Dorsal root ganglion-pulsed neuromodulation radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients.

BACKGROUND: Chronic spinal-origin pain poses a substantial clinical challenge, prompting the investigation of novel treatment modalities. This study aims to evaluate the potential application of spinal nerve dorsal root ganglion (DRG) radiofrequency treatment in addressing chronic spinal-origin pain. METHODS: The study encompassed patients undergoing treatment for chronic spinal-origin pain, with a particular focus on those experiencing pain localized in specific regions. Inclusion criteria comprised patients with conditions such as a herniated intervertebral disc or foraminal stenosis leading to compression of descending or exiting nerve roots, accompanied by reported radicular pain in the lower limb. RESULTS: There was no significant difference in comparability between the two groups (p > 0.05). The clinical effective rate in the study group was significantly higher than that in the control group (p < 0.05). The VAS scores of the study group at 2 weeks and 1 month after treatment were significantly lower than those of the control group (p < 0.05). The PSQI index of the study group after treatment was significantly lower than that of the control group (p < 0.05). There was no significant difference in the incidence of complications between the two groups (p > 0.05). CONCLUSION: Spinal nerve DRG radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients. The occurrence of complications is relatively low, and it can be reduced through strict operational standards and preoperative and postoperative management. However, caution should be exercised in its widespread application, but it is worthy of broad clinical use.

Psychological effects of traditional Chinese mind-body exercises for low back pain: A protocol for meta-analysis.

INTRODUCTION: Several studies reported that traditional Chinese mind-body exercises showed beneficial effects on improving anxiety and depression of patients with low back pain (LBP) in recent years. However, the effects of traditional Chinese mind-body exercises on improving psychological disorders of patients with LBP remain controversial. Most previous reviews only focused on the effects of traditional Chinese mind-body exercises for LBP on pain and dysfunction. Therefore, the present systematic review and meta-analysis will be conducted to evaluate the evidence on psychological effects of traditional Chinese mind-body exercises for LBP. METHODS AND ANALYSIS: The electronic databases (PubMed, Embase, MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, China Knowledge Resource Integrated Database, and Wanfang Data) will be searched. The search will include all documents from their inception to February 2021. The Physiotherapy Evidence Database scale will be used for quality assessment of eligible studies. Risk of bias of eligible studies will also be assessed by Cochrane tool. The meta-analysis will be conducted using the Review Manager Version 5.3 software. The Higgins I2 statistic will be performed to examine for heterogeneity. The subgroup analysis will be conducted based on different types of traditional Chinese mind-body exercises, different intervention time, and different outcomes. Quality of evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation. ETHICS AND DISSEMINATION: No ethical statement will be required for the performance of this review and meta-analysis. The results of this review will be published in an international peer-reviewed journal. INPLASY REGISTRATION NUMBER: INPLASY202130075.

Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway.

Intervertebral disc degeneration (IDD) is accompanied by nucleus pulposus (NP) cell apoptosis, inflammation, and extracellular matrix degradation. Tumour necrosis factor receptor 1 (TNFR1) is a receptor of TNF-α, and is deeply involved in the processes of IDD. However, the effect of TNFR1 inhibition on IDD is not clear. Herein, we report that TNFR1 was increased in LPS-treated HNPCs. The aim of this study was to investigate the potential therapeutic effect of TNFR1 siRNA and selective antagonists of TNFR1 (GSK1995057) on HNPC damage. The results showed that the blockade of TNFR1 by TNFR1 siRNA and GSK1995057 effectively suppressed the cell viability loss, apoptosis, and inflammation induced by LPS in HNPCs. Furthermore, we found that TNFR1 siRNA and GSK1995057 inhibited activation of the NF-KB and MAPK signalling pathways in LPS-stimulated HNPCs. In summary, the blockade of TNFR1 effectively suppressed LPS-induced apoptosis and inflammation in HNPCs through the NF-KB and MAPK signalling pathways. This revealed that the blockade of TNFR1 may provide a potential therapeutic treatment for IDD.