Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.

Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, P(combined)=4.41 × 10⁻9 and rs1060573, P(combined)=1.28 × 10⁻8) and 1q24.2 (SELL, rs7531806, P(combined)=1.20 × 10⁻8) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne.

Hair removal utilizing the LightSheer Duet HS hand piece and the LightSheer ET: a comparative study of two diode laser systems in Chinese women.

OBJECTIVE: To compare the clinical efficacy, safety and pain associated with the use of the LightSheer Duet HS as compared to the original LightSheer ET diode Laser for axillae hair removal in Chinese women. METHODS: Thirty-six Chinese women received three axillae laser hair removal treatments using the LightSheer Duet HS on one side and the LightSheer ET on the other side. Subjects were evaluated for hair removal efficiency. The immediate pain associated with the treatments was noted. RESULTS: At 1 month following the final laser treatment, hair reduction on the LightSheer Duet HS side and on the LightSheer ET side was 81 ± 13% and 85 ± 9% respectively. There was no statistical difference. Immediate pain scores at the first session on the LightSheer Duet HS sites and LightSheer ET sites was 5.71 ± 1.74 and 6.86 ± 1.80 respectively, which was statistically significant (p < 0.05). Following the second and third sessions, immediate pain scores of the LightSheer Duet HS sites were both less than those of the LightSheer ET sites, but the differences were not statistically significant. CONCLUSIONS: The LightSheer Duet HS laser is a safe and effective method of hair removal in Chinese women. Treatment with the LightSheer Duet HS causes less pain.

Hair removal using a new intense pulsed light source in Chinese patients.

BACKGROUND: Unwanted hair is a widespread cosmetic problem. Several lasers and intense pulsed light (IPL) have been utilized for this purpose. A new IPL device (Lumenis One) with OPT is one of the newer modalities to be studied in Chinese patients. OBJECTIVE: This study evaluates the short-term efficacy and side effects of the new IPL device for epilation in Chinese patients. METHODS: Eighteen Chinese women with Fitzpatrick skin types III-V and black hair, were treated four times at 4 to 6-week intervals using IPL (Lumenis One) on the axillae (n=13) and the upper lip (n=5). The energy density for treatment ranged from 14 to 22 J/cm(2). Parameters utilized were 695-/755-nm filters, triple pulse for patients on the axillae, and 640-/695-nm filters, double pulse for patients on the upper lip (3.5- to 7-ms pulse, 30- to 90-ms pulse delay, 15x35 mm spot size). Hair reduction was assessed at baseline, immediately before each treatment session, and at 4 weeks after the fourth treatment. Patient's satisfaction on a 5-point scale was also evaluated. RESULTS: The average hair reduction for all sites was 49.9% after one session, 58.6% after two sessions, 79.3% after three sessions, and 83.8% after four sessions (p=0.001). The hair reduction of 44.1%, 52.1%, 81.1%, and 86.0% were achieved after each treatment for axillae, with 65.1%, 75.7%, 74.6%, and 78.0% for upper lip. Patients got more satisfaction after four sessions (score 3.1) than that after two sessions (2.0) (p=0.001). In both the assessments, upper lip appeared to show a better response than axillae after two IPL treatments, which reversed after four treatments. No significant complications or adverse events were reported. CONCLUSION: The new IPL device provides a safe and effective means of hair removal for Chinese patients. Treatment efficacy varies with the anatomic location and number of treatments. However, further study is necessary to determine the long-term clinical efficacy in Chinese patients.

[Photoaging: laser and light-based therapy].

Photoaging is clinical character by dyspigmentations, telangiectacia, and wrinkles. Therefore, the assessment of therapeutic effects of photoaging depends on the management results of these three lesions. This article introduces the effect of laser and light-based therapies on photoaging.