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1.
Environ Sci Pollut Res Int ; 29(60): 90567-90579, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35871196

RESUMEN

Herbal products have become widely used in managing and treating a wide range of illnesses. Therefore, this study aimed to evaluate the total phenolic and flavonoid contents, antioxidant and protective effects of Cymbopogon citratus ethyl acetate and Ficus carica hexane leave extract (200 mg/kg b.w for both) on sodium benzoate (SB) (200 mg/kg b.w) toxicity in rats. For 6 weeks, four groups of five rats each (control, SB, F. carica + SB, and C. citrates + SB). Blood sample (liver, kidney) tissue and histological examination were used at the end of the experiment. According to the findings, the extracts have significant concentrations of total flavonoids, total phenolics, and antioxidant activity. Oxidative stress caused by SB exposure induced an increase in ALT, AST, ALP, glucose, urea, creatinine, uric acid, TG, TC, LDL, and MDA, while insulin and SOD were decreased. Furthermore, the biochemical alterations generated by SB in the blood serum, homogenate, liver, and kidney tissue were significantly reduced by C. citratus ethyl acetate and F. carica hexane leave extracts (P < 0.05). The leaf extracts of the examined plants had significant curative and preventive effects in SB-induced liver and kidney damage, resulting in diminished liver and kidney biomarker enzymes, an improved antioxidant defense system, and lipid peroxidation inhibition.


Asunto(s)
Cymbopogon , Ficus , Animales , Ratas , Benzoato de Sodio , Hexanos , Extractos Vegetales/farmacología
2.
Catheter Cardiovasc Interv ; 57(3): 312-7, 2002 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-12410505

RESUMEN

We compared the safety, efficacy, and cost of the newly introduced percutaneous metallic commissurotome (PMC) with the results of Inoue balloon mitral valvuloplasty (BMV) in 80 patients with mitral stenosis (MS). The mean increase in mitral valve area (MVA) was 0.95 +/- 0.19 to 1.7 +/- 0.35 cm(2) for PMC and 0.97 +/- 0.15 to 1.81 +/- 0.36 cm(2) for BMV (P = NS). The Wilkins echocardiographic scores before dilatation did not correlate with any difference in MVA after dilatation. Bilateral commissural splitting was significantly more common with PMC than with BMV (30/39 patients, 76.9%, vs. 21/40 patients, 52.5%; P = 0.02). Postprocedural severe mitral regurgitation occurred in 1/39 (2.6%) in the PMC group and in 4/41 (9.8%) in the BMV group. Because the PMC device is resterilizable, we estimated the cost to be one-fourth the cost of BMV with the Inoue balloon. The estimated device cost ratio of PMC to BMV for each patient was 1 to 4.25. The early results of PMC on the MVA are comparable to BMV. However, PMC had better results not only in patients with high echocardiographic scores, but the PMC device splits commissural calcification better than BMV.


Asunto(s)
Cateterismo , Ecocardiografía , Prótesis Valvulares Cardíacas , Válvula Mitral/diagnóstico por imagen , Válvula Mitral/cirugía , Adulto , Cateterismo/economía , Costos y Análisis de Costo , Ecocardiografía/economía , Egipto/epidemiología , Seguridad de Equipos/economía , Femenino , Enfermedades de las Válvulas Cardíacas/complicaciones , Enfermedades de las Válvulas Cardíacas/diagnóstico por imagen , Enfermedades de las Válvulas Cardíacas/terapia , Prótesis Valvulares Cardíacas/economía , Humanos , Incidencia , Masculino , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Cardiopatía Reumática/complicaciones , Cardiopatía Reumática/diagnóstico por imagen , Cardiopatía Reumática/terapia , Índice de Severidad de la Enfermedad , Factores de Tiempo , Resultado del Tratamiento
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