RESUMEN
The sol-gel entrapment of nanostructured Bi2WO6 enhances the activity and the selectivity of the short-gap semiconductor in the sunlight-driven photo-oxidation of trans-ferulic and trans-cinnamic acid dissolved in water with air as the primary oxidant. Valuable products such as vanillin, benzaldehyde, benzoic acid and vanillic acid are obtained. This provides the proof of concept that photocatalysis could be a promising technology in tomorrow's solar biorefineries.
Asunto(s)
Bismuto/química , Procesos Fotoquímicos , Luz Solar , Compuestos de Tungsteno/química , Tungsteno/química , Benzaldehídos/síntesis química , Benzaldehídos/química , Ácido Benzoico/síntesis química , Ácido Benzoico/química , Catálisis , Cinamatos/química , Ácidos Cumáricos/química , Estructura Molecular , Nanoestructuras/química , Oxidación-Reducción , Ácido Vanílico/síntesis química , Ácido Vanílico/química , Agua/químicaRESUMEN
Fungal laccases have been highlighted as a catalytic tool for transforming phenols. Here we demonstrate that fungal laccase-catalyzed oxidations can transform naturally occurring phenols into plant fertilizers with properties very similar to those of commercial humic acids. Treatments of Arabidopsis thaliana with highly cross-linked polyphenolic products obtained from a mixture of catechol and vanillic acid were able to enhance the germination and salt tolerance of this plant. These results revealed that humic-like organic fertilizers can be produced via in vitro enzymatic oxidation reactions. In particular, the root elongation pattern resulting from the laccase products was comparable to that resulting from an auxin-like compound. A detailed structural comparison of the phenol variants and commercial humic acids revealed their similarities and differences. Analyses based on SEM, EFM, ERP, and zeta-potential measurement showed that they both formed globular granules bearing various hydrophilic/polar groups in aqueous and solid conditions. Solid-phase 13C NMR, FT-IR-ATR, and elemental analyses showed that more nitrogen-based functional and aliphatic groups were present in the commercial humic acids. Significant differences were also identifiable with respect to particle size and specific surface area. High-resolution (15 T) FT-ICR mass spectrometry-based van Krevelen diagrams showed the compositional features of the variants to be a subset of those of the humic acids. Overall, our study unraveled essential structural features of polyaromatics that affect the growth of plants, and also provided novel bottom-up ecofriendly and finely tunable pathways for synthesizing humic-like fertilizers.
Asunto(s)
Arabidopsis/efectos de los fármacos , Fertilizantes , Germinación/efectos de los fármacos , Lacasa/metabolismo , Fenoles/farmacología , Arabidopsis/fisiología , Catecoles/síntesis química , Catecoles/metabolismo , Catecoles/farmacología , Proteínas Fúngicas/química , Proteínas Fúngicas/metabolismo , Tecnología Química Verde/métodos , Sustancias Húmicas , Lacasa/química , Espectroscopía de Resonancia Magnética , Oxidación-Reducción , Fenoles/síntesis química , Fenoles/metabolismo , Tolerancia a la Sal , Espectroscopía Infrarroja por Transformada de Fourier , Trametes/enzimología , Ácido Vanílico/síntesis química , Ácido Vanílico/metabolismo , Ácido Vanílico/farmacologíaRESUMEN
Methyl vanillate (1) showed strong degranulation inhibitory activity among vanillin derivatives tested. In order to find structure-activity relationships for developing anti-allergic agents with simple structures and potent activity, we synthesized several vanillic acid (VA) ester derivatives with C1-C4 and C8 alkyl chains and evaluated their degranulation inhibitory activities. The most active compound of VA ester derivatives was derivative 5 with a C4 straight alkyl chain, and derivative 5 exhibited approximately three-fold greater inhibitory activity than that of 1. Moreover, we designed 8 types of analogs based on 5, and we found that the minimum structure for potent degranulation inhibitory activity requires direct connection of the butyl ester moiety on the benzene ring and at least one hydroxyl group on the benzene ring. Butyl meta or para hydroxyl benzoate (10 or 11) has a simpler structure than that of 5 and exhibited more potent degranulation inhibitory activity than that of 5.
Asunto(s)
Antígenos/metabolismo , Ésteres/farmacología , Leucemia Basofílica Aguda/tratamiento farmacológico , Ácido Vanílico/farmacología , Animales , Línea Celular Tumoral , Relación Dosis-Respuesta a Droga , Ésteres/síntesis química , Ésteres/química , Leucemia Basofílica Aguda/metabolismo , Leucemia Basofílica Aguda/patología , Estructura Molecular , Ratas , Relación Estructura-Actividad , Ácido Vanílico/síntesis química , Ácido Vanílico/químicaRESUMEN
A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the activity of Aurora A, B, and C, and WEE1 kinase activity at concentrations <10% of their IC(50) growth inhibitory ones, accounting, at least partly, for their cytostatic effects in cancer cells and to a lesser extent in normal cells. Compounds 6b and 13c represent interesting starting points for the development of cytostatic agents to combat cancers, which are naturally resistant to pro-apoptotic stimuli, including metastatic malignancies.
Asunto(s)
Citostáticos/síntesis química , Neoplasias/tratamiento farmacológico , Ácido Vanílico/síntesis química , Apoptosis/efectos de los fármacos , Aurora Quinasas , Proteínas de Ciclo Celular/antagonistas & inhibidores , Citostáticos/farmacología , Concentración 50 Inhibidora , Neoplasias/patología , Proteínas Nucleares/antagonistas & inhibidores , Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores , Proteínas Tirosina Quinasas/antagonistas & inhibidores , Relación Estructura-Actividad , Ácido Vanílico/farmacología , Ácido Vanílico/uso terapéuticoRESUMEN
The synthesis, characterization and antimicrobial evaluation of a new series of veratric acid derivatives are presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including Gram-positive and Gram-negative bacteria and fungi. Some of the veratric acid derivatives exhibited significant in vitro antimicrobial activity. QSAR investigation applied to find a correlation between different physicochemical parameters of the veratric acid derivatives and their antimicrobial activity indicated the importance of topological parameters in describing the antimicrobial activity.
Asunto(s)
Antiinfecciosos/síntesis química , Ácido Vanílico/análogos & derivados , Antiinfecciosos/farmacología , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Relación Estructura-Actividad , Ácido Vanílico/síntesis química , Ácido Vanílico/farmacologíaRESUMEN
A simple and general synthesis of vanillamides was developed and employed to screen acids from the fatty and isoprenoid pools for new acyl templates of biological relevance as capsaicin analogues. Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety. The activity of the unsaturated analogues was maintained or even increased by cyclopropanation, while omega dimerization led to a substantial increase of activity. Because of the wide structural diversity of the library of compounds screened, these observations could not be translated into a single framework of structure-activity relationships. Nevertheless, a series of new highly active leads was identified, validating the pharmacological potential of the unnatural combination of natural building blocks to provide new bioactive compounds.
Asunto(s)
Amidas/síntesis química , Capsaicina/metabolismo , Receptores de Droga/agonistas , Ácido Vanílico/análogos & derivados , Ácido Vanílico/síntesis química , Amidas/química , Amidas/farmacología , Animales , Sitios de Unión , Línea Celular , Ácidos Grasos/síntesis química , Ácidos Grasos/química , Ácidos Grasos/farmacología , Ganglios Espinales/metabolismo , Humanos , Técnicas In Vitro , Ratas , Receptores de Droga/metabolismo , Terpenos/síntesis química , Terpenos/química , Terpenos/farmacología , Ácido Vanílico/química , Ácido Vanílico/farmacologíaRESUMEN
Vanillate esters with multifunctional groups the react with metal oxides to give chain-extended molecules have been synthesized. Divanillates were obtained from vanillic acid and the corresponding polymethylenediols. Methacryloylethyl vanillate (MEV) and vanillyl methacrylates were prepared respectively from hydroxyethyl vanillate or vanillyl alcohol and methacryloyl chloride. The properties of cements prepared with liquids incorporating these compounds were determined. Liquids containing divanillates dissolved in the reactive chelating agent o-ethoxybenzoic acid (EBA) when mixed with zinc oxide powders harden within a few minutes. The resulting cements have a tensile strength much higher than the commonly used zinc oxide-eugenol cements, have low solubility, do not inhibit polymerization, and adhere well to metallic substrates. Similarly, liquids with MEV as an ingredient yield cements with excellent strength and good adhesion to stainless steel and composites. Their brittleness can be overcome by addition of an oligomeric methacryloylethyl vanillate to the liquid or silanized glass to the powder ingredient. These cements, subject to their biocompatibility to oral tissues, could be most useful for a number of dental applications.
Asunto(s)
Acrilatos , Cementos Dentales , Hidroxibenzoatos , Metacrilatos , Ácido Vanílico , Acrilatos/síntesis química , Fenómenos Químicos , Química , Humanos , Hidroxibenzoatos/síntesis química , Indicadores y Reactivos , Metacrilatos/síntesis química , Relación Estructura-Actividad , Resistencia a la Tracción , Ácido Vanílico/análogos & derivados , Ácido Vanílico/síntesis químicaRESUMEN
A series of 5-substituted 3-hydroxy-4-methoxybenzoic acids (isovanillic acids) and -benzaldehydes (isovanillins) have been synthesized and evaluated as inhibitors of rat liver catechol O-methyltransferase. The compounds exhibited either noncompetitive or competitive patterns of inhibition when 3,4-dihydroxybenzoic acid was the variable substrate. The benzaldehydes were significantly more potent inhibitors than the corresponding benzoic acids, and electron-withdrawing substituents in the 5 position greatly enhanced their inhibitory activity.