[Epidemiological study of rotavirus diarrhea in Beijing area from 2010 to 2012].

OBJECTIVE: To investigate the epidemic of diarrhea caused by rotavirus infection among children treated at the Beijing Friendship Hospital in a period of 2 years. METHODS: Stool samples were collected from 972 diarrheic children from January 2010 to January 2012. The antigen of rotavirus was detected by the gold imunochromatography assay (GICA). RESULT: Among the samples studied, 370 out of 972 cases (38.1%) were positive for rotavirus antigen. The ratio of infected boys and girls was 2.14:1. Most infected children (91.4%) were under the age of two. The viral infection takes place all year round but breaks out mainly within a cold season that lasts from October through March, with a peak in November and December. Even in the spring and summer, however, its prevalence rates were quite significant among the children with diarrhea, ranging from 11.1% to 41.7%. CONCLUSION: In Beijing area, rotavirus is the major etiologic cause of diarrhea in children, especially in those under the age of 2. The peak prevalence occurs at any given time during the late fall and early spring seasons. It is necessary, therefore, to strengthen the surveillance of rotavirus infection in the spring and summer seasons in order not only to predict and prevent a potential outbreak in the end of the year, but also collect and provide more dynamic data for the further epidemiologic research of rotavirus diarrhea in the children.

[Effects on development of the testicle in diet-induced obesity rats].

OBJECTIVE: We established diet-induced obesity animal model and observed the influence of obesity on testicle of the male rats. METHODS: Rats in model group were fed with fat-enriched diet for 6 weeks. We measured the body weight and the testis weight and observed the development of testicle by microscope, and compared with those of control group. Meanwhile, we measured the serum levels of testosterone (T) and estradiol (E2). RESULTS: The average body weight in model group rats was higher 29% than that in control group at 6 weeks old, 30% at 9 weeks old. We observed under microscope that most of the convoluted seminiferous tubule developed no good in model group, the 4 layer cells was sparse and the arrangement of them was not in order. The testosterone to estradiol ratios(T/E2) in model group was significant lower then that of control group (P < 0.05). CONCLUSION: The fat-enriched fat diet can induce obesity. It influenced the development of the testicle. This probably related to decrease of the testosterone to estradiol ratios.