All-solid highly sensitive fiber-tip magnetic field sensor based on a Fabry-Perot interferometer with a breakpoint structure.

An all-solid fiber-tip Fabry-Perot interferometer (FPI) coated with a nickel film is proposed and experimentally verified for magnetic field sensing with high sensitivity. It is fabricated by splicing a segment of a thin-wall capillary tube to a standard single-mode fiber (SMF), then inserting a tiny segment of fiber with a smaller diameter into the capillary tube, and creating an ultra-narrow air-gap at the SMF end to form an FPI. When the device is exposed to magnetic field, the capillary tube is strained due to the magnetostrictive effect of the nickel film coated on its outer surface. In addition, owing to the unique breakpoint sensitivity-enhancement structure of the air-gap FPI, the elongation of the capillary tube whose length is over 100 times longer than the air-gap width is entirely transferred to the cavity length change of the FPI, and the sensor is extremely sensitive to the magnetic field as proved by our experiments, achieving a high sensitivity of up to 2.236 nm/mT for a linear magnetic field range from 40 to 60 mT, as well as a low-temperature cross-sensitivity of 56 µT/°C. The all-solid stable structure, compact size (total length of ∼3.0 mm), and reflective working mode with high magnetic field sensitivity indicate that this sensor has good application prospects.

A hydrogel optical fibre sensor for rapid on-site ethanol determination.

Ethanol plays a critical role in the modern chemical industry, food production, and medical research. Given its wide applications, the detection of ethanol concentration is very necessary. In this paper, a fibre device for rapid ethanol detection is proposed. The sensing head was fabricated with multimode fibre. The hydrogel was photo-cured on the fibre tip from polyethylene glycol diacrylate (PEGDA). In the hydrogel, rhodamine 6G (R6G) was immobilized as the fluorescent indicator. The sensor was designed based on the swelling behaviour of the hydrogel in liquid. The transparency of the hydrogel was modulated by the component of the water-ethanol mixture, thus, the fluorescence intensity of R6G was monitored for the determination of ethanol. Within the range of 0-62.2 vol%, the detection limit (LOD) was 0.4 vol%. A detailed comparison with other detection methods showed that the proposed sensor has the advantages of being single-ended, low LOD, cost-effective, and easy to prepare. It has great potential for on-site ethanol detection applications.

Partially coherent twisted vector vortex beam enabling manipulation of high-dimensional classical entanglement.

In this paper, we present a novel form of a partially coherent beam characterized by classical entanglement in higher dimensions. We coin the term "twisted vector vortex (TVV) beam" to describe this phenomenon. Similar to multi-partite quantum entangled states in higher dimensions, the partially coherent twisted vector vortex beam possesses distinct properties such as non-uniform polarization, vortex phase, and twist phase. Through experiments, we offer empirical evidence for these three degrees-of-freedom in the light field. The results demonstrate that the state of the light is inseparable in terms of polarization and orbital angular momentum (OAM) modes. Additionally, the twist phase introduces an additional dimension in controlling the vector vortex beam. This research reveals the possibility of new controlling dimensions in classical entanglement through the chirality of coherence within partially coherent light. Consequently, this opens up new avenues for the utilization of partially coherent light in both classical and quantum domains.

Phase-insensitive amplifier gain estimation at Cramér-Rao bound for two-mode squeezed state of light.

Phase-insensitive amplifiers (PIAs), as a class of important quantum devices, have found significant applications in the subtle manipulation of multiple quantum correlation and multipartite quantum entanglement. Gain is a very important parameter for quantifying the performance of a PIA. Its absolute value can be defined as the ratio of the output light beam power to the input light beam power, while its estimation precision has not been extensively investigated yet. Therefore, in this work, we theoretically study the estimation precision from the vacuum two-mode squeezed state (TMSS), the estimation precision of the coherent state, and the bright TMSS scenario, which has the following two advantages: it has more probe photons than the vacuum TMSS and higher estimation precision than the coherent state. The advantage in terms of estimation precision of the bright TMSS compared with the coherent state is researched. We first simulate the effect of noise from another PIA with gain M on the estimation precision of the bright TMSS, and we find that a scheme in which the PIA is placed in the auxiliary light beam path is more robust than two other schemes. Then, a fictitious beam splitter with transmission T is used to simulate the noise effects of propagation loss and imperfect detection, and the results show that a scheme in which the fictitious beam splitter is placed before the original PIA in the probe light beam path is the most robust. Finally, optimal intensity difference measurement is confirmed to be an accessible experimental technique to saturate estimation precision of the bright TMSS. Therefore, our present study opens a new avenue for quantum metrology based on PIAs.

Generating a hollow twisted correlated beam using correlated perturbations.

In this study, a twisted correlated optical beam with a dark hollow center in its average intensity is synthesized by correlated correlation perturbation and incoherent mode superposition. This new hollow beam has a topological charge (TC) mode with a zero value compared with a coherence vortex that has a TC mode with a nonzero value. We transform the twisted correlated beam from solid centered to dark hollow centered by constructing a correlation between the twist factor and the spot structure parameter. Theoretical and experimental results show that twist correlation makes the random optical beam an asymmetric orbital angular momentum spectral distribution and a tunable intensity center. Controlling the correlation parameters can make the focal spot of the twisted beam a dark core when the dominant mode of the TC is still zero. The new nontrivial beams and their proposed generation method provide important technical preparations for the optical particle manipulation with low coherence environment.

A dual-mode optical fiber sensor for SERS and fluorescence detection in liquid.

The in vivo detection of biomarkers in a liquid environment is very important for the early diagnosis of diseases. Spectroscopy methods are employed in ultraviolet-visible-infrared wavelengths, fluorescence or Raman spectra are detected for clinical diagnose. The dual-mode image can provide more diagnostic information and has been realized in some research work. However, there is still lacking simple and sensitive dual-mode sensors to satisfy the in vivo detecting demands. In this paper, a dual-mode fiber sensor for Surface-enhanced Raman Scattering (SERS) and fluorescence detection is proposed. The sensor is formed by a tapered optical fiber, half of the fiber tip surface is coated with Ag nanoparticles. In the detection of Rhodamine 6G (R6G) aqueous solution, the minimum detectable concentrations in SERS and fluorescence tests are of the same order of magnitude. By combining the Raman spectral features and the fluorescence intensity, the recognition and quantitation of target molecules were obtained reliably. It is the first time, to our knowledge, that the Raman-fluorescence dual-mode detection is realized in one single fiber, which was manufactured with micro-machinery techniques. It is a label-free, general-purpose fiber sensor, which can be applied for liquid biopsy, helping to diagnose and treat diseases in vivo.

Nomogram for prediction of severe community-acquired pneumonia development in diabetic patients: a multicenter study.

BACKGROUND: Diabetic patients with community-acquired pneumonia (CAP) have an increased risk of progressing to severe CAP. It is essential to develop predictive tools at the onset of the disease for early identification and intervention. This study aimed to develop and validate a clinical feature-based nomogram to identify diabetic patients with CAP at risk of developing severe CAP. METHOD: A retrospective cohort study was conducted between January 2019 to December 2020. 1026 patients with CAP admitted in 48 hospitals in Shanghai were enrolled. All included patients were randomly divided into the training and validation samples with a ratio of 7:3. The nomogram for the prediction of severe CAP development was established based on the results of the multivariate logistic regression analysis and other predictors with clinical relevance. The nomogram was then assessed using receiver operating characteristic curves (ROC), calibration curve, and decision curve analysis (DCA). RESULTS: Multivariate analysis showed that chronic kidney dysfunction, malignant tumor, abnormal neutrophil count, abnormal lymphocyte count, decreased serum albumin level, and increased HbA1c level at admission was independently associated with progression to severe CAP in diabetic patients. A nomogram was established based on these above risk factors and other predictors with clinical relevance. The area under the curve (AUC) of the nomogram was 0.87 (95% CI 0.83-0.90) in the training set and 0.84 (95% CI 0.78-0.90). The calibration curve showed excellent agreement between the predicted possibility by the nomogram and the actual observation. The decision curve analysis indicated that the nomogram was applicable with a wide range of threshold probabilities due to the net benefit. CONCLUSION: Our nomogram can be applied to estimate early the probabilities of severe CAP development in diabetic patients with CAP, which has good prediction accuracy and discrimination abilities. Since included biomarkers are common, our findings may be performed well in clinical practice and improve the early management of diabetic patients with CAP.

Control of orbital angular momentum of optical vortex beams with complex wandering perturbations.

This work investigates how independent perturbations and cross-correlation perturbations affect optical vortex beams. Theoretical and experimental results show that both perturbations cause the intensity, average orbital angular momentum (OAM), and the OAM spectrum of the vortex beam to vary periodically with the perturbation direction, but with different periods. When the beam is subjected to independent perturbations, the average OAM changes periodically with θ in every π/2; when the beam is subjected to cross-correlation perturbations, the average OAM varies with θ in every π. The results of this work provide a method to control the OAM and regulate low-coherence vortex beams in turbulent environments.

Demodulation of Fabry-Perot sensors using random speckles.

Random speckles are proposed to demodulate Fabry-Perot (FP) sensors in this study. A piece of multimode fiber is used to interrogate the FP transmission spectrum, and tiny spectral changes lead to significant variations in the generated speckle patterns. In the demonstration experiments, the pressure resolution of 0.001 MPa can be obtained from an open cavity FP sensor based on the convolutional neural network (CNN) demodulation algorithm. It is worth noting that the spectral differences in neighboring orders can be precisely distinguished due to the high sensitivity of speckles. Thus, the fringe-order ambiguity problem is solved and the dynamic measurement range can be greatly improved. The speckle-based demodulation scheme provides a new way to balance resolution, dynamic range, speed, and cost of FP sensors.

Deep-learning-assisted fiber Bragg grating interrogation by random speckles.

Fiber Bragg gratings (FBGs) have been widely employed as a sensor for temperature, vibration, strain, etc. measurements. However, extant methods for FBG interrogation still face challenges in the aspects of sensitivity, measurement speed, and cost. In this Letter, we introduced random speckles as the FBG's reflection spectrum information carrier for demodulation. Instead of the commonly used InGaAs cameras, a quadrant detector (QD) was first utilized to record the speckle patterns in the experiments. Although the speckle images were severely compressed into four channel signals by the QD, the spectral features of the FBGs can still be precisely extracted with the assistance of a deep convolution neural network (CNN). The temperature and vibration experiments were demonstrated with a resolution of 1.2 pm. These results show that the new, to the best of our knowledge, speckle-based demodulation scheme can satisfy the requirements of both high-resolution and high-speed measurements, which should pave a new way for the optical fiber sensors.

Variable-fiber optical power splitter design based on a triangular prism.

Fiber optical power splitters (OPSs) have been widely employed in optical communications, optical sensors, optical measurements, and optical fiber lasers. It has been found that OPSs with variable power ratios can simplify the structure and increase the flexibility of optical systems. In this study, a variable-fiber OPS based on a triangular prism is proposed and demonstrated. By adjusting the output beam width of the prism, the power ratio can be continuously tuned. The optical simulations show that the horizontal displacement design is better than the traditional tilt angle design. Our scheme combines a dual-fiber collimator, a focus lens, and a triangular prism with a vertex angle of 120°. By changing the axial displacement of the prism, the power splitting ratio can be altered from 50:50 to 90:10. The polarization and wavelength dependence of the variable OPS were also investigated.

Optical Fiber Based Mach-Zehnder Interferometer for APES Detection.

A 3-aminopropyl-triethoxysilane (APES) fiber-optic sensor based on a Mach-Zehnder interferometer (MZI) was demonstrated. The MZI was constructed with a core-offset fusion single mode fiber (SMF) structure with a length of 3.0 cm. As APES gradually attaches to the MZI, the external environment of the MZI changes, which in turn causes change in the MZI's interference. That is the reason why we can obtain the relationships between the APES amount and resonance dip wavelength by measuring the transmission variations of the resonant dip wavelength of the MZI. The optimized amount of 1% APES for 3.0 cm MZI biosensors was 3 mL, whereas the optimized amount of 2% APES was 1.5 mL.

Ultra-high sensitivity strain sensor based on biconical fiber with a bulge air-bubble.

An ultra-high sensitivity Fabry-Perot interferometer (FPI) strain sensor is proposed and experimentally demonstrated. It is composed of a biconical fiber with a bulge air-bubble at its waist. Because of the good stress concentration capability of the tapered fiber, the bulge air-bubble is easily deformed when it is stressed, resulting in an ultra-high strain sensitivity of 101.7 pm/µÉ›, which is the highest strain sensitivity among the direct wavelength interrogation-based strain sensors reported so far, to the best of our knowledge. Moreover, the proposed sensor has a low temperature sensitivity of ∼1pm/∘C; thus an extreme low temperature cross sensitivity of less than 10 nɛ/°C can be achieved.

Nonlinear interferometric surface-plasmon-resonance sensor.

A nonlinear interferometer can be constructed by replacing the beam splitter in the Mach-Zehnder interferometer with four-wave mixing (FWM) process. Meanwhile, the conventional surface plasmon resonance (SPR) sensors can be extensively used to infer the information of refractive index of the sample to be measured via either angle demodulation technique or intensity demodulation technique. Combined with a single FWM process, a quantum SPR sensor has been realized, whose noise floor is reduced below standard quantum limit with sensitivity unobtainable with classical SPR sensor. Therefore, in this work we have theoretically proposed a nonlinear interferometric SPR sensor, in which a conventional SPR sensor is placed inside nonlinear interferometer, which is called as I-type nonlinear interferometric SPR sensor. We demonstrate that near resonance angle I-type nonlinear interferometric SPR sensor has the following advantages: its degree of intensity-difference squeezing, estimation precision ratio, and signal-noise-ratio are improved by the factors of 4.6 dB, 2.3 dB, and 4.6 dB respectively than that obtained with a quantum SPR sensor based on a single FWM process. In addition, the theoretical principle of this work can also be expanded to other types of sensing, such as bending, pressure, and temperature sensors based on a nonlinear interferometer.

Rapid and label free detection of aflatoxin B1 in alcoholic beverages with a microfluid fiber device.

A rapid and label free aflatoxin B1 (AFB1) microfluid sensor was proposed and tested. The device was fabricated with hollow-core photonics crystal fiber infiltrated with the AFB1 solution. The autofluorescence emitting from the AFB1 molecules was detected. The sensor length was optimized. The AFB1 concentration was tested with a 4 cm long sensor. The best limit of detection was achieved as low as 1.34 ng/ml, which meets the test requirement of the national standards for AFB1 in food. The effectiveness of this sensor being applied in beer solution was also verified to be a little more sensitive than in aqueous solution. Compared with traditional AFB1 detection methods, the proposed single-ended device perfectly satisfies the demand of process control in alcoholic beverages manufacture.

PDMS-filled Fabry-Perot interferometer-based multipoint temperature measurement using an array-waveguide grating.

In this paper, a multipoint temperature measurement scheme based on Fabry-Perot interferometers (FPIs) multiplexing is proposed. The FPI sensor is constructed as a section of hollow-core fiber (HCF) partially filled with polydimethylsiloxane (PDMS) spliced to a single-mode fiber. An array-waveguide grating with 16 channels is used for the FPI sensors' multiplexing and demultiplexing, and a broadband source is used as the light source. The corresponding theoretical model was built for analysis of the scheme, and the simulation results shown the FPI working principle can be simplified as a dual-beam interference. Two channels connected to two FPI sensors were experimentally tested for the concept verification. The temperature sensitivities of the proposed two sensors are 1.090 dB/°C and 1.210 dB/°C from 30°C to 40°C, respectively. There is no interchannel cross talk observed. Hence, FPI temperature sensors can work simultaneously in this structure, proving the validity of the multipoint temperature measurement concept.

Microfluidic flow direction and rate vector sensor based on a partially gold-coated TFBG.

In microfluidic chips applications, the monitoring of the rate and the direction of a microfluidic flow is very important. Here, we demonstrate a liquid flow rate and a direction sensor using a partially gold-coated tilted fiber Bragg grating (TFBG) as the sensing element. Wavelength shifts and amplitude changes of the TFBG transmission resonances in the near infrared reveal the direction of the liquid flowing along the fiber axis in the vicinity of the TFBG due to a nanoscale gold layer over part of the TFBG. For a device length of 10 mm (and a diameter of 125 µm for easy insertion into microfluidic channels), the flow rates and the direction can be detectable unequivocally. The TFBG waveguiding properties allow such devices to function in liquids with refractive indices ranging from 1.33 to about 1.40. In addition, the proposed sensor can be made inherently temperature-insensitive by referencing all wavelengths to the wavelength of the core mode resonance of the grating, which is isolated from the fiber surroundings.

High-sensitivity hydraulic pressure sensor based on Fabry-Perot interferometer filled with polydimethylsiloxane film.

A high-sensitivity hydraulic pressure sensor is proposed, which consists of a Fabry-Perot interferometer (FPI) filled with a polymer film of polydimethylsiloxane (PDMS). The FPI structure is fabricated by splicing a section of hollow core fiber (HCF) to the end-face of a lead-in single mode fiber (SMF). Then, the PDMS is filled into the HCF which acts as a light reflector and a diaphragm to detect external pressure variation. As a result, the length of the FPI cavity and the thickness of the PDMS are 137.8 µm and 33.8 µm, respectively. Experimental results indicate that the sensor's wavelength exhibits a linear response to the hydraulic pressure, which function is described as y = -7.35 × 10-3x + 1536.395. Here, x and y represent the hydraulic pressure and the wavelength, respectively. The pressure sensitivity is up to -7.35 nm/kPa. Besides, a temperature compensation method based on a fiber Bragg grating is proposed to eliminate the influence of temperature. Experiments show that the scheme can effectively eliminate the influence of temperature and achieve accurate measurement of hydraulic pressure.

Vernier effect of two cascaded in-fiber Mach-Zehnder interferometers based on a spherical-shaped structure.

The Vernier effect of two cascaded in-fiber Mach-Zehnder interferometers (MZIs) based on a spherical-shaped structure has been investigated. The envelope based on the Vernier effect is actually formed by a frequency component of the superimposed spectrum, and the frequency value is determined by the subtraction between the optical path differences of two cascaded MZIs. A method based on band-pass filtering is put forward to extract the envelope efficiently; strain and curvature measurements are carried out to verify the validity of the method. The results show that the strain and curvature sensitivities are enhanced to -8.47 pm/µÎµ and -33.70 nm/m-1 with magnification factors of 5.4 and -5.4, respectively. The detection limit of the sensors with the Vernier effect is also discussed.

Highly sensitive PDMS-filled Fabry-Perot interferometer temperature sensor based on the Vernier effect.

A highly sensitive temperature sensor is demonstrated experimentally, which is fabricated based on a Fabry-Perot interferometer (FPI) filled with polydimethylsiloxane (PDMS). The sensor's sensitivity is -0.653 nm/°C by utilizing the thermal expansion effect of PDMS, which has been greatly improved compared to that of the traditional FPI temperature sensor. Moreover, in order to further improve the sensitivity, a scheme where two parallel FPI structures are used to form the Vernier effect is proposed, which are a sensing FPI and reference FPI, respectively. Such a temperature sensor based on the FPI filled with PDMS and the Vernier effect exhibits a high temperature sensitivity of 17.758 nm/°C. Meanwhile, the proposed sensors show the advantages of high sensitivity, simplicity, and low cost.