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1.
Kaohsiung J Med Sci ; 34(4): 243-248, 2018 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29655414

RESUMEN

The OSCE is a reliable evaluation method to estimate the preclinical examination of dental students. The most ideal assessment for OSCE is used the augmented reality simulator to evaluate. This literature review investigated a recently developed in virtual reality (VR) and augmented reality (AR) starting of the dental history to the progress of the dental skill. As result of the lacking of technology, it needs to depend on other device increasing the success rate and decreasing the risk of the surgery. The development of tracking unit changed the surgical and educational way. Clinical surgery is based on mature education. VR and AR simultaneously affected the skill of the training lesson and navigation system. Widely, the VR and AR not only applied in the dental training lesson and surgery, but also improved all field in our life.


Asunto(s)
Odontología/métodos , Educación en Odontología/métodos , Enseñanza , Realidad Virtual , Rendimiento Académico/estadística & datos numéricos , Simulación por Computador , Humanos , Estudiantes de Odontología
2.
Biochim Biophys Acta Gen Subj ; 1861(3): 624-635, 2017 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-28063985

RESUMEN

BACKGROUND: Focal adhesions (FAs) are large, dynamic protein complexes located close to the plasma membrane, which serve as the mechanical linkages and a biochemical signaling hub of cells. The coordinated and dynamic regulation of focal adhesion is required for cell migration. Degradation, or turnover, of FAs is a major event at the trailing edge of a migratory cell, and is mediated by Ca2+/calpain-dependent proteolysis and disassembly. Here, we investigated how Ca2+ influx induces cascades of FA turnover in living cells. METHODS: Images obtained with a total internal reflection fluorescence microscope (TIRFM) showed that Ca2+ ions induce different processes in the FA molecules focal adhesion kinase (FAK), paxillin, vinculin, and talin. Three mutated calpain-resistant FA molecules, FAK-V744G, paxillin-S95G, and talin-L432G, were used to clarify the role of each FA molecule in FA turnover. RESULTS: Vinculin was resistant to degradation and was not significantly affected by the presence of mutated calpain-resistant FA molecules. In contrast, talin was more sensitive to calpain-mediated turnover than the other molecules. Three-dimensional (3D) fluorescence imaging and immunoblotting demonstrated that outer FA molecules were more sensitive to calpain-mediated proteolysis than internal FA molecules. Furthermore, cell contraction is not involved in degradation of FA. CONCLUSIONS: These results suggest that Ca2+-mediated degradation of FAs was mediated by both proteolysis and disassembly. The 3D architecture of FAs is related to the different dynamics of FA molecule degradation during Ca2+-mediated FA turnover. GENERAL SIGNIFICANCE: This study will help us to clearly understand the underlying mechanism of focal adhesion turnover by Ca2+.


Asunto(s)
Calcio/metabolismo , Calpaína/metabolismo , Adhesiones Focales/metabolismo , Adhesión Celular/fisiología , Línea Celular , Membrana Celular/metabolismo , Quinasa 1 de Adhesión Focal/metabolismo , Proteína-Tirosina Quinasas de Adhesión Focal/metabolismo , Humanos , Paxillin/metabolismo , Proteolisis , Transducción de Señal/fisiología , Talina/metabolismo , Vinculina/metabolismo
3.
Australas J Dermatol ; 51(3): 198-201, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20695860

RESUMEN

Ulceration of non-caseating granulomas is a rare cutaneous presentation of sarcoidosis. Granulomatous vasculitis is classically associated with Wegener's granulomatosis, lymphomatoid granulomatosis or Churg-Strauss syndrome. It is also commonly noted in pulmonary sarcoidosis, but has seldom been reported in cutaneous sarcoidosis, particularly the ulcerative variant. We present a rare case of sarcoidosis with multiple purpuric leg ulcers showing a granulomatous vasculitis histologically.


Asunto(s)
Granuloma de Células Gigantes/diagnóstico , Úlcera de la Pierna/diagnóstico , Sarcoidosis/diagnóstico , Vasculitis Sistémica/diagnóstico , Adulto , Azatioprina/uso terapéutico , Granuloma de Células Gigantes/tratamiento farmacológico , Granuloma de Células Gigantes/patología , Humanos , Úlcera de la Pierna/tratamiento farmacológico , Úlcera de la Pierna/patología , Masculino , Prednisolona/uso terapéutico , Sarcoidosis/tratamiento farmacológico , Sarcoidosis/patología , Vasculitis Sistémica/tratamiento farmacológico , Vasculitis Sistémica/patología , Enfermedades Testiculares/diagnóstico , Enfermedades Testiculares/tratamiento farmacológico , Enfermedades Testiculares/patología
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