RESUMEN
Head and neck squamous cell carcinoma (HNSCC) has been characterized by a low therapeutic response and poor prognosis. Currently, there are no reliable predictive models for HNSCC progression and therapeutic efficacy. This study explores the role of diverse patterns of cell death in tumor development, positing them as predictive factors of HNSCC prognosis. We utilized bulk transcriptome and single-cell transcriptome, align with clinical information from TCGA and GEO database, to analyze genes associated with 15 types of cell death and construct a cell death index (CDI) signature. The associations of CDI with tumor-infiltrating immune cells and immunotherapy-related biomarkers were also evaluated using various algorithms. The CDI signature emerged as a robust prognosis biomarker that could identify patients who can benefit potentially from immunotherapy, thus improving diagnostic accuracy and optimizing clinical decisions in HNSCC management. Notably, we discovered that CAAP1 deficiency not only induced apoptosis but also enhanced anti-tumor immunity, suggesting its potential as a target for clinical drug development.
RESUMEN
Objective:To explore the application value of video head impulse testï¼vHITï¼, caloric testï¼CTï¼ and the dizziness handicap inventoryï¼DHIï¼ in the diagnosis of acoustic neuromaï¼ANï¼, to analyze the correlation between vHIT and CT, and to determine the correlationsof tumor size, vHIT, CT and DHI score. Methods:The clinical data of 24 patients with AN who underwent surgery in our department from January 2019 to January 2022 were analyzed retrospectively, including craniocerebral MRI, vHIT, caloric test and DHI score. All the data were statistically analyzed by GraphPadPrism9.0. Results:There was a significant negative correlation between the UW value of CT and the vestibular eye reflex gain of vHITï¼P<0.01, r=-0.62ï¼. The tumor size was significantly correlated with the increase of UW value of CTï¼P<0.01, r=0.69ï¼, and with the decrease of vestibulo-ocular reflex gain of vHITï¼P<0.01, r=-0.53ï¼. The average Dizziness Handicap Inventory score was 8.9±16.2, which was not correlated with tumor sizeï¼P>0.05ï¼. Conclusion:Both vHIT and CT can effectively evaluate the vestibular function of patients with ANï¼and they are complementaryï¼, and they are related to the size of the tumor and have certain value in the diagnosis of acoustic neuroma.
