The influence of MTAD and QMix on the accuracy of electronic apex locator in locating simulated perforations.

Aims and Background: The aim of this study was to evaluate the accuracy of the electronic actual length in detecting artificial perforations of the root canal in the presence of saline solution (NaCl, (Eczacibasi, Istanbul, Turkey), chlorhexidine [CHX (Werax, Tunadent, Izmir, Turkey)], QMix (Dentsply Tulsa, Maillefer, Ballaigues, Switzerland), and MTAD (Dentsply, Tulsa Dental, Tulsa, OK, USA). Materials and Methods: The root canals of 25 single-rooted extracted human teeth were perforated artificially in the middle section of the root. The actual lengths up to the perforation site were measured and then, the teeth were embedded in an alginate mold. Electronic measurements of the perforations were obtained by an electronic apex locator according to the manufacturers' recommendations under dry conditions and in the presence of NaCl, CHX, MTAD, and QMix using a #20 K-file. Each canal was irrigated with distilled water and then dried with paper points between the measurements. Statistical analyses were performed using the Friedman test and Spearman Rank correlation coefficient to assess the correlations between the measurement methods. Results: Highest correlation between the actual length and the electronic measurement was observed under dry conditions and NaCl solution (r: 0.932, r: 0.940 respectively), and the least correlation was observed with MTAD solution (r: 0.697) using statistical analysis. Moreover, the accuracy of the electronic apex locator with different irrigation solutions was statistically different from each other (P = 0.001). Conclusion: The most accurate electronic measurements of artificial perforation were obtained under dry conditions or with NaCl.

Evaluation of various filling techniques in distal canals of mandibular molars instrumented with different single-file nickel-titanium systems.

BACKGROUND AND AIMS: The aim of this study was to evaluate the quality of various filling techniques in distal canals of mandibular molars instrumented with different single-file nickel-titanium (NiTi) systems. MATERIALS AND METHODS: A total of 150 distal roots of mandibular molar teeth were randomly assigned into three main groups and instrumented by using Reciproc (VDW, Munich, Germany), WaveOne (Dentsply Tulsa, Tulsa, OK, USA), or One Shape (MicroMega, Besancon, France) NiTi file systems. The roots were then treated using one of five filling techniques: (1) Matched-single-cone, (2) cold lateral compaction with matched gutta-percha (GP) cone, (3) Thermafil filling, (4) System B/Obtura II, and (5) lateral compaction with standardized GP cones. The roots were then sectioned at three levels (coronal, middle, and apical). Photographs were acquired under a stereomicroscope, and the percentage of GP-filled areas (PGFAs), percentage of sealer-filled areas (PSFAs), and voids were measured using the ImageJ software. Comparisons between groups were applied using Student's t-test or one-way ANOVA for normally distributed data. The Mann-Whitney U-test or Kruskal-Wallis test was used when variables were not normally distributed. RESULTS: Canals filled with the System B/Obtura showed the highest PGFA and lowest PSFA, whereas those filled with matched-single-cone showed the highest PSFA and lowest PGFA (P < 0.05). The cold lateral compaction with matched GP cone group, lateral compaction group, and Thermafil filling group showed no statistically significant differences in PSFA and PGFA (P > 0.05). CONCLUSIONS: System B/Obtura technique appears to be the best technique to properly fill root canals, whereas the matched-single-cone technique in oval-shaped distal canals of mandibular molars was inadequate.

Effects of seven different irrigation techniques on debris and the smear layer: a scanning electron microscopy study.

AIM: Conventional manual irrigation with a syringe and needle remains widely accepted technique in the irrigation procedures. However, its flushing action has some limitations. Currently, several techniques and systems are available and reported to improve the insufficiency of syringe irrigation. The aim of this study was to evaluate the effectiveness of 7 different irrigation techniques compared to standard irrigation. MATERIALS AND METHODS: Straight roots from 80 extracted human maxillary central incisors were collected, and root canals were instrumented with K-files up to apical size 50. The teeth were randomly divided into 8 groups (n = 10), and final irrigation procedures were performed with 17% ethylenediaminetetraacetic acid and 5.25% NaOCl solutions using following irrigation agitation techniques: RinsEndo, EndoVac, Canal CleanMax, sonic, Canal Brush, NaviTip FX, manual dynamic irrigation, and conventional irrigation. The presence of debris and smear layer (SL) at coronal, middle, and apical thirds was evaluated by using a 5-grade scoring system with ×200 and ×1000 magnification, respectively. RESULTS: Concerning debris removal, the MM 1500 sonic group reduced apical debris significantly better than the other groups tested (P < 0.05). There was no significant difference among the tested groups (P > 0.05) related SL removal in all levels. CONCLUSIONS: MM 1500 scored best with debris removal; however, there was no significant reduction in the SL in apical third with any of the methods tested.

Retracted: Postoperative pain after irrigation with Vibringe versus a conventional needle: a randomized controlled trial.

The following article from International Endodontic Journal, 'Postoperative pain after irrigation with Vibringe versus a conventional needle: a randomized controlled trial' by D. Bilgili, S. Yilmaz, A. Dumani & O. Yoldas, published online on 29 February 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Journal Editor in Chief, Prof. Paul Dummer, and John Wiley & Sons Ltd. The retraction has been agreed because the corresponding author did not contact the first author who carried out the work before alterations to the article were made prior to submission. This damages the integrity of the work and there are additional concerns over the number of patients and the accuracy of the results and conclusions.

Does tamoxifen citrate prevent pulmonary fibrosis due to silica inhalation?

BACKGROUND: As shown in several studies, besides being used in breast cancer, tamoxifen is also known for its antifibrotic effects via reducing the serum TGF-beta levels. We investigated the possible preventive effect of tamoxifen in rats exposed to silica particles depending on the antifibrotic effect. MATERIALS AND METHODS: A total of 102 adult female Wistar Albino rats were divided into five groups. First two groups (control and tmx) were free of silica and the last three groups (slc, tmx1 and tmx 10) were exposed to crystalline silica. The rats in tmx, tmx1 and tmx10 groups received 10 mg/kg, 1 mg/kg and 10 mg/kg of body weight tamoxifen, respectively. On day 84, all rats were sacrified and tissue samples were obtained together with blood samples. The differences in serum TGF-ß levels, histological grades of fibrosis and inflammation in the lung and liver tissues together with addional biochemical markers were calculated between the groups. RESULTS: Silicosis occurred in slc, tmx1 and tmx10 groups in 100%, 91.7% and 52.1%, respectively. Liver fibrosis did not occur. The highest mean lung fibrosis scores were obtained in slc group while the scores were lower in tmx1 group and the lowest in tmx10 within silica-exposed rats. Nevertheless, the inflammation scores were higher in tamoxifen-administered rats in a dose-dependent pattern. CONCLUSION: Silica inhalation did not result in liver fibrosis. Tamoxifen is found to prevent lung fibrosis and reduce serum TGFß-1 levels while increasing lung inflammation (Tab. 3, Fig. 3, Ref. 27).

Early laparoscopic cholecystectomy with continuous pressurized irrigation and dissection in acute cholecystitis.

Background. The aim of this study was to evaluate the preliminary results of a new dissection technique in acute cholecystitis. Material and Method. One hundred and forty-nine consecutive patients with acute cholecystitis were operated on with continuous pressurized irrigation and dissection technique. The diagnosis of acute cholecystitis was based on clinical, laboratory, and radiological evidences. Age, gender, time from symptom onset to hospital admission, operative risk according to the American Society of Anesthesiologists (ASA) score, white blood cell count, C-reactive protein test levels, positive findings of radiologic evaluation of the patients, operation time, perioperative complications, mortality, and conversion to open surgery were prospectively recorded. Results. Of the 149 patients, 87 (58,4%) were female and 62 (41,6%) were male. The mean age was 46.3 ± 6.7 years. The median time from symptom onset to hospital admission 3.2 days (range, 1-6). There were no major complications such as bile leak, common bile duct injury or bleeding. Subhepatic liquid collection occurred in 3 of the patients which was managed by percutaneous drainage. Conversion to open surgery was required in four (2,69%) patients. There was no mortality in the study group. Conclusion. Laparoscopic cholecystectomy with continuous pressurized irrigation and dissection technique in acute cholecystitis seems to be an effective and reliable procedure with low complication and conversion rates.

Diagnostic laparoscopy for pneumatosis intestinalis: to do or not to do?

Pneumatosis intestinalis (PI) is a rare clinical condition, which is commonly associated with mesenteric vascular ischemia, bowel obstruction, and chemotherapy. Although the pathophysiology of PI remains unclear, 2 theories, one mechanical and the other bacterial, have been proposed. Nonoperative medical treatment and observation should be considered in mild cases, but occasionally, the situation requires emergency surgical intervention. In cases of suspectful complicated PI, the clinician should not avoid performing diagnostic laparoscopy to rule out bowel ischemia and perforation.

Coexistence of gallbladder agenesis and cholangiocarcinoma: report of a case.

Gallbladder agenesis (GA) is a rare condition and was first described by Lemary in 1701. Nearly 400 cases of GA is described in the literature and it is associated with various congenital abnormalities and malformations in some cases. Cholangiocarcinoma (CCA) is the malignant tumor arising from bile ducts. A wide range of risk factors have been identified for cholangiocarcinoma. A case of cholangiocarcinoma in which gallbladder agenesis was found incidentally was described in this study.

Prognostic value of plasma D-dimer levels in patients with colorectal cancer.

OBJECTIVE: Plasma D-dimer levels have been shown to be increased in patients with various solid tumours including lung, prostate, cervical, ovarian, breast and colon cancer. The purpose of this prospective study was to estimate the plasma D-dimer level of patients with colorectal cancer before surgery and to assess whether it has a prognostic value. METHOD: The study comprised 51 patients with colorectal cancer. Variables including demographic, clinical, operative and pathological findings and routine laboratory tests were recorded. In addition, tumour markers, coagulation tests and plasma D-dimer levels were evaluated. RESULTS: Histological types other than well-differentiated adenocarcinoma, relatively advanced tumour stage and a high preoperative plasma D-dimer level were the prognostic factors that were associated with shorter postoperative survival according to univariate analyses. The presence of vascular invasion was associated with higher preoperative D-dimer levels. However, there was no statistically significant relationship between postoperative survival and the presence of vascular invasion. CONCLUSION: Postoperative survival was significantly shorter in colorectal cancer patients with elevated preoperative D-dimer levels. Evaluation of preoperative D-dimer level can be used to predict postoperative survival.

Cooling for the reduction of postoperative pain: prospective randomized study.

Hernia surgery has been associated with severe pain within the first 24 h postoperatively. The application of cold or cryotherapy has been in use since at least the time of Hippocrates. The physiological and biological effects from the reduction of temperature in various tissues include local analgesia, inhibited oedema formation and reduced blood circulation. Our hypothesis was that cold therapy, applied by means of ice packs, following inguinal hernia surgery, controlled pain postoperatively. Forty patients scheduled for inguinal hernia repair were enrolled in a double-blind, randomized study. Postoperatively, chipped ice in a plastic bag (cold group), and a plastic bag containing only room temperature water (control) were placed over the incision for 20 min. Postoperative pain data were collected at 2, 6 and 24 h after operation according to the well validated visual analogue scale (VAS). The highest pain levels were recorded 2 h postoperatively for both groups. Pain levels then gradually decreased for both the trial groups during the first 24 h postoperatively. There were significant differences in the VAS scores between the groups at 2, 6 and 24 h. We conclude that local cooling is a safe and effective technique for providing analgesia following inguinal hernia repair.

An experimental analysis of stresses in simulated flared root canals subjected to various post-core applications.

Cervical root fracture is a major clinical problem in flared root canals treated with different post and core applications. This in vitro study evaluated the stress transfer of different post and core systems to the cervical part of the artificially created flared root canals, by using strain gauges. The post-core systems investigated were: (a) cast post-core system without resin reinforcement, (b) cast post-core system with resin reinforcement, (c) pre-fabricated post and resin core with resin reinforcement. The post-core systems which were cemented on simulated roots were subjected to a load applied at an angle of 45 degrees to the long axis of the simulated roots. The strain gauges which were cemented to the cervical part of simulated roots were connected to the data acquisition module to measure and record the changes in strain data. Specimens restored with resin reinforcement either with cast post-core or pre-fabricated post and resin core transferred the stress to the cervical part of the artificial roots at a rate lower than conventional cast post-core system (P = 0.001; anova and Tukey's post hoc test). It was concluded that the resin reinforcement of root canals before post-core applications reduces the stresses at the cervical part of the root surfaces.

The effect of two different calcium hydroxide combinations on root dentine microhardness.

AIM: To evaluate the effect of a calcium hydroxide and glycerine mix and a calcium hydroxide and water mix on the microhardness of human root dentine. METHODOLOGY: Eleven freshly extracted maxillary canine and central incisor teeth were used. The teeth were sectioned transversally to produce a total of 22 dentine discs from the middle-third of the root. The specimens were divided into two groups of 11 discs each. Dentine samples were treated with either a Ca(OH)2-glycerine combination or a Ca(OH)2-distilled water combination for 1, 3 and 7 days. Dentine microhardness was measured with a Knoop indenter with a load of 100 g for 15 s before and during the experimental period. Each root disc received a series of three indentations around the pulp space, 1 mm from canal wall. RESULTS: Statistical analysis showed that both combinations significantly decreased dentine microhardness after 3 and 7 days (P < 0.01). The reduction in dentine microhardness following the use of a Ca(OH)2-glycerine combination was significantly greater than that after a Ca(OH)2-distilled water combination after 3 and 7 days (P < 0.01). CONCLUSION: The use of Ca(OH)2 combinations for intracanal dressing softens dentine.

Comparison of quality-of-life outcomes of Stoppa vs bilateral Lichtenstein procedure.

Hernia repair is one of the most frequent procedures in surgery. The aim of this study is to compare the early and long-term health status and clinical outcomes of patients in the postoperative period of Stoppa and bilateral Lichtenstein hernia repair in bilateral groin hernias. The Stoppa group consisted of 22 patients, and the bilateral Lichtenstein group had 23 patients. Both groups were similar with respect to age, gender, ASA score, and postoperative follow-up periods. A multidimensional measure of health status, the Short Form-36 (SF-36), was administered at 15 days and 6 months postoperatively. Although there is no difference between the two groups in the early postoperative period, three of eight health concepts measured with SF-36 (physical functioning, role limitation-physical, general health perception) showed a significant difference in long-term health status. We conclude that long-term quality of life following Stoppa operations is superior to bilateral Lichtenstein hernia repair in bilateral groin hernias.