[Studies on chemical constituents of Peucedanum delavayi].

OBJECTIVE: To study the chemical constituents of the radix and rhizome of Peucedanum delavayi. METHODS: The chemical constituents had been separated by manifold chromato-graphy methods, and their structures were determined by spectral analysis. RESULTS: Fifteen compounds were isolated and identified as Umbelliferone(I), Coumurayin(II), Mexoticin(III), Marmesin (IV), Ammijin(V), Delton (VI), Selinidin(VII), Anomalin(VII), Isopteryxin(IX), Ferulic acid(X), Falcarindiol(XI), Stearic acid(XII), beta-sitosterol(X III), Daucosterol(XIV) and d-Mannitol(XV). CONCLUSION: All these compounds are isolated from Peucedanum delavayi for the first time.

[Hypnotic effect of Chinese materia medica Cynanchum chinese in mice].

OBJECTIVE: To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice. METHOD: The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test. RESULT: the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment. CONCLUSION: The extract compounds from C. chinese showed inhibitional effect on CNS.