1.
Org Lett
; 24(30): 5557-5561, 2022 08 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35867631
RESUMEN
An efficient method for the synthesis of ß,ß-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic simplicity. By taking advantage of DMSO as a less-toxic promoter and solvent for the difluoroalkylation and C-P bond functionalization, the use of transition-metal catalysts and sensitive additives could be avoided.