Effect of mirror system and scanner bed of a flatbed scanner on lateral response artefact in radiochromic film dosimetry.

Radiochromic film, evaluated with flatbed scanners, is used for practical radiotherapy QA dosimetry. Film and scanner component effects contribute to the Lateral Response Artefact (LRA), which is further enhanced by light polarisation from both. This study investigates the scanner bed's contribution to LRA and also polarisation from the mirrors for widely used EPSON scanners, as part of broader investigations of this dosimetry method aiming to improve processes and uncertainties. Alternative scanner bed materials were compared on a modified EPSON V700 scanner. Polarisation effects were investigated for complete scanners (V700, V800, on- and off-axis, and V850 on-axis), for a removed V700 mirror system, and independently using retail-quality single mirror combinations simulating practical scanner arrangements, but with varying numbers (0-5) and angles. Some tests had no film present, whilst others included films (EBT3) irradiated to 6 MV doses of 0-11.3 Gy. For polarisation analysis, images were captured by a Canon 7D camera with 50 mm focal length lens. Different scanner bed materials showed only small effects, within a few percent, indicating that the normal glass bed is a good choice. Polarisation varied with scanner type (7-11%), increasing at 10 cm lateral off-axis distance by around a further 6%, and also with film dose. The V700 mirror system showed around 2% difference to the complete scanner. Polarization increased with number of mirrors in the single mirror combinations, to 14% for 4 and 5 mirrors, but specific values depend on angles and mirror quality. Novel film measurement methods could reduce LRA effect corrections and associated uncertainties.

An Optical Reusable 2D Radiochromic Gel-Based System for Ionising Radiation Measurements in Radiotherapy.

This work describes the development of a reusable 2D detector based on radiochromic reaction for radiotherapy dosimetric measurements. It consists of a radiochromic gel dosimeter in a cuboidal plastic container, scanning with a flatbed scanner, and data processing using a dedicated software package. This tool is assessed using the example of the application of the coincidence test of radiation and mechanical isocenters for a medical accelerator. The following were examined: scanning repeatability and image homogeneity, the impact of image processing on data processing in coincidence tests, and irradiation conditions-monitor units per radiation beam and irradiation field are selected. Optimal conditions for carrying out the test are chosen: (i) the multi-leaf collimator gap should preferably be 5 mm for 2D star shot irradiation, (ii) it is recommended to apply ≥2500-≤5000 MU per beam to obtain a strong signal enabling easy data processing, (iii) Mean filter can be applied to the images to improve calculations. An approach to dosimeter reuse with the goal of reducing costs is presented; the number of reuses is related to the MUs per beam, which, in this study, is about 5-57 for 30,000-2500 MU per beam (four fields). The proposed reusable system was successfully applied to the coincidence tests, confirming its suitability as a new potential quality assurance tool in radiotherapy.

3D Polymer Gel Dosimeters with iCBCT 3D Reading and polyGeVero-CT Software Package for Quality Assurance in Radiotherapy.

Dynamically evolving radiotherapy instruments require advancements in compatible 3D dosimetry systems. This paper reports on such tools for the coincidence test of the mechanical and radiation isocenter for a medical accelerator as part of the quality assurance in routine radiotherapy practice. Three-dimensional polymer gel dosimeters were used in combination with 3D reading by iterative cone beam computed tomography and 3D data processing using the polyGeVero-CT software package. Different polymer gel dosimeters were used with the following acronyms: VIP, PAGAT, MAGIC, and NIPAM. The same scheme was used for each dosimeter: (i) irradiation sensitivity test for the iterative cone beam computed tomography reading to determine the appropriate monitor unit for irradiation, and (ii) verification of the chosen irradiation conditions by a star-shot 2D irradiation of each 3D dosimeter in the direction of performing the test. This work concludes with the optimum monitor unit per beam for each selected 3D dosimeter, delivers schemes for quick and easy determination of the radiation isocenter and performing the coincidence test.

Determination of intrinsic energy dependence of point-like inorganic scintillation detector in brachytherapy.

BACKGROUND: Inorganic scintillation detectors (ISDs) are promising for in vivo dosimetry in brachytherapy (BT). ISDs have fast response, providing time resolved dose rate information, and high sensitivity, attributed to high atomic numbers. However, the conversion of the detector signal to absorbed dose-to-water is highly dependent on the energy spectrum of the incident radiation. This dependence is comprised of absorbed dose energy dependence, obtainable with Monte Carlo (MC) simulation, and the absorbed dose-to-signal conversion efficiency or intrinsic energy dependence requiring measurements. Studies have indicated negligible intrinsic energy dependence of ZnSe:O-based ISDs in Ir-192 BT. A full characterization has not been performed earlier. PURPOSE: This study characterizes the intrinsic energy dependence of ZnSe:O-based ISDs for kV X-ray radiation qualities, with energies relevant for BT. METHODS: Three point-like ISDs made from fiber-coupled cuboid ZnSe:O-based scintillators were calibrated at the Swedish National Metrology Laboratory for ionizing radiation. The calibration was done in terms of air kerma free-in-air, K air ${K}_{{\mathrm{air}}}$ , in 13 X-ray radiation qualities, Q $Q$ , from 25 to 300 kVp (CCRI 25-250 kV and ISO 4037 N-series), and in terms of absorbed dose to water, D w ${D}_{\mathrm{w}}$ , in a Co-60 beam, Q 0 ${Q}_0$ . The mean absorbed dose to the ISDs, relative to K air ${K}_{{\mathrm{air}}}$ and D w ${D}_{\mathrm{w}}$ , were obtained with the MC code TOPAS (Geant4) using X-ray spectra obtained with SpekPy software and laboratory filtration data and a generic Co-60 source. The intrinsic energy dependence was determined as a function of effective photon energy, E e f f ${E}_{eff}$ , (relative to Co-60). The angular dependence of the ISD signal was measured in a 25 kVp (0.20 mm Al HVL) and 135 kVp beam (0.48 mm Cu HVL), by rotating the ISDs 180° around the fiber's longitudinal axis (perpendicular to the beam). A full 360° was not performed due to setup limitations. The impact of detector design was quantified with MC simulation. RESULTS: Above 30 keV E e f f ${E}_{eff}$ the intrinsic energy dependence varied with less than 5 ± 4% from unity for all detectors (with the uncertainty expressed as the mean of all expanded measurement uncertainties for individual E e f f ${E}_{eff}$ above 30 keV, k = 2). Below 30 keV, it decreased with up to 17% and inter-detector variations of 13% were observed, likely due to differences in detector geometry not captured by the simulations using nominal geometry. In the 25 kVp radiation quality, the ISD signal varied with 24% over a ∼45° rotation. For 135 kVp, the corresponding variation was below 3%. Assuming a 0.05 mm thicker layer of reflective paint around the sensitive volume changed the absorbed dose with 6.3% at the lowest E e f f ${E}_{eff}$ , and with less than 2% at higher energies. CONCLUSION: The study suggests that the ISDs have an intrinsic energy dependence relative to Co-60 lower than 5 ± 4% in radiation qualities with E e f f ${E}_{eff}\ $ > 30 keV. Therefore, they could in principle be calibrated in a Co-60 beam quality and transferred to such radiation qualities with correction factors determined only by the absorbed dose energy dependence obtained from MC simulations. This encourages exploration of the ISDs' applications in intensity modulated BT with Yb-169 or other novel intermediate energy isotopes.

Magnetic field influence on the light yield from fiber-coupled BCF-60 plastic scintillators of relevance for output factor dosimetry in MR-linacs.

Organic plastic scintillators are of interest for ionizing radiation dosimetry in megavoltage photon beams because plastic scintillators have a mass density very similar to that of water. This leads to insignificant perturbation of the electron fluence at the point of measurement in a water phantom. This feature is a benefit for dosimetry in strong magnetic fields (e.g., 1.5 T) as found in linacs with magnetic resonance imaging. The objective of this work was to quantify if the light yield per dose for the scintillating fiber BCF-60 material from Saint-Gobain Ceramics and Plastics Inc. is constant regardless of the magnetic flux density. This question is of importance for establishing traceable measurement in MR linacs using this detector type. Experiments were carried out using an accelerator combined with an electromagnet (max 0.7 T). Scintillator probes were read out using chromatic stem-removal techniques based on two optical channels or full spectral information. Reference dosimetry was carried out with PTW31010 and PTW31021 ionization chambers. TOPAS/GEANT4 was used for modelling. The light yield per dose for the BCF-60 was found to be strongly influenced by the magnitude of the magnetic field from about 1 mT to 0.7 T. The light yield per dose increased (1.3 ± 0.2)% (k = 1) from 1 mT to 10 mT and it increased (4.5 ± 0.9)% (k = 1) from 0 T to 0.7 T. Previous studies of the influence of magnetic fields on medical scintillator dosimetry have been unable to clearly identify if observed changes in scintillator response with magnetic field strength were related to changes in dose, stem signal removal, or scintillator light yield. In the current study of BCF-60, we see a clear change in light yield with magnetic field, and none of the other effects.

Evaluation of a new radiochromic film dosimeter, Gafchomic EBT4, for VMAT, SABR and HDR treatment delivery verification.

Objective.To evaluate a new film for radiotherapy dosimetry, Gafchromic EBT4, compared to the current EBT3. To evaluate dose-response and verify test cases in MV external beam and HDR brachytherapy.Approach. Three lots (batches) of EBT4 and three lots of EBT3 films were calibrated at 6 MV over 0-1200 cGy range, using FilmQAPro software. Signal-to-noise of pixel value, reported dose (RD), and factors affecting dosimetry accuracy were evaluated (rotation of the film at scanning, energy response and post-exposure darkening). Both films were exposed to clinical treatment plans (VMAT prostate, SABR lung, single HDR source dwell, and 'pseudo' 3-channel HDR cervix brachytherapy). Film-RD was compared to TPS-calculated dose.Main results.EBT4 calibration curves had characteristics more favourable than EBT3 for radiation dosimetry, with improved signal to noise in film-RD of EBT4 compared to EBT3 (increase of average 46% in red and green channels at 500 cGy). Film rotation at scanning and post-exposure darkening was similar for the two films. The energy response of EBT4 is similar to EBT3. For all clinical case studies, EBT4 provided better agreement with the TPS-planned doses than EBT3. VMAT prostate gamma 3%/3 mm passing rate, EBT4 100.0% compared to EBT3 97.9%; SABR lung gamma 2%/2 mm, EBT4 99.6% and EBT3 97.9%; HDR cervix gamma 3%/2 mm, EBT4 97.7% and EBT3 95.0%.Significance.These results show EBT4 is superior to EBT3 for radiotherapy dosimetry validation of TPS plan delivery. Fundamental improvements in noise profile and calibration curve are reported for EBT4. All clinical test cases showed EBT4 provided equivalent or smaller difference in measured dose to TPS calculated dose than EBT3. Baseline data is presented on the achievable accuracy of film dosimetry in radiotherapy using the new Gafchromic EBT4 film.

A novel approach for eliminating metal artifacts based on MVCBCT and CycleGAN.

Purpose: To develop a metal artifact reduction (MAR) algorithm and eliminate the adverse effects of metal artifacts on imaging diagnosis and radiotherapy dose calculations. Methods: Cycle-consistent adversarial network (CycleGAN) was used to generate synthetic CT (sCT) images from megavoltage cone beam CT (MVCBCT) images. In this study, there were 140 head cases with paired CT and MVCBCT images, from which 97 metal-free cases were used for training. Based on the trained model, metal-free sCT (sCT_MF) images and metal-containing sCT (sCT_M) images were generated from the MVCBCT images of 29 metal-free cases and 14 metal cases, respectively. Then, the sCT_MF and sCT_M images were quantitatively evaluated for imaging and dosimetry accuracy. Results: The structural similarity (SSIM) index of the sCT_MF and metal-free CT (CT_MF) images were 0.9484, and the peak signal-to-noise ratio (PSNR) was 31.4 dB. Compared with the CT images, the sCT_MF images had similar relative electron density (RED) and dose distribution, and their gamma pass rate (1 mm/1%) reached 97.99% ± 1.14%. The sCT_M images had high tissue resolution with no metal artifacts, and the RED distribution accuracy in the range of 1.003 to 1.056 was improved significantly. The RED and dose corrections were most significant for the planning target volume (PTV), mandible and oral cavity. The maximum correction of Dmean and D50 for the oral cavity reached 90 cGy. Conclusions: Accurate sCT_M images were generated from MVCBCT images based on CycleGAN, which eliminated the metal artifacts in clinical images completely and corrected the RED and dose distributions accurately for clinical application.

Features of 2Day.QA® as a 2D radiation dosimeter.

PURPOSE: A new commercial 2D ionising radiation dosimeter (2Day.QA®) was developed. This work aims to introduce the basic functions of 2Day.QA®. METHODS: The dosimeter is made mainly of a linear polysaccharide consisting of ß(1 â†’ 4) linked d-glucose units and radiation active substances, which make it environmentally friendly. For 2Day.QA® irradiation, radiotherapy ionising radiation sources were used. The analysis of 2Day.QA® was performed using three scanners: Vidar® Red LED Dosimetry Pro Advantage™, Vidar® VXR 12-plus™ and HP Scanjet G3010 flatbed scanner. The stability of 2Day.QA® was tested. Exemplary applications of 2DayQA® for QA studies of accelerator light and radiation field coincidence and brachytherapy source position were carried out. RESULTS: The dosimeter responded to the lowest applied dose of 0.95 Gy and saturated at over 94.9 Gy. The quasi-linear dose response is below 20 Gy. Vidar® Red LED Dosimetry Pro Advantage™ has proven to be superior to other scanners at determining dose effects in 2Day.QA®. The stability of the non-irradiated 2Day.QA® is at least 18 months. After 18 months of storage, the dosimeter reacted to irradiation. In the case of the irradiated samples, a slight color drift related to the absorbed dose was observed. Tests of the use of 2Day.QA® to control the quality of the accelerator light and radiation field coincidence and brachytherapy source position have shown that it can be used for such applications. CONCLUSIONS: The study reveals the potential of 2Day.QA® for 2D radiation dosimetry and concludes with recommendations for the use of the dosimeter for radiotherapy QA tests.

Impact of Salt on Thermal Stability and Dose Response of the Fricke-XO-Pluronic F-127 3D Radiotherapy Dosimeter.

Fricke-XO-Pluronic F-127 has recently been proposed as a 3D dosimeter for radiotherapy. It contains the typical ingredients of the Fricke ionizing radiation dosimeter, which are embedded in a physical gel of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127). The main reactions upon irradiation are the conversion of Fe+2 to Fe+3 and the formation of a colored complex with XO ([XO-Fe]+3). The study attempts to optimize the dosimeter in terms of its solution-to-gel transition temperature. In order to lower this temperature, the use of NaCl salt has been proposed. The new composition was characterized in order to obtain information on its thermal performance, storage stability, dose response to irradiation with a medical accelerator emitting different types of radiation, and tissue equivalence. The results obtained show an improvement in the sol-gel transition temperature and dose sensitivity compared to the composition without NaCl and broaden the knowledge of the Fricke-XO-Pluronic F-127.

Effect of scanner lens on lateral response artefact in radiochromic film dosimetry.

Radiochromic film is a good dosimeter choice for patient QA for complex treatment techniques because of its near tissue equivalency, high spatial resolution and established method of use. Commercial scanners are typically used for film dosimetry, with Epson scanners being the most common. Radiochromic film dosimetry is not straightforward having some well-defined problems which must be considered, one of the main ones being the Lateral Response Artefact (LRA) effect. Previous studies showed that the contributing factors to LRA are from the structure of the active ingredients of the film and the components and construction of the flatbed scanner. This study investigated the effect of the scanner lens on the LRA effect, as part of a wider investigation of scanner design effects and uncertainties. Gafchromic EBT3 films were irradiated with 40 × 40 cm2 field size 6 MV beams. Films were analysed using images captured by a Canon 7D camera utilising 18 mm, 50 mm and 100 mm focal length lenses compared to images scanned with a conventional Epson V700 scanner. The magnitude of the LRA was observed to be dependent on the focal length of the lens used to image the film. A substantial reduction in LRA was seen with the use of the 50 mm and 100 mm lenses, by factors of 3-5 for the 50 mm lens and 4-30 for the 100 mm lens compared to conventional desktop scanner techniques. This is expected to be from the longer focal length camera lens system being able to collect more light from distant areas compared to the scanner-based system. This provides an opportunity to design film dosimetry systems that minimise this artefact.

Features of PABIGnx 3D Polymer Gel as an Ionising Radiation Dosimeter.

This work presents the features of the PABIGnx 3D polymer gel dosimeter. It consists of two cross-linkers: poly(ethylene glycol) diacrylate (PEGDA), as one biacrylic component, and N,N'-methylenebisacrylamide (MBA), which is another cross-linker often used in 3D dosimeters. Additionally, it contains oxygen scavenges of copper sulfate pentahydrate and ascorbic acid. All ingredients are embedded in a physical gel matrix of gelatine. Upon irradiation, the biacrylic cross-linking agents (PEGDA and MBA) undergo radical polymerisation and cross-linking, which is manifested by the appearance of the opacity of the intensity related to the absorbed dose. PABIGnx was irradiated with an oncological source of ionising radiation, and analysed by using a nuclear magnetic resonance (0.5 T). The following characteristics were obtained: (i) linear and dynamic dose-response of 0.5 to ~18 Gy and 40 Gy, respectively, (ii) dose sensitivity of 0.071 ± 0.001 Gy-1 s-1, (iii) integral 3D dose distribution for at least 24 days after irradiation, (iv) adequate batch-to-batch reproducibility, (v) dose-response independent of irradiation with 6 MV photons, 15 MV photons, 6 MV photons FFF of 0.0168-0.1094 Gy/s dose rates, and (vi) soft tissue equivalence. The study showed that the features of PABIGnx confirm its suitability for use in 3D radiotherapy dosimetry.

Efficient dose-rate correction of silicon diode relative dose measurements.

PURPOSE: Silicon diodes are often the detector of choice for relative dose measurements, particularly in the context of radiotherapy involving small photon beams. However, a major drawback lies in their dose-rate dependency. Although ionization chambers are often too large for small field output factor (OF) measurements, they are valuable instruments to provide reliable percent-depth dose (PDD) curves in reference beams. The aim of this work is to propose a practical and accurate method for the characterization of silicon diode dose-rate dependence correction factors using ionization chamber measurements as a reference. METHODS: The robustness of ionization chambers for PDD measurements is used to quantify the dose-rate dependency of a diode detector. A mathematical formalism, which exploits the error induced in percent-depth ionization (PDI) curves for diodes by their dose-rate dependency, is developed to derive a dose-rate correction factor applicable to diode relative measurements. The method is based on the definition of the recombination correction factor given in the addendum to TG 51 and is applied to experimental measurements performed on a CyberKnife M6 radiotherapy unit using a PTW 60012 diode detector. A measurement-based validation is provided by comparing corrected PDI curves to measurements performed with a PTW 60019 diamond detector, which does not exhibit dose-rate dependence. RESULTS: Results of dose-rate correction factors for PDI curves, off-axis ratios (OARs), tissue-phantom ratios, and small field OFs are coherent with the expected behavior of silicon diode detectors. For all considered setups and field sizes, the maximum correction and the maximum impact of the uncertainties induced by the correction are obtained for OARs for the 60 mm collimator, with a correction of 2.5% and an uncertainty of 0.34%. For OFs, corrections range from 0.33% to 0.82% for all field sizes considered, and increase with the reduction of the field size. Comparison of PDI curves corrected for dose-rate and for in-depth beam quality variations illustrates excellent agreement with measurements performed using the diamond detector. CONCLUSION: The proposed method allows the efficient and precise correction of the dose-rate dependence of silicon diode detectors in the context of clinical relative dosimetry.

Medical Range Radiation Dosimeter Based on Polymer-Embedded Fiber Bragg Gratings.

Fiber Bragg gratings (FBGs) are valuable dosimeters for doses up to 100 kilograys (kGy), but have hardly been used for the low-dose range of a few grays (Gy) required in medical radiation dosimetry. We report that embedding a doped silica fiber FBG in a polymer material allows a minimum detectable dose of 0.3 Gy for γ-radiation. Comparing the detector response for different doped silica fibers with various core doping, we obtain an independent response, in opposition to what is reported for high-dose range. We hypothesized that the sensor detection is based on the radio-induced thermal expansion of the surrounding polymer. Hence, we used a simple physical model based on the thermal and mechanical properties of the surrounding polymer and obtained good accordance between measured and calculated values for different compositions and thicknesses. We report that over the 4 embedding polymers tested, polyether ether ketone and polypropylene have respectively the lowest (0.056 pm/Gy) and largest sensitivity (0.087 pm/Gy). Such FBG-based dosimeters have the potential to be distributed along the fiber to allow multipoint detection while having a sub-millimeter size that could prove very useful for low-dose applications, in particular for radiotherapy dosimetry.

Exposure of the oesophagus in breast cancer radiotherapy: A systematic review of oesophagus doses published 2010-2020.

BACKGROUND AND PURPOSE: Breast cancer radiotherapy can increase the risk of subsequent primary oesophageal cancer, with risk increasing according to oesophagus radiation dose. We describe oesophagus exposure from modern breast cancer regimens and discuss the risks of oesophageal cancer for women irradiated recently. MATERIALS AND METHODS: A systematic review was undertaken of oesophagus doses from breast cancer radiotherapy regimens published during 2010-2020. Mean and maximum oesophagus doses were described for different target regions irradiated and different radiotherapy techniques. RESULTS: In 112 published regimens from 18 countries, oesophagus doses varied with target region. For partial breast irradiation, average mean oesophagus dose was 0.2 Gy (range 0.1-0.4) in four regimens; maximum dose was not reported. For breast or chest wall radiotherapy, average oesophagus doses were mean 1.8 Gy (range 0.1-10.4) in 24 regimens and maximum 6.7 Gy (range 0.4-14.3) in seven regimens. For radiotherapy including a nodal region, average oesophagus doses were higher: mean 11.4 Gy (range <0.1-29.3) in 61 regimens and maximum 34.4 Gy (range 3.4-51.3) in 55 regimens. Average mean oesophagus doses were >10 Gy for intensity modulated nodal radiotherapy, but lower for other node techniques. CONCLUSIONS: Mean oesophagus doses from partial breast and breast/chest wall regimens were usually less than 2 Gy, hence radiation-risks will be very small. However, for radiotherapy including lymph nodes, average mean oesophagus dose of 11.4 Gy may nearly double oesophageal cancer risk. Consideration of oesophageal exposure during nodal radiotherapy planning may reduce the risks of radiation-related oesophageal cancer for women irradiated today.

Laser Light Trapping Phenomenon in a 3D Radiotherapy Polymer Gel Dosimeter.

This paper aims to explain the phenomenon of laser light trapping (LLT) in a 3D polymer gel dosimeter. A VIC-T polymer gel dosimeter containing 17% N-vinylpyrrolidone, 8% N,N'-methylenebisacrylamide, 12% tert-butyl alcohol, 5% gelatine, 0.02% hydroquinone and 14 mM tetrakis(hydroxymethyl)phosphonium chloride was used in this study. It was exposed to green laser light with a wavelength of 532 nm. A film was recorded during the exposure. After exposure, Raman spectroscopy was used to study the reactions taking place inside the dosimeter. The obtained results were used to explain what the LLT phenomenon is, what are the consequences for the dosimeter in which such a phenomenon occurs, and what dosimeter components play an important role in the occurrence of LLT. In addition, the conditions under which 3D polymer gel dosimeters can be measured using optical computed tomography at short wavelengths of visible laser light are indicated.

Anisotropic diffusion of Fe ions in Fricke-XO-Pluronic F-127 and Fricke-XO-gelatine 3D radiotherapy dosimeters.

A new radiochromic dosimeter was examined with Raman spectroscopy and an optical approach for assessment of 3D dose distribution integrity. The acronym of the dosimeter is Fricke-XO-Pluronic F-127, where XO denotes xylenol orange; Pluronic F-127 is a copolymer matrix of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), and the dosimeter contains the components of a Fricke dosimetric solution. Two dosimeter samples in cuvettes were partially irradiated such that a radiation dose was absorbed at the bottom of the cuvettes. After irradiation, one sample was stored upside down such that the irradiated part was at the top and another one was stored with the irradiated part at the bottom. Two diffusion coefficients of ferric ion complexes with XO ([XO-Fe]+3) were calculated. They were compared with those for similar dosimeter, however with gelatine matrix instead of Pluronic F-127. The results obtained indicate an impact of the gravitational force on the diffusion of [XO-Fe]+3ions over time after irradiation and thus a possibility of severely undermining the integrity of a dose distribution in irradiated dosimeter. The conclusions drawn suggest the necessity of examination of different 3D Fricke dosimeter compositions for anisotropic diffusion of ferric ions.

Clinical radiotherapy application of N-vinylpyrrolidone-containing 3D polymer gel dosimeters with remote external MR-reading.

PURPOSE: Advanced 3D dosimetry is required for verifications of complex dose distributions in modern radiotherapy. Two 3D polymer gel dosimeters, coupled with magnetic resonance (MR) imaging (3 T MRI) readout and data processing with polyGeVero® software, were tested for the verification of calculated 3D dose distributions by a treatment planning system (TPS) and ArcCHECK®-3DVH®, related to eradication of a lung tumour. METHODS: N-vinylpyrrolidone-containing 3D polymer gel dosimeters were used: VIC (containing ascorbic acid and copper sulfate pentahydrate) and VIC-T (containing tetrakis(hydroxymethyl)phosphonium chloride). Three remote centers were involved in the dosimeters preparation and irradiation (Poland), and MRI (Austria). Cross beam calibration of the dosimeters and verification of a 3D dose distribution calculated with an Eclipse External Beam TPS and ArcCHECK®-3DVH® were performed. The 3D-to-3D comparisons of the VIC and VIC-T with TPS and ArcCHECK®-3DVH® along with ArcCHECK®-3DVH® versus TPS dose matrixes were performed with the aid of the polyGeVero® by analyzing dose profiles, isodoses lines, gamma index, gamma angle, dose difference, and related histograms. RESULTS: The measured MR-relaxation rate (R2 = 1/T2) for the dosimeters relates to the dose, as follows: R2 = 0.0928 ± 0.0008 [Gy-1 s-1] × D [Gy] + 2.985 ± 0.012 [s-1] (VIC) and 0.1839 ± 0.0044 [Gy-1 s-1] × D [Gy] + 2.519 ± 0.053 [s-1] (VIC-T). The 3D-to-3D comparisons revealed a good agreement between the measured and calculated 3D dose distributions. CONCLUSIONS: VIC and VIC-T with 3T MRI readout and polyGeVero® showed potential for verifications of calculated irradiation plans. The results obtained suggest the implementation of the irradiation plan for eradication of the lung tumour.

Calculation of kQ factors for Farmer-type ionization chambers following the recent recommendations on new key dosimetry data.

PURPOSE: To calculate by Monte Carlo simulations kQ factors for Farmer-type ionization chambers in megavoltage photon beams using the new key dosimetry data recommended by the International Commission on Radiation Units and Measurements (ICRU) Report 90. METHODS: Monte Carlo calculations were performed with the EGSnrc code system using both the ICRU 90 and the ICRU 37 data. Farmer-type ionization chambers with graphite and plastic walls and with graphite wall and a plastic waterproofing sleeve were considered (Nuclear Enterprise NE 2571, IBA FC65-G and FC65-P). kQ factors were calculated for photon beams in the range 6-25 MV using phase-space files as input radiation sources. The photon beam qualities in terms of TPR20,10 and %dd(10)x were established by simulating the depth-dose curves in water. Absorbed doses to the air cavity and to water were calculated using the egs_chamber user code with a target statistical uncertainty below 0.1%. RESULTS: The update of key dosimetry data according to the ICRU report 90 had an impact of -0.2% in the absorbed dose to water and up to 0.5% in the absorbed dose to the air cavity. Nevertheless, changes partially offset each other when entering in kQ as ratio, and the final impact on the kQ values was below 0.3%. CONCLUSIONS: The calculated values of kQ tend to be lower than the current values in the IAEA TRS-398 protocol with differences up to about 0.5%. A slightly better agreement (within 0.3%) is observed with the Monte-Carlo calculated values provided by the addendum to the AAPM's TG-51 protocol.

PENELOPE/PRIMO-calculated photon and electron spectra from clinical accelerators.

BACKGROUND: The availability of photon and electron spectra in digital form from current accelerators and Monte Carlo (MC) systems is scarce, and one of the packages widely used refers to linacs with a reduced clinical use nowadays. Such spectra are mainly intended for the MC calculation of detector-related quantities in conventional broad beams, where the use of detailed phase-space files (PSFs) is less critical than for MC-based treatment planning applications, but unlike PSFs, spectra can easily be transferred to other computer systems and users. METHODS: A set of spectra for a range of Varian linacs has been calculated using the PENELOPE/PRIMO MC system. They have been extracted from PSFs tallied for field sizes of 10 cm × 10 cm and 15 cm × 15 cm for photon and electron beams, respectively. The influence of the spectral bin width and of the beam central axis region used to extract the spectra have been analyzed. RESULTS: Spectra have been compared to those by other authors showing good agreement with those obtained using the, now superseded, EGS4/BEAM MC code, but significant differences with the most widely used photon data set. Other spectra, particularly for electron beams, have not been published previously for the machines simulated in this work. The influence of the bin width on the spectrum mean energy for 6 and 10 MV beams has been found to be negligible. The size of the region used to extract the spectra yields differences of up to 40% for the mean energies in 10 MV beams, but the maximum difference for TPR 20,10 values derived from depth-dose distributions does not exceed 2% relative to those obtained using the PSFs. This corresponds to kQ differences below 0.2% for a typical Farmer-type chamber, considered to be negligible for reference dosimetry. Different configurations for using electron spectra have been compared for 6 MeV beams, concluding that the geometry used for tallying the PSFs used to extract the spectra must be accounted for in subsequent calculations using the spectra as a source. CONCLUSIONS: An up-to-date set of consistent spectra for Varian accelerators suitable for the calculation of detector-related quantities in conventional broad beams has been developed and made available in digital form.

Monte Carlo simulations in radiotherapy dosimetry.

BACKGROUND: The use of the Monte Carlo (MC) method in radiotherapy dosimetry has increased almost exponentially in the last decades. Its widespread use in the field has converted this computer simulation technique in a common tool for reference and treatment planning dosimetry calculations. METHODS: This work reviews the different MC calculations made on dosimetric quantities, like stopping-power ratios and perturbation correction factors required for reference ionization chamber dosimetry, as well as the fully realistic MC simulations currently available on clinical accelerators, detectors and patient treatment planning. CONCLUSIONS: Issues are raised that include the necessity for consistency in the data throughout the entire dosimetry chain in reference dosimetry, and how Bragg-Gray theory breaks down for small photon fields. Both aspects are less critical for MC treatment planning applications, but there are important constraints like tissue characterization and its patient-to-patient variability, which together with the conversion between dose-to-water and dose-to-tissue, are analysed in detail. Although these constraints are common to all methods and algorithms used in different types of treatment planning systems, they make uncertainties involved in MC treatment planning to still remain "uncertain".