Role of scientific and technological innovations on industrial upgradation in China: A spatial econometric analysis.

China is in a phase of high-quality development, where scientific and technological innovations are serving as the primary driving force for its development strategy. This emphasis on innovations is expected to fuel the upgrading of the industrial structure. This study investigates the role of scientific and technological innovations in industrial upgradation in China using spatial econometric analysis. Leveraging the data of 31 provinces of China from 2005 to 2022, we employed a spatial Durbin model to determine the spatial spillover effects of scientific and technological innovations on industrial upgradation. Our findings reveal the significant positive spatial spillover effects, indicating that provinces with higher levels of scientific and technological innovations tend to experience greater industrial upgradation, which in turn contributes to regional economic development. Furthermore, the findings suggest a strong spatial correlation between innovation and the upgrading of industrial structures, indicating that regional innovations have the potential to drive China's industrial upgradation. These results underscore the critical role of scientific and technological innovations in promoting industrial upgradation and regional development in China.

Time-varying causality relationships between trade openness, technological innovation, industrialization, financial development, and carbon emissions in Thailand.

Over the last twenty years, there has been swift growth in industrialization and technological advancements, driving economic progress. Nevertheless, it is inevitable that these sectors will bring about environmental shifts. Thus far, endeavors have been undertaken to assess the influence of industrialization and technological advancements on environmental deterioration. Additionally, the extensive discussion surrounding the impact of financial development, trade openness, and technological innovation on the environment has not yielded conclusive empirical findings. Studies often operate under the assumption of symmetric relationships, potentially leading to biased results. Adding to the discussion on the drivers of carbon neutrality, the time-dependent effects of critical aspects such as financial development and technological innovation should inform meaningful policies for environmental management. This article explores the time-varying causal association between trade openness, industrialization, financial development, technological innovation, and CO2 emissions in Thailand using novel time-varying Granger causality tests. The time-varying causality outcomes demonstrate that the associations change significantly over time, in contrast to the results of Toda-Yamamoto causality. Overall, there exists a bidirectional relationship between industrialization, financial development, trade openness, technological innovation, and CO2 emissions over different time sequences. These outcomes have implications for both policy and research.

Analysis of the spatial and temporal evolution process and development trend of innovation capability of Chinese sports industry.

The paper uses spatial panel data on the number of patents in the field of sports in each province from 2017-2022 to explore the spatial and temporal evolution process of the innovation capacity of China's sports industry and analyze its development trend based on theories related to economic geography, using exploratory spatial data analysis (ESDA) and Spatial-temporal correlation analysis research methods. The study shows that: 1. there is a large spatial regional disparity in the innovation capacity of China's sports industry, showing an obvious pattern of strength in the east and weakness in the west. 2. there is an obvious phenomenon of spatial agglomeration in the innovation capacity of China's sports industry and the agglomeration phenomenon in space is gradually increasing. 3. there is a spatial spillover effect in the innovation capacity of China's sports industry, and the inward spillover continues to strengthen mainly into Zhejiang, Fujian and Jiangsu provinces, while the outward spillover mainly goes to Guangdong, Hubei, Hebei, Hunan, Sichuan. Sports industry innovation capacity development put forward three suggestions: to promote the development of sports industry in the northwest region; to play the advantages of regional characteristics of sports industry; to accelerate the integration of neighboring regions to build the process. in order to help the high-quality development of sports industry.

Evaluation of tourism competitiveness and mechanisms of spatial differentiation in Xinjiang, China.

Evaluation of tourism competitiveness is useful for measuring the level of regional tourism development. It is of great importance to understand the advantages and disadvantages of tourism development correctly and formulate corresponding development strategies. To investigate tourism competitiveness, this paper established an evaluation index system, including tourism development competitiveness, tourism resource competitiveness, and tourism-support competitiveness, for 14 prefectures and cities in Xinjiang in China. The characteristics and laws of spatial differentiation were analyzed. Factor analysis was applied to examine the spatial differentiation of regional tourism competitiveness. The results showed an obvious spatial differentiation in tourism competitiveness among the 14 prefectures and cities. In terms of development competitiveness, Yili and Urumqi constituted the spatial center, followed by Changji, Altay, and Ba Prefecture. As the provincial capital, Urumqi has political, economic, cultural, transportation, and geographic advantages, but its competitiveness is not prominent in terms of monopoly and efficiency. In terms of resource competitiveness, Yili is the core attraction, while Urumqi, Kashgar, Altay, and Ba Prefecture are dominant attractions. With respect to supporting competitiveness, Bo Prefecture has high value, followed by Urumqi City and Aksu. Hetian and Ke Prefecture have the lowest values. The comprehensive competitiveness of tourism is centered on Yili. Urumqi and Bo Prefecture are subcenters, and Changji, Altay, Ba Prefecture, Aksu, and Kashgar are characterized as multi-polar competition areas. Using the KMO and Bartlett's sphericity tests, the cumulative contribution variance of the eigenvalues of the eight factors extracted by the maximum variance rotation method was found to be 92.714%. Socio-economic conditions, tourism resources, infrastructure construction, regional cultural influence, ecological environment carrying capacity, tertiary industry development, tourism service level, and living security system are the main driving factors affecting the spatial differentiation of tourism competitiveness in Xinjiang. Analyzing the spatial evolution characteristics and the driving factors of the regional tourism competitiveness in Xinjiang, this paper seeks to promote the optimal allocation of tourism production factors in the macro regional system, and provide theoretical guidance and an empirical basis for the comprehensive and harmonic development of regional tourism.

Project-based maturity assessment model for smart transformation in Taiwanese enterprises.

As smart technology proliferates, enterprises must engage not only in the transformation of intelligence but contend with pressure do so as soon as possible. Smart transformation is critical for manufacturing enterprises in the development of smart manufacturing. This study addressed the gap between maturity models and project management by designing an effective assessment framework for smart transformation. It adopts the Smart Industry Readiness Index, created by the Singapore Economic Development Board, as a maturity assessment model to analyze enterprises' smart transformation and formulate project management strategies. Enterprises can use this model to examine the maturity level of their transformation and assess scope for improvement in their project strategies and implementation barriers. This study focuses on Taiwanese enterprises using data collected from 165 valid questionnaires and subjected to a cluster analysis. Enterprises were divided into three categories. The results reveal that, first, most enterprises' smart transformation is at an immature or medium-maturity level, and is therefore amenable to further improvement. Second, inconsistent with research findings, many enterprises invest in transformation projects but fail to advance these projects to maturity. Third, most enterprises' project management plans fail to meet actual transformation needs. Using the thematically oriented maturity model proposed in this study, Taiwanese enterprises can effectively evaluate the maturity of their transformation projects. In conclusion, the study highlights that Taiwanese enterprises must identify more effective external resources to strengthen their competitiveness.

Towards population-scale long-read sequencing.

Long-read sequencing technologies have now reached a level of accuracy and yield that allows their application to variant detection at a scale of tens to thousands of samples. Concomitant with the development of new computational tools, the first population-scale studies involving long-read sequencing have emerged over the past 2 years and, given the continuous advancement of the field, many more are likely to follow. In this Review, we survey recent developments in population-scale long-read sequencing, highlight potential challenges of a scaled-up approach and provide guidance regarding experimental design. We provide an overview of current long-read sequencing platforms, variant calling methodologies and approaches for de novo assemblies and reference-based mapping approaches. Furthermore, we summarize strategies for variant validation, genotyping and predicting functional impact and emphasize challenges remaining in achieving long-read sequencing at a population scale.

Reconstruction of ancient microbial genomes from the human gut.

Loss of gut microbial diversity1-6 in industrial populations is associated with chronic diseases7, underscoring the importance of studying our ancestral gut microbiome. However, relatively little is known about the composition of pre-industrial gut microbiomes. Here we performed a large-scale de novo assembly of microbial genomes from palaeofaeces. From eight authenticated human palaeofaeces samples (1,000-2,000 years old) with well-preserved DNA from southwestern USA and Mexico, we reconstructed 498 medium- and high-quality microbial genomes. Among the 181 genomes with the strongest evidence of being ancient and of human gut origin, 39% represent previously undescribed species-level genome bins. Tip dating suggests an approximate diversification timeline for the key human symbiont Methanobrevibacter smithii. In comparison to 789 present-day human gut microbiome samples from eight countries, the palaeofaeces samples are more similar to non-industrialized than industrialized human gut microbiomes. Functional profiling of the palaeofaeces samples reveals a markedly lower abundance of antibiotic-resistance and mucin-degrading genes, as well as enrichment of mobile genetic elements relative to industrial gut microbiomes. This study facilitates the discovery and characterization of previously undescribed gut microorganisms from ancient microbiomes and the investigation of the evolutionary history of the human gut microbiota through genome reconstruction from palaeofaeces.

Relationships between migration and the fiscal sustainability of the pension system in China.

There are a few existing studies on whether domestic migration improves China's pension system's fiscal sustainability in the context of rapid urbanization and industrialization. In this paper, we systematically investigate the impact of migration on the solvency of the worker's old-age insurance for urban employees by constructing actuarial and econometric models. We use panel data from 2002 to 2018, collected from 31 provinces in China. The results show that the association between migration and the solvency of pensions is an inverted-U shape along the urbanization process. Further regional comparison showed that the above-stated inverted-U curve is more pronounced in the central and western regions. We also established that the number of participants and the contribution base are the main contributors to these results. Our conclusions are important for future population policies and public pension systems in China.

Hotter and sicker: External energy expenditure and the tangled evolutionary roots of anthropogenic climate change and chronic disease.

BACKGROUND: The dual crises of climate change and chronic, or non-communicable, disease (NCD) have emerged worldwide as the global economy has industrialized over the past two centuries. AIMS: In this synthesis I examine humans' dependence on external (non-metabolic) energy expenditure (e.g., fire, fossil fuels) as a common, root cause in these modern crises. MATERIALS AND METHODS: Using fossil, archeological, and historical evidence I show that the human lineage has been dependent on external energy sources since the control of fire in the Paleolithic. This reliance has grown with the development of agriculture, the use of wind- and water-power, and the most recently with industrialization and the transition to fossil fuels. To place industrialization in context I develop a Rule of 50, whereby individuals in industrialized economies consume roughly 50-times more external energy and manufacture roughly 50-times more material than do hunter-gatherers. RESULTS: Industrialization and mechanization, powered by fossil fuels, have promoted centralization and processing in food production, reduced physical activity, and increased air pollution (including greenhouse gas emissions). These developments have led in turn to NCD and climate change. DISCUSSION AND CONCLUSION: Climate change and NCD are connected both to one another and to our species' deep evolutionary dependence on external energy. Transitioning to carbon-free energy is essential to reduce the existential risks of climate change, but will likely have only modest effects on NCD. With the impending exhaustion of oil, coal, and natural gas reserves, developing replacements for fossil fuels is also critical to maintaining our species' external energy portfolio.

Medical Education in Nepal: Impact and Challenges of the COVID-19 Pandemic.

During the COVID-19 pandemic, there has been a global shift toward online distance learning due to travel limitations and physical distancing requirements as well as medical school and university closures. In low- and middle-income countries like Nepal, where medical education faces a range of challenges-such as lack of infrastructure, well-trained educators, and advanced technologies-the abrupt changes in methodologies without adequate preparation are more challenging than in higher-income countries. In this article, the authors discuss the COVID-19-related changes and challenges in Nepal that may have a drastic impact on the career progression of current medical students. Outside the major cities, Nepal lacks dependable Internet services to support medical education, which frequently requires access to and transmission of large files and audiovisual material. Thus, students who are poor, who are physically disadvantaged, and who do not have a home situation conducive to online study may be affected disproportionately. Further, the majority of teachers and students do not have sufficient logistical experience and knowledge to conduct or participate in online classes. Moreover, students and teachers are unsatisfied with the digital methodologies, which will ultimately hamper the quality of education. Students' clinical skills development, research activities, and live and intimate interactions with other individuals are being affected. Even though Nepal's medical education system is struggling to adapt to the transformation of teaching methodologies in the wake of the pandemic, it is important not to postpone the education of current medical students and future physicians during this crisis. Looking ahead, medical schools in Nepal should ensure that mechanisms are proactively put into place to embrace new educational opportunities and technologies to guarantee a regular supply of high-quality physicians capable of both responding effectively to any future pandemic and satisfying the nation's future health care needs.

The influence of machine learning-based knowledge management model on enterprise organizational capability innovation and industrial development.

The aims are to explore the construction of the knowledge management model for engineering cost consulting enterprises, and to expand the application of data mining techniques and machine learning methods in constructing knowledge management model. Through a questionnaire survey, the construction of the knowledge management model of construction-related enterprises and engineering cost consulting enterprises is discussed. First, through the analysis and discussion of ontology-based data mining (OBDM) algorithm and association analysis (Apriori) algorithm, a data mining algorithm (ML-AR algorithm) on account of ontology-based multilayer association and machine learning is proposed. The performance of the various algorithms is compared and analyzed. Second, based on the knowledge management level, analysis and statistics are conducted on the levels of knowledge acquisition, sharing, storage, and innovation. Finally, according to the foregoing, the knowledge management model based on engineering cost consulting enterprises is built and analyzed. The results show that the reliability coefficient of this questionnaire is above 0.8, and the average extracted value is above 0.7, verifying excellent reliability and validity. The efficiency of the ML-AR algorithm at both the number of transactions and the support level is better than the other two algorithms, which is expected to be applied to the enterprise knowledge management model. There is a positive correlation between each level of knowledge management; among them, the positive correlation between knowledge acquisition and knowledge sharing is the strongest. The enterprise knowledge management model has a positive impact on promoting organizational innovation capability and industrial development. The research work provides a direction for the development of enterprise knowledge management and the improvement of innovation ability.

Historical Trend of Work-Related Musculoskeletal Disorders in the Meatpacking and Auto Industries, 1980s-Present.

Occupational Applications This paper provides a historical overview of the rise of Work-Related Musculoskeletal Disorders (WMSDs) in the U.S. from the 1980s to the present, with a special focus on the two industries with the highest recorded rates: Meatpacking and Auto Assembly. The activities underlying this account amount to a major occupational health success story (although still incomplete) in the recognition of these disorders and the development of a nation-wide effort for prevention. An obstacle in creating the data presented here was that the system of recordkeeping changed in multiple ways, making it difficult to compare WMSD rates over time. The work summarized here evaluated the effect of these changes and combined temporal segments that were judged to be the most accurate to create an overall trend line. These results can aid in: 1) showing the overall history of the recognition and prevention of WMSDs, 2) understanding the effects of the recordkeeping changes, and 3) allowing international comparisons of the trends.

The Rise of Shop Floor Ergonomics: A Personal Perspective.

OCCUPATIONAL APPLICATIONS Based on a 45-year career as a practitioner in industrial ergonomics, I offer in this paper a personal memoir on how ergonomics came to the shop floor in North America, involving ordinary workers in an early effort to prevent what was at the time an unknown problem - work-related Musculoskeletal Disorders. The actions included the beginning of a low-tech, practical improvement process that is still effective today. In total, the experience can provide encouragement to everybody to be confident in their ability when trying new endeavors and to remember that small initial steps can eventually lead to major change.

Technology Use for Adolescent Health and Wellness.

As avid users of technology, adolescents are a key demographic to engage when designing and developing technology applications for health. There are multiple opportunities for improving adolescent health, from promoting preventive behaviors to providing guidance for adolescents with chronic illness in supporting treatment adherence and transition to adult health care systems. This article will provide a brief overview of current technologies and then highlight new technologies being used specifically for adolescent health, such as artificial intelligence, virtual and augmented reality, and machine learning. Because there is paucity of evidence in this field, we will make recommendations for future research.

Impact of land use land cover changes on ecosystem service value - A case study of Guangdong, Hong Kong, and Macao in South China.

The rapid increase in anthropogenic activities, socioeconomic development, and land use land cover (LULC) changes since the opening of economic reforms (1978), have changed the ecosystem service value (ESV) in Guangdong, Hong Kong, and Macao (GKHM) region located in South China. This leads to the requirement of a significant tailored analysis of ecosystem services regarding incisive and relevant planning to ensure sustainability at regional level. This study focuses on the use of Landsat satellite imagery to quantify the precise impact of LULC changes on the ecosystem services in GHKM over the past three decades (1986-2017). The most renowned established unit value transfer method has been employed to calculate the ESV. The results show that the total ecosystem service value in GHKM has decreased from 680.23 billion CNY in 1986 to 668.45 billion CNY in 2017, mainly due to the decrease in farmland and fishponds. This overall decrease concealed the more dynamic and complex nature of the individual ESV. The most significant decrease took place in the values of water supply (-22.20 billion CNY, -14.72%), waste treatment (-20.77 billion CNY, -14.63%), and food production (-7.96 billion CNY, -33.18%). On the other hand, the value of fertile soil formation and retention (6.28 billion CNY, +7.26%) and recreation and culture (5.09 billion CNY, +12.91%) increased. Furthermore, total ESV and ESV per capita decreased significantly with the continuous increase in total gross domestic product (GDP) and GDP per capita. A substantial negative correlation exists between farmland ESV and GDP indicating human encroachment into a natural and semi natural ecosystems. The results suggest that in the rapidly urbanizing region, the protection of farmland and to control the intrusion of urban areas has marked an important societal demand and a challenge to the local government. This required a pressing need for smart LULC planning and to improve policies and regulation to guarantee ecosystem service sustainability for acceptable life quality in the study area and other fast expanding urban areas in China.

Recent technological advancements in regional anesthesia.

Just two decades ago, regional anesthesia was performed blindly with dubious outcomes and little support from surgeons and patients. Technological advances in regional anesthesia have revolutionized techniques and largely improved outcomes. Ultrasound (US) technology continues to advance and has become more affordable. Improvements have come in the form of picture quality, resolution, portability, and smaller equipment. The US technology can identify otherwise unrecognized pathology and can help to optimize patient flow by allowing for more accurate triage and effective treatments and providing timelier interventions. In recent years, several different strategies to help improve and ease US-guided needle identification and placement have been developed, including magnetically guided needle US technology. Three-dimensional (3D) and four-dimensional (4D) US use is another potential way to help improve first-pass success and limit patient harm for regional anesthetics. The advent of echogenic needles and the resulting improvement in needle visualization under US has had a positive impact on physician comfort in performing regional anesthesia and on visualization time of the needle during US-guided procedures. To reduce variability and to reduce the anesthesiologist's workload, the use of robots in regional anesthesia has been assessed in recent years. Peripheral nerve stimulation (PNS) has also demonstrated efficacy in acute and chronic pain settings. Additional research and randomized controlled trials are necessary to evaluate novel technologies.

A Mobile-Based Patient-Centric Passive System for Guiding Patients Through the Hospital Workflow: Design and Development.

BACKGROUND: A hospital is an unfamiliar place to patients because of its style, atmosphere, and procedures. These hospital characteristics cause patients to become confused about responding to protocols, which slows down the procedural flows. Some additional information technology infrastructure facilities and human resources may be needed to solve these problems. However, this solution needs high investment and cannot guarantee an accuracy of information sent to patients. To handle this limitation, EasyHos has been developed to help patients recognize their status (for example, "waiting for an appointment at 11am") during their stay in a hospital using all existing infrastructure and hospital data and without changing existing hospital's process. OBJECTIVE: The objective of this study was to provide a design of the EasyHos system and the case study in hospitals in Thailand. The design is usable and repeatable for small- and medium-sized hospitals where internet infrastructure is in place. METHODS: The EasyHos system has been designed based on existing infrastructure, hospital data and hospital processes. The main components include mobile devices, existing hospital data, wireless communication network. The EasyHos was deployed at 2 hospitals in Thailand, one small and the other with a medium size. The experimental process was focused on solving the problem of unfamiliarity in the hospital. The criteria and pretest conditions regarding the unexpected problem have been defined before the experiment. RESULTS: The results are presented in terms of criteria, pretest conditions, posttest conditions in the hospitals. The posttest conditions show the experimental results and impact of the system on users such as hospital nurses/staff and patients. For example, the questions from patients were reduced by 83.3% after using EasyHos system while nurses/hospital staff had 5 min more to do their routine work each day. In addition, another impact is that hospitals can create new information values from existing data, which now can be visible and valuable to patients. CONCLUSIONS: Hospitals' unexpected problems have been reduced by the EasyHos system. The EasyHos system has been developed with self-service and patient-centered concepts to assist patients with necessary information. The system makes interaction easier for nurses/hospital staff members and patients working or waiting in the hospital. The nurses/hospital staff members would have more time to do their routine works. Hospitals can easily set up the EasyHos system, which will have a low or nearly zero implementation cost.

Deindustrialization, the Linwood Car Plant and Scotland's Political Divergence from England in the 1960s and 1970s.

Scotland's political divergence from England is a key theme in late twentieth century British history. Typically seen in terms of the post-1979 Thatcher effect, this in fact developed over a longer timeframe, rooted in industrial changes revealed by analysis of the Linwood car plant in Renfrewshire. Conservatism and Unionism was an eminent political force in Scotland in the 1940s and 1950s. But in all general elections from 1959 onwards the vote share of Conservative and Unionist candidates was lower in Scotland than in England. From the late 1960s onwards there were also ambitions for constitutional change. This article breaks new conceptual and empirical ground by relating these important markers of political divergence to popular understanding among Scottish workers of deindustrialization. A Thompsonian moral economy framework is deployed. Expectations were elevated by industrial restructuring from the 1950s, with workers exchanging jobs in the staples for a better future in assembly goods. Labour governments earned a reputation in Scotland as better managers of this process than Conservative governments. The 1979 general election showed that Labourism was growing in popularity in Scotland just as its appeal faded in England. At Linwood moral economy expectations were compromised, chiefly by intermittent redundancy and recurrent threat of closure, which was averted in 1975 by Labour government intervention. When the plant was shut in 1981 criticisms of UK political-constitutional structures and Conservativism were intensified.