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1.
Sci Total Environ ; 742: 140602, 2020 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-32640389

RESUMEN

Biochar is a good adsorbent for water pollutants. However, the effects of biochar on aquatic organisms are not well understood. In this study, different amounts of biochar (CK, 0 mg/g; T1, 10 mg/g; T2, 30 mg/g) were added to sediment to study changes in water quality and its impact on three submerged macrophytes (Hydrilla verticillata, Vallisneria natans, and Ceratophyllum demersum) and the sediment microbial community. The results indicated that biochar treatments significantly increased the water pH and conductivity. Compared with the initial values, the total phosphorus (P) contents in the water of the CK, T1, and T2 treatments decreased by 78.5%, 95.0%, and 58.3%, respectively, while the total nitrogen contents increased by 26.26%, -5.81%, and 19.70%, respectively. Compared with those in CK, the relative growth rates of H. verticillata, V. natans, and C. demersum in T1 increased by 28.4%, 163.1%, and 61.3%, respectively, while those in T2 showed no significant difference except that the growth rates of H. verticillata decreased by 17.7%. The P contents of the three submerged macrophytes increased with the increase of biochar addition, except that there was no significant difference between T2 and CK for H. verticillata. Biochar treatments reduced the biomass of total microbial, bacterial, and fungal phospholipid fatty acids in the sediment for H. verticillata and V. natans, and they increased fungal: bacterial ratios in the low-dose biochar treatments for V. natans and C. demersum. This study demonstrates that the addition of biochar to sediment significantly increased the pH and conductivity, and decreased total P contents in the water. Low-dose biochar treatments were more beneficial for water quality improvements and the growth of submerged macrophytes than high-dose biochar.


Asunto(s)
Hydrocharitaceae , Calidad del Agua , Carbón Orgánico , Nitrógeno , Fósforo
2.
World J Gastroenterol ; 24(20): 2191-2202, 2018 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-29853737

RESUMEN

AIM: To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus (HCV) infection (OCI). METHODS: One hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection (CHC) were diagnosed at five Liver Centers in Northeastern China, from 2012 to 2016. CXCL10 rs1439490, rs1440802, and IL-28B rs12979860 were analyzed by sequencing. Serum CXCL10 was measured by ELISA. Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring. Liver necroinflammation and fibrosis were scored according to the METAVIR system. RESULTS: CXCL10 rs1439490 G/G was more prevalent in OCI patients (n = 93/103; 90.3%) than in CHC patients (n = 116/155; 74.8%; P = 0.008). OCI patients had lower serum CXCL10 levels than CHC patients (192.91 ± 46.50 pg/mL vs 354.78 ± 102.91 pg/mL, P < 0.0001). Of IL-28B rs12979860 C/C patients, OCI patients with rs1439490 G/G had lower serum and liver levels of CXCL10 and lower levels of liver necroinflammation and fibrosis than non-G/G patients. OCI patients had higher alanine aminotransferase normalization rates after Peg-interferon treatment than CHC patients (P < 0.05) and serum CXCL10 decreased significantly (P < 0.0001). Liver necroinflammation and fibrosis were alleviated in 8 OCI patients after treatment. Multivariate analysis indicated that rs1439490 G/G significantly influenced the occurrence of OCI in HCV infection (OR = 0.31, 95%CI: 0.15-0.66, P = 0.002). CONCLUSION: CXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome.


Asunto(s)
Antivirales/uso terapéutico , Quimiocina CXCL10/genética , Hepacivirus/aislamiento & purificación , Hepatitis C Crónica/genética , Interleucinas/genética , Adulto , Biopsia , Quimiocina CXCL10/sangre , China , Femenino , Hepacivirus/genética , Hepatitis C Crónica/sangre , Hepatitis C Crónica/tratamiento farmacológico , Hepatitis C Crónica/virología , Humanos , Interferón-alfa/uso terapéutico , Interferones , Hígado/enzimología , Hígado/patología , Hígado/virología , Cirrosis Hepática/sangre , Cirrosis Hepática/tratamiento farmacológico , Cirrosis Hepática/patología , Cirrosis Hepática/virología , Pruebas de Función Hepática , Masculino , Persona de Mediana Edad , Polietilenglicoles/uso terapéutico , Polimorfismo de Nucleótido Simple , ARN Viral/aislamiento & purificación , Proteínas Recombinantes/uso terapéutico , Ribavirina/uso terapéutico , Pruebas Serológicas , Resultado del Tratamiento
3.
Artículo en Chino | MEDLINE | ID: mdl-21110426

RESUMEN

OBJECTIVE: To investigate the characteristics of HCV genotypes of Han and Korean in Yanbian area of Jilin Province. METHODS: The HCV RNA load and genotypes of the 119 chronic hepatitis C patients in Yanbian area of Jilin Province were determined by real-time PCR and LiPA. The differences of the HCV genotypes in Han and Korean cases, in severity of the diseases, in HCV-RNA load, and in the relation with type 2 diabetes mellitus were analyzed. RESULTS: There was no significant difference in the distribution of each HCV genotype between Han and Korean patients (P > 0.05) with chronic hepatitis C. The difference between HCV genotype and HCV-RNA load was not significant (P > 0.05). With and without type 2 diabetes mellitus in these patients. The distribution of HCV genotype was also not significantly different (P > 0.05). The type 1b of HCV genotype in the moderate to severe chronic hepatitis C patients accounted for 58.06%. It was different compared with mild chronic hepatitis C patients (P < 0.05). CONCLUSION: 1) The type 1b is the most popular HCV genotype in Yanbian area of Jilin Province, type 2a is the second and there are still a few other genotypes. 2) There is no significant difference in the distribution of HCV genotypes between Han and Korean cases. 3) The HCV genotypes has nothing to do with the load of HCV-RNA. 4) The distribution of HCV genotypes in chronic hepatitis C patients with and without diabetes mellitus is not significantly different. 5) Type 1b of HCV infection is relatively severe.


Asunto(s)
Hepacivirus/genética , Hepatitis C/virología , Adolescente , Adulto , Anciano , Diabetes Mellitus Tipo 2/complicaciones , Femenino , Genotipo , Hepatitis C/complicaciones , Hepatitis C/epidemiología , Humanos , Corea (Geográfico)/epidemiología , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Adulto Joven
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