RESUMEN
NIR persistent luminescence nanoparticles (PLNPs) are appealing for bio-imaging because of the properties of extremely low autofluorescence interference and deep tissue penetrating ability. However, current preparation methods can hardly simultaneously endow PLNPs with nano-scale size, long persistent luminescence (PersL) life, and high luminescence intensity, which can hardly meet the requirements of bio-imaging. Herein, we report a new synthetic route to nano-sized chromium-doped zinc gallate (ZGC) via a removable MOF template, i.e., one-pot hydrothermal synthesis of an intermediate followed by its calcination at 1100 °C in air. By exploiting the regulatory effect of the intermediate on Zn and Ga, the depth of traps in 170 nm-sized ZGC nanoparticles was enhanced to above 0.8 eV, and the PersL duration to more than 24 h, with an average lifetime of up to 216 s. An in vivo experiment shows that tumors can be accurately delineated for more than 3 hours. This strategy largely resolves the conflict between the particle size and PersL properties of PLNPs, and expands the application of PLNPs in bio-imaging.
