1.
Org Biomol Chem
; 22(11): 2241-2251, 2024 Mar 13.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38372133
RESUMEN
A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed. Under transition metal-free conditions, 36 quinazolinone derivatives containing an amide moiety were successfully synthesized, with the highest yield being 81%. This method involves the preparation of aminoacyl fused quinazolinone derivatives under mild conditions, offering advantages such as a high yield, a broad substrate compatibility, and a high atom economy.