Asunto(s)
Infecciones por VIH , Sífilis , Humanos , Sífilis/diagnóstico , Sífilis/complicaciones , Infecciones por VIH/complicaciones , Masculino , Diagnóstico Diferencial , Condiloma Acuminado/complicaciones , Condiloma Acuminado/diagnóstico , Adulto , Enfermedades del Ano/microbiología , Enfermedades del Ano/diagnósticoRESUMEN
Patients with anal condyloma acuminatum (CA) are at risk of developing anal cancer which is associated with oncogenic human papillomavirus (HPV) infection. Investigation of anal HPV prevalence and risk factors can provide effective strategies for the prevention of anal cancer. A retrospective study was conducted among 549 patients with anal CA in the Third People's Hospital of Shenzhen between January 2019 and October 2021. HPV prevalence and HIV antibodies were detected by fluorescent PCR and ELISA, respectively. Logistic regression model and structural equation modeling (SEM) were conducted to analyzed the risk factors of oncogenic HPV infection. The overall prevalence of HPV was 96.72%. Both HPV6 (N = 285, 51.91%) and HPV11 (N = 300, 54.64%) were more than half infected and the most frequent Hr-HPV genotype was HPV16 (N = 138, 25.14%). HIV-positive (AOR: 5.02, 95% CI: 2.98-8.60, p < 0.0001) and history of syphilis (AOR: 4.24, 95% CI: 2.31-8.46, p < 0.0001) were independent risk factors statistically associated with oncogenic HPV infection. Ever had anal sex (AOR: 3.40, 95% CI: 1.28-11.81, p = 0.0267) and age 35 years and older (AOR: 2.79, 95% CI: 1.53-5.15, p = 0.0009) were associated with HPV16 and HPV52, respectively. SEM analyses showed that HIV-positive (b = 1.549, p < 0.001) and history of syphilis (b = 1.450, p < 0.001) had significant positive effects on oncogenic HPV infection. Ever had anal sex (b = 1.243, p = 0.025) and Age (b = 0.043, p = 0.002) positively drived HPV16 and HPV52 infection, respectively. Anal CA patients who are HIV-positive, have a history of syphilis, or at least 35 years old should be considered for Hr-HPV, cytology and other anal cancer related tests to reduce the risk of cancer development.
Asunto(s)
Neoplasias del Ano , Condiloma Acuminado , Infecciones por VIH , Seropositividad para VIH , Infecciones por Papillomavirus , Sífilis , Masculino , Humanos , Adulto , Infecciones por Papillomavirus/complicaciones , Infecciones por Papillomavirus/epidemiología , Estudios Retrospectivos , Infecciones por VIH/complicaciones , Infecciones por VIH/epidemiología , Homosexualidad Masculina , Sífilis/complicaciones , Prevalencia , Factores de Riesgo , Canal Anal , Condiloma Acuminado/complicaciones , Condiloma Acuminado/epidemiología , Neoplasias del Ano/epidemiología , Neoplasias del Ano/complicaciones , Papillomaviridae/genética , Papillomavirus Humano 16/genéticaRESUMEN
Background: Human immunodeficiency virus (HIV)-positive patients with anal condyloma acuminata (CA) present an increased risk of anal cancer progression associated with oncogenic human papillomavirus (HPV) infection. It is essential to explore determinants of anal infection by oncogenic HPV among HIV-positive patients with CA. Methods: A retrospective cohort study was performed in HIV-positive patients with CA between January 2019 to October 2021 in Shenzhen, Southeast China. Exfoliated cells were collected from CA lesions and the anal canal of HPV genotypes detected by fluorescence PCR. Unconditional logistic regression analysis was used to probe associations of independent variables with oncogenic HPV infection. Results: Among HIV-positive patients with CA, the most prevalent oncogenic genotypes were HPV52 (29.43%), HPV16 (28.93%), HPV59 (19.20%), and HPV18 (15.96%). Risk of oncogenic HPV infection increased with age at enrollment (COR: 1.04, 95% CI: 1.01-1.07, p = 0.022). In the multivariable analysis, age ≥ 35 years (AOR: 2.56, 95% CI: 1.20-5.70, p = 0.02) and history of syphilis (AOR: 3.46, 95% CI: 1.90-6.79, p < 0.01) were independent risk factors statistically associated with oncogenic HPV infection. History of syphilis (AOR: 1.72, 95% CI: 1.08-2.73, p < 0.02) was also an independent risk factor statistically associated with HPV16 or HPV18 infection. Conclusion: In clinical practice, HIV-positive CA patients aged ≥35 years or with a history of syphilis should carry out HR-HPV testing and even anal cancer-related examinations to prevent the occurrence of anal cancer.
Asunto(s)
Enfermedades del Ano , Neoplasias del Ano , Condiloma Acuminado , Seropositividad para VIH , Infecciones por Papillomavirus , Sífilis , Masculino , Humanos , Infecciones por Papillomavirus/complicaciones , Infecciones por Papillomavirus/epidemiología , Homosexualidad Masculina , Estudios Retrospectivos , Seropositividad para VIH/epidemiología , Seropositividad para VIH/genética , Seropositividad para VIH/patología , Condiloma Acuminado/complicaciones , Condiloma Acuminado/epidemiología , Condiloma Acuminado/patología , Factores de Riesgo , Enfermedades del Ano/epidemiología , Enfermedades del Ano/patología , Neoplasias del Ano/epidemiología , China/epidemiología , Papillomaviridae/genéticaRESUMEN
24-year-old man with positive HIV, with a giant exofitic anal condyloma, with a clinical presentation of a painfull suppurative anal condyloma with a pathology report of an in situ squamous cell carcinoma. The purpose of the investigation is a case report and the procedure was observational. The finding was a Buschke-Lowenstein tumor.
Varón de 24 años, con infección por el virus de la inmunodeficiencia humana, que presenta una tumoración exofítica, dolorosa y supurativa, con reporte positivo de virus de papiloma humano y reporte histopatológico de carcinoma espinocelular sin evidencia de diseminación (in situ). El propósito de la investigación es un reporte de caso y el procedimientos fue observacional. El hallazgo fue un tumor de Buschke-Lowenstein.
Asunto(s)
Tumor de Buschke-Lowenstein , Carcinoma de Células Escamosas , Condiloma Acuminado , Masculino , Humanos , Tumor de Buschke-Lowenstein/cirugía , Tumor de Buschke-Lowenstein/patología , Condiloma Acuminado/complicaciones , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/cirugía , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/cirugía , Canal AnalRESUMEN
Giant condyloma acuminata (GCA), or Buschke-Löwenstein tumor, is a rare exophytic cauliflower-like growth in the anogenital region. The spectrum of treatment options is wide, ranging from the application of topical ointments to the performance of an abdominoperineal resection. Currently, wide local excision is the most common approach and may entail the creation of a protective loop ileostomy or implementation of flaps or grafts that facilitate closure. We describe a unique surgical approach for the management of circumferential GCA void of the use a protective loop ileostomy, flaps, or grafts. Our report highlights that the implementation of a radical, circumferential, wide excision resulting in "free-floating anus" and healing via secondary intention can ultimately lead to excellent functional and cosmetic results and therefore may be considered a minimally invasive surgical option for patients afflicted with a large, circumferential GCA.
Asunto(s)
Neoplasias del Ano , Tumor de Buschke-Lowenstein , Condiloma Acuminado , Humanos , Tumor de Buschke-Lowenstein/cirugía , Tumor de Buschke-Lowenstein/complicaciones , Tumor de Buschke-Lowenstein/patología , Canal Anal/patología , Condiloma Acuminado/cirugía , Condiloma Acuminado/complicaciones , Condiloma Acuminado/patología , Neoplasias del Ano/patología , Colgajos Quirúrgicos , Márgenes de EscisiónAsunto(s)
Condiloma Acuminado , Exantema , Neoplasias Cutáneas , Sífilis Cutánea , Sífilis , Humanos , Sífilis/complicaciones , Sífilis/diagnóstico , Sífilis Cutánea/complicaciones , Sífilis Cutánea/diagnóstico , Condiloma Acuminado/complicaciones , Condiloma Acuminado/diagnóstico , Neoplasias Cutáneas/complicaciones , Exantema/complicacionesAsunto(s)
Condiloma Acuminado , Exantema , Neoplasias Cutáneas , Sífilis Cutánea , Sífilis , Humanos , Sífilis/complicaciones , Sífilis/diagnóstico , Sífilis Cutánea/complicaciones , Sífilis Cutánea/diagnóstico , Condiloma Acuminado/complicaciones , Condiloma Acuminado/diagnóstico , Neoplasias Cutáneas/complicaciones , Exantema/complicacionesRESUMEN
Epidermodysplasia verruciformis (EDV) is a rare genodermatosis that predisposes individuals to persistent infection with ß-human papillomavirus (HPV) genotypes. The term EDV acanthoma may be applied to lesions with incidental findings of EDV-defining histopathological features without clinical signs of EDV. We report a case of HPV-14- and -21-positive EDV acanthoma arising in association with condyloma in a female patient with a history of low-grade squamous intraepithelial lesion of the cervix positive for high-risk HPV (non-16/18), chronic kidney disease, and systemic lupus erythematosus. The patient had no family or personal history of EDV, but the patient was on immunosuppressive therapy with mycophenolate mofetil and prednisone. A biopsy specimen from one of the perianal lesions revealed histopathologic changes consistent with EDV in the setting of condyloma. Molecular testing showed HPV-14 and -21, which supported the coexistence of condyloma with EDV acanthoma.
Asunto(s)
Acantoma , Condiloma Acuminado , Epidermodisplasia Verruciforme , Infecciones por Papillomavirus , Neoplasias Cutáneas , Humanos , Femenino , Acantoma/complicaciones , Virus del Papiloma Humano , Epidermodisplasia Verruciforme/complicaciones , Epidermodisplasia Verruciforme/patología , Infecciones por Papillomavirus/patología , Condiloma Acuminado/complicaciones , Papillomaviridae , Neoplasias Cutáneas/complicacionesRESUMEN
Background: The spirochaete Treponema pallidum subsp. pallidum, which causes the infectious disease syphilis, can be spread through sexual contact or perinatal transmission. In recent years, cases of syphilis have increased, especially among individuals engaging in behaviour that makes them more vulnerable (condomless sex and multiple sexual partners). Condylomata acuminata (external genital warts) is one of the most common viral sexually transmitted infections (STIs). Individuals who are behaviourally vulnerable are also highly prone to two or more STIs. Our case exemplifies the occurrence of two STIs in a young man who was behaviourally vulnerable to acquiring STIs. Case: We report a case of a 21-year-old year old heterosexual man presenting with concomitant primary syphilis and genital warts. He presented with a painless genital ulcer and warty growths on his glans penis. Examination showed a painless indurated ulcer and multiple genital warts. Serology was positive for quantitative Venereal disease research laboratory test (1:16 titre). The patient was diagnosed with two concomitant STIs. He was treated as per the latest Centers for Disease Control and Prevention (CDC) guidelines for primary syphilis and podophyllin resin for genital warts. After four weeks, the genital ulcer showed complete healing and there was a significant reduction of genital warts. Conclusions: Individuals with multiple sexual partners engaging in sexual activity without the use of prevention tools are at a greater chance of acquiring two or more STIs. To reduce concomitant transmission, preventive measures against genital ulcer diseases like syphilis, herpes, and chancroid, such as early identification and treatment, and condom distribution, must be strengthened as part of national STI prevention. Patients with two or more STIs should be followed regularly to assess the progress of infection and should be offered timely medical treatment.
Asunto(s)
Condiloma Acuminado , Sífilis , Humanos , Masculino , Adulto Joven , Sífilis/complicaciones , Condiloma Acuminado/complicaciones , Enfermedades de Transmisión Sexual/complicaciones , Enfermedades de Transmisión Sexual/diagnóstico , AdultoRESUMEN
PURPOSE: To provide an understanding of the changes in sexual function in women with genital warts. METHODS: In this review study, databases searched included: PubMed, Science Direct, Scopus, Web of Science, Cochrane Library of Systematic Reviews, Google Scholar, ProQuest, Wiley, and Highwire Press. No study design limitations were applied to the initial search, and qualitative and quantitative studies published between 2005 and 2021 were included. RESULTS: 19 articles were selected and analyzed narratively. The quality of the studies was almost good. The findings were classified into three groups: The prevalence of sexual dysfunction in women with genital warts (GWs) and Human Papillomavirus (HPV); Types of sexual dysfunction in women with genital warts, and associated factors; Psychosexual effects of genital warts. CONCLUSION: This study provides up-to-date evidence of the changes in sexual function in women with genital warts. Although the results of most studies showed that women with genital warts experienced sexual dysfunction in almost all dimensions, differences in study design and study population made it difficult to determine the specific type of disorder such as libido, or arousal disorders in these women. Based on the findings of this review, more research in this field is recommended for the future. SYSTEMATIC REVIEW REGISTRATION: (PROSPERO: CRD42020188584, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=188584 ).
Asunto(s)
Condiloma Acuminado , Humanos , Femenino , Condiloma Acuminado/complicaciones , Condiloma Acuminado/epidemiología , PrevalenciaRESUMEN
RATIONALE: Extramammary Paget's disease (EMPD) is a rare skin cancer that commonly occurs in sites rich in apocrine glands, such as perineum, vulva, axilla, scrotum, and penis. On the other hand, condyloma acuminatum (CA; also referred to as anogenital warts) is a common benign neoplasm caused by human papillomavirus. Few cases of coexistent EMPD and CA have been reported because of the rarity of the condition. PATIENT CONCERNS AND DIAGNOSIS: A 72-year-old man with a genital mass, which appeared to be composed of multiple papillomatous masses, was referred for surgical resection. The lesion was first noticed 6 months previously and grew rapidly. CO2 ablative laser therapy was performed twice at a primary clinic, but the mass recurred. INTERVENTION AND OUTCOMES: Excisional biopsy revealed the presence of coexistent EMPD and CA. Additional wide excision was performed, and postoperative biopsy confirmed no residual tumor. Two years after surgery, no recurrence had occurred. LESSONS: CA can co-occur with several types of skin malignancies, and a skin malignancy coexisting with CA is difficult to diagnose visually. Therefore, even if a skin lesion in the genital region is considered to be CA, we recommend punch biopsy before treatment because it can benefit prognosiss.
Asunto(s)
Condiloma Acuminado , Enfermedad de Paget Extramamaria , Neoplasias Cutáneas , Masculino , Femenino , Humanos , Anciano , Enfermedad de Paget Extramamaria/diagnóstico , Enfermedad de Paget Extramamaria/cirugía , Escroto/patología , Condiloma Acuminado/complicaciones , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/cirugía , Pene/patología , Neoplasias Cutáneas/patologíaRESUMEN
BACKGROUND: Syphilis is known as the "great imitator" because of its polymorphic clinical manifestations. Condyloma lata are an uncommon mucocutaneous manifestation of secondary syphilis, generally localized in intertriginous areas, such as the genitals and anus. Extragenital localization of condyloma lata is considered unusual. METHODS: A case study of extra-genital condylomata is presented. To contextualise the case, a literature review of extra-genital condylomata lata was subsequently undertaken. The authors searched MEDLINE/PubMed, Scopus and Excerpta Medica/EMBASE English-language sources using the following keywords: "condyloma lata", "condylomata lata", and "condyloma latum". RESULTS: Thirty-five papers (from 1940 to 2021) describing an extra-anogenital localization of condyloma lata were found and are summarized in Table 1. Patients were mainly males (82.1%), with a mean age of 31.9 years. Most of them showed other manifestations of secondary syphilis (53.9%). In a minority of cases (39.0%), concomitant anogenital condyloma lata were present, thus making the diagnosis easier. The toe web localization was the most documented (26.2%) followed by the oral cavity (23.8%). CONCLUSION: In the presence of extra-genital condyloma lata, the differential diagnosis is not always clear, especially when no other muco-cutaneous lesions are observed. In the case of eroded or wet lesions involving any cutaneous fold, associated or not with other cutaneous manifestations, a sexual history should be obtained, and syphilis must be considered.
Asunto(s)
Condiloma Acuminado , Enfermedades Gastrointestinales , Sífilis Cutánea , Sífilis , Masculino , Humanos , Adulto , Femenino , Sífilis/complicaciones , Sífilis Cutánea/diagnóstico , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/complicaciones , Genitales/patología , Enfermedades Gastrointestinales/complicacionesRESUMEN
Giant condyloma acuminatum (GCA) is a rare disease characterized by cauliflower-like tumors in the genital area, with a peculiar smell, bleeding, and local infection. Its occurrence is related to a variety of risk factors, such as human papillomavirus infection, immune deficiency, poor sanitary conditions, multiple sexual partners, and chronic genital infection. Surgical resection is still the preferred treatment for the disease. This paper reports that a patient with GCA complicated by systemic lupus erythematosus (SLE) and persistent thrombocytopenia who could not be treated surgically was treated with modified photodynamic therapy (M-PDT) in our outpatient department. After several treatments, the pain, odor, and secretion on the surface of the wart were significantly reduced, although the size of the wart was not significantly improved. Unfortunately, the patient died subsequently due to the aggravation of SLE. However, clinical treatment with M-PDT may be used as a palliative treatment when similar patients are encountered.
Asunto(s)
Tumor de Buschke-Lowenstein , Condiloma Acuminado , Lupus Eritematoso Sistémico , Infecciones por Papillomavirus , Fotoquimioterapia , Humanos , Fotoquimioterapia/métodos , Tumor de Buschke-Lowenstein/complicaciones , Tumor de Buschke-Lowenstein/tratamiento farmacológico , Condiloma Acuminado/complicaciones , Condiloma Acuminado/tratamiento farmacológico , Condiloma Acuminado/cirugía , Infecciones por Papillomavirus/tratamiento farmacológico , Lupus Eritematoso Sistémico/complicaciones , Lupus Eritematoso Sistémico/tratamiento farmacológicoRESUMEN
Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the role of underlying HPV infections, and human genetic and immunological determinants of BLT.
Asunto(s)
Alphapapillomavirus , Tumor de Buschke-Lowenstein , Condiloma Acuminado , Infecciones por Papillomavirus , Tumor de Buschke-Lowenstein/complicaciones , Tumor de Buschke-Lowenstein/patología , Condiloma Acuminado/complicaciones , Condiloma Acuminado/patología , Factores de Intercambio de Guanina Nucleótido , Humanos , Papillomaviridae/genética , Infecciones por Papillomavirus/complicacionesRESUMEN
Bowen's disease (BD) is an intraepidermal squamous cell carcinoma (SCC) with the capacity to become invasive SCC giving rise to distant metastasis. In rare cases it can be associated with human papillomavirus (HPV) infection, specifically with HPV types 16, 18, 31, 32, and 34. Here we report a case of an immunocompetent white male, age 37, with an erythematous, irregularly-shaped patch in his suprapubic region, appearing 1 year after treatment for condylomata acuminata with cryotherapy and podophyllin in the same area. At the time of clinically active disease, a urethral smear was positive for high-risk HPV types. The lesion was considered a scar by several physicians because it emerged in an area of previous postinflammatory hyperpigmentation. The aim of this report is to raise awareness of the emerging causative association between anogenital HPV infection and the development of BD, which was the possible etiological agent in the case of the patient presented here. Hereby we also advocate primary preventive measures in terms of safe sexual habits and HPV vaccination.
Asunto(s)
Enfermedad de Bowen , Condiloma Acuminado , Infecciones por Papillomavirus , Neoplasias Cutáneas , Adulto , Enfermedad de Bowen/etiología , Enfermedad de Bowen/terapia , Condiloma Acuminado/complicaciones , Condiloma Acuminado/terapia , Humanos , Masculino , Papillomaviridae , Infecciones por Papillomavirus/complicaciones , Neoplasias Cutáneas/complicacionesRESUMEN
Human papillomavirus (HPV) infection is one of the most frequent sexually transmitted infections in the world, with great importance due to its oncogenic potential. Both the risk of infection and the development of neoplasia are increased in people with human immunodeficiency virus (HIV) infection, so HPV vaccination should be recommended in these patients.
Asunto(s)
Neoplasias del Ano , Carcinoma de Células Escamosas , Condiloma Acuminado , Infecciones por VIH , Infecciones por Papillomavirus , Neoplasias del Ano/complicaciones , Neoplasias del Ano/patología , Carcinoma de Células Escamosas/complicaciones , Condiloma Acuminado/complicaciones , Condiloma Acuminado/patología , Infecciones por VIH/complicaciones , Papillomavirus Humano 16 , Humanos , Huésped Inmunocomprometido , Papillomaviridae , Infecciones por Papillomavirus/complicacionesRESUMEN
BACKGROUND: Anorectal condyloma is the representative venereal disease caused by human papilloma virus (HPV), which has more 180 subtypes. Although there are various known risk factors for recurrence, few studies have investigated the influence of HPV subtypes. OBJECTIVE: We aimed to investigate the correlation between the recurrence of anorectal condyloma and HPV subtypes. METHODS: We analyzed the clinical and histopathological information of 143 patients who underwent surgery for anorectal condyloma at the National Medical Center between March 2016 and September 2020. PCR analyses were performed to confirm the HPV subtype in 24 patients. RESULTS: Recurrence was confirmed in 63 patients through outpatient follow-up over a median of 31.7 months (range: 0-56.2) after surgery. Recurrence was significantly associated with anorectal condyloma severity (p < 0.001), but there were no differences between the primary and recurrent groups, CD4-positive cell counts, or human immunodeficiency virus loads. The high-risk HPV subtype was associated with a high recurrence rate. Furthermore, the overall recurrence rate in anorectal condyloma patients was 44.1%. CONCLUSION: These results suggest that recurrence of anorectal condyloma has a significant association with high-risk HPV subtypes. Therefore, it is necessary to check for recurrences during follow-up after surgery.
Asunto(s)
Alphapapillomavirus , Condiloma Acuminado , Infecciones por Papillomavirus , Condiloma Acuminado/complicaciones , Condiloma Acuminado/patología , Condiloma Acuminado/cirugía , Humanos , Papillomaviridae/genética , Infecciones por Papillomavirus/complicaciones , Factores de RiesgoAsunto(s)
Condiloma Acuminado , Enfermedades Gastrointestinales , Infecciones por VIH , Neoplasias Cutáneas , Sífilis Cutánea , Sífilis , Humanos , Sífilis/complicaciones , Sífilis/tratamiento farmacológico , Sífilis/patología , Doxiciclina/uso terapéutico , Sífilis Cutánea/patología , Condiloma Acuminado/complicaciones , Condiloma Acuminado/tratamiento farmacológico , Infecciones por VIH/complicaciones , Infecciones por VIH/tratamiento farmacológicoRESUMEN
Adolescence is a transition period during which sexual experiences gain importance. Genital warts are sexually transmitted lesions that have been shown to negatively affect sexual perception. This study aimed to evaluate the impact of genital warts on female sexual function and sexuality-related distress in adolescence. A total of 90 female adolescents between the ages of 17 and 21 who had regular sexual intercourse with heterosexual partners were included in this prospective case-control study. Female Sexual Function Index, Arizona Sexual Experiences Scale, and Female Sexual Distress Scale-Revised scores of adolescents with genital warts (n = 45) were compared to healthy subjects (n = 45). Total Female Sexual Function Index and Arizona Sexual Experiences Scale scores revealed significant dysfunction in adolescents with genital warts (20.7 ± 4.13 (20.9) vs. 28.2 ± 3.51 (28.7), p < 0.0001; 17.1 ± 3.61 (17) vs. 13.02 ± 3.01 (13), p < 0.0001, respectively). Total Female Sexual Distress Scale-Revised score was significantly decreased in the presence of genital warts (23.82 ± 9.73 (23) vs. 8.8 ± 7.38 (6), p < 0.0001). Significant correlations were found between the total Female Sexual Distress Scale-Revised score and the total Female Sexual Function Index score, and the Arizona Sexual Experiences Scale score (r = -0.78, p < 0.0001; r = 0.68, p < 0.0001, respectively). This study revealed that genital warts have significantly unfavorable effects on sexuality in adolescence leading to sexual dysfunction as well as sexuality-related distress. Regarding to the present findings, promoting sexual health in addition to physical well-being may increase success in clinical management of genital warts.