CLINICAL AND GENETIC FEATURES OF PERSONALIZED ANTIPSYCHOTIC THERAPY OF PATIENTS WITH PARANOID SCHIZOPHRENIA OF THE KAZAKH ETHNIC GROUP IN THE REPUBLIC OF KAZAKHSTAN.

The problems of schizophrenia therapy occupy a leading place in both foreign and domestic clinical psychiatry. The paper presents the results of a study to identify reliable biomarkers for predicting antipsychotic therapy of patients with paranoid schizophrenia of the Kazakh ethnic group in the Republic of Kazakhstan, conducted within the framework of the project: "National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan" IRN ОР12165486. The effectiveness and tolerability of antipsychotic drugs used in the treatment of paranoid schizophrenia in the Republic of Kazakhstan according to clinical treatment protocols are analyzed. Gender and age-specific dynamics in the clinic of paranoid schizophrenia in antipsychotic therapy in persons of Kazakh ethnicity are described. Certain genetic features of representatives of the Kazakh ethnic group have been identified, which can influence the effectiveness and tolerability of antipsychotic drugs, which determines the basis of an innovative approach to personalized therapy of paranoid schizophrenia in patients of the Kazakh ethnic group in the Republic of Kazakhstan.

GENETIC PREDICTORS OF SCHIZOPHRENIA AND THEIR FEATURES IN INDIVIDUAL ETHNIC POPULATIONS (REVIEW ARTICLE).

The paper presents a review of current literature data on ongoing international studies to identify genetic predictors of schizophrenia, since heredity and family predisposition to schizophrenia have been known for several decades. New data on the interaction between genetic variants, epigenetic marks, including cross interaction between the processes of DNA methylation and histone modification, affecting the regulation of gene expression under the influence of the environment, are reflected. Particular attention is paid to studies devoted to identifying the features of genetic predictors of schizophrenia in certain ethnic populations, in particular in relation to persons of the Kazakh ethnic group in the Republic of Kazakhstan. The study was carried out within the framework of the project: "National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan" IRN OR12165486.