RESUMEN
ABSTRACT The authors describe an unusual association between posterior keratoconus and iris atrophy, confirmed by a complete ocular evaluation, scheimpflug imaging and pachymetric curve. A hypothesis for concomitant findings is discussed.
RESUMO Os autores descrevem a rara associação entre ceratocone posterior e atrofia de íris, confirmada por avaliação oftalmológica completa, imagens de scheimpflug e curva paquimétrica. Sugere-se uma hipótese que explique a concomitância de ambas as alterações.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Iris/patología , Enfermedades del Iris/complicaciones , Queratocono/complicaciones , Astigmatismo/complicaciones , Astigmatismo/patología , Atrofia , Ambliopía/complicaciones , Ambliopía/patología , Topografía de la Córnea/métodos , Paquimetría Corneal/métodos , Queratocono/patologíaRESUMEN
The authors describe an unusual association between posterior keratoconus and iris atrophy, confirmed by a complete ocular evaluation, scheimpflug imaging and pachymetric curve. A hypothesis for concomitant findings is discussed.
Asunto(s)
Enfermedades del Iris/complicaciones , Iris/patología , Queratocono/complicaciones , Ambliopía/complicaciones , Ambliopía/patología , Astigmatismo/complicaciones , Astigmatismo/patología , Atrofia , Paquimetría Corneal/métodos , Topografía de la Córnea/métodos , Femenino , Humanos , Queratocono/patología , Persona de Mediana EdadRESUMEN
Importance. Autologous serum (AS) eye drops are recommended for severe dry eye in patients with ocular surface disease. No description of the antioxidant balance of AS eye drops has been reported in the literature. Objective. This study sought to evaluate the total reactive antioxidant potential (TRAP) and concentration of reactive oxygen species (ROS) in samples of 50% AS eye drops and their correlations with the demographic characteristics and lifestyle habits of patients with ocular surface disease and healthy controls. Design. This was a case-control study with a 3-month follow-up period. Participants. 16 patients with severe dry eye disease of different etiologies and 17 healthy controls matched by age, gender, and race were included. Results. TRAP and ROS were detected at all evaluated times. There were no differences in the mean ROS (p = 0.429) or TRAP (p = 0.475) levels between cases and controls. No statistically significant differences in the concentrations of ROS or TRAPs were found at 0, 15, or 30 days (p for ROS = 0.087 and p for TRAP = 0.93). Neither the demographic characteristics nor the lifestyle habits were correlated with the oxidative balance of the 50% AS eye drops. Conclusions and Relevance. Both fresh and frozen 50% AS eye drops present antioxidant capacities and ROS in an apparently stable balance. Moreover, patients with ocular surface disease and normal controls produce equivalent AS eye drops in terms of oxidative properties.
