RESUMEN
The glycaemic response to feeding increased loads of glucose and sucrose was investigated in man and rat. Assessed were the tolerance tests after feeding 10-100 g glucose or 10-20 g sucrose to hospitalized diabetic or non-diabetic patients and after loading 30-450 mg glucose or sucrose per 100 g body weight to alloxan-diabetic or non-diabetic rats. The maximal levels of tolerance curves, the increase in blood glucose levels and the sum of the glycaemic values reflecting the areas under the curves were chosen as criteria. The correlation between the dose of ingested carbohydrates and the glyucaemic effect was not necessarily linear, but blood glucose values following the carbohydrate loads were concentrated in ranges, corresponding to groups of load sizes. These observations may be practical for the diagnostic procedure and dietetic treatment of the diabetic patient.
Asunto(s)
Glucemia/análisis , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus/metabolismo , Carbohidratos de la Dieta/metabolismo , Anciano , Aloxano , Animales , Relación Dosis-Respuesta a Droga , Femenino , Prueba de Tolerancia a la Glucosa , Humanos , Persona de Mediana Edad , RatasRESUMEN
A study based on 55 hospital patients (age groups 40-59, 60-69, 70-79) demonstrated a significant correlation between the glomerular filtration rate (as expressed by endogenous creatinine clearance) and the mean urinary calcium concentration. Excluded were patients with thyroidal or hypophyseal disorders, osteoporosis, renal stones immobilizing conditions, or those treated with corticosteroids. The study patients had a normal fluid intake and did not receive any diuretics. The urinary calcium concentration test is less laborious and less liable to laboratory errors than the creatinine clearance test, which requires a 24-hour urine collection. Because of the gradual decrease in the glomerular filtration rate in the elderly, this test should be of value in geriatric practice.
