Absorption, Metabolism, and Excretion of [14C]-Labeled Anaprazole: A New Proton Pump Inhibitor, After a Single Oral Administration in Healthy Chinese Male Subjects.

Anaprazole is a proton pump inhibitor. This study aims to elucidate absorption, metabolism, and excretion pathways of anaprazole sodium in the human body. A total of 4 healthy Chinese male subjects were administered a single oral dose of 20 mg/100 µCi of [14C]-anaprazole sodium enteric-coated capsules. The whole blood, plasma, and excreta were analyzed for a total radioactivity (TRA) and metabolite profile. The cumulative radioactivity excretion rate was 93.2%, with 53.3% and 39.9% of the radioactive dose excreted in urine and feces, respectively, and 91.6% of dose recovered within 96 hours after dosing. The parent drug, anaprazole, showed good absorption and was extensively metabolized majorly to thioether M8-1 via nonenzymatic metabolism. Overall, 35 metabolites were identified in plasma, urine, and fecal samples. Anaprazole was the most abundant component in plasma followed by the thioether M8-1, accounting for 28.3% and 16.6%, respectively, of the plasma TRA. Thioether carboxylic acid XZP-3409 (26.3% of urine TRA) and XZP-3409 oxidation and dehydrogenation product M417a (15.1% of fecal TRA) were the major metabolites present in urine and feces, respectively. Anaprazole was undetectable in urine, while fecal samples showed traces (0.07% dose). Blood/plasma ratios of the radioactivity (approximately 0.60) remained consistent over time. Anaprazole showed good absorption and was extensively metabolized majorly to thioether M8-1 via nonenzymatic metabolism, and cytochrome P450 3A4 also contributed to its metabolism in healthy individuals.

Changes of lake organic carbon sinks from closed basins since the Last Glacial Maximum and quantitative evaluation of human impacts.

BACKGROUND: Closed basins occupy 21% of the world's land area and can substantially affect global carbon budgets. Conventional understanding suggests that the terminal areas of closed basins collect water and carbon from throughout the entire basin, and changes in lake organic carbon sinks are indicative of basin-wide organic carbon storages. However, this hypothesis lacks regional and global validation. Here, we first validate the depositional process of organic carbon in a typical closed-basin region of northwest China using organic geochemical proxies of both soil and lake sediments. Then we estimate the organic carbon sinks and human impacts in extant closed-basin lakes since the Last Glacial Maximum (LGM). RESULTS: Results show that 80.56 Pg organic carbon is stored in extant closed-basin lakes mainly found in the northern mid-latitudes. Carbon accumulation rates vary from 17.54 g C m-2 yr-1 during modern times, 6.36 g C m-2 yr-1 during the mid-Holocene and 2.25 g C m-2 yr-1 during the LGM. Then, we evaluated the influence by human activities during the late Holocene (in the past three thousand years). The ratio of human impacts on lake organic carbon storage in above closed basins is estimated to be 22.79%, and human-induced soil organic carbon emissions in the past three thousand years amounted to 207 Pg. CONCLUSIONS: While the magnitude of carbon storage is not comparable to those in peatland, vegetation and soil, lake organic carbon sinks from closed basins are significant to long-term terrestrial carbon budget and contain information of climate change and human impact from the whole basins. These observations improve our understanding of carbon sinks in closed basins at various time scales, and provide a basis for the future mitigation policies to global climate change.

Neurosyphilis complicated with pial arteriovenous fistula: A rare case report.

INTRODUCTION: Neurosyphilis is a chronic, infectious disease of the central nervous system. Pial arteriovenous fistulae (PAVF) are rare vascular malformations. Both can cause vascular damage, but it is quite rare for both to present at the same time. PATIENT CONCERNS: Here we present a 66-year-old man with affective disorder, hypomnesia, and recent convulsions. Magnetic resonance imaging revealed cerebral swelling, hyperintensity in the cortex/subcortex, and multiple lacunar cerebral infarctions. Computed tomography angiography revealed the presence of a pial arteriovenous fistula. DIAGNOSES: Based on laboratory tests and imaging, diagnoses of neurosyphilis and pial arteriovenous fistula were made. INTERVENTIONS: Antisyphilis therapy was provided. OUTCOMES: Symptoms improved and antisyphilis treatment continued as an outpatient. No intracranial hemorrhage was seen 6 months later. CONCLUSION: Treponema pallidum infection may be related to the formation of PAVF, and may also promote the progression of it; however, further work is required to confirm this.

Terrestrial organic carbon storage modes based on relationship between soil and lake carbon, China.

Terrestrial ecosystems have received considerable attention as a significant sink for organic carbon at regional to global scales. Previous studies were focused on assessment and quantification of carbon sinks for one ecotype, and few have worked on the interconnection of terrestrial sinks. In this paper, we synthesized the data from China's second national soil survey and direct measurements from 54 lakes. Meanwhile, we investigated the controlling factors of carbon accumulation dynamics in soils and lakes. Results showed varied spatial distribution of soil and lake organic carbon in different regions, and three storage modes were found. The storage mode of watershed collection was observed in the region of the Qinghai-Tibetan Plateau, while the northeast China and Yunnan-Guizhou Plateau revealed another storage mode of autochthonous deposition, and the mode of human activities affection was represented by the East Plain and Mongolia-Xinjiang Plateau. The spatial difference throughout China was regulated by various climate patterns, geological conditions and anthropogenic interference. Our results provide insights into carbon storage modes in various regions, and also inform strategies for enhancing global carbon sequestration and future mitigation policies towards global climate change.