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1.
BMC Cardiovasc Disord ; 19(1): 16, 2019 01 14.
Artículo en Inglés | MEDLINE | ID: mdl-30642255

RESUMEN

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a myocardial disease. However, the coexistence of HCM with muscular ventricular septal defect (VSD), especially those with both incomplete spontaneous closure and coronary abnormal origin, is relatively rare. CASE PRESENTATION: We report herein a unique case of HCM accompanied with incomplete spontaneous closure of muscular VSD and abnormal origin of right coronary artery (RCA) in a 26-year-old man, which was diagnosed by combination of transthoracic 2-dimensional (2D), color Doppler, Contrast-enhanced echocardiography and computed tomography angiography (CTA). CONCLUSIONS: To our knowledge, this is the first report that HCM along with the incomplete spontaneous closure of muscular VSD and anomalous RCA arising from left coronary sinus was revealed through combination of transthoracic 2D, color Doppler, Contrast-enhanced echocardiography and CTA. These observations indicated that other associated anomalies in patients with HCM could be easily missed if examined by the single echocardiography. Therefore, HCM-associated congenital abnormalities should be screened by combination of transthoracic 2D, color Doppler, contrast-enhanced echocardiography, and CTA.


Asunto(s)
Cardiomiopatía Hipertrófica/diagnóstico por imagen , Angiografía por Tomografía Computarizada , Angiografía Coronaria/métodos , Anomalías de los Vasos Coronarios/diagnóstico por imagen , Ecocardiografía Doppler en Color , Defectos del Tabique Interventricular/diagnóstico por imagen , Adulto , Cardiomiopatía Hipertrófica/complicaciones , Anomalías de los Vasos Coronarios/complicaciones , Defectos del Tabique Interventricular/complicaciones , Humanos , Masculino , Imagen Multimodal , Valor Predictivo de las Pruebas
2.
Fa Yi Xue Za Zhi ; 29(2): 91-5, 2013 Apr.
Artículo en Chino | MEDLINE | ID: mdl-23930499

RESUMEN

OBJECTIVE: By observing the cerebral beta-amyloid precursor protein (beta-APP) expression in the chronic alcoholism rats with slight cerebral injury, to discuss the correlation of chronic alcoholism and death caused by traumatic subarachnoid haemorrhage (TSAH). METHODS: Sixty male SD rats were randomly divided into watering group, watering group with strike, alcoholism group and alcoholism group with strike. Among them, the alcohol was used for continuous 4 weeks in alcoholism groups and the concussion was made in groups with strike. In each group, HE staining and immunohistochemical staining of the cerebral tissues were done and the results were analyzed by the histopathologic image system. RESULTS: In watering group, there was no abnormal. In watering group with strike, mild neuronic congestion was found. In alcoholism group, vascular texture on cerebral surface was found. And the neurons arranged in disorder with dilated intercellular space. In alcoholism group with strike, diffuse congestion on cerebral surface was found. And there was TSAH with thick-layer patches around brainstem following irregular axonotmesis. The quantity of beta-APP IOD in alcoholism group was significantly higher in the frontal lobe, hippocampus, cerebellum, brainstem than those in watering group with strike and alcoholism group with strike. CONCLUSION: The cerebral tissues with chronic alcoholism, due to the decreasing tolerance, could cause fatal TSAH and pathological changes in cerebral tissues of rats under slight cerebral injury.


Asunto(s)
Alcoholismo/complicaciones , Precursor de Proteína beta-Amiloide/metabolismo , Conmoción Encefálica/complicaciones , Encéfalo/metabolismo , Hemorragia Subaracnoidea Traumática/etiología , Alcoholismo/metabolismo , Alcoholismo/patología , Animales , Encéfalo/patología , Conmoción Encefálica/metabolismo , Conmoción Encefálica/patología , Modelos Animales de Enfermedad , Etanol/efectos adversos , Masculino , Neuronas/metabolismo , Neuronas/patología , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley , Hemorragia Subaracnoidea Traumática/mortalidad , Hemorragia Subaracnoidea Traumática/patología
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