Development and Validation of Paradigms Based on the Global-First Topological Approach for Alzheimer's Disease Severity Staging.

Introduction: Conventional methods like patient history, neuropsychological testing, cerebrospinal fluid examination, and magnetic resonance imaging are widely used to diagnose cases in the current clinical setting but are limited in classifying Alzheimer's disease (AD) stages. Patients with AD exhibit visual perception deficits, which may be a potential target to assess the severity of the disease according to visual paradigms. However, owing to the inconsistent forms of perceived objects, the defects of current visual processing paradigms often lead to inconsistent results and a lack of sensitivity and specificity. Methods: We develop two paradigms based on global-first topological approach of visual perception, which avoids inconsistent results and lack of sensitivity and specificity owing to the inconsistent forms of perceived objects in traditional paradigms, delineate a unique detection strategy from perception organization (Experiment 1) and visual working memory (VWM) (Experiment 2). Results: Except for the significant differences of the reaction times (RTs) between groups, significant differences were found when AD subjects recognize small figures due to the consistency of global and local figures in similarity test. The difference of RTs between recognizing global and local figures can be recognized in AD and mild cognitive impairment (MCI) group compared to healthy elderly (HE) in similarity test (Experiment 1). The memory capacity of AD patients was significantly lower than MCI group. Topological interference effect was observed in MCI and HE group, whereas MCI patients may have a greater difference trend in non-topological and topological changes than HE (Experiment 2). Conclusion: Our paradigms provide a new strategy, which can assist clinical severity staging and linking topological approach of visual perception with pathophysiological processes in AD.

The effects of visual and auditory synchrony on human foraging.

Can synchrony in stimulation guide attention and aid perceptual performance? Here, in a series of three experiments, we tested the influence of visual and auditory synchrony on attentional selection during a novel human foraging task. Human foraging tasks are a recent extension of the classic visual search paradigm in which multiple targets must be located on a given trial, making it possible to capture a wide range of performance metrics. Experiment 1 was performed online, where the task was to forage for 10 (out of 20) vertical lines among 60 randomly oriented distractor lines that changed color between yellow and blue at random intervals. The targets either changed colors in visual synchrony or not. In another condition, a non-spatial sound additionally occurred synchronously with the color change of the targets. Experiment 2 was run in the laboratory (within-subjects) with the same design. When the targets changed color in visual synchrony, foraging times were significantly shorter than when they randomly changed colors, but there was no additional benefit for the sound synchrony, in contrast to predictions from the so-called "pip-and-pop" effect (Van der Burg et al., Journal of Experimental Psychology, 1053-1065, 2008). In Experiment 3, task difficulty was increased as participants foraged for as many 45° rotated lines as possible among lines of different orientations within 10 s, with the same synchrony conditions as in Experiments 1 and 2. Again, there was a large benefit of visual synchrony but no additional benefit for sound synchronization. Our results provide strong evidence that visual synchronization can guide attention during multiple target foraging. This likely reflects the local grouping of the synchronized targets. Importantly, there was no additional benefit for sound synchrony, even when the foraging task was quite difficult (Experiment 3).

Interaction of contour geometry and optic flow in determining relative depth of surfaces.

Dynamic occlusion, such as the accretion and deletion of texture near a boundary, is a major factor in determining relative depth of surfaces. However, the shape of the contour bounding the dynamic texture can significantly influence what kind of 3D shape, and what relative depth, are conveyed by the optic flow. This can lead to percepts that are inconsistent with traditional accounts of shape and depth from motion, where accreting/deleting texture can indicate the figural region, and/or 3D rotation can be perceived despite the constant speed of the optic flow. This suggests that the speed profile of the dynamic texture and the shape of its bounding contours combine to determine relative depth in a way that is not explained by existing models. Here, we investigated how traditional structure-from-motion principles and contour geometry interact to determine the relative-depth interpretation of dynamic textures. We manipulated the consistency of the dynamic texture with rotational or translational motion by varying the speed profile of the texture. In Experiment 1, we used a multi-region figure-ground display consisting of regions with dots moving horizontally in opposite directions in adjacent regions. In Experiment 2, we used stimuli including two regions separated by a common border, with dot textures moving horizontally in opposite directions. Both contour geometry (convexity) and the speed profile of the dynamic dot texture influenced relative-depth judgments, but contour geometry was the stronger factor. The results underscore the importance of contour geometry, which most current models disregard, in determining depth from motion.

A CODE model bridging crowding in sparse and dense displays.

Visual crowding is arguably the strongest limitation imposed on extrafoveal vision, and is a relatively well-understood phenomenon. However, most investigations and theories are based on sparse displays consisting of a target and at most a handful of flanker objects. Recent findings suggest that the laws thought to govern crowding may not hold for densely cluttered displays, and that grouping and nearest neighbour effects may be more important. Here we present a computational model that accounts for crowding effects in both sparse and dense displays. The model is an adaptation and extension of an earlier model that has previously successfully accounted for spatial clustering, numerosity and object-based attention phenomena. Our model combines grouping by proximity and similarity with a nearest neighbour rule, and defines crowding as the extent to which target and flankers fail to segment. We show that when the model is optimized for explaining crowding phenomena in classic, sparse displays, it also does a good job in capturing novel crowding patterns in dense displays, in both existing and new data sets. The model thus ties together different principles governing crowding, specifically Bouma's law, grouping, and nearest neighbour similarity effects.

Prägnanz in visual perception.

How do we perceptually and cognitively organize incoming stimulation? A century ago, Gestalt psychologists posited the law of Prägnanz: psychological organization will always be as 'good' as possible given the prevailing conditions. To make the Prägnanz law a useful statement, it needs to be specified further (a) what a 'good' psychological organization entails, (b) how the Prägnanz tendency can be realized, and (c) which conditions need to be taken into account. Although the Gestalt school did provide answers to these questions, modern-day mentions of Prägnanz or good Gestalt often lack these clarifications. The concept of Prägnanz has been (mis)understood in many different ways, and by looking back on the rich history of the concept, we will attempt to present a more fine-grained view and promote a renewed understanding of the central role of Prägnanz in visual perception and beyond. We review Gestalt psychology's answers to the questions listed above, and also discuss the four main uses of the Prägnanz concept in more detail: (a) a Prägnanz tendency in each organizational process, (b) Prägnanz as a property of a Gestalt, (c) Prägnanz steps as internal reference points, and (d) Prägnanz in relation to aesthetic appreciation. As a key takeaway, Prägnanz is a multifaceted Gestalt psychological concept indicating the "goodness" of an experienced organization. Both the removal of unnecessary details and the emphasis on characteristic features of the overall organization compared to a reference organization can contribute to the emergence of a 'better' Gestalt. The stimulus constellation is not the only factor in determining the goodness of an organization, also the stimulus' interaction with an individual in a specific spatial and temporal context plays a role. Taking the ideas on Prägnanz as a generative framework and keeping the original Gestalt psychological context in mind, future research on perceptual organization can improve our understanding of the principles underlying psychological organization by further specifying how different organizational principles interact in concrete situations. Public significance statement: This paper reviews what a 'good' psychological organization entails, and how the incoming stimulation is clarified in human perception to achieve the best possible psychological organization. The review debunks common misconceptions on the meaning of "goodness" and synthesizes the most important perspectives and developments on "goodness" from its conception until now.

At what level is the gap transfer illusion illusory?

The gap transfer illusion is an auditory phenomenon in which a temporal gap in a longer glide transfers perceptually to a crossing shorter glide, making the longer glide illusorily continuous. This continuity is often considered a variation of classic illusory auditory continuity attributed to auditory peripheral activity, but a new view is given here supported by a series of sound demonstrations indicating that this illusory continuity is purely caused by a higher mechanism of perceptual organization.

Masked priming under the Bayesian microscope: Exploring the integration of local elements into global shape through Bayesian model comparison.

To investigate whether local elements are grouped into global shapes in the absence of awareness, we introduced two different masked priming designs (e.g., the classic dissociation paradigm and a trial-wise probe and prime discrimination task) and collected both objective (i.e., performance based) and subjective (using the perceptual awareness scale [PAS]) awareness measures. Prime visibility was manipulated using three different prime-mask stimulus onset asynchronies (SOAs) and an unmasked condition. Our results showed that assessing prime visibility trial-wise heavily interfered with masked priming preventing any prime facilitation effect. The implementation of Bayesian regression models, which predict priming effects for participants whose awareness levels are at chance level, provided strong evidence in favor of the hypothesis that local elements group into global shape in the absence of awareness for SOAs longer than 50 ms, suggesting that prime-mask SOA is a crucial factor in the processing of the global shape without awareness.

Additivity of grouping by proximity and luminance similarity is dependent on relative grouping strength: An analysis of individual differences in grouping sensitivity.

It has previously been shown that grouping by proximity is well described by a linear function relating the perceived orientation of a dot lattice to the ratio of the distances between the dots in the different orientations. Similarly, luminance influences how observers perceptually group stimuli. Using the dot lattice paradigm, it has been shown that proximity and luminance similarity interact additively, which means that their effects can be summed to predict an observers' percept. In this study, we revisit the additive interplay between proximity and luminance similarity and we ask whether this pattern might be the result of inappropriately averaging different types of observers or the imbalance between the strength of proximity grouping and luminance similarity grouping. To address these questions, we first ran a replication of the original study reporting the additive interplay between proximity and luminance similarity. Our results showed a convincing replication at the aggregate and individual level. However, at the individual level, all observers showed grouping by proximity whereas some observers did not show grouping by luminance similarity. In response, we ran a second experiment with enlarged luminance differences to reinforce the strength of grouping by luminance similarity and balance the strength of the two grouping cues. Interestingly, in this second experiment, additivity was not observed but instead a significant interaction was obtained. This disparity suggests that the additivity or interaction between two grouping cues in a visual stimulus is not a general rule of perceptual grouping but a consequence of relative grouping strength.

Perceptual organization and visual awareness: the case of amodal completion.

We investigated the involvement of visual awareness in amodal completion, and specifically, whether visual awareness plays a differential role in local versus global completion, using a primed shape discrimination paradigm and the color-opponent flicker technique to render the prime invisible. In four experiments, participants discriminated the shape of a target preceded by a partly occluded or a neutral prime. All primes were divergent occlusion patterns in which the local completion is based on good continuation of the contours at the point of occlusion and the global completion is based on maximum symmetry. The target corresponded to the shape that could arise as a result of local or global completion of the occluded prime. For each experiment with an invisible prime we conducted a version with a visible prime. Our results suggest that local completion, but not global completion, of a partly occluded shape can take place in the absence of visual awareness, but apparently only when the visible occluded shape generates a single, local completion. No completion, either local or global, appears to take place in the absence of visual awareness when the visible occluded shape generates multiple completions. The implications of these results to the differential role of visual awareness in local and global completions and to the relationship between multiple completions and unconscious amodal completions are discussed.

The contralateral organization of the human nervous system as a quantum unfolded, holographic-like, artifactual representation of the underlying dynamics of a fundamentally two-dimensional universe.

A working hypothesis is put forward in this article that the contralateral organization of the human nervous system appears to function like a quantum unfolded holographic apparatus by appearing to invert and reverse quantum unfolded visual and non-visual spatial information. As such, the three-dimensional contralateral organization would be an artifactual representation of the underlying dynamics of a fundamentally two-dimensional universe. According to the holographic principle, nothing that is experienced as three-dimensional could have been processed in a three-dimensional brain. Everything we would experience at a two-dimensional level would appear as a three-dimensional holographic representation, including the architecture of our brains. Various research observations reported elsewhere are reviewed and interpreted here as they may be related in a process that is fundamental to the underlying two-dimensional dynamics of the contralateral organization. The classic holographic method and characteristics of image formation contained by a holograph are described as they relate to the working hypothesis. The double-slit experiment is described and its relevance to the working hypothesis.

Does training with blurred images bring convolutional neural networks closer to humans with respect to robust object recognition and internal representations?

It has been suggested that perceiving blurry images in addition to sharp images contributes to the development of robust human visual processing. To computationally investigate the effect of exposure to blurry images, we trained convolutional neural networks (CNNs) on ImageNet object recognition with a variety of combinations of sharp and blurred images. In agreement with recent reports, mixed training on blurred and sharp images (B+S training) brings CNNs closer to humans with respect to robust object recognition against a change in image blur. B+S training also slightly reduces the texture bias of CNNs in recognition of shape-texture cue conflict images, but the effect is not strong enough to achieve human-level shape bias. Other tests also suggest that B+S training cannot produce robust human-like object recognition based on global configuration features. Using representational similarity analysis and zero-shot transfer learning, we also show that B+S-Net does not facilitate blur-robust object recognition through separate specialized sub-networks, one network for sharp images and another for blurry images, but through a single network analyzing image features common across sharp and blurry images. However, blur training alone does not automatically create a mechanism like the human brain in which sub-band information is integrated into a common representation. Our analysis suggests that experience with blurred images may help the human brain recognize objects in blurred images, but that alone does not lead to robust, human-like object recognition.

The effect of perceptual organization on numerical and preference-based decisions shows inter-subject correlation.

Individual differences in cognitive processing have been the subject of intensive research. One important type of such individual differences is the tendency for global versus local processing, which was shown to correlate with a wide range of processing differences in fields such as decision making, social judgments and creativity. Yet, whether these global/local processing tendencies are correlated within a subject across different domains is still an open question. To address this question, we develop and test a novel method to quantify global/local processing tendencies, in which we directly set in opposition the local and global information instead of instructing subjects to specifically attend to one processing level. We apply our novel method to two different domains: (1) a numerical cognition task, and (2) a preference task. Using computational modeling, we accounted for classical effects in choice and numerical-cognition. Global/local tendencies in both tasks were quantified using a salience parameter. Critically, the salience parameters extracted from the numerical cognition and preference tasks were highly correlated, providing support for robust perceptual organization tendencies within an individual.

The competition between grouping cues can be resolved under inattention.

We investigated whether attention is required for the resolution of the competition between conflicting grouping cues. Participants performed a demanding change-detection task on a small matrix presented on a backdrop composed of two organizations that could change or stay the same between two consecutive displays independently from changes in the target. We hypothesized that if the competition between the backdrop organizations can be resolved without attention, congruency effects should emerge between changes in the target and changes in the organization that won the competition, but not for the other organization. Three trial types were examined: no-conflict trials, where the two grouping cues formed the same organization (e.g., columns by proximity and by color similarity); conflict trials, where the two cues formed conflicting organizations (e.g., columns by proximity and rows by color similarity); and mixed trials, where one backdrop display depicted no conflict while the other depicted conflicting organizations. Congruency effects were elicited by one organization (Experiment 1-proximity, Experiment 2-common region) but not by the other (color similarity, Experiments 1-2), in the no-conflict and mixed trials, suggesting that if one display in a trial was well organized it facilitated the resolution of the competition in the other display. However, when resolving the competition was required for both displays within a trial, it was not accomplished without attention. Thus, this study shows novel results revealing some of the conditions in which the competition between grouping cues can be resolved without attention.

The Order & Complexity Toolbox for Aesthetics (OCTA): A systematic approach to study the relations between order, complexity, and aesthetic appreciation.

Do individuals prefer stimuli that are ordered or disordered, simple or complex, or that strike the right balance of order and complexity? Earlier research mainly focused on the separate influence of order and complexity on aesthetic appreciation. When order and complexity were studied in combination, stimulus manipulations were often not parametrically controlled, only rather specific types of order (i.e., balance or symmetry) were usually studied, and/or the multidimensionality of order and complexity was largely ignored. Progress has also been limited by the lack of an easy way to create reproducible and expandible stimulus sets, including both order and complexity manipulations. The Order & Complexity Toolbox for Aesthetics (OCTA), a Python toolbox that is also available as a point-and-click Shiny application, aims to fill this gap. OCTA provides researchers with a free and easy way to create multi-element displays varying qualitatively (i.e., different types) and quantitatively (i.e., different levels) in order and complexity, based on regularity and variety along multiple element features (e.g., shape, size, color, orientation). The standard vector-based output is ideal for experiments on the web and the creation of dynamic interfaces and stimuli. OCTA will not only facilitate reproducible stimulus construction and experimental design in research on order, complexity, and aesthetics. In addition, OCTA can be a very useful tool in any type of research using visual stimuli, or even to create digital art. To illustrate OCTA's potential, we propose several possible applications and diverse questions that can be addressed using OCTA.

Mirror symmetry and aging: The role of stimulus figurality and attention to colour.

Symmetry perception studies have generally used two stimulus types: figural and dot patterns. Here, we designed a novel figural stimulus-a wedge pattern-made of centrally aligned pseudorandomly positioned wedges. To study the effect of pattern figurality and colour on symmetry perception, we compared symmetry detection in multicoloured wedge patterns with nonfigural dot patterns in younger and older adults. Symmetry signal was either segregated or nonsegregated by colour, and the symmetry detection task was performed under two conditions: with or without colour-based attention. In the first experiment, we compared performance for colour-symmetric patterns that varied in the number of wedges (24 vs. 36) and number of colours (2 vs. 3) and found that symmetry detection was facilitated by attention to colour when symmetry and noise signals were segregated by colour. In the second experiment, we compared performance for wedge and dot patterns on a sample of younger and older participants. Effects of attention to colour in segregated stimuli were magnified for wedge compared with dot patterns, with older and younger adults showing different effects of attention to colour on performance. Older adults significantly underperformed on uncued wedge patterns compared with dot patterns, but their performance improved greatly through colour cueing, reaching performance levels similar to young participants. Thus, while confirming the age-related decline in symmetry detection, we found that this deficit could be alleviated in figural multicoloured patterns by attending to the colour that carries the symmetry signal.

From perceptual organization to visual illusions and back.

In modern vision science, illusions are compelling phenomena useful as tools to explore vision under limiting psychophysical conditions. Illusions manifest at least two issues that challenge scientists. The first issue is related to the definition of illusion and to the complexity of the mismatch between the geometrical/physical and the phenomenal domains. The second issue concerns two different meanings of the term "illusion," respectively related to the demonstration of the illusion through the mismatch between domains and to the phenomenal illusoriness, i.e., the perception of something having the nature of an illusion, unreal, ambiguous, fallacious, and deceptive. In this work, we explored the notion of illusion starting from the principles of perceptual organization as described by Gestalt psychologists. On the basis of several phenomenal conditions, step by step, we suggested some new hypotheses, whose purpose was to answer the following questions: what is physical and what is phenomenal? Is there and, if any, what is the dividing line between illusions and non-illusions? Is it true that illusions are rare phenomena? Why do illusions exist? What is their perceptual and evolutionist role? These questions and the related issues were phenomenally discussed by deepening and extending the notion of perceptual organization and by exploring the biological implications of both illusions and illusoriness. On the basis of our results, the perception of illusion and illusoriness can be considered as a further challenge for vision scientists useful to shed new insights within the biological meanings of visual perception and within the no-man land between sensory and cognitive processes that elicit visual consciousness not fully explored yet.

The aesthetics of frieze patterns: Effects of symmetry, motif, and element size.

Frieze patterns appear frequently in architectural designs and ornamental patterning but their aesthetic qualities have never been studied experimentally. In the first experiment, 39 undergraduates used a seven-point rating scale to assess the perceived beauty of the seven basic frieze types presented at a horizontal orientation. The friezes consisted of individual curved and linear motifs as well as random textures. Friezes that filled the entire pattern region and which contained emergent global features were preferred the most. In a second experiment, we utilized horizontal texture friezes that were completely filled and which varied in size and number of elements. Participants preferred patterns with larger features, probably because they make detection of the symmetric transformations more visible. The frieze with the greatest number of symmetries was preferred most but symmetric complexity by itself could not completely account for the predicted preference ordering. In both studies, friezes containing horizontal mirrors (translation, 180° rotation, horizontal mirror, vertical mirror, and glide reflection and translation, horizontal mirror, and glide reflection) were preferred far more than any other condition. Horizontal symmetry may enhance perceived beauty in these cases because it runs parallel to and so emphasizes the overall frieze orientation.

The combination of target motion and dynamic changes in context greatly enhance visual size illusions.

Perceived size is a function of viewing distance, retinal images size, and various contextual cues such as linear perspective and the size and location of neighboring objects. Recently, we demonstrated that illusion magnitudes of classic visual size illusions may be greatly enhanced or reduced by adding dynamic elements. Specifically, a dynamic version of the Ebbinghaus illusion (classically considered a "size contrast" illusion) led to a greatly enhanced illusory effect, whereas a dynamic version of the Corridor illusion (a "size constancy" illusion) led to a greatly diminished illusory effect. Although these differences may arise from the different processes underlying these illusions (size contrast vs. size constancy), the dynamic variants we tested in our previous work also differed in the nature of the dynamic elements; specifically, whereas the Dynamic Ebbinghaus included a moving target and inducers that changed size and position, the Dynamic Corridor only included a moving target on a static background. Here, we explore further dynamic versions of the Ebbinghaus illusion and the Corridor and Ponzo illusions by separately manipulating three types of dynamic elements: target motion, context translation, and dynamic changes in context. Across five experiments examining 21 dynamic illusory configurations, adding target motion or a dynamically changing context separately resulted in little-to-no illusory effect. In contrast, the combination of target motion and a dynamically changing context led to a robust size illusion, consistent with an interactive effect. However, illusory effects that exceeded the matched classic, static illusory configuration were only observed for the dynamic versions of the Ebbinghaus illusion and the Revealed Ponzo illusions, in which the contextual elements changed size. We conclude that the combination of target motion and a dynamically changing context are necessary to produce dynamic size illusions, but that enhancement above and beyond static illusions may be largely specific to size contrast effects. Our results have important implications for the integration of motion signals, a ubiquitous environmental stimulus, in the perception of object size.

The induced motion effect is a high-level visual phenomenon: Psychophysical evidence.

Induced motion is the illusory motion of a target away from the direction of motion of the unattended background. If it is a result of assigning background motion to self-motion and judging target motion relative to the scene as suggested by the flow parsing hypothesis then the effect must be mediated in higher levels of the visual motion pathway where self-motion is assessed. We provide evidence for a high-level mechanism in two broad ways. Firstly, we show that the effect is insensitive to a set of low-level spatial aspects of the scene, namely, the spatial arrangement, the spatial frequency content and the orientation content of the background relative to the target. Secondly, we show that the effect is the same whether the target and background are composed of the same kind of local elements-one-dimensional (1D) or two-dimensional (2D)-or one is composed of one, and the other composed of the other. The latter finding is significant because 1D and 2D local elements are integrated by two different mechanisms so the induced motion effect is likely to be mediated in a visual motion processing area that follows the two separate integration mechanisms. Area medial superior temporal in monkeys and the equivalent in humans is suggested as a viable site. We present a simple flow-parsing-inspired model and demonstrate a good fit to our data and to data from a previous induced motion study.