[Effects of winter cropping mode on soil organic carbon and carbon management index of double rice paddy]. / 双季稻田冬季种植模式对土壤有机碳和碳库管理指数的影响.

To explore the effects of winter crops recycling into paddy field on soil carbon pool, we cultivated rape, Chinese milk vetch, ryegrass and potato in winter season after harvesting double-season rice, with fallow as control (CK). The contents of soil organic carbon (SOC) and labile organic carbon (LOC) in the harvest of early and late rice were measured, and the stable carbon, activity of carbon pool, carbon pool index, carbon pool activity index and carbon pool management index (CMI) were calculated. Results showed that winter cover crops returning increased SOC content by 1%-8% and 3%-18% after harvest of early rice and late rice, respectively in comparison with CK. Cultivating rape, Chinese milk vetch and ryegrass all increased the LOC content, with enhancement of 16.2%-84.2% and 24.4%-28.1% after harvest of early rice and late rice, respectively. The CMI of all winter crop treatments presented a growth ratio of 1.4%-41.8% compared to CK. In conclusion, the cultivation of winter crop and recycling to field promoted soil carbon fixation and soil quality, among which the ryegrass and Chinese milk vetch showed better comprehensive effect.

High IDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia.

The prognostic value of IDH1 mutations has been systematically evaluated in acute myeloid leukemia (AML) patients recently. However, the role of IDH1 expression in AML is still under exploration. To investigate the clinical significance, we analyzed the IDH1/2 expression in 320 patients with cytogenetically normal AML (CN-AML) by quantitative real-time reverse-transcription polymerase chain reaction. High expression of IDH1 was predominant in patients with FLT3-ITD and DNMT3A mutations and less prevalent in cases with CEBPA double allele mutations. Strong association was observed between high IDH1 expression and low expression of microRNA 181 family. Prognosis was adversely affected by high IDH1 expression, with shorter overall survival and event-free survival in the context of clinical characteristics, including age, WBC count, and gene mutations of NPM1, FLT3-ITD, CEBPA, IDH1, IDH2 and DNMT3A in CN-AML. Moreover, the clinical outcome of IDH1 expression in terms of overall survival, event-free survival and complete remission rate still remained in multivariate models in CN-AML. Importantly, the prognostic value was validated using the published microarray data from 79 adult patients treated according to the German AMLCG-1999 protocol. Our results demonstrated that high IDH1 expression is associated with a poor prognosis of CN-AML.