Recent development of azole-sulfonamide hybrids with the anticancer potential.

Cancer exhibits heterogeneity that enables adaptability and remains grand challenges for effective treatment. Chemotherapy is a validated and critically important strategy for the treatment of cancer, but the emergence of multidrug resistance which may lead to recurrence of disease or even death is a major hurdle for successful chemotherapy. Azoles and sulfonamides are important anticancer pharmacophores, and azole-sulfonamide hybrids have the potential to simultaneously act on dual/multiple targets in cancer cells, holding great promise to overcome drug resistance. This review outlines the current scenario of azole-sulfonamide hybrids with the anticancer potential, and the structure-activity relationships as well as mechanisms of action are also discussed, covering articles published from 2020 onward.

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A distinctive Eocene Asian monsoon and modern biodiversity resulted from the rise of eastern Tibet.

The uplift of eastern Tibet, Asian monsoon development and the evolution of globally significant Asian biodiversity are all linked, but in obscure ways. Sedimentology, geochronology, clumped isotope thermometry, and fossil leaf-derived numerical climate data from the Relu Basin, eastern Tibet, show at âˆ¼50-45 Ma the basin was a hot (mean annual air temperature, MAAT, ∼27 °C) dry desert at a low-elevation of 0.6 ± 0.6 km. Rapid basin rise to 2.0 ± 0.9 km at 45-42 Ma and to 2.9 ± 0.9 km at 42-40 Ma, with MAATs of âˆ¼20 and âˆ¼16 °C, respectively, accompanied seasonally varying increased annual precipitation to > 1500 mm. From âˆ¼39 to 34 Ma, the basin attained 3.5 ± 1.0 km, near its present-day elevation (∼3.7 km), and MAAT cooled to âˆ¼6 °C. Numerically-modelled Asian monsoon strength increased significantly when this Eocene uplift of eastern Tibet was incorporated. The simulation/proxy congruence points to a distinctive Eocene Asian monsoon, quite unlike that seen today, in that it featured bimodal precipitation and a winter-wet regime, and this enhanced biodiversity modernisation across eastern Asia. The Paleogene biodiversity of Asia evolved under a continually modifying monsoon influence, with the modern Asian monsoon system being unique to the present and a product of a long gradual development in the context of an ever-changing Earth system.

Perceived gaze direction affects recollection processes in recognition of concrete and abstract words: electrophysiological evidence.

Studies have revealed that memory performance can be affected by perceived gaze direction. However, it remains unclear whether direct gaze promotes or hinders word memory, and the effect of gaze direction on memory of words with different concreteness requires investigation. In the study phase, concrete and abstract words were presented on direct- or averted-gaze faces, and participants were instructed to judge gaze direction and memorize words. In the test phase, participants were asked to discriminate whether a word was old or new. Electroencephalogram recordings were taken in both phases. Behavioral and time-frequency results verified the direct-gaze memory advantage, showing that memory performance was better in the direct-gaze condition than the averted-gaze condition for both concrete and abstract words. Event-related potential results showed that in both direct- and averted-gaze conditions, the early old/new effects (FN400) associated with familiarity were only elicited for concrete words but not abstract words. The late old/new effects (LPC) associated with recollection were elicited in all conditions. More importantly, concrete words elicited greater LPC than abstract words in the direct-gaze condition, whereas there was no such significant LPC difference in the averted-gaze condition. Topographic map analysis found that neural generators between concrete and abstract words differed in the direct-gaze condition but not in the averted-gaze condition. The study supports the hypothesis that direct-gaze promotes memory performance. Furthermore, it is mainly in memory recollection that gaze direction affects words with different concreteness.

Sandwich-type CoSe2-CNWs@rGO/S composites with efficient trapping and catalytic conversion of polysulfides in lithium-sulfur batteries.

Although lithium-sulfur batteries (LSBs) are very promising in energy storage devices, their low conductivity, shuttle effect, and volume expansion unfavorably lead to sluggish kinetics and worsening electrochemical performance. To address these problems, we firstly prepared conductive carbon nanowires embedded with lithiophilic CoSe2 nanoparticles (CoSe2-CNWs), and utilized CoSe2-CNWs to construct reduced graphene oxide (rGO) sheets; thereby, sandwich-type CoSe2-CNWs@rGO composites were assembled. CoSe2-CNWs@rGO composites were taken as the sulfur host. Due to the alternating rGO sheets and active sulfur, the special sandwich structure can maximize the use of sulfur, confine polysulfides physically, favor electron transport, and cushion the volume change during cycling. The interlayer CoSe2-CNWs network also can entrap polysulfides chemically, promote the electron transfer, and improve the reaction kinetics, owing to the synergetic merits of high polarity and conductivity. Compared with CoSe2-CNWs/S and Co-CNWs/S, the CoSe2-CNWs@rGO/S cathode shows a significant improvement in cell performance. Its specific capacity decreases from 1137.9 mA h g-1 at 0.1 C to 649.7 mA h g-1 at 2 C, demonstrating the optimal rate performance. The cycling capacity also slowly reduces from 975.4 mA h g-1 to 839.7 mA h g-1 after 150 cycles at 0.5 C, showing a high retention of 86.1% with a tiny average fading rate (0.093%).

The rise and demise of the Paleogene Central Tibetan Valley.

Reconstructing the Paleogene topography and climate of central Tibet informs understanding of collisional tectonic mechanisms and their links to climate and biodiversity. Radiometric dates of volcanic/sedimentary rocks and paleotemperatures based on clumped isotopes within ancient soil carbonate nodules from the Lunpola Basin, part of an east-west trending band of basins in central Tibet and now at 4.7 km, suggest that the basin rose from <2.0 km at 50 to 38 million years (Ma) to >4.0 km by 29 Ma. The height change is quantified using the rates at which wet-bulb temperatures (Tw) decline at land surfaces as those surface rise. In this case, Tw fell from ~8°C at ~38 Ma to ~1°C at 29 Ma, suggesting at least ~2.0 km of surface uplift in ~10 Ma under warm Eocene to Oligocene conditions. These results confirm that a Paleogene Central Tibetan Valley transformed to a plateau before the Neogene.

Employing synergetic effect of ZnSe quantum dots and layered Ni(OH)2to boost the performance of lithium-sulfur cathodes.

The low sulfur utilization, cycling instability, and sluggish kinetics are the critical obstructions to practical applications of lithium-sulfur batteries (LSBs). Constructing sulfur hosts with high conductivity, suppressed shuttle effect, and rapid kinetics is essential for their practical application in LSBs. Here, we synthetically utilized the merits of ZnSe quantum dots (QDs) and layered Ni(OH)2to boost the performance of LSBs. A novel core-shell ZnSe-CNTs/S@Ni(OH)2was constructed using the ZnSe-CNTs network as framework to load sulfur and following with Ni(OH)2encapsulation. The CNT network decorated with ZnSe QDs not only serves as a conductive framework providing fast electron/ion transfer channels, but also limits polysulfide diffusion physically and chemically. Layered Ni(OH)2, the wrinkled encapsulation, not only permits fast electron/ion transfer, but also buffers the expansion, confines active materials, and limits the polysulfide dissolution chemically. When used as a cathode, ZnSe-CNTs/S@Ni(OH)2presents enhanced electrochemistry performance compared with ZnSe-CNTs/S and CNTs/S. The average specific capacity decreases from 1021.9 mAh g-1at 0.2 C to 665.0 mAh g-1at 2 C, showing rate capacity much higher than ZnSe-CNTs/S and CNTs/S. After 150 cycles, the capacity at 0.5 C slowly reduces from 926.7 to 789.0 mAh g-1, showing high retention of 85.1%. Therefore, our investigation provides a new strategy to construct a promising sulfur cathode for LSBs.

A special core-shell ZnS-CNTs/S@NH cathode constructed to elevate electrochemical performances of lithium-sulfur batteries.

Lithium-sulfur batteries (LSBs) are regarded as promising candidates for next-generation electrochemical energy storage systems due to their low cost and high energy density. However, the insulative sulfur, the volume expansion and high soluble polysulfides are three roots impeding their practical applications, and consequently bring challenges of low sulfur utilization, poor cyclic stability and sluggish redox kinetics. Herein, a special core-shell ZnS-CNTs/S@Ni(OH)2 (labeled as ZnS-CNTs/S@NH) cathode has been designed to overcome above obstacles and elevate the electrochemical performance. The ZnS-CNTs/S@NH cathode is synthesized via a facile step-by-step strategy, in which ZnS-decorated CNTs was used as a framework to load sulfur and followed with a ultrathin Ni(OH)2 (NH) layer encapsulation. The ZnS-CNT core combines merits of CNT network and polar ZnS quantum dots (QDs), accommodating the volume change, offering efficient pathways for fast electron/ion transport, and anchoring polysulfides through polar interactions. The outer Ni(OH)2 shell physically confines the active material and meanwhile provides plenty of catalytic sites for effective polysulfide chemisorption. Benefiting from these merits, the ZnS-CNTs/S@NH cathode exhibits excellent cell performances in comparison with ZnS-CNTs/S and CNTs/S. Its discharge capacity at different C-rates is optimal in the three cathodes, which decreases from 1037.0 mAh g-1 at 0.1 C to 646.1 mAh g-1 at 2.0 C. Its cyclic capacity also manifests the slowest reduction from 861.1 to 760.1 mAh g-1 after 150 cycles at 0.5 C, showing a high retention (88.3%) and a tiny average fading rate (0.078%). The strategy in this work provides a feasible approach to design and construct core-shell cathode materials for realizing practically usable Li-S batteries.

Perceived gaze direction affects concreteness effects in words memory: an event-related potentials study.

Previous studies have revealed that word concreteness effects could be influenced by contextual cues such as emotional context. However, it is unclear whether concreteness effects might be influenced by social context such as perception of gaze direction, which plays an important role in social interaction. This study uses event-related potentials (ERPs) to investigate whether perceived gaze direction could affect concreteness effects in words memory. Concrete and abstract words were presented on direct- or averted-gaze faces, and participants were asked to memorize the words. Behavioral results verified the direct-gaze memory advantage, showing that memory performance was better for words presented with direct gaze than with averted gaze. ERP results showed that concrete words were associated with a larger N400 and a smaller late positive component (LPC) than abstract words. ERP results also revealed a significant interaction between gaze direction and word concreteness on the LPC component: specifically, the LPC concreteness effect occurred only in the direct-gaze condition. Our results suggested that the gaze direction could be interpreted as a complex social context that differs from pure emotional cues in its influence on mental imagery in concreteness effects. This study provides a new perspective for investigating word concreteness effects with contextual cues.

Trends of Healthy Life Expectancy of the Elderly in China in 1994-2015: Revisiting From the Perspective of Morbidity Transition.

Research on healthy life expectancy (HLE) in China has been fueled by a spate of new data sources and studies, yet no consensus is reached on the pattern of HLE changes and the underlying mechanism. This study examined the change of HLE in China over 20 years with long term national data. Health status, measured by activities of daily living, is combined with mortality to calculate the disability-free life expectancy by the Sullivan method. The results show that the HLE rose slower than life expectancy (LE) in 1994-2004, indicating morbidity expansion. However, in 2010-2015, the proportion of HLE to LE increased, manifesting morbidity compression. A counterfactual analysis further shows that health improvement has been increasingly important in increasing HLE in 2010-2015, despite the dominance of mortality decline. The findings suggest that morbidity can transition between compression, expansion and dynamic equilibrium over a long period due to different combinations of mortality and health improvements. Given the limited data in this study, whether and how morbidity transitions unfold in the future remains open and requires further research.

Incorporation ZnS quantum dots into carbon nanotubes for high-performance lithium-sulfur batteries.

Constructing sulfur hosts with high electronic conductivity, large void space, strong chemisorption, and rapid redox kinetics is critically important for their practical applications in lithium-sulfur batteries (LSBs). Herein, by coupling ZnS quantum dots (QDs) with carbon nanotubes (CNTs), one multifunctional sulfur host CNT/ZnS-QDs is designed via a facile one-step hydrothermal method. SEM and TEM analyses reveal that small ZnS-QDs (<5 nm) are uniformly anchored on the CNT surface as well as encapsulated into CNT channels. This special architecture ensures sulfur direct contacting with highly conductive CNTs; meanwhile, the catalytic effect of anchored ZnS-QDs improves the chemisorption and confinement to polysulfides. Benefiting from these merits, when used as sulfur hosts, this special architecture manifests a high specific capacity, superior rate capability, and long-term cycling stability. The ZnS-QDs dependent electrochemical performance is also evaluated by adjusting the mass ratio of ZnS-QDs, and the host of CNT/ZnS-QDs 27% owns the optimal cell performance. The specific capacity decreases from 1051 mAh g-1 at 0.2 C to 544 mAh g-1 at 2.0 C, showing rate capability much higher than CNT/S and other CNT/ZnS-QDs/S samples. After 150 cycles, the cyclic capacity at 0.5 C exhibits a slow reduction from 1051 mAh g-1 to 771 mAh g-1, showing a high retention of 73.4% with a coulombic efficiency of over 99%. The electrochemical impedance spectroscopy analyses demonstrate that this special architecture juggles high conductivity and excellent confinement of polysulfides, which can significantly suppress the notorious shuttle effect and accelerate the redox kinetics. The strategy in this study provides a feasible approach to design efficient sulfur hosts for realizing practically usable LSBs.