Novel ferrocenylbisphosphonate hybrid compounds: Synthesis, characterization and potent activity against cancer cell lines.

The toxicity of existing anticancer agents on healthy cells and the emergence of multidrug-resistance cancer cells have led to the search for less toxic anticancer agents with different mechanisms of action. In this study, a novel class of ferrocenylbisphosphonate hybrid compounds (H1-H8) were designed and characterized using NMR, IR and HRMS. The in vitro anticancer activity of the hybrid compounds on HeLa (cervix adenocarcinoma) and A549 (non-small cell lung cancer cell lines) was evaluated. The structure-activity relationship of the hybrid molecules was also studied. The lead compound, tetraethyl (3-(4-oxo-4-ferrocenylbutanamido) propane-1-1-diylbis(phosphonate) (H6) exhibited higher cytotoxicity on A549 (IC50 = 28.15 µM) than cisplatin (IC50 = 58.28 µM), while its activity on HeLa cells (IC50 = 14.69 µM) was equivalent to that of cisplatin 15.10 µM (HeLa cells). H6 (IC50 = 95.58 µM) was also five times less toxic than cisplatin (IC50 = 20.86 µM) on fibroblast NIH3T3 suggesting that H6 can be a future replacement for cisplatin due to its non-toxicity to healthy cells. Interestingly, some ferrocene and bisphosphonate parent compounds exhibited promising anticancer activity with 4-ferrocenyl-4-oxobutanoic acid (FI) exhibiting higher cytotoxic activity (IC50 = 1.73 µM) than paclitaxel (IC50 = 3.5 µM) on A549 cell lines. F1 also exhibited lower cytotoxicity than paclitaxel and cisplatin on the normal murine fibroblast cell line (NIH3T3). The molecular docking studies showed H6 strong binding affinity for the STAT3 signaling pathway in A549 cell line, and the MAdCAM-1 and cellular tumor antigen p53 proteins in HeLa cell lines.

Descriptive data on trichloroethylene and Congo red dye adsorption from wastewater using bio nanosponge phosphorylated-carbon nanotube/nanoparticles polyurethane composite.

The availability and quality of water resources is currently the primary concern in Southern Africa. The challenge is to improve or develop water treatment materials or methods to solve this problem of potable water scarcity. Hence, this article presents the analyzed data, which are supplementary data information on the study of bio nanosponge phosphorylated-carbon nanotube/nanoparticles polyurethane composite (pMWCNT/ß-CD/TiO2-Ag) as polymeric nanobiosorbent, for water treatment. The developed polymeric nanobiosorbent (pMWCNT/ß-CD/TiO2-Ag) was synthesized using combined methods of amidation reaction, cross polymerization, and sol-gel process. The removal of water pollutants (trichloroethylene (TCE) and Congo red (CR) dye) was conducted by the batch adsorption method. The conditions used during the adsorption experiments and methods (applied to quantify the water samples after adsorption studies) are described. Additional data obtained on the effect of pH, isotherm, kinetic, and thermodynamic studies are also illustrated.

Recent development in antimicrobial activity of biopolymer-inorganic nanoparticle composites with water disinfection potential: a comprehensive review.

Nowadays, water-borne diseases including hepatitis remain the critical health challenge due to the inadequate supply of potable and safe water for human activities. The major cause is that the pathogenic microorganisms causing diseases have developed resistance against common techniques used by sewage water treatment plants for water disinfection. Therefore, there is a need to improve these conventional water treatment techniques by taking into consideration the application of nanotechnology for wastewater purification. The main aim of this paper is to provide a review on the synthesis of biopolymer-inorganic nanoparticle composites (BINCs), their used as antimicrobial compounds for water disinfection, as well as to elaborate on their antimicrobial mechanism of action. The microbial properties affecting the activity of antimicrobial compounds are also evaluated.

Chitosan nanocomposites for water treatment by fixed-bed continuous flow column adsorption: A review.

Nowadays, access to clean water sources worldwide and particularly in Southern Africa is inadequate because of its pollution by organic, inorganic, and microorganism contaminants. A range of conventional water treatment techniques has been used to resolve the problem. However, these methods are currently facing the confronts posed by new emerging contaminants. Therefore, there is a need to develop simple and lower cost-effective water purification methods that use recyclable bio-based natural polymers such as chitosan modified with nanomaterials. These novel functional chitosan-based nanomaterials have been proven to effectively eliminate the different environmental pollutants from wastewater to acceptable levels. This paper aims to present a review of the recent development of functional chitosan modified with carbon nanostructured and inorganic nanoparticles. Their application as biosorbents in fixed-bed continuous flow column adsorption for water purification is also discussed.

Nanosponge cyclodextrin polyurethanes and their modification with nanomaterials for the removal of pollutants from waste water: A review.

Water is a worldwide vital resource for sustaining life and due to the pollution of water by different classes of pollutants (inorganic, organic and pathogens), many ongoing studies in water purification remain a critical issue to governments, scientists and industries. The challenge is to develop a water purification technology which will be effective at removing these contaminants simultaneously and reducing their concentrations to ultra low levels from waste water. This review article serves to give an overview on cyclodextrin nanosponge adsorbents which have already been used for water treatment. The modification of these cyclodextrin nanosponges with existing adsorbent nanomaterials (carbon nanotubes, TiO2 and silver nanoparticles) and the factors affecting the adsorption capacity of these nanosorbents are discussed. The nanotoxicity of these engineered nanosorbents material is also addressed since nanotoxicity is a major concern to human health and environment.