Dual-mode fluorescence and colorimetric smartphone-based sensing platform with oxidation-induced self-assembled nanoflowers for sarcosine detection.

BACKGROUND: Early prostatic cancer (PCa) diagnosis significantly improves the chances of successful treatment and enhances patient survival rates. Traditional enzyme cascade-based early cancer detection methods offer efficiency and signal amplification but are limited by cost, complexity, and enzyme dependency, affecting stability and practicality. Meanwhile, sarcosine (Sar) is commonly considered a biomarker for PCa development. It is essential to develop a Sar detection method based on cascade reactions, which should be efficient, low skill requirement, and suitable for on-site testing. RESULTS: To address this, our study introduces the synthesis of organic-inorganic self-assembled nanoflowers to optimize existing detection methods. The Sar oxidase (SOX)-inorganic hybrid nanoflowers (Cu3(PO4)2:Ce@SOX) possess inherent fluorescent properties and excellent peroxidase activity, coupled with efficient enzyme loading. Based on this, we have developed a dual-mode multi-enzyme cascade nanoplatform combining fluorescence and colorimetric methods for the detection of Sar. The encapsulation yield of Cu3(PO4)2:Ce@SOX reaches 84.5 %, exhibiting a remarkable enhancement in catalytic activity by 1.26-1.29 fold compared to free SOX. The present study employing a dual-signal mechanism encompasses 'turn-off' fluorescence signals ranging from 0.5 µM to 60 µM, with a detection limit of 0.226 µM, and 'turn-on' colorimetric signals ranging from 0.18 µM to 60 µM, with a detection limit of 0.120 µM. SIGNIFICANCE: Furthermore, our study developed an intelligent smartphone sensor system utilizing cotton swabs for real-time analysis of Sar without additional instruments. The nano-platform exhibits exceptional repeatability and stability, rendering it well-suited for detecting Sar in authentic human urine samples. This innovation allows for immediate analysis, offering valuable insights for portable and efficient biosensors applicable to Sar and other analytes.

Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition.

Crop yield potential is constrained by the inherent trade-offs among traits such as between grain size and number. Brassinosteroids (BRs) promote grain size, yet their role in regulating grain number is unclear. By deciphering the clustered-spikelet rice germplasm, we show that activation of the BR catabolic gene BRASSINOSTEROID-DEFICIENT DWARF3 (BRD3) markedly increases grain number. We establish a molecular pathway in which the BR signaling inhibitor GSK3/SHAGGY-LIKE KINASE2 phosphorylates and stabilizes OsMADS1 transcriptional factor, which targets TERMINAL FLOWER1-like gene RICE CENTRORADIALIS2. The tissue-specific activation of BRD3 in the secondary branch meristems enhances panicle branching, minimizing negative effects on grain size, and improves grain yield. Our study showcases the power of tissue-specific hormonal manipulation in dismantling the trade-offs among various traits and thus unleashing crop yield potential in rice.

Mechanically Tunable Circularly Polarized Luminescence of Liquid Crystal-Templated Chiral Perovskite Quantum Dots.

Endowing perovskite quantum dots (PQDs) with circularly polarized luminescence (CPL) offers great promise for innovative chiroptical applications, but the existing strategies are inefficient in acquiring stimuli-responsive flexible chiral perovskite films with large, tunable dissymmetry factor (glum) and long-term stability. Here, we report a strategy for the design and synthesis of luminescent cholesteric liquid crystal elastomer (Lumin-CLCE) films with mechanically tunable CPL, which is enabled by liquid crystal-templated chiral self-assembly and in situ covalent cross-linking of judiciously designed photopolymerizable CsPbX3 (X=Cl, Br, I) PQD nanomonomers into the elastic polymer networks. The resulting Lumin-CLCE films showcase circularly polarized structural color in natural light and noticeable CPL with a maximum glum value of up to 1.5 under UV light. The manipulation of CPL intensity and rotation direction is achieved by controlling the self-assembled helicoidal nanostructure and the handedness of soft helices. A significant breakthrough lies in the achievement of a reversible, mechanically tunable perovskite-based CPL switch activated by biaxial stretching, which enables flexible, dynamic anti-counterfeiting labels capable of decrypting preset information in specific polarization states. This work can provide new insights for the development of advanced chiral perovskite materials and their emerging applications in information encryption, flexible 3D displays, and beyond.

Closed-loop process for selective leaching and recovery of palladium from spent auto-exhaust catalysts using iodotrihalide ionic liquids.

The recovery of palladium from spent auto-exhaust catalysts (SAE-catalysts) is of great significance for resource sustainability. Herein, we proposed an efficient closed-loop leaching and recovery method for palladium from SAE-catalysts using iodotrihalide ionic liquids (ILs). Recovery design was explored aimed at green leaching and process simplification. Iodotrihalide ILs exhibited exceptional performance in terms of leaching efficiency (99.1%), selectivity (selectivity > 6.8 ×103) and reusability (over 6 cycles). The mechanism study revealed that excellent leaching performance was attributed to the redox and complexation. Additionally, the chemical reaction-controlled model was best suited to describe the leaching process. Notably, under the optimal conditions determined by the response surface methodology, a high-purity Pd(II) solution (purity > 99.8%) was obtained. More significantly, it was ideal for practical applications due to the low-viscosity (36.0 cP), mild (55 °C) and one-step leaching and recovery. In conclusion, this work provides an eco-friendly method for recovering palladium from SAE-catalysts with its non-high corrosiveness and low environmental impact.

Consistency of Monoenergetic Attenuation Measurements for a Clinical Dual-Source Photon-Counting Detector CT System Across Scanning Paradigms: A Phantom Study.

BACKGROUND. Use of virtual monoenergetic images (VMIs) from multienergy CT scans can mitigate inconsistencies in traditional attenuation measurements that result from variation in scan-related factors. Photon-counting detector (PCD) CT systems produce VMIs as standard image output under flexible scanning conditions. OBJECTIVE. The purpose of this article was to evaluate the consistency of monoenergetic attenuation measurements obtained from a clinical PCD CT scanner across a spectrum of scanning paradigms. METHODS. A phantom with 10 tissue-simulating inserts was imaged using a clinical dual-source PCD CT scanner. Nine scanning paradigms were obtained across combinations of tube voltages (90, 120, and 140 kVp) and image quality (IQ) levels (80, 145, and 180). Images were reconstructed at VMI levels of 50, 60, 70, and 80 keV. Consistency of attenuation measurements was assessed, using the 120 kVp with IQ level of 145 scanning paradigm as the reference scan. RESULTS. For all scanning paradigms, attenuation measurements showed intra-class correlation of 0.999 and higher with respect to the reference scan. Across inserts, mean bias relative to the reference scan ranged from -14.9 to 13.6 HU, -2.7 to 1.7 HU, and -3.9 to 3.8 HU at tube voltages of 90, 120, and 140 kVp, respectively; and from -14.9 to 13.6 HU, -6.4 to 3.8 HU, -3.7 to 1.4 HU, and -7.2 to 4.3 HU at VMI levels of 50, 60, 70, and 80 keV, respectively. Thus, mean bias did not exceed 5 HU for any insert at tube potentials of 120 kVp and 140 kVp, nor for any insert at a VMI level of 70 keV. At a VMI level of 50 keV and tube potential of 90 kVp, mean bias exceeded 5 HU for 14 of 30 possible combinations of inserts and scanning paradigms and exceeded 10 HU for four of 30 such combinations. At VMI levels of both 60 and 80 keV, mean bias exceeded 5 HU for only two combinations of inserts and scanning paradigms, all at a tube potential of 90 kVp. CONCLUSION. PCD CT generally provided consistent attenuation measurements across combinations of scanning paradigms and VMI levels. CLINICAL IMPACT. PCD CT may facilitate quantitative applications of CT data in clinical practice.

Leveraging brassinosteroids towards the next Green Revolution.

The use of gibberellin-related dwarfing genes significantly increased grain yield during the Green Revolution. Brassinosteroids (BRs) play a vital role in regulating agronomic traits and stress resistance. The potential of BR-related genes in crop improvement has been well demonstrated, positioning BRs as crucial targets for the next agricultural biotechnological revolution. However, BRs exert pleiotropic effects on plants, and thus present both opportunities and challenges for their application. Recent research suggests promising strategies for leveraging BR regulatory molecules for crop improvement, such as exploring function-specific genes, identifying beneficial alleles, inducing favorable mutations, and optimizing spatial hormone distribution. Advancing our understanding of the roles of BRs in plants is imperative to implement these strategies effectively.

Mechanochromic and ionic conductive cholesteric liquid crystal elastomers for biomechanical monitoring and human-machine interaction.

Cholesteric liquid crystal elastomers (CLCEs) that combine rubbery elasticity with structural colour from self-assembled helical nanostructures are of paramount importance for diverse applications such as biomimetic skins, adaptive optics and soft robotics. Despite great advances, it is challenging to integrate electrical sensing and colour-changing characteristics in a single CLCE system. Here, we report the design and synthesis of an ionic conductive cholesteric liquid crystal elastomer (iCLCE) through in situ Michael addition and free-radical photopolymerization of CLCE precursors on silane-functionalized polymer ionic liquid networks, in which robust covalent chemical bonding was formed at the interface. Thanks to superior mechanochromism and ionic conductivity, the resulting iCLCEs exhibit dynamic colour-changing and electrical sensing functions in a wide range upon mechanical stretching, and can be used for biomechanical monitoring during joint bending. Importantly, a capacitive elastomeric sensor can be constructed through facilely stacking iCLCEs, where the optical and electrical dual-signal reporting performance allows intuitive visual localization of pressure intensity and distribution. Moreover, proof-of-concept application of the iCLCEs has been demonstrated with human-interactive systems. The research disclosed herein can provide new insights into the development of bioinspired somatosensory materials for emerging applications in diverse fields such as human-machine interaction, prostheses and intelligent robots.

Ceria-Based Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing.

In recent years, there has been a notable increase in interest surrounding nanozymes due to their ability to imitate the functions and address the limitations of natural enzymes. The scientific community has been greatly intrigued by the study of nanoceria, primarily because of their distinctive physicochemical characteristics, which include a variety of enzyme-like activities, affordability, exceptional stability, and the ability to easily modify their surfaces. Consequently, nanoceria have found extensive use in various biosensing applications. However, the impact of its redox activity on the enzymatic catalytic mechanism remains a subject of debate, as conflicting findings in the literature have presented both pro-oxidant and antioxidant effects. Herein, we creatively propose a seesaw model to clarify the regulatory mechanism on redox balance and survey possible mechanisms of multienzyme mimetic properties of nanoceria. In addition, this review aims to showcase the latest advancements in this field by systematically discussing over 180 research articles elucidating the significance of ceria-based nanozymes in enhancing, downsizing, and enhancing the efficacy of point-of-care (POC) diagnostics. These advancements align with the ASSURED criteria established by the World Health Organization (WHO). Furthermore, this review also examines potential constraints in order to offer readers a concise overview of the emerging role of nanoceria in the advancement of POC diagnostic systems for future biosensing applications.

Three-dimensional magnetic resonance elastography combining proton-density fat fraction precisely identifies metabolic dysfunction-associated steatohepatitis with significant fibrosis.

PURPOSE: Patients with metabolic dysfunction-associated steatohepatitis (MASH) and significant fibrosis (fibrosis stage≥2), known as Fibro-MASH, are at increased risk of liver-related outcomes and lower rates of spontaneous disease regression. The aim was to investigate three-dimensional MR elastography (3D-MRE) combining proton-density fat fraction (PDFF) as a means of identifying Fibro-MASH. METHODS: Forty-eight New Zealand rabbits were fed a high-fat/cholesterol or standard diet to obtain different disease activity and fibrosis stages. Shear stiffness (SS) and Damping Ratio (DR) were derived from 3D-MRE, whereas PDFF was from a volumetric 3D imaging sequence. Steatosis grade, metabolic dysfunction-associated steatotic liver disease activity score (MAS), and fibrosis stage were diagnosed histologically. Serum markers of fibrosis and inflammation were also measured. Correlation and comparison analysis, Receiver operating characteristic curves (ROC), Delong test, logistic regression analysis, and Net reclassification improvement (NRI) were performed. RESULTS: PDFF correlated with steatosis grade (rho = 0.853). SS increased with developed liver fibrosis (rho = 0.837). DR correlated with MAS grade (rho = 0.678). The areas under the ROC (AUROCs) of SS for fibrosis grading were 0.961 and 0.953 for ≥F2, and ≥ F3, respectively. All the biochemical parameters were considered but excluded from the logistic regression analysis to identify Fibro-MASH. FF, SS, and DR were finally included in the further analysis. The three-parameter model combining PDFF, SS, and DR showed significant improvement in NRI over the model combining SS and PDFF (AUROC 0.973 vs. 0.906, P = 0.081; NRI 0.28, P < 0.05). CONCLUSION: 3D-MRE combining PDFF may characterize the state of fat content, disease activity and fibrosis, thus precisely identify Fibro-MASH.

High nitrogen content bimolecular co-functionalized graphene nanoflakes for hypertoxic Cr(VI) removal: Insights into adsorption behavior and mechanisms.

The proven high carcinogenicity to humans and high destructive force to the environment determine the extreme urgency of eliminating hypertoxic Cr(VI) in water bodies. Herein, a route of room temperature synthesis and secondary grafting was proposed to fabricate graphene oxide-based nanoadsorbent co-functionalized with polydopamine and branched polyethyleneimine (GOPP) to remove Cr(VI). The flexible decoration of polydopamine and polyethyleneimine on GO flakes could gradually enhance the amount of N-containing functional groups and realize selective removal of Cr(VI) with the maximum experimental adsorption capacity of 564.7 mg/g, displaying a significantly high separation factor against alkali metal, alkaline earth metal, and other transition metal ions. Various combination mechanisms, such as electrostatic attraction, reduction, complexation, and hydrogen bonding, were demonstrated to be involved in the adsorption process of Cr(VI) by XPS, ESP, and DFT calculations. And the interaction energies of the five protonated configurations of primary amine, tertiary amine, secondary amine, imine, and secondary amine on the ring with HCrO4- were: -22.66, -12.08, -24.92, -24.26, -27.64 kcal/mol. In the actual industrial wastewater study, a Cr(VI) removal rate of 85.8% was realized. This work provided a viable idea for the elimination of Cr(VI) and was expected to be applied in the field of wastewater treatment.

Hollow porphyrin-based porous organic polymer with dual enzyme-like activities for ultra-fast colorimetric detection of Cr (VI) in wastewater.

A hollow porphyrin-based porous organic polymer (H-Fe-POP) was prepared for rapid and sensitive colorimetric determination of Cr(VI), which exhibited excellent dual enzyme-like activities, including oxidase-like and peroxidase-like activities. Due to the specific binding of 8-hydroxyquinoline (8-HQ) to Cr(VI), 3,3',5,5'-tetramethylbenzidine (TMB) was liberated, and TMB was oxidized to blue ox-TMB catalyzed by H-Fe-POP. Based on the excellent oxidase-like activity of H-Fe-POP, an ultra-fast colorimetric platform for the detection of Cr(VI) was constructed, allowing the quantification of Cr(VI) in the range 2-130 µM within 30 s with a detection limit of 0.23 µM. Importantly, the sensor can accurately determine Cr(VI) in industrial wastewater, indicating its high potential for environmental monitoring.

Mechanochromic and Conductive Chiral Nematic Nanostructured Film for Bioinspired Ionic Skins.

Chameleon skin is naturally adaptive and can sense environmental changes and transform sensing into bioelectrical and optical signals by manipulating ion transduction and photonic nanostructures. The increasing interest in mimicking biological skins has considerably promoted the development of advanced photonic materials with an increasing ionic conductivity. Herein, we report the judicious design and fabrication of a bioinspired mechanochromic chiral nematic nanostructured film with good ionic conductivity by infiltrating fluorine-rich ionic liquids (FILs) into a swollen self-assembled cellulose nanocrystal (CNC) film with helical nanoarchitectures. Notably, the introduction of 2-hydroxyethyl acrylate considerably enhances the compatibility of hydrophobic FILs and hydrophilic CNCs. The resulting FIL-CNC nanostructured films exhibited excellent mechanochromism, good ionic conductivity, and outstanding optical/electrical dual-signal sensing performance when used as a bioinspired ionic skin for real-time monitoring of human motions. Owing to the integration of FILs, the underwater stability of the chiral liquid crystal nanostructures of CNCs was significantly enhanced. Notably, underwater contact/contactless sensing modes and encrypted information transmission have been achieved with the FIL-CNC nanostructured film. This study can offer great insights for the advancement of biomimetic multifunctional artificial skins and emerging interactive devices, which can find important applications in wearable iontronics, human-machine interactions, and intelligent robots.

Spatiotemporal Characteristics of Food Supply-Demand Balance in Uzbekistan under Different Scenarios.

The food supply-demand balance is a perpetual concern for many countries, especially developing countries, such as Uzbekistan. Using the land resource carrying capacity model, here, food supply and demand for the cereals and calories in Uzbekistan during 1995-2020 were revealed. Despite increased demand for cereals and calories, unstable crop production has led to volatile growth patterns. The carrying capacity of cropland resources under Uzbekistan's consumption standard shifted from overload to surplus and then to balance. Moreover, the carrying capacity of cropland resources under the healthy diet standard moved from balance to surplus in the past 25-years. Additionally, the calorific equivalent land resource carrying capacity under Uzbekistan's consumption standard fluctuated, with the carrying state shifting from balance to surplus, and the healthy diet standard still in overload. These findings can help guide sustainable production and consumption strategies in Uzbekistan and other countries by analyzing the consumption structure and changes in supply and demand relationships.

Wireless Power Transfer to Electrothermal Liquid Crystal Elastomer Actuators.

Wireless actuation of electrically driven soft actuators is of paramount importance for the development of bioinspired soft robotics without physical connection or on-board batteries. Here, we demonstrate untethered electrothermal liquid crystal elastomer (LCE) actuators based on emerging wireless power transfer (WPT) technology. We first design and fabricate electrothermal LCE-based soft actuators that consist of an active LCE layer, a conductive liquid metal-filled polyacrylic acid (LM-PA) layer, and a passive polyimide layer. LM can function not only as an electrothermal transducer to endow resulting soft actuators with electrothermal responsiveness but also as an embedded sensor to track the resistance changes. Various shape-morphing and locomotive modes such as directional bending, chiral helical deformation, and inchworm-inspired crawling can be facilely obtained through appropriately controlling the molecular alignment direction of monodomain LCEs, and the reversible shape-deformation behaviors of resulting soft actuators can be monitored in real-time through resistance changes. Interestingly, untethered electrothermal LCE-based soft actuators have been achieved by designing a closed conductive LM circuit within the actuators and combining it with inductive-coupling WPT technology. When the resulting soft actuator approaches a commercially available wireless power supply system, an induced electromotive force can be generated within the closed LM circuit, which results in Joule heating and wireless actuation. As proof-of-concept illustrations, wirelessly driven soft actuators that can exhibit programmable shape-morphing behaviors are demonstrated. The research disclosed herein can provide insights into the development of bioinspired somatosensory soft actuators, battery-free wireless soft robots, and beyond.

Flow diagram of the differential diagnosis and clinical decision making in a rare case of contrast-induced encephalopathy following cardiac catheterization: a case report.

BACKGROUND: Contrast-induced encephalopathy (CIE) is considered as an uncommon complication following cardiac catheterization. Due to the varied manifestations, CIE has no formal diagnostic criteria. In fact, the incidence of CIE may be greatly underestimated because of the difficulty in its differential diagnosis with other cerebrovascular complications. Thus, making a flow diagram according to patients' clinical symptoms and examinations after cardiac catheterization to help clinicians diagnose CIE is important and needed. CASE PRESENTATION: In this report, we describe a case of probable CIE in a 66-year-old Chinese man with hypertension who underwent cardiac catheterization with stents placement in the bifurcation lesion, during which 80 ml iopromide contrast was used. About 2 h following the procedure, the patient lost his consciousness suddenly and suffered from a status epilepticus. Malignant arrhythmias were not found through continuous electrocardiogram monitoring, but mild ST-segment elevation was displayed in leads I and aVL. The echocardiography, plasma glucose and electrolyte levels were normal. Emergency re-angiography with percutaneous transluminal coronary angioplasty was performed in the culprit lesion, which involved 60 ml iopromide contrast. However, the patient remained unconsciousness and epilepticus. Non-contrast computed tomography (CT) of the head showed cortical and subarachnoid enhancement as well as prolonged retention of contrast media in the middle cerebral artery. With supportive treatment of intravenous hydration, sedative and dehydrant, the patient recovered 3 h later and finally discharged without any neurological deficits. CONCLUSIONS: CIE is an acute reversible encephalopathy induced by contrast media. It is exceptionally challenging to make the diagnosis of CIE following cardiac catheterization since there is a lack of consensus on the definition of CIE. Via this case we reviewed the related literatures, through which a flow diagram of the differential diagnosis and clinical decision making was given, which could help to differentiate CIE from other neurological complications following cardiac catheterization.

First principles terahertz spectroscopy of molecular crystals: the crucial role of periodic boundary conditions benchmarked with experimental L-ascorbic acid spectra.

The terahertz (THz) region vibration spectral signatures of molecular crystals can usually be ascribed to the low-frequency vibrational modes related to weak intermolecular interactions, e.g. van der Waals (vdW) interactions or hydrogen bonding. These interactions collectively dictate the compositional units deviating from their equilibrium configurations. The collective movements are intrinsically long-range, and hence the boundary conditions used for theoretical calculation can affect the corresponding potential energy gradients and alter the vibrational features. In this work, we constructed a series of finite-sized cluster models with varying sizes and an extended periodic crystal model for L-ascorbic acid (L-AA) crystals. Density functionals with both semi-local contributions and nonlocal vdW terms, implemented with either atom-centered Gaussian basis or plane waves, were tested. By comparing first principles calculations with experimental time-domain spectra (TDS), we found that the non-local vdW functional opt-B88 combined with a periodic boundary condition is capable of assigning all the experimental features in the 0.2-1.6 THz region. Calculations with cluster models failed in this task. Even worse, the deficiency of the cluster models varied with cluster sizes, and did not converge as the cluster size grew. Our results demonstrate that an appropriate periodic boundary condition is essential to correctly assign and analyze the THz vibration spectra of molecular crystals.

Does Nepal Have the Agriculture to Feed Its Population with a Sustainable Diet? Evidence from the Perspective of Human-Land Relationship.

Nepal is one of the least developed countries in the world, with more than 80% of the population engaged in agricultural production and more than two-fifths of the population still living below the poverty line. Ensuring food security has always been a key national policy in Nepal. Using a nutrient conversion model and an improved resource carrying capacity model as well as statistical data and household questionnaires, an analysis framework for food supply balance is developed in this study, which quantitatively analyzes the balance of food supply and demand in Nepal from the perspectives of food and calories during the period 2000-2020. Nepal's agricultural production and consumption have increased significantly, and the diet has been relatively stable over the past two decades. The diet structure is stable and homogeneous, with plant products occupying the absolute position in overall dietary consumption. The supply of food and calories varies widely from region to region. Although the increasing supply level at the national scale can meet the needs of the current population, the food self-sufficiency level cannot meet the needs of the local population development at the county level due to the influence of population, geographical location, and land resources. We found that the agricultural environment in Nepal is fragile. The government can improve agricultural production capacity by adjusting the agricultural structure, improving the efficiency of agricultural resources, improving the cross-regional flow of agricultural products, and improving international food trade channels. The food supply and demand balance framework provided a reference for achieving balance between the supply and demand of food and calories in a resource-carrying land and provides a scientific basis for Nepal to achieve zero hunger under the framework of the Sustainable Development Goals. Furthermore, development of policies in order to increase agricultural productivity will be critical for improving food security in agricultural countries such as Nepal.

Coupling of Oxygen Vacancies and Heterostructure on Fe3 O4 via an Anion Doping Strategy to Boost Catalytic Activity for Lithium-Sulfur Batteries.

The sluggish reaction kinetics and severe shutting behaviors of sulfur cathodes are the major roadblocks to realizing the practical application of lithium-sulfur (Li-S) batteries and need to be solved through designing/constructing rational sulfur hosts. Herein, an effective alternative material of Fe3 O4- x /FeP in-situ embedded in N-doped carbon-tube (Fe3 O4- x /FeP/NCT) is proposed. In this fabricated heterostructure, NCT skeleton works as a sulfur host provides physical barrier for lithium polysulfides (LiPSs), while Fe3 O4- x /FeP heterostructure with abundant oxygen vacancies provides double active centers to simultaneously accelerate e- /Li+ diffusion/transport kinetics and catalysis for LiPSs. Through the respective advantages, Fe3 O4- x /FeP/NCT exhibits synergy enhancement effect for restraining sulfur dissolution and enhancing its conversion kinetics. Furthermore, the promoted ion diffusion kinetics, enhanced electrical conductivity, and increased active sites of Fe3 O4- x /FeP/NCT are enabled by oxygen vacancies as well as the heterogeneous interfacial contact, which is clearly confirmed by experimental and first-principles calculations. By virtue of these superiorities, the constructed cathode shows excellent long-term cycling stability and a high-rate capability up to 10 C. Specially, a high areal capacity of 7.2 mAh cm-2 is also achieved, holding great promise for utilization in advanced Li-S batteries in the future.

Diagnostic performance of deep learning-based vessel extraction and stenosis detection on coronary computed tomography angiography for coronary artery disease: a multi-reader multi-case study.

BACKGROUND: Post-processing and interpretation of coronary CT angiography (CCTA) imaging are time-consuming and dependent on the reader's experience. An automated deep learning (DL)-based imaging reconstruction and diagnosis system was developed to improve diagnostic accuracy and efficiency. METHODS: Our study including 374 cases from five sites, inviting 12 radiologists, assessed the DL-based system in diagnosing obstructive coronary disease with regard to diagnostic performance, imaging post-processing and reporting time of radiologists, with invasive coronary angiography as a standard reference. The diagnostic performance of DL system and DL-assisted human readers was compared with the traditional method of human readers without DL system. RESULTS: Comparing the diagnostic performance of human readers without DL system versus with DL system, the AUC was improved from 0.81 to 0.82 (p < 0.05) at patient level and from 0.79 to 0.81 (p < 0.05) at vessel level. An increase in AUC was observed in inexperienced radiologists (p < 0.05), but was absent in experienced radiologists. Regarding diagnostic efficiency, comparing the DL system versus human reader, the average post-processing and reporting time was decreased from 798.60 s to 189.12 s (p < 0.05). The sensitivity and specificity of using DL system alone were 93.55% and 59.57% at patient level and 83.23% and 79.97% at vessel level, respectively. CONCLUSIONS: With the DL system serving as a concurrent reader, the overall post-processing and reading time was substantially reduced. The diagnostic accuracy of human readers, especially for inexperienced readers, was improved. DL-assisted human reader had the potential of being the reading mode of choice in clinical routine.

Pattern changes of ecological product trade in countries along the Belt and Road.

The Belt and Road Initiative (BRI) was designed to promote economic and trade cooperation between countries along the Belt and Road (B&R), specifically by building an international trade network. Ecological resources are the basis for human survival. Countries along the B&R transform ecological resources into ecological products by production activities. These products can then be used for trade, thereby driving the countries' economic development. This study uses net primary productivity (NPP) as a unified measure of ecological products, and explores the pattern changes of ecological product trade in countries along the B&R, from 2013 to 2019 (from the BRI proposal to the outbreak of COVID-19). The purpose of the study is to reveal the impact of the BRI on the trade of ecological products. The results show that (1) the trade scale of ecological products in the B&R region has changed significantly. The total volume of traded ecological products increased from 2071.74 to 2631.00 TgC. This represented an increase of about 26.99%, or 7.41% higher than the global average. (2) The spatial distribution pattern of ecological product trade did not change significantly in countries along the B&R. However, the gravity centers of the total and net trade volume of ecological products moved 120.74 km to the northeast and 392.98 km to the southeast, respectively. (3) The trade structure of ecological products in the B&R region, six sub-regions, and most countries remained relatively stable. Only the proportion of the livestock products trade in Mongolia and the proportion of the forest products trade in Bhutan have increased significantly. This finding suggests that the strength and breadth of the construction of unimpeded trade in countries along the B&R still need to further strengthened, in order to accelerate the realization of the vision of the Green Silk Road.