ANCW: Affective norms for 4030 Chinese words.

Affective information contained in words is gaining increased attention among neurolinguists and psycholinguists around the world. This study established the Affective Norms for Chinese Words (ANCW) with valence, arousal, dominance, and concreteness ratings for 4030 words that were Chinese adaptations of the CET-4 (The National College English Test Band 4) official syllabus. Despite the existing Chinese affective norms such as the Chinese Affective Words System (CAWS), the ANCW provides much more and richer Chinese vocabulary. By using 7-point (ranging from 1 to 7) Likert scales in a paper-and-pencil procedure, we obtained ratings for all variables from 3717 Chinese undergraduates. The ANCW norms possessed good response reliability and were compatible with prior normative studies in Chinese. The pairwise correlation analysis revealed quadratic relations between valence and arousal, arousal and dominance, as well as valence and concreteness. Additionally, valence and dominance, as well as arousal and concreteness, presented a linear correlation, and concreteness and dominance were correlated. The ANCW provides reliable and standardized stimulus materials for further research involving emotional language processing.

Retraction of "Cu(II)-Containing Metal-Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells".

[This retracts the article DOI: 10.1021/acsomega.0c06270.].

A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies.

BACKGROUND: Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with complex pathogenesis. Currently, the pathogenesis of ASD is not fully understood. Moreover, current treatments do not effectively alleviate the primary symptoms of ASD social disorder (SCDA). Jiawei Yinhuo Tang (JWYHT) is an improved version of the classic prescription Yinhuo Tang. Although this medication has been shown to improve social behavior in ASD patients, the mechanism by which it works remains unknown. METHODS: In this study, network pharmacology bioinformatics analysis was used to identify the key targets, biological functions, and signal pathways of JWYHT in SCDA. Then, molecular docking and molecular dynamic simulation were used to validate the activity and stability of the active ingredient and the target protein during the binding process. RESULTS: The analysis identified 157 key targets and 9 core targets of JWYHT (including proto-oncogene (FOS), caspase 3 (CASP3), mitogen-activated protein kinase-3 (MAPK3), interleukin-6 (IL6), mitogen-activated protein kinase-1 (MAPK1), tumor necrosis factor (TNF), mitogen-activated protein kinase-8 (MAPK8), AKT serine/threonine kinase 1 (AKT1), and 5-hydroxytryptamine receptor 1B (5HT1B)) in SCDA. In addition, the Kyoto Encyclopedia of Gene and Genome results, as well as the staggering network analyses, revealed 20 biological processes and 20 signal pathways targeted by JWYHT in SCDA. Finally, molecular docking analysis was used to determine the binding activity of the main active components of JWYHT to the key targets. The binding activity and stability of methyl arachidonate and MAPK8 were demonstrated using molecular dynamics simulation. CONCLUSION: This study demonstrates that JWYHT regulates neuronal development, synaptic transmission, intestinal and cerebral inflammatory response, and other processes in SCDA.

Changes in the secondary structures and zeta potential of soybean peptide and its calcium complexes in different solution environments.

To illustrate the relationship between environment hydrophobicity and soybean peptide and its calcium complexes when they are absorbed transmembrane, different solution environments (HBS buffer, TFE hydrophobic solution and cell suspension) were used to simulate hydrophilic and hydrophobic environments. In this study, soybean peptides (10-30 kDa) with a high calcium binding capacity were prepared by enzymatic hydrolysis and ultrafiltration. The results of cell experiments showed that the peptide could transport calcium into cells for absorption. Secondary structure changes of the peptide and its calcium complexes in different solution environments showed that the secondary structure of the peptide changed during the transmembrane absorption, and the contents of α-helix and ß-sheet structures increased. Besides, the ß-sheet structures in the peptide-calcium complexes were further converted to an α-helix structure. This conversion may be induced by the hydrophobicity of peptide solutions. In addition, when the conformation changes, the positively charged peptides in the sample will be exposed and then interact with cells, which is beneficial for the transmembrane of peptide-calcium complexes.

Cu(II)-Containing Metal-Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells.

A novel metal-organic framework (MOF) has been produced via Cu(NO3)2·6H2O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)2(H2O)2](H2O)8) n } (1). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a.

Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins.

BACKGROUND Bone morphogenetic proteins (BMPs) are widely involved in cancer development. However, a wealth of conflicting data raises the question of whether BMPs serve as oncogenes or as cancer suppressors. MATERIAL AND METHODS By integrating multi-omics data across cancers, we comprehensively analyzed the genomic and pharmacogenomic landscape of BMP genes across cancers. RESULTS Surprisingly, our data indicate that BMPs are globally downregulated in cancers. Further genetics and epigenetics analyses show that this abnormal expression is driven by copy number variations, especially heterozygous amplification. We next assessed the BMP-associated pathways and demonstrated that they suppress cell cycle and estrogen hormone pathways. Bone morphogenetic protein interacts with 58 compounds, and their dysfunction can induce drug sensitivity. CONCLUSIONS Our results define the landscape of the BMP family at a systems level and open potential therapeutic opportunities for cancer patients.

Changes of blood pressure and heart rate during sexual activity in healthy adults.

OBJECTIVE: This study is to observe the changes of blood pressure (BP), heart rate (HR), double product (DP) and heart rate variability during sexual activity in healthy adults before we cover patients with chronic cardiovascular disease. METHODS: Forty-nine participants grouped by sex, 22 males, aged 40.6+/-7.8 years; 27 females, aged 40.3+/-7.8 years, underwent simultaneous ambulatory monitoring of BP and HR for 24 h. During the monitoring period, sexual activity of the participants with man-on-top in their familiar environment was performed. Participants were requested to measure BP manually at the beginning of each sexual phase and three times after orgasm in every 10-min interval and 60 min after orgasm. For each individual, eight measuring values, respectively, about BP, HR, DP and heart rate variability were obtained from baseline to 1 h after orgasm. The data were statistically analyzed with paired t-test and the significant level was set at P<0.05. RESULTS: In both groups, the peak BP did not appear at orgasm, but at the beginning of plateau and dropped to baseline level at 10 min after orgasm (male 141.41+/-17.13/91.05+/-13.69 vs. 120.14+/-11.07/72.86+/-7.78 mmHg, female 121.67+/-16.61/77.37+/-15.03 vs. 109.37+/-10.54/67.19+/-9.41 mmHg). The peak HR occurred at the beginning of orgasm, and dropped to baseline level 10-20 min after orgasm (male 96.36+/-11.96 vs. 75.41+/-9.02 bpm, female 90.19+/-10.38 vs. 71.44+/-5.68 bpm). DP of both groups elevated at the beginning of plateau and orgasm then decreased to baseline level 10 min after orgasm (male 12964.27+/-2659.17 vs. 9134.09+/-1469.58 mmHg bpm, female 10044.48+/-1777.89 vs. 7841.30+/-1023.79 mmHg bpm). All the results showed that BP, HR and DP have mild to moderate changes during sexual activity in healthy adults. CONCLUSION: Using ambulatory technology to monitor BP and HR helps us to get the real data in participants during sexual activity. BP, HR and DP increase just slightly for a short time and recover to baseline level soon after sexual activity in healthy adults. The physical exhaustion during sexual activity is within the range of the daily-life workload.