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Org Biomol Chem ; 21(10): 2086-2090, 2023 03 08.
Artículo en Inglés | MEDLINE | ID: mdl-36806856

RESUMEN

The enantioselective conjugate addition of malonates to α,ß-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase is described. High conversions, high enantioselectivities, and good isolation yields were achieved for a range of substrates. We further completed a four-step synthesis of the antidepressant (+)-femoxetine by utilizing this reaction and an enzymatic reductive amination reaction.


Asunto(s)
Aldehídos , Malonatos , Estereoisomerismo , Isomerasas , Catálisis
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