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1.
Cancer Manag Res ; 10: 4325-4331, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30349366

RESUMEN

OBJECTIVE: Surgical resection serves an important role in the multidisciplinary treatment of cerebral metastases (CMs). Conventional white-light, microsurgical, and circumferential stripping of CMs is standard neurosurgical procedure, but is associated with a high recurrence rate. Based on this outcome, there is an urgent need for a new surgical strategy, such as fluorescence-guided resection, for CMs, in order to achieve total removal. METHODS: A retrospective study was carried out in 38 patients clinically and pathologically diagnosed with breast cancer brain metastasis at three medical centers from May 2012 to June 2016. The study comprised group 1 (fluorescein-guided surgery) and group 2 (standard microsurgery). In group 1, 5 mg/kg of fluorescein sodium was injected intravenously after an allergy test and before general anesthesia for 17 patients. A yellow 560 filter was employed for microsurgical tumor resection. Group 2 consisted of 21 patients for whom fluorescein was not administered. RESULTS: Surgical outcomes were assessed concerning the extent of resection and Karnofsky performance status. Gross total resection was achieved in these patients, with high fluorescence markedly enhancing tumor visibility. The extent of resection had a powerful influence on performance status. Overall survival after CM was 24.1 months in patients given fluorescein and was 22.8 months in the nonfluorescein group. CONCLUSION: Fluorescein-guided surgery is a simple, safe, and practical method to resect breast cancer brain metastasis, and leads to a higher proportion of resection compared to common microsurgery. This offers a tremendous advantage when navigating a tiny tumor, and improves the quality of life of patients with CM.

2.
World J Surg Oncol ; 15(1): 186, 2017 Oct 17.
Artículo en Inglés | MEDLINE | ID: mdl-29041974

RESUMEN

BACKGROUND: We investigated the functional status of adult supratentorial superficial low-grade glioma (ASS-LGG) after surgery and analyzed its relevant factors to guide the therapeutic strategy and improve the life quality of these patients. METHODS: Clinical materials from January 2008 to December 2010 in 104 adults with ASS-LGG were analyzed retrospectively. The follow-up period ranged from 6 months to 1.5 years. The logistic regression was used to evaluate the preoperative and postoperative variation of functional status in patients to disclose the relevant factors affecting postoperative functional status, such as age, gender, the duration of symptom, size and location of the tumor, hemisphere, resection degree, and tumor pathologic grade and preoperative Karnofsky performance status (Pre-KPS). RESULTS: Four out of nine candidate factors are related to the postoperative functional status. They are age less than 40 years, the size of tumor less than 5 cm in diameter, tumor located in the right hemisphere, and limited resection of tumor in the eloquent area. CONCLUSIONS: It seems more meaningful to evaluate the functional status of the patients with ASS-LGG on the basis of these clinical features, involving age, tumor size, location, and extent of resection.


Asunto(s)
Glioma/cirugía , Estado de Ejecución de Karnofsky , Procedimientos Neuroquirúrgicos/efectos adversos , Calidad de Vida , Neoplasias Supratentoriales/cirugía , Adulto , Factores de Edad , Femenino , Estudios de Seguimiento , Glioma/patología , Humanos , Masculino , Clasificación del Tumor , Procedimientos Neuroquirúrgicos/métodos , Periodo Posoperatorio , Pronóstico , Estudios Retrospectivos , Neoplasias Supratentoriales/patología
3.
World J Surg Oncol ; 15(1): 46, 2017 Feb 14.
Artículo en Inglés | MEDLINE | ID: mdl-28196488

RESUMEN

BACKGROUND: Pilocytic astrocytomas (PAs) are slow growing neoplasms and usually located at the cerebellum. There has been certainty regarding the truthful benefit of surgical resection for patients with PA. Gross total resection (GTR) of PAs, especially those being situated in deep regions, remains a surgical challenge. Generally, they are considered as benign and usually develop in young patients. PAs, belonging to WHO I can be cured by radical resection. The patients with PA have excellent prognosis if complete resection can be conducted. The use of fluorescein in vermis PA surgery has not been yet reported. Our data presents fluorescein facilitates surgical resection of vermis PA. METHODS: Five milligrams per kilogram of fluorescein sodium was intravenously injected directly before general anesthesia for the three patients with PA. The yellow 560 filter was employed for microsurgical tumor resection. Surgical outcomes were assessed concerning the extent of resection. RESULTS: Most portion of PA in the three cases was found to be highly fluorescent after intravenous fluorescein sodium injection, which markedly enhanced tumor visibility. Gross total resection in all of the patients was achieved without further neurological deficits. No adverse effects and complications resulting from fluorescein sodium were observed over the postoperative course. CONCLUSIONS: Intraoperative guidance by fluorescein sodium as a new, simple, safe, and practical procedure can enhance the fidelity of tumor tissue and increase the possibility of completely resecting PAs.


Asunto(s)
Astrocitoma/cirugía , Neoplasias Encefálicas/cirugía , Vermis Cerebeloso/cirugía , Medios de Contraste/metabolismo , Fluoresceína/metabolismo , Astrocitoma/diagnóstico por imagen , Astrocitoma/patología , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/patología , Vermis Cerebeloso/diagnóstico por imagen , Vermis Cerebeloso/patología , Humanos , Imagen por Resonancia Magnética/métodos , Procedimientos Neuroquirúrgicos , Pronóstico
4.
Neurol Sci ; 33(1): 143-5, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21617950

RESUMEN

Atypical meningiomas of sylvian fissure are extremely rare. We reported a case of sylvian fissure atypical meningioma with a 20-year history. The tumor was excised subtotally, thereafter a postoperative radiation therapy was done. The patient had a favorable outcome during the two-year follow-up. The possible pathogenesis of this case was hypothesized and analyzed in this article.


Asunto(s)
Corteza Cerebral/patología , Neoplasias Meníngeas/patología , Meningioma/patología , Convulsiones/patología , Corteza Cerebral/cirugía , Humanos , Masculino , Neoplasias Meníngeas/complicaciones , Neoplasias Meníngeas/cirugía , Meningioma/complicaciones , Meningioma/cirugía , Persona de Mediana Edad , Convulsiones/etiología , Convulsiones/cirugía , Resultado del Tratamiento
5.
Neurol Sci ; 33(1): 151-4, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21710127

RESUMEN

Intracranial extraaxial ependymomas (IEAEs) are extremely rare. We present a pediatric patient with IEAE misdiagnosed as a meningioma preoperatively, successfully treated surgically with a favorite outcome. The literature about IEAEs was briefly reviewed. Thereafter we discuss the clinical characteristics of the disease.


Asunto(s)
Neoplasias Encefálicas/patología , Ependimoma/patología , Lóbulo Frontal/patología , Lóbulo Temporal/patología , Neoplasias Encefálicas/cirugía , Niño , Ependimoma/cirugía , Lóbulo Frontal/cirugía , Humanos , Masculino , Lóbulo Temporal/cirugía , Resultado del Tratamiento
6.
Neurol Sci ; 31(6): 817-20, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-20454817

RESUMEN

A cranial spinal fluid fistula through left lumbar region following a ventriculoperitoneal (VP) shunt is an extremely rare complication. We report a 25-year-old man who presented with the leakage of clear fluid from the left lumbar region, 3 years after a VP shunt surgery. Computerized tomography scan of abdomen revealed that the distal end of the catheter penetrated into the inner layer of the wall of left lumbar region. He was managed successfully with abdominal part of shunt catheter removal from primary cervical and abdominal incision, a new abdominal part of VP shunt catheter replacement and prophylactic antibiotic.


Asunto(s)
Lesiones Encefálicas/cirugía , Fístula/diagnóstico por imagen , Fístula/etiología , Región Lumbosacra/lesiones , Derivación Ventriculoperitoneal/efectos adversos , Adulto , Líquido Cefalorraquídeo/metabolismo , Remoción de Dispositivos/métodos , Fístula/metabolismo , Humanos , Región Lumbosacra/diagnóstico por imagen , Masculino , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/metabolismo , Radiografía
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