RESUMEN
Canine eyelid masses (tumors) should include the differential clinical diagnoses of neoplasia and blepharitis. They have many common clinical signs including tumor, alopecia, and hyperemia. Biopsy and histologic examination remains the most effective diagnostic test to establish a confirmed diagnosis and appropriate treatment. Neoplasms are typically benign (tarsal gland adenomas, melanocytomas, and so forth) with the exception of lymphosarcoma. Blepharitis is noted in 2 age groups including dogs aged less than 1.5 years and middle aged to older dogs. Most blepharitis cases will respond to specific therapy once an accurate diagnosis is established.
Asunto(s)
Blefaritis , Enfermedades de los Perros , Neoplasias , Perros , Animales , Blefaritis/diagnóstico , Blefaritis/tratamiento farmacológico , Blefaritis/patología , Blefaritis/veterinaria , Piel , Glándulas Tarsales/patología , Neoplasias/diagnóstico , Neoplasias/veterinaria , Diagnóstico Diferencial , Enfermedades de los Perros/diagnósticoRESUMEN
Purpose: To compare the ocular surface and meibum microbial communities of humans with Demodex Blepharitis (DB) and healthy controls. Methods: Conjunctival sac and meibum samples from 25 DB patients and 11 healthy controls were analyzed using metagenomic next-generation sequencing (mNGS). Results: The alpha-diversity of the conjunctival sac microbiome of the DB group (observed, Chao1, ACE) was lower than that of the control group, whereas all meibum diversity indicators were similar. In conjunctival samples, the relative abundance (RA) of the phylum Proteobacteria was significantly higher (p=0.023), and the RA of both phyla Actinobacteria and Firmicutes was significantly lower (p=0.002, 0.025, respectively) in the DB group than that in the control group. In meibum samples, the RA of the phyla Proteobacteria and Actinobacteria were similar, whereas that of the phylum Firmicutes was significantly lower in the DB group (p=0.019) than that in the control group. Linear discriminant analysis with effect size measurement of the conjunctival and meibum microbiomes showed that Sphingobium sp. YG1 and Acinetobacter guillouiae were enriched in the DB group. Sphingobium sp. YG1, Acinetobacter guillouiae and Pseudomonas putida in the DB group were related to more severe ocular surface clinical parameters. Discriminative genera's principal coordinate analysis separated all control and DB microbiomes into two distinct clusters. Conclusions: Proteobacteria's increased prevalence may indicate ocular microbial community instability. The species Sphingobium sp. YG1 and Acinetobacter guillouiae are potentially pathogenic bacterial biomarkers in DB. Demodex infection mainly affects the ocular surface microbiome rather than penetrating deeper into the meibomian gland.
Asunto(s)
Acinetobacter , Blefaritis , Microbiota , Bacterias/genética , Blefaritis/epidemiología , Blefaritis/patología , Humanos , Glándulas Tarsales/patología , Microbiota/genética , ProteobacteriaRESUMEN
Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with consecutive sight-threatening consequences. The therapeutic "window of opportunity" is narrow, and current treatment options are limited and often insufficient. To achieve new insights into the pathogenesis and to develop new therapeutic approaches, clinically relevant models of oGVHD are desirable. In this study, the ocular phenotype was described in a murine, chemotherapy-based, minor-mismatch GVHD model mimicking early-onset chronic oGVHD, with corneal epitheliopathy, inflammation of the lacrimal glands, and blepharitis. Additionally, corneal lymphangiogenesis was observed as part of oGVHD pathogenesis for the first time, thus opening up the investigation of lymphangiogenesis as a potential therapeutic and diagnostic tool.
Asunto(s)
Antineoplásicos/toxicidad , Blefaritis/patología , Córnea/irrigación sanguínea , Enfermedad Injerto contra Huésped/patología , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Inflamación/patología , Aparato Lagrimal/patología , Animales , Blefaritis/etiología , Blefaritis/metabolismo , Modelos Animales de Enfermedad , Femenino , Enfermedad Injerto contra Huésped/etiología , Enfermedad Injerto contra Huésped/metabolismo , Inflamación/etiología , Inflamación/metabolismo , Aparato Lagrimal/metabolismo , Linfangiogénesis , Ratones , Ratones Endogámicos C57BLAsunto(s)
Blefaritis/microbiología , Piodermia/patología , Enfermedades Cutáneas Bacterianas/patología , Estomatitis/patología , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Antivirales/uso terapéutico , Blefaritis/diagnóstico , Blefaritis/etiología , Blefaritis/patología , Enfermedad de Crohn/complicaciones , Diagnóstico Diferencial , Femenino , Glucocorticoides/administración & dosificación , Glucocorticoides/uso terapéutico , Herpes Simple/genética , Humanos , Persona de Mediana Edad , Mucosa Bucal/patología , Mucosa Bucal/virología , Piodermia/microbiología , Salmonella/genética , Salmonella/aislamiento & purificación , Enfermedades Cutáneas Bacterianas/complicaciones , Enfermedades Cutáneas Bacterianas/microbiología , Enfermedades Cutáneas Bacterianas/virología , Estomatitis/diagnóstico , Estomatitis/virología , Resultado del TratamientoRESUMEN
The purpose of this randomized clinical trial is to evaluate the effect of eyelid hygiene on subjective symptoms, anterior blepharitis, and meibomian gland dysfunction (MGD) after cataract surgery. Subjects with obstructive MGD who underwent cataract surgery were randomly divided into two groups. In the eyelid hygiene group, eyelid hygiene was performed twice a day for 10 days from 3 days before to 1 week after cataract surgery. The control group did not perform eyelid hygiene. A subjective symptom questionnaire of SPEED, anterior blepharitis grade, and meibum quality and quantity was evaluated at baseline and at postoperative 1 and 4 weeks. The eyelid hygiene group (n = 36) showed decreased SPEED score after cataract surgery and the control group (n = 33) did not. Anterior blepharitis grade was worse 1 week after surgery in the control group but not in the eyelid hygiene group. The control group had significantly decreased meibum quality and quantity in both the upper and lower eyelids after cataract surgery, but the eyelid hygiene group did not. Eyelid hygiene before/after cataract surgery improved postoperative subjective symptoms and prevented postoperative exacerbation of anterior blepharitis and MGD. Thus, perioperative eyelid hygiene is recommended for patients with obstructive MGD who undergo cataract surgery.
Asunto(s)
Blefaritis/etiología , Extracción de Catarata/efectos adversos , Higiene , Disfunción de la Glándula de Meibomio/etiología , Complicaciones Posoperatorias , Anciano , Blefaritis/metabolismo , Blefaritis/patología , Catarata/complicaciones , Femenino , Humanos , Masculino , Disfunción de la Glándula de Meibomio/diagnóstico , Persona de Mediana Edad , Proyectos Piloto , Resultado del TratamientoRESUMEN
Demodex folliculorum is a mite that commonly inhabits the pilosebaceous units of facial skin, particularly in a perioral and periorbital distribution. While typically an incidental and asymptomatic parasite, Demodex spp. are proposed to contribute to the pathogenesis of facial folliculitis, chronic blepharitis and papulopustular rosacea. Reports of demodicosis in anatomic locations other than the face are exceedingly rare. Here we report a 36-year-old woman with symptomatic Demodex spp. infestation of Fordyce spots of the labia minora. She was referred to dermatology after a 9-month history of tender red bumps on the vulva that would arise and drain over a 24 to 72 hours period, several times per week. Physical examination revealed erythema of the labia minora and introitus with a 4 mm, pink, dome-shaped soft papule on the left labium minus. Wet mount, microbiologic cultures and sexually transmitted infection (STI) screenings were unremarkable. Histopathologic examination revealed a well-circumscribed nodule of suppurative granulomatous inflammation arising in a background of mucosa with Fordyce spots, the majority of which were infiltrated by Demodex spp. Treatment with oral ivermectin and topical metronidazole cream resulted in a symptom-free period of 22 months. This case represents an unusual presentation of symptomatic Demodex infestation.
Asunto(s)
Dermatosis Facial/parasitología , Infestaciones por Ácaros/diagnóstico , Ácaros/parasitología , Rosácea/diagnóstico , Vulva/patología , Administración Oral , Administración Tópica , Adulto , Animales , Antiparasitarios/administración & dosificación , Antiparasitarios/uso terapéutico , Antiprotozoarios/administración & dosificación , Antiprotozoarios/uso terapéutico , Blefaritis/patología , Quimioterapia Combinada , Eritema/patología , Femenino , Foliculitis/patología , Humanos , Ivermectina/administración & dosificación , Ivermectina/uso terapéutico , Metronidazol/administración & dosificación , Metronidazol/uso terapéutico , Infestaciones por Ácaros/complicaciones , Infestaciones por Ácaros/parasitología , Rosácea/patología , Enfermedades de la Piel/patología , Resultado del TratamientoRESUMEN
Purpose: : To present histopathological and immunohistochemical analysis of idiopathic inflammatory diseases of orbit and ocular adnexa. Methods: Design- A retrospective laboratory-based study. The study was carried out in an ocular pathology laboratory in a tertiary institute of northeast India where analysis of 93 cases was done in 5 years, during the period from 2011 to 2016. Hematoxylin--eosin and special stains were done for the diagnoses. Immunohistochemistry (IHC) panel was also carried out. For infectious pathology, Grocott's methenamine silver (GMS) stain for fungus, tissue Gram's stain for bacteria's, and acid-fast stains for tubercular bacilli were done. IHC panels were done for CD 20 (B-cells), CD-3 (T-cells), CD-45 (Leukocyte common antigen, LCA), BCL-2, CD-138 (Plasma cells), Kappa, Lambda, IgG-4 in tissue, IgG-4 in serum, etc. IHCs were done using kit methods (standardized) and adequate controls were taken for each sample. Results: 93 cases of nonspecific orbital inflammation were reported out of 1,467 specimens. Orbital pseudotumors (idiopathic orbital inflammatory disease, IOID) were seen in 27 cases (sclerosing variety-6); benign lymphoid hyperplasia in two cases; reactive lymphoid hyperplasia in 10 cases; atypical plasma lymphoproliferative reactive (polyclonal immunophenotypically, IgG4 negative) lesions in four cases; IgG-4 related disease in one case; nonspecific inflammatory reactions (conjunctiva, sclera, and lid) in 49 cases. In all the diagnoses, infections and lymphomas were excluded. Conclusion: Biopsy supported study on nonspecific orbital inflammation was important to know the pattern.
Asunto(s)
Blefaritis/patología , Conjuntivitis/patología , Seudotumor Orbitario/patología , Escleritis/patología , Adulto , Anciano , Antígenos CD/metabolismo , Linfocitos B/inmunología , Blefaritis/inmunología , Conjuntivitis/inmunología , Femenino , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Celulitis Orbitaria/inmunología , Celulitis Orbitaria/patología , Miositis Orbitaria/inmunología , Miositis Orbitaria/patología , Seudotumor Orbitario/inmunología , Seudolinfoma/inmunología , Seudolinfoma/patología , Estudios Retrospectivos , Escleritis/inmunología , Linfocitos T/inmunologíaRESUMEN
ABSTRACT A 12-year-old girl presented with recurrent crusty debris and dandruff at the base of both eyelashes despite having completed different medical treatments. She had had a hoarse voice since her early childhood. Upon anterior segment examination of the eyes, we found yellow-white, bead-like papules on the margins of the eyelids. An otolaryngologist detected multiple nodules on the vocal cords and buccal mucosa. Ultrasonography revealed salivary stones in the main parotid ducts. And a dermatological examination revealed thickened skin lesions on the elbows and knees with a biopsy showing histopathological findings of lipoid proteinosis. We diagnosed the patients as having Urbach-Wiethe syndrome or lipoid proteinosis, a rare autosomal recessive multisystem disorder with variable manifestations vary that difficult the diagnosis. The ocular manifestations are not well known among ophthalmologists, but the typical lid lesions are pathognomonic and ophthalmologists should be aware of this presentation to identify patients with Urbach-Wiethe syndrome.
RESUMO Uma menina de 12 anos apresentava restos crostosos e caspa recorrente na base de ambos os cílios, apesar de ter completado diferentes tratamentos médicos. Ela tinha uma voz rouca desde a infância. No exame do segmento anterior dos olhos, encontramos pápulas amarelo-esbranquiçadas nas margens das pálpebras. Um otorrinolaringologista detectou múltiplos nódulos nas cordas vocais e na mucosa bucal. A ultrassonografia revelou cálculos salivares nos principais ductos parotídeos. Um exame dermatológico revelou lesões cutâneas espessas nos cotovelos e joelhos com uma biópsia mostrando os achados histopatológicos de proteinose lipoide. Diagnosticamos os pacientes da síndrome de Urbach-Wiethe ou proteinose lipoide, um distúrbio multissistêmico autossômico recessivo raro, com manifestações variáveis, que dificultam o diagnóstico. Manifestações oculares não são bem conhecidas entre oftalmologistas, mas as lesões típicas da pálpebra são patognomônicas e os oftalmologistas devem estar atentos a essa apresentação para identificar pacientes com síndrome de Urbach-Wiethe.
Asunto(s)
Humanos , Femenino , Niño , Blefaritis/diagnóstico , Blefaritis/patología , Proteinosis Lipoidea de Urbach y Wiethe/diagnóstico , Proteinosis Lipoidea de Urbach y Wiethe/patología , Piel/patología , Pliegues Vocales/patología , Biopsia , Diagnóstico Diferencial , Hialina , Mucosa Bucal/patologíaRESUMEN
A 12-year-old girl presented with recurrent crusty debris and dandruff at the base of both eyelashes despite having completed different medical treatments. She had had a hoarse voice since her early childhood. Upon anterior segment examination of the eyes, we found yellow-white, bead-like papules on the margins of the eyelids. An otolaryngologist detected multiple nodules on the vocal cords and buccal mucosa. Ultrasonography revealed salivary stones in the main parotid ducts. And a dermatological examination revealed thickened skin lesions on the elbows and knees with a biopsy showing histopathological findings of lipoid proteinosis. We diagnosed the patients as having Urbach-Wiethe syndrome or lipoid proteinosis, a rare autosomal recessive multisystem disorder with variable manifestations vary that difficult the diagnosis. The ocular manifestations are not well known among ophthalmologists, but the typical lid lesions are pathognomonic and ophthalmologists should be aware of this presentation to identify patients with Urbach-Wiethe syndrome.
Asunto(s)
Blefaritis/diagnóstico , Blefaritis/patología , Proteinosis Lipoidea de Urbach y Wiethe/diagnóstico , Proteinosis Lipoidea de Urbach y Wiethe/patología , Biopsia , Niño , Diagnóstico Diferencial , Femenino , Humanos , Hialina , Mucosa Bucal/patología , Piel/patología , Pliegues Vocales/patologíaRESUMEN
BACKGROUND: Blepharitis is a common finding in many dogs with various skin diseases. OBJECTIVES: To establish a definition for canine blepharitis versus periocular dermatitis (POD), to evaluate the clinical findings and underlying skin diseases of blepharitis, and to document the effects of blepharitis on tear production in dogs. ANIMALS: One hundred and two privately owned dogs with clinical signs of blepharitis and a definitive diagnosis of skin disease. METHODS AND MATERIALS: Prospective evaluation of clinical signs and underlying diseases in dogs with blepharitis alone compared to dogs with blepharitis and POD. RESULTS: Brachycephalic dogs were significantly more likely to present with blepharitis than other breeds. Twenty five dogs had blepharitis alone [three dogs (2.9%) without and 22 dogs (21.5%) with cutaneous lesion beyond the periocular skin]. Seventy one of 102 (69%) presented with POD in addition to blepharitis. In six cases a differentiation between blepharitis and POD was not possible. Typical lesions included alopecia/hypotrichosis (97%), erythema (93%), eyelid oedema (50%) and crusts (39.2%). Allergic skin disease (52%) was the most common underlying cause of blepharitis, followed by infectious/parasitic diseases (21.5%), autoimmune disorders (17.7%) and neoplasia (4.9%). Four dogs could not be allocated to any of these disease groups. A diagnosis of parasitism was always accompanied by POD. Reduced tear production was detected in ten of the 53 dogs tested (18.8%). CONCLUSION: Blepharitis occurring in the absence of other skin lesions is rare. The most common underlying cause of blepharitis is allergic dermatitis. Measurement of tear production should be recommended in all cases of blepharitis.
Asunto(s)
Blefaritis/veterinaria , Dermatitis Atópica/veterinaria , Enfermedades de la Piel/veterinaria , Piel/patología , Animales , Biopsia , Blefaritis/etiología , Blefaritis/patología , Dermatitis Alérgica por Contacto/complicaciones , Dermatitis Alérgica por Contacto/veterinaria , Dermatitis Atópica/complicaciones , Enfermedades de los Perros/patología , Perros , Femenino , Masculino , Estudios Prospectivos , Enfermedades de la Piel/complicaciones , Lágrimas/fisiologíaAsunto(s)
Blefaritis/inducido químicamente , Dermatitis Alérgica por Contacto/etiología , Queratoconjuntivitis/inducido químicamente , Soluciones Oftálmicas/efectos adversos , Fenilefrina/efectos adversos , Blefaritis/diagnóstico , Blefaritis/patología , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/patología , Diagnóstico Diferencial , Párpados , Femenino , Humanos , Queratoconjuntivitis/diagnóstico , Persona de Mediana Edad , Pruebas del Parche , Índice de Severidad de la Enfermedad , Piel/efectos de los fármacos , Piel/patología , Síndrome de Stevens-Johnson/diagnóstico , Síndrome de Stevens-Johnson/patología , Uveítis/tratamiento farmacológicoRESUMEN
PURPOSE: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis. METHODS: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14 days and 28 days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline. RESULTS: We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group. CONCLUSION: This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.
Asunto(s)
Blefaritis/tratamiento farmacológico , Glándulas Tarsales/patología , Tacrolimus/administración & dosificación , Administración Tópica , Adulto , Blefaritis/patología , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Femenino , Estudios de Seguimiento , Humanos , Inmunosupresores/administración & dosificación , Masculino , Glándulas Tarsales/efectos de los fármacos , Persona de Mediana Edad , Pomadas , Estudios Prospectivos , Microscopía con Lámpara de Hendidura , Resultado del TratamientoAsunto(s)
Absceso/diagnóstico por imagen , Blefaritis/diagnóstico por imagen , Dacriocistitis/diagnóstico por imagen , Histiocitosis de Células de Langerhans/diagnóstico , Enfermedades Orbitales/diagnóstico por imagen , Absceso/patología , Absceso/cirugía , Enfermedad Aguda , Antibacterianos/uso terapéutico , Blefaritis/patología , Blefaritis/cirugía , Terapia Combinada , Dacriocistitis/patología , Dacriocistitis/cirugía , Diagnóstico Diferencial , Histiocitosis de Células de Langerhans/patología , Histiocitosis de Células de Langerhans/cirugía , Humanos , Hepatopatías/diagnóstico por imagen , Hepatopatías/patología , Masculino , Enfermedades Orbitales/patología , Enfermedades Orbitales/cirugía , Tomografía Computarizada por Tomografía de Emisión de Positrones , Tomografía Computarizada por Rayos X , Ultrasonografía , Adulto JovenAsunto(s)
Blefaritis/patología , Granulomatosis con Poliangitis/patología , Antiinflamatorios/uso terapéutico , Ciclofosfamida/uso terapéutico , Granulomatosis con Poliangitis/complicaciones , Granulomatosis con Poliangitis/tratamiento farmacológico , Humanos , Masculino , Metilprednisolona/uso terapéutico , Persona de Mediana Edad , NecrosisRESUMEN
Despite the fact that cosmetic products undergo rigorous testing to ensure they are safe for human use, some users report mild discomfort following their application. The cutaneous changes, such as allergic dermatitis, are well reported, but the ocular changes associated with eye cosmetic use are less so. Some pigmented cosmetic products may accumulate within the lacrimal system and conjunctivae over many years of use, but immediate reports of eye discomfort after application are most common. Changes to the tear film and its stability may occur shortly after application, and contact lens wearers can also be affected by lens spoliation from cosmetic products. Additionally, creams used in the prevention of skin aging are often applied around the eyes, and retinoids present in these formulations can have negative effects on meibomian gland function and may be a contributing factor to dry eye disease. The aim of this review is to summarize current knowledge regarding the impact of cosmetic products on the eye, ocular surface, and tear film.
Asunto(s)
Cosméticos/efectos adversos , Ojo/efectos de los fármacos , Ojo/microbiología , Ojo/patología , Ojo/fisiopatología , Alérgenos/efectos adversos , Animales , Antioxidantes/efectos adversos , Bimatoprost/efectos adversos , Blefaritis/etiología , Blefaritis/patología , Blefaritis/fisiopatología , Conjuntiva/microbiología , Conjuntiva/patología , Conjuntiva/fisiopatología , Enfermedades de la Conjuntiva/etiología , Lentes de Contacto , Contraindicaciones , Cosméticos/farmacología , Cosméticos/toxicidad , Síndromes de Ojo Seco/etiología , Síndromes de Ojo Seco/fisiopatología , Infecciones del Ojo/etiología , Infecciones del Ojo/microbiología , Humanos , Aparato Lagrimal/patología , Aparato Lagrimal/fisiopatología , Glándulas Tarsales/efectos de los fármacos , Glándulas Tarsales/fisiopatología , Ácaros/microbiología , Retinoides/efectos adversos , Piel/microbiología , Piel/fisiopatología , Tensoactivos/efectos adversos , Lágrimas/fisiologíaRESUMEN
Abstract: Morbihan Syndrome is a rare entity with unknown etiology. It is clinically characterized by chronic erythematous edema on the face - especially in the middle and upper third of the face - and creates abnormal facial contours that are initially intermitent but become permanent with the development of the syndrome. The histopathology is nonspecific and its therapy is a major challenge due to poor response to the various treatment options. We present the case of a male patient with a five-month-history of disease.
Asunto(s)
Humanos , Masculino , Adulto , Edema/patología , Eritema/patología , Dermatosis Facial/patología , Síndrome , Blefaritis/patología , Enfermedad CrónicaAsunto(s)
Blefaritis/genética , Blefaritis/patología , Proteinosis Lipoidea de Urbach y Wiethe/genética , Proteinosis Lipoidea de Urbach y Wiethe/patología , Adolescente , Biopsia con Aguja , Blefaritis/diagnóstico , Humanos , Inmunohistoquímica , Proteinosis Lipoidea de Urbach y Wiethe/diagnóstico , Masculino , Linaje , Enfermedades Raras , Índice de Severidad de la Enfermedad , HermanosRESUMEN
Morbihan Syndrome is a rare entity with unknown etiology. It is clinically characterized by chronic erythematous edema on the face - especially in the middle and upper third of the face - and creates abnormal facial contours that are initially intermitent but become permanent with the development of the syndrome. The histopathology is nonspecific and its therapy is a major challenge due to poor response to the various treatment options. We present the case of a male patient with a five-month-history of disease.