RESUMEN
Lectins are glycoproteins that can bind to specific carbohydrates, and different lectin families exhibit different biological activities. They are also present in the cyanobacteria and many of them have shown excellent therapeutic effect, which deserve for bioprospecting. However, in comparison to those from terrestrial plants, the current knowledge on cyanobacterial lectins is very limited. To this end, genome-wide analyses were performed to find out their evolutionary mode and motif patterns in 316 genomes of representative taxa. In results, 196 putative cyanobacterial lectins were dig out and 105 of them were classified into known families. Seven lectins were found to be belonged to distinct two lectin families, and they may have the potential activities of both lectin families. Whereas no MFP-2, Chitin, and Nictaba family lectins were found. What's more, the Legume lectin-like lectin family was found to be the richest and most complex in cyanobacteria, which could be a main research direction for future cyanobacterial lectin bioprospecting and development. Our classification and prediction of cyanobacteria lectins is expected to provide assistance in the development of lectin-based medicine and provide solutions to the current thorny viral and tumor diseases in humans.
Asunto(s)
Cianobacterias , Lectinas , Humanos , Lectinas/genética , Estudio de Asociación del Genoma Completo , Cianobacterias/genética , Cianobacterias/metabolismo , Evolución Biológica , Glicoproteínas , Lectinas de Plantas/genéticaRESUMEN
Autopsy by forensic pathologist is a main mean currently to determine the cause of sudden unexpected death. Retinal examination is important but seldom performed during a forensic autopsy for various reasons. The value of retina examination has not been recognized. With invention of ophthalmic endoscopy and its subsequent application in postmortem retina examination, it has proved to be useful adjunct to determine the cause of death and to estimate the postmortem interval.
Asunto(s)
Autopsia , Causas de Muerte , Patologia Forense/métodos , Oftalmoscopía , Retina/patología , Adulto , Traumatismos Craneocerebrales/patología , Enfermedad de Descompresión/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Hemorragia Subaracnoidea/patología , Síndrome , Hemorragia Vítrea/patologíaRESUMEN
Individual response to drugs, toxicants, environmental chemicals and allergens varies with genotype. Some respond well to these substances without significant consequences, while others may respond strongly with severe consequences and even death. Toxicogenetics and toxicogenomics as well as pharmacogenetics explain the genetic basis for the variations of individual response to toxicants by sequencing the human genome and large-scale identification of genome polymorphism. The new disciplines will provide a new route for forensic specialists to determine the cause of death.
Asunto(s)
Sistema Enzimático del Citocromo P-450/genética , Medicina Legal , Farmacogenética , Polimorfismo de Nucleótido Simple , Toxicogenética , Hipersensibilidad a las Drogas/genética , Predisposición Genética a la Enfermedad/genética , Genoma Humano , Humanos , Farmacogenética/tendencias , Farmacocinética , Toxicogenética/tendenciasRESUMEN
As a "Gold Standard" in clinical diagnosis of cerebrovascular disease, cerebral angiography also plays an important role in forensic postmortem examination. The key roles of identifying the site of cerebrovascular disease and the cause of death as well as providing guidance for autopsy and postmortem sampling and the broad future application of cerebral angiography in forensic practice are reviewed.