Nationwide Trends in Dispensing of Sodium Glucose Cotransporter 2 Inhibitors.

Background: Three large cardiovascular outcome trials have investigated the safety of sodium glucose cotransporter 2 (SGLT2) inhibitors. Objective: To analyze the nationwide dispensing of SGLT2 inhibitors before and after the publication of these trials. Methods: A cross-sectional study was conducted of monthly prescription dispensing of SGLT2 inhibitors from May 23, 2014, to April 30, 2019, using nationwide data for Canada. An autoregressive integrated moving average (ARIMA) model was fitted to the monthly number of tablets dispensed for each SGLT2 inhibitor; the model included a ramp intervention function at the publication dates of interest to estimate the impact on SGLT2 inhibitor dispensing patterns. Results: The rate of canagliflozin and dapagliflozin dispensing declined after publication of results of the empagliflozin cardiovascular trial in September 2015. After publication of results of the canagliflozin trial in June 2017, which indicated a reduction in cardiovascular events and an increase in the risk of lower-limb amputation, canagliflozin remained the most commonly dispensed SGLT2 inhibitor, but its rate of dispensing declined further. In contrast, the rate of empagliflozin dispensing increased, while the rate of dapagliflozin dispensing was unchanged. After publication of the dapagliflozin trial in November 2018, which indicated no clear reduction in cardiovascular events, short-term trends in dispensing of canagliflozin, empagliflozin, and dapagliflozin were largely unaffected. Conclusions: The cardiovascular outcome trials appeared to have an important impact on the dispensing of SGLT2 inhibitors in Canada.

Contexte: Trois grands essais portant sur les résultats cardiovasculaires avaient pour objet l'étude de l'innocuité des inhibiteurs du cotransporteur sodium-glucose de type 2 (SGLT2). Objectif: Analyser la délivrance nationale des inhibiteurs du SGLT2 avant et après la publication de ces essais. Méthodes: Une étude transversale a été menée sur la délivrance d'ordonnances mensuelles d'inhibiteurs du SGLT2 du 23 mai 2014 au 30 avril 2019, à l'aide de données nationales pour le Canada. Un modèle de moyenne mobile intégrée autorégressive (ARIMA) a été adapté au nombre mensuel de comprimés distribués pour chaque inhibiteur du SGLT2; le modèle comprenait une fonction d'intervention progressive aux dates de publication d'intérêt pour estimer l'effet sur les schémas de délivrance d'inhibiteurs du SGLT2. Résultats: Le taux de délivrance de canagliflozine et de dapagliflozine a diminué après la publication des résultats de l'essai cardiovasculaire empagliflozine en septembre 2015. Après la publication des résultats de l'essai cardiovasculaire canagliflozine en juin 2017, qui indiquaient une réduction des événements cardiovasculaires et une augmentation du risque d'amputation des membres inférieurs, la canagliflozine est restée l'inhibiteur du SGLT2 le plus couramment délivré, mais son taux de délivrance a encore diminué. En revanche, le taux d'empagliflozine délivré a augmenté, tandis que le taux de délivrance de dapagliflozine est resté identique. Après la publication de l'essai sur la dapagliflozine en novembre 2018, qui n'indiquait aucune réduction nette des événements cardiovasculaires, les tendances à court terme de la délivrance de la canagliflozine, de l'empagliflozine et de la dapagliflozine n'ont pratiquement pas changé. Conclusions: Les essais portant sur les résultats cardiovasculaires semblaient avoir un effet important sur la délivrance des inhibiteurs du SGLT2 au Canada.

The Comparison of China and Iran Response to COVD-19 Pandemic: Lessons Learn for Health Policy.

Currently, despite the change in the course of diseases, attention to infectious diseases and their integration has decreased. The prevalence of remerging infectious diseases has led to the need for appropriate preparation programs. There are still problems in controlling infectious diseases with the outbreak of coronavirus. The outbreak of the disease affected many countries in a short period. Therefore, by examining the actions of the two countries, it is possible to gain appropriate experiences in dealing with infectious diseases. This study was conducted using a gray literature review to examine all applied actions for the response to COVID-19 epidemics and their impacts on the prevalence of this disease in China and Iran. Examination of the documents shows that disease prevention is the most critical action, and we have witnessed a decrease in the number of patients with this disease by the introduction of prevention policies. The implementation problems of quarantine programs were meeting the basic needs of the people and continuing to implement this program. The issue of education was also one of the leading problems.

[Continued care during and after the Covid-19 pandemic]. / Continuer à soigner pendant et après la pandémie de Covid-19.

Covid-19 hit hospitals that were already weakened, and care work that had been reconfigured as a result of managerial approaches and financial austerity policies. However, care workers continued to pay attention, to care for patients by mobilising their representations of care.

[COVID-19, student aid, public health and solicitude]. / Covid-19, aide aux étudiants, santé publique et sollicitude.

Student aid policies are broad organizational lines. They must not be confused, despite the obvious solicitude of public actors, with the caregiver's posture. It is then necessary to reinterrogate solicitude to defend a form of prevention by the mobilization of the actors, namely the students themselves.

Social Democratic Solidarity and the Welfare State: Health Care and Single-Tier Universality in Sweden and Canada.

Although it is not generally done, it is useful to compare the history of the evolution of universal health coverage (UHC) in Canada and Sweden. The majority of citizens in both countries have shared, and continue to share, a commitment to a strong form of single-tier universality in the design of their respective UHC systems. In the postwar era, they also share a remarkably similar timeline in the emergence and entrenchment of single-tier UHC, despite the political and social differences between the two countries. At the same time, UHC was initially designed, implemented, and managed by social democratic governments that held power for long periods of time, creating a path dependency for single-tier Medicare that was difficult for future governments of different ideological persuasions to alter.

Lay counselors: Thoughts on the crossing of ecological frameworks and the use of lay counselors in the scale up of early infant mental health interventions.

The recent call for the scale-up of evidence-based early childhood development interventions, in lower and middle-income countries and for minority groups in high-income countries, has seen numerous suggestions to train greater numbers of lay mental health workers to fulfill these functions. While studies have found that concepts from developed country settings, such as attachment, parental sensitivity, and containment, find purchase and relevance within developing settings, the management of contextual and cultural factors and the tensions of cultural interfacing in the rollout of these programs in developing country settings require consideration. Drawing on the experiences of two successful South African mother-infant home-visiting programs as examples, this article discusses some of the challenges in provision of attachment-based infant mental health programs and highlights the need for careful consideration of a number of factors pertaining to the recruitment, supervision, and management of lay mental health workers before large-scale rollout is conducted.

La reciente llamada para aumentar proporcionalmente las intervenciones sobre el desarrollo en la niñez con base en la evidencia, en países de ingresos más bajos e ingresos medios, y en el caso de grupos minoritarios en países de ingresos altos, ha visto numerosas sugerencias para entrenar un mayor número de trabajadores laicos de la salud mental que puedan realizar estas funciones. Mientras que los estudios han concluido con que conceptos provenientes de ambientes de países desarrollados, tales como afectividad, sensibilidad de los padres y contención, venden y encuentran relevancia dentro de escenarios de países en desarrollo, el tratamiento de factores contextuales y culturales y las tensiones de interconexiones culturales en la introducción de estos programas en escenarios de países en desarrollo requiere consideración. Utilizando las experiencias de dos exitosos programas madre-infante de visitas a casa en Sudáfrica como ejemplos, este artículo discute algunos de los retos en cuanto a la provisión de programas de salud mental infantil basados en la afectividad y subraya la necesidad de la cuidadosa consideración de un número de factores referentes al reclutamiento, supervisión y dirección de trabajadores laicos de la salud mental antes de que se lleve a cabo la introducción a gran escala.

L'injonction récente à intensifier les programmes d'intervention de développement de la petite enfance fondés sur des données probantes, dans des pays en voie de développement, et pour des groupes minoritaires dans les pays riches, a déclenché de nombreuses suggestions de formation d'un plus grand nombre de travailleurs laïcs de la santé mentale afin de remplir ces fonctions. Alors que des études ont établi que des concepts issus de contextes de pays développés, tels que l'attachement, la sensibilité parentale et la discipline trouvent acquisition et raison d'être au sein de contextes développés, la gestion de facteurs contextuels et culturels et les tensions d'interfaçage culturel dans le lancement de ces programmes dans des contextes de pays en voie de développement exigent d'être considérées et tenues en compte. A partir des expériences de deux programmes de Visite à Domicile Mère-Nourrisson Sud- Africains comme exemples, cet article discute certains des défis dans la prestation de programmes de Santé Mentale du Nourrisson basés sur l'attachement et met en lumière le besoin de considération attentionnée à un nombre de facteurs ayant trait au recrutement, à la supervision et à la gestion de travailleurs laïcs de santé avant que soit lancée une version à grande échelle du programme.

[The contribution of the fight against AIDS to the health democracy]. / Les apports de la lutte contre le sida à la démocratie en santé.

There is a debate on the place and the role of users in the healthcare system. It is important to remember that the people concerned by AIDS and associations fighting against this pathology have initiated a new type of patient involvement in care and public policies. This could be taken as a model.

[Is the collecting activity of regional pharmacovigilance centers influenced by regional demographic or health determinants?] / L'activité de recueil des centres régionaux de pharmacovigilance est-elle influée par des déterminants régionaux démographiques ou sanitaires ?

PURPOSE: To compare the regional demographic and health indicators to the pharmacovigilance activity of the regional pharmacovigilance centers in terms of number of cases collected, responses to information requests and signal detection in 2015. METHODS: The pharmacovigilance activity parameters (collected cases reports, information requests, reported serious cases) were expressed in regional proportions to population size and compared to regional demographic and health indicators (population, individuals aged 60 and over, individuals aged under 20, socio-professional categories, health facilities per capita, hospital beds [medicine, surgery and obstetrics] per capita, physicians and pharmacists per capita, mortality rate and drug consumption per capita) in 12 French metropolitan areas. The Spearman correlation between these two parameters was analyzed. RESULTS: The territorial distribution of all demographic and health indicators and pharmacovigilance activity indicators in proportion to population size was different between regions (P<0.001): individuals aged 60 and over, individuals aged under 20, socio-professional categories, health facilities per capita, hospital beds per capita, health professionals per capita, mortality rate, drug consumption per capita, reported pharmacovigilance cases, information requests and reported serious cases. The number of regional collected pharmacovigilance cases per capita was negatively correlated with the territorial distribution of managers and intermediate professions (respectively r=-0.60 and -0.68; P=0.04 and 0.02). The regional number of reported serious cases per capita was statistically correlated with the regional number of hospital beds per capita (r=0.60; P=0.04) and inversely correlated with the territorial distribution of intermediate professions (r=-0.60; P=0.04). CONCLUSION: Size of population is not the only determinant of the regional level of pharmacovigilance activity. Regional demographic and health parameters (age, socio-professional categories, hospital beds and drugs consumed) may partly explain the difference between regions.

[Pace of care and wellbeing at work, exploratory study]. / Cadence des soins et bien-être au travail, étude exploratoire.

The economic models developed in health policies force hospitals to make decisions with regard to the reorganisation of work. These have impacts on nursing competences and ergonomics in particular. A study analysing a situation of ten minutes of nursing work highlighted the work pace as well as the mental, emotional and physical strains put upon the professional.

[The French health care funding system for research and innovation in oncology]. / Place des missions d'intérêt général (MIG) relatives à la recherche et à l'innovation dans le financement des établissements de santé en cancérologie.

INTRODUCTION: This article provides an overview of the French health system with respect to allocation of public resources to hospitals, to encourage research and innovation, particularly in the field of oncology. It is explained in a historical, economic and scientific perspective. RESULTS: Important structural and conceptual reforms (T2A, HPST law, etc.) have been carried out. These have significantly impacted the way public funding is allocated. Funding of innovation and research has been modified into a more incentive logic, aimed at strengthening competitiveness between all health care actors. The funding allocation system has evolved towards a more ubiquitous redistribution, including non-academic and private institutions. The baseline endowment includes indicators relating to scientific publications (60% of the endowment), teaching (25%) and clinical trials (15%). Research funding is then redistributed by regional health agencies, and used in health care institutions at the discretion of the directorates. Other funding sources such as calls for grants, funding for mobile research centers and teams, tumor banks and temporary user licenses are also part of the funding by the French Ministry of health. CONCLUSION: Changes in the health research funding system have an incentive purpose. They have significantly modified the global healthcare landscape. Feedback on these changes will be necessary to assess the success of the reinforcement of the dynamics of research and innovation.

Impact of China's essential medicines scheme and zero-mark-up policy on antibiotic prescriptions in county hospitals: a mixed methods study.

OBJECTIVE: To evaluate the impact of the national essential medicines scheme and zero-mark-up policy on antibiotic prescribing behaviour. METHODS: In rural Guangxi, a natural experiment compared one county hospital which implemented the policy with a comparison hospital which did not. All outpatient and inpatient records in 2011 and 2014 were extracted from the two hospitals. Primary outcome indicator was antibiotic prescribing rate (APR) among children aged 2-14 presenting in outpatients with a primary diagnosis of upper respiratory tract infection (URTI). We organised independent physician reviews to determine inappropriate prescribing for inpatients. Difference-in-difference analyses based on multivariate regressions were used to compare APR over time after adjusting potential confounders. We conducted 12 in-depth interviews with paediatricians, hospital directors and health officials. RESULTS: A total of 8219 and 4142 outpatient prescriptions of childhood URTIs were included in the intervention and comparison hospitals, respectively. In 2011, APR was 30% in the intervention and 88% in the comparison hospital. In 2014, the intervention hospital significantly reduced outpatient APR by 21% (95% CI:-23%, -18%), intravenous infusion by 58% (95% CI: -64%, -52%) and prescription cost by 31 USD (95% CI: -35, -28), compared with the controls. We collected 251 inpatient records, but did not find reductions in inappropriate antibiotic use. Interviews revealed that the intervention hospital implemented a thorough antibiotics stewardship programme containing training, peer review of prescriptions and restrictions for overprescribing. CONCLUSION: The national essential medicines scheme and zero-mark-up policy, when implemented with an antimicrobial stewardship programme, may be associated with reductions in outpatient antibiotic prescribing and intravenous infusions.

The Dishwater Menace: Healthy Drinking Spaces and the Public Good in Post-Prohibition Ontario.

This paper examines inter-bureaucracy tension, negotiation, and resolution in the case of the oversight of beverage room sanitation in Ontario in the 1930s and 1940s. Both the Liquor Control Board of Ontario (LCBO) and various public health authorities claimed authority over the health status of public drinking spaces. But the LCBO had legislative priority. The ensuing debates regarding health and cleanliness linked issues of beverage room glass sanitation to a biopolitical approach to public drinking. Developing a more scientifically sophisticated approach to beverage glass cleaning required a balancing of administrative priorities. Perfect sanitation was expensive and complicated, and the LCBO's mandate demanded attention to the financial viability of beverage rooms. The LCBO needed to forge a trade off between safety and viability, while maintaining a public drinking system that dissuaded illegal drinking. The subsequent compromise in beverage room glass sanitation tied contemporary chemical sanitizers to the challenging economics of depression-era beverage room management.

Contribution des acteurs régionaux à la réduction des inégalités sociales de santé : le cas de la France.

Depuis le rapport de la Commission sur les Déterminants Sociaux de la Santé, plusieurs pays ont commencé à intégrer à leurs plans de santé la question des déterminants et de leur impact sur les inégalités de santé. En France, la création des Agences Régionales de Santé en 2009 est considérée comme une opportunité pour agir sur les inégalités sociales de santé (ISS) avec les instances régionales, départementales et locales qui détiennent les leviers appropriés. A la suite d'une analyse thématique des projets régionaux de santé, visant à identifier l'intégration des ISS ainsi que les approches retenues pour les aborder, quatre régions ont été étudiées plus finement. Des entretiens collectifs et individuels ( N = 45 interviewés) ont été menés auprès d'acteurs de terrain et institutionnels, afin de mieux comprendre et identifier les types de programmes et processus pour réduire les ISS. Nos analyses font ressortir une prise en compte généralisée des ISS dans les documents de planification et de programmation des instances régionales, des stratégies régionales qui restent centrées sur les populations vulnérables avec une faible considération du gradient social, l'existence d'instances de concertations intersectorielles dans les quatre régions qui constituent un potentiel de gouvernance important à mieux exploiter, l'existence de modalités de suivi et d'évaluation des ISS qui restent à consolider, et une forte mobilisation de plusieurs secteurs dans les processus régionaux de consultation des publics et des acteurs, mais des résultats variables, souvent reliés au niveau de ressources investies et des approches privilégiées. L'analyse de ces expériences françaises démontre un intérêt croissant pour l'action sur les déterminants sociaux de la santé et les ISS ; mais leur opérationnalisation, toujours en cours, appelle à des analyses plus fines qui permettront de mieux éclairer les politiques publiques.

[Reflection on the psychiatric financial allocation in France]. / Réflexion sur la péréquation financière de psychiatrie en France.

For 25years work has been underway in France for the implementation of an alternative to public financing of health care. In the absence of progress, some regional health agencies are engaged in work related to the reallocation of public finances between psychiatric institutions. We propose a reflection with suggestion on the method proposed by the Provence Alpes Côte d'Azur Regional Health Agency. Without questioning the need for a reallocation of resources between psychiatric institutions, the method proposed here needs to evolve further to be applied in a legitimate and appropriate manner. There is a kind of urgency for a reallocation of resources between psychiatric institutions in France, but it implies a collective thinking and especially the definition of evaluation procedures for the selected models. These conditions are necessary to guarantee the quality of French psychiatry and equity in access to psychiatric care.

[Support and training of nursing teams in elective abortions]. / Accompagnement et formation des équipes soignantes à l'IVG.

The pathway of patients requesting an elective abortion, while improved, is not always easy. To investigate this observation further, it is interesting to analyse the existing structures and the professionals working in this field. Do the health policies and training envisaged for supporting these caregivers enable them to meet women's needs everywhere across the country?

[The fight against bacterial resistance, a public health priority]. / La lutte contre la résistance bactérienne, une priorité de santé publique.

The increase in the number of antibiotic resistant bacteria represents a major danger for the health of humans and animals. Combined with an almost complete absence of new antibiotics, it is one of the most alarming public health issues of our time. Measures must be taken in order to control the use of these drugs and safeguard their effectiveness.

Medical pluralism among indigenous peoples in northeast India - implications for health policy.

OBJECTIVES: The government of India is promoting and increasing investment in the traditional medicine systems of Ayurveda, Yoga, Unani, Siddha and Homeopathy (AYUSH) in the northeast region of India. But there are few empirical data that support this policy decision. This study estimates the awareness and use of the different medical systems in rural Meghalaya, a state in north-east India with a predominantly ethnic tribal population. METHOD: We conducted a cross-sectional multistage random sample household survey across all districts of Meghalaya. To enable appropriate estimates for the whole of rural Meghalaya, the data were weighted to allow for the probability of selection of households at each stage of the sampling process. RESULTS: Both local tribal medicine and biomedicine were widely accepted and used, but the majority (68.7%, 95% CI: 51.9-81.7) had not heard of AYUSH and even fewer had used it. Tribal medicine was used (79.1%, 95% CI 66.3-88.0), thought to be effective (87.5%, 95% CI: 74.2-94.1) and given in a variety of disorders, including both minor and major diseases. In the 3 months prior to the survey, 46.2% (95% CI: 30.5-62.8) had used tribal medicine. Only 10.5% (95% CI: 6.1-17.6) reported ever using any of the AYUSH systems. CONCLUSION: Our comparative estimates of the awareness and use of tribal medicine, different systems of AYUSH and of biomedicine among indigenous populations of India question the basis on which AYUSH is promoted in the northeast region of India and in the state of Meghalaya in particular.

Health policy for sickle cell disease in Africa: experience from Tanzania on interventions to reduce under-five mortality.

Tanzania has made considerable progress towards reducing childhood mortality, achieving a 57% decrease between 1980 and 2011. This epidemiological transition will cause a reduction in the contribution of infectious diseases to childhood mortality and increase in contribution from non-communicable diseases (NCDs). Haemoglobinopathies are amongst the most common childhood NCDs, with sickle cell disease (SCD) being the commonest haemoglobinopathy in Africa. In Tanzania, 10,313 children with SCD under 5 years of age (U5) are estimated to die every year, contributing an estimated 7% of overall deaths in U5 children. Key policies that governments in Africa are able to implement would reduce mortality in SCD, focusing on newborn screening and comprehensive SCD care programmes. Such programmes would ensure that interventions such as prevention of infections using penicillin plus prompt diagnosis and treatment of complications are provided to all individuals with SCD.

Early career retention of Malawian medical graduates: a retrospective cohort study.

OBJECTIVE: There have been longstanding concerns over Malawian doctors migrating to high-income countries. Early career is a particularly vulnerable period. After significant policy changes, we examined the retention of recent medical graduates within Malawi and the public sector. METHODS: We obtained data on graduates between 2006 and 2012 from the University of Malawi College of Medicine and Malawi Ministry of Health. We utilised the alumni network to triangulate official data and contacted graduates directly for missing or uncertain data. Odds ratios and chi-squared tests were employed to investigate relationships by graduation year and gender. RESULTS: We traced 256 graduates, with complete information for more than 90%. Nearly 80% of registered doctors were in Malawi (141/178, 79.2%), although the odds of emigration doubled with each year after graduation (odds ratio = 1.98, 95% CI = 1.54-2.56, P < 0.0001). Of the 37 graduates outside Malawi (14.5%), 23 (62.2%) were training in South Africa under a College of Medicine sandwich programme. More than 80% of graduates were working in the public sector (185/218, 82.6%), with the odds declining by 27% for each year after graduation (odds ratio = 0.73, 95% CI = 0.61-0.86, P < 0.0001). CONCLUSIONS: While most doctors remain in Malawi and the public sector during their early careers, the odds of leaving both increase with time. The majority of graduates outside Malawi are training in South Africa under visa restrictions, reflecting the positive impact of postgraduate training in Malawi. Concerns over attrition from the public sector are valid and require further exploratory work.