROUND: Music therapy (MT) has received increasing attention from scholars in the efficacy treatment of anxiety symptoms, which is of great significance to human physical and mental health. The visual mapping functionality of CiteSpace and Vosviewer software was applied in this study to assess the status of MT in the treatment of anxiety symptoms. METHODS: In order to find research on MT and anxiety that were relevant for this research, we searched the Web of Science database. We also utilized CiteSpace and VOSviewer software to examine institutions, journals, authors, publications, and keywords for scientometric and visual analysis. RESULTS: Our findings show that since 2009, the field has developed rapidly and publications on MT and anxiety have gradually increased. The journal Complement Therapies In Medicine published the most relevant articles, the Cochrane Database Of Systematic Reviews journal had the highest citation frequency, and the United States had the most publications. The majority of the top academic institutions in the region are found in the United States, with the University of London having the most publications. The evolution of this field was significantly influenced by Gold C., the author with the most publications, and Bradt J., the author with the most co-citations. The topics of anxiety, nursing, cancer, and pain management have been the focus of this research. CONCLUSION: This study has the potential to increase public understanding of MT and anxiety as well as mental health awareness, all of which are crucial for lowering the prevalence of mental diseases.
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Musicoterapia , Humanos , Revisiones Sistemáticas como Asunto , Ansiedad/terapia , Trastornos de Ansiedad , BibliometríaAsunto(s)
Leucemia Mielógena Crónica BCR-ABL Positiva , Proteínas de Fusión Oncogénica , Factor de Transcripción PAX5 , Humanos , Factor de Transcripción PAX5/genética , Factor de Transcripción PAX5/metabolismo , Leucemia Mielógena Crónica BCR-ABL Positiva/genética , Leucemia Mielógena Crónica BCR-ABL Positiva/patología , Proteínas de Fusión Oncogénica/genética , Masculino , Femenino , Crisis Blástica/genética , Crisis Blástica/patología , Crisis Blástica/metabolismo , Persona de Mediana Edad , AdultoRESUMEN
Hydrogen energy and biomass energy are green and sustainable forms that can solve the energy crisis all over the world. Electrocatalytic water splitting is a marvelous way to produce hydrogen and biomass platform molecules can be added into the electrolyte to reduce the overpotential and meanwhile are converted into some useful organics, but the key point is the design of electrocatalyst. Herein, ultralow noble metal Ru is doped into NiS2 to form RuO2@NiS2 heterojunction. Amongst them, the 0.06 RuO2@NiS2 has low overpotentials of 363 mV for OER and 71 mV for HER in 1 m KOH, which are superior to the RuO2 and Pt/C. Besides, the 0.06 RuO2@NiS2 shows a low overpotential of 173 mV in 1 m KOH+0.1 m glycerol, and the glycerol is oxidized to glyceraldehyde and formic acid via the high Faraday efficiency GlyOR process, and the splitting voltage is only 1.17 V. In addition, the 0.06 RuO2@NiS2 has a low overpotential of 206 mV in 1 m KOH+0.1 m glucose, and the glucose is converted to glucaric acid, lactic acid, and formic acid. This work has a "one stone three birds" effect for the production of hydrogen, low splitting voltage, and high-value-added biomass chemicals.
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Background: This study aims to delineate the burden of congenital birth defects (CBDs) in children under 14 years of age from 1990 to 2019, using an age-period-cohort framework to analyse data from the Global Burden of Disease Study (GBD). Methods: Data on prevalence cases, age-standardised prevalence rates (ASPRs), death cases, and age-standardised death rates (ASDRs) of congenital birth defects (CBDs) from 1990 to 2019 were obtained from GBD 2019. Using this data set, we conducted an age-period-cohort (APC) analysis to examine patterns and trends in mortality, prevalence, and disability-adjusted life years (DALYs) associated with CBDs, while exploring correlations with age, time periods, and generational birth cohorts. Furthermore, to quantify the temporal trends, we calculated the estimated annual percentage changes (EAPCs) for these parameters. Results: The global prevalence of CBDs decreased from 1404.22 to 1301.66 per 100 000 with an EAPC of -0.18% from 1990 to 2019. CBD mortality decreased by 42.52% between 1990 and 2019, with the global age-standardised death rate declining from 49.72 to 25.58 per 100 000. The age-standardised DALY rate decreased from 4529.16 to 2393.61 per 100 000. Prevalence declined most notably among older children. The risk of CBDs reached its lowest during adolescence (10-14 years) across all regions. The most recent period (2015-2019) showed a reduced risk of prevalence compared to 2000-2004. Earlier birth cohorts displayed declining tendencies followed by slight increases in risk. Conclusions: This study demonstrates encouraging global reductions in the burden of CBDs among children over the past three decades. Prevalence, mortality, and DALYs attributable to CBDs have exhibited downward trajectories, although regional disparities remain. APC analysis provides valuable insights to inform prevention and management strategies for pediatric CBDs.
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Carga Global de Enfermedades , Muerte Perinatal , Adolescente , Femenino , Humanos , Niño , Años de Vida Ajustados por Discapacidad , Estudios de CohortesRESUMEN
Compared with individuals with hearing loss, tinnitus patients without hearing loss have more psychological or emotional problems. Tinnitus is closely associated to abnormal metabolism and function of the limbic system, a key brain region for emotion experience, but the underlying molecular mechanism remains unknown. Using whole-brain microvasculature dynamics imaging, the anterior cingulate cortex (ACC) is identified as a key brain region of limbic system involve in the onset of salicylate-induced tinnitus in mice. In the tinnitus group, there is enhanced purine metabolism, oxidative phosphorylation, and a distinct pattern of phosphorylation in glutamatergic synaptic pathway according to the metabolome profiles, quantitative proteomic, and phosphoproteomic data of mice ACC tissue. Electroencephalogram in tinnitus patients with normal hearing thresholds show that the functional connectivity between pregenual anterior cingulate cortex and the primary auditory cortex is significantly increased for high-gamma frequency band, which is positively correlated with the serum glutamate level. These findings indicate that ACC plays an important role in the pathophysiology of tinnitus by interacting with the primary auditory cortex and provide potential molecular targets in the ACC for tinnitus treatment.