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1.
Conscious Cogn ; 123: 103718, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38880020

RESUMEN

The phenomenon of "hearing voices" can be found not only in psychotic disorders, but also in the general population, with individuals across cultures reporting auditory perceptions of supernatural beings. In our preregistered study, we investigated a possible mechanism of such experiences, grounded in the predictive processing model of agency detection. We predicted that in a signal detection task, expecting less or more voices than actually present would drive the response bias toward a more conservative and liberal response strategy, respectively. Moreover, we hypothesized that including sensory noise would enhance these expectancy effects. In line with our predictions, the findings show that detection of voices relies on expectations and that this effect is especially pronounced in the case of unreliable sensory data. As such, the study contributes to our understanding of the predictive processes in hearing and the building blocks of voice hearing experiences.


Asunto(s)
Percepción Auditiva , Detección de Señal Psicológica , Humanos , Femenino , Adulto , Masculino , Adulto Joven , Percepción Auditiva/fisiología , Detección de Señal Psicológica/fisiología , Voz/fisiología , Anticipación Psicológica/fisiología , Alucinaciones/fisiopatología
2.
J Sports Sci ; 42(7): 629-637, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38762895

RESUMEN

Decision accuracy is a crucial factor in the evaluation of refereeing performance. In sports research, officials' decision-making is frequently assessed outside real games through video-based decision experiments, where they evaluate recorded game situations from a third-person perspective. This study examines whether the inclusion of the first-person perspective influences decision accuracy and certainty. Twenty-four professional officials from the first and second German basketball leagues participated in the study. The officials assessed 50 game situations from both first-person and third-person perspectives, indicating their decisions and certainty levels. The statistical analysis utilises signal detection theory to evaluate the efficacy of the first-person perspective compared to the third-person perspective in identifying rule violations and no-calls in video recordings. The findings indicate that the first-person perspective does not yield superior accuracy in identifying foul calls. However, scenes from the first-person perspective exhibit a significant 9% increase in correctly identifying no-calls. Furthermore, officials report significantly higher levels of decision certainty and comfort when using the first-person perspective. The study suggests that sports officials may benefit from incorporating additional scenes from the first-person perspective into video-based decision training. Future studies should explore whether this additional perspective improves the training effect and translates into enhanced in-game performance.


Asunto(s)
Baloncesto , Toma de Decisiones , Grabación en Video , Humanos , Baloncesto/fisiología , Baloncesto/psicología , Masculino , Adulto , Femenino , Detección de Señal Psicológica , Persona de Mediana Edad
3.
Emotion ; 24(6): 1494-1502, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38557028

RESUMEN

Numerous studies have tested the hypothesis that facial identity and emotional expression are independently processed, but a solid conclusion has been difficult to reach, with the literature showing contradictory results. We argue that this is partly due to different researchers using different definitions of perceptual integration and independence, usually vague and/or simply operational, and also due to lack of proper stimulus control. Here, we performed a study using three-dimensional realistic computer-generated faces for which the discriminability of identities and expressions, the intensity of the expressions, and low-level features of the faces were controlled. A large number of participants, distributed across twelve experimental groups, performed identification tasks for the six basic emotional expressions and the neutral expression (between 2018 and 2019). A multidimensional signal detection model was utilized to analyze the data, which allowed us to dissociate between multiple formally defined notions of independence and holism. Results showed strong and robust violations of perceptual independence that were consistent across all experiments and suggest Gestalt-like perceptual integration of face identity and expression. To date, our results provide the strongest evidence for holistic/Gestalt processing found among face perception studies that have used formal definitions of independence and holism. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Asunto(s)
Emociones , Expresión Facial , Reconocimiento Facial , Humanos , Reconocimiento Facial/fisiología , Femenino , Emociones/fisiología , Masculino , Adulto , Adulto Joven , Detección de Señal Psicológica/fisiología , Teoría Gestáltica
4.
J Cogn Neurosci ; 36(8): 1546-1556, 2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-38527082

RESUMEN

Results from paradigms like change blindness and inattentional blindness indicate that observers are unaware of numerous aspects of the visual world. However, intuition suggests that perceptual experience is richer than these results indicate. Why does it feel like we see so much when the data suggests we see so little? One possibility stems from the fact that experimental studies always present observers with stimuli that they have never seen before. Meanwhile, when forming intuitions about perceptual experience, observers reflect on their experiences with scenes with which they are highly familiar (e.g., their office). Does prior experience with a scene change the bandwidth of perceptual awareness? Here, we asked if observers were better at noticing alterations to the periphery in familiar scenes compared with unfamiliar scenes. We found that observers noticed changes to the periphery more frequently with familiar stimuli. Signal detection theoretic analyses revealed that when observers are unfamiliar with a stimulus, they are less sensitive at noticing (d') and are more conservative in their response criterion (c). Taken together, these results suggest that prior knowledge expands the bandwidth of perceptual awareness. It should be stressed that these results challenge the widely held idea that prior knowledge fills in perception. Overall, these findings highlight how prior knowledge plays an important role in determining the limits of perceptual experience and is an important factor to consider when attempting to reconcile the tension between empirical observation and personal introspection.


Asunto(s)
Concienciación , Reconocimiento en Psicología , Humanos , Concienciación/fisiología , Reconocimiento en Psicología/fisiología , Adulto Joven , Femenino , Masculino , Percepción Visual/fisiología , Adulto , Estimulación Luminosa , Detección de Señal Psicológica/fisiología
5.
J Exp Anal Behav ; 121(3): 294-313, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38426657

RESUMEN

Discrimination performance in perceptual choice tasks is known to reflect both sensory discriminability and nonsensory response bias. In the framework of signal detection theory, these aspects of discrimination performance are quantified through separate measures, sensitivity (d') for sensory discriminability and decision criterion (c) for response bias. However, it is unknown how response bias (i.e., criterion) changes at the single-trial level as a consequence of reinforcement history. We subjected rats to a two-stimulus two-response conditional discrimination task with auditory stimuli and induced response bias through unequal reinforcement probabilities for the two responses. We compared three signal-detection-theory-based criterion learning models with respect to their ability to fit experimentally observed fluctuations of response bias on a trial-by-trial level. These models shift the criterion by a fixed step (1) after each reinforced response or (2) after each nonreinforced response or (3) after both. We find that all three models fail to capture essential aspects of the data. Prompted by the observation that steady-state criterion values conformed well to a behavioral model of signal detection based on the generalized matching law, we constructed a trial-based version of this model and find that it provides a superior account of response bias fluctuations under changing reinforcement contingencies.


Asunto(s)
Toma de Decisiones , Aprendizaje Discriminativo , Refuerzo en Psicología , Animales , Ratas , Masculino , Modelos Psicológicos , Detección de Señal Psicológica , Condicionamiento Operante , Conducta de Elección , Estimulación Acústica , Discriminación en Psicología
6.
Behav Res Methods ; 56(6): 6223-6247, 2024 09.
Artículo en Inglés | MEDLINE | ID: mdl-38485882

RESUMEN

Decisions in forensic science are often binary. A firearms expert must decide whether a bullet was fired from a particular gun or not. A face comparison expert must decide whether a photograph matches a suspect or not. A fingerprint examiner must decide whether a crime scene fingerprint belongs to a suspect or not. Researchers who study these decisions have therefore quantified expert performance using measurement models derived largely from signal detection theory. Here we demonstrate that the design and measurement choices researchers make can have a dramatic effect on the conclusions drawn about the performance of forensic examiners. We introduce several performance models - proportion correct, diagnosticity ratio, and parametric and non-parametric signal detection measures - and apply them to forensic decisions. We use data from expert and novice fingerprint comparison decisions along with a resampling method to demonstrate how experimental results can change as a function of the task, case materials, and measurement model chosen. We also graphically show how response bias, prevalence, inconclusive responses, floor and ceiling effects, case sampling, and number of trials might affect one's interpretation of expert performance in forensics. Finally, we discuss several considerations for experimental and diagnostic accuracy studies: (1) include an equal number of same-source and different-source trials; (2) record inconclusive responses separately from forced choices; (3) include a control comparison group; (4) counterbalance or randomly sample trials for each participant; and (5) present as many trials to participants as is practical.


Asunto(s)
Ciencias Forenses , Humanos , Ciencias Forenses/métodos , Testimonio de Experto , Toma de Decisiones , Detección de Señal Psicológica
7.
Mem Cognit ; 52(4): 793-825, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38177559

RESUMEN

Signal detection theory (SDT) and two-high threshold models (2HT) are often used to analyze accuracy data in recognition memory paradigms. However, when reaction times (RTs) and/or confidence levels (CLs) are also measured, they usually are analyzed separately or not at all as dependent variables (DVs). We propose a new approach to include these variables based on multinomial processing tree models for discrete and continuous variables (MPT-DC) with the aim to compare fits of SDT and 2HT models. Using Juola et al.'s (2019, Memory & Cognition, 47[4], 855-876) data we have found that including CLs and RTs reduces the standard errors of parameter estimates and accounts for interactions among accuracy, CLs, and RTs that classical versions of SDT and 2HT models do not. In addition, according to the simulations, there is an increase in the proportion of correct model selections when relevant DV are included. We highlight the methodological and substantive advantages of MPT-DC in the disentanglement of contributing processes in recognition memory.


Asunto(s)
Modelos Psicológicos , Tiempo de Reacción , Reconocimiento en Psicología , Humanos , Reconocimiento en Psicología/fisiología , Tiempo de Reacción/fisiología , Detección de Señal Psicológica/fisiología , Modelos Estadísticos , Adulto
8.
Psychol Res ; 88(1): 81-90, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37318596

RESUMEN

In the current investigation, we modified the high Go, low No-Go Sustained Attention to Response Task (SART) by replacing the single response on Go trials with a dual response to increase response uncertainty. In three experiments, a total of 80 participants completed either the original SART with no response uncertainty regarding the Go stimuli, or versions of the dual response SART in which response probabilities for the two possible responses to the Go stimuli varied from 0.9-0.1, 0.7-0.3, to 0.5-0.5. This resulted in a scale of increasing response uncertainty based on information theory to the Go stimuli. The probability of No-Go withhold stimuli was kept.11 in all experiments. Using the Signal Detection Theory perspective proposed by Bedi et al. (Psychological Research: 1-10, 2022), we predicted that increasing response uncertainty would result in a conservative response bias shift, noted by decreased errors of commission and slower response times to both Go and No-Go stimuli. These predictions were verified. The errors of commission in the SART may not be a measures of conscious awareness per se, but instead indicative of the level of participant trigger happiness-the willingness to respond quickly.


Asunto(s)
Desempeño Psicomotor , Detección de Señal Psicológica , Humanos , Desempeño Psicomotor/fisiología , Incertidumbre , Detección de Señal Psicológica/fisiología , Tiempo de Reacción/fisiología , Estado de Conciencia
11.
Psicol. ciênc. prof ; 44: e258093, 2024. tab, graf
Artículo en Portugués | LILACS, INDEXPSI | ID: biblio-1558749

RESUMEN

Este estudo avaliou o reconhecimento (imitação, identidade e identificação) e a nomeação de estímulos emocionais de valência negativa (raiva e tristeza) e positiva (alegria e surpresa) em conjunto com a influência dos tipos de estímulos utilizados (social-feminino, social-masculino, familiar e emoji) em crianças e jovens adultos com autismo ou síndrome de Down, por meio de tarefas aplicadas pela família e mediadas por recursos tecnológicos durante a pandemia de covid-19. Participaram cinco crianças e dois jovens adultos com autismo e uma criança e dois jovens adultos com síndrome de Down. Foram implementadas tarefas de identidade, reconhecimento, nomeação e imitação, com estímulos faciais de função avaliativa (sem consequência diferencial) e de ensino (com consequência diferencial, uso de dicas e critério de aprendizagem), visando a emergência da nomeação emocional por meio do ensino das tarefas de reconhecimento. Os resultados da linha de base identificaram que, para os participantes que apresentaram menor tempo de resposta para o mesmo gênero, a diferença de tempo de resposta foi em média 57,28% menor. Em relação à valência emocional, 50% dos participantes apresentaram diferenças nos acertos, a depender da valência positiva e negativa, sendo que 66,66% apresentaram diferenças para o tempo de resposta a depender da valência emocional. Após o procedimento de ensino, os participantes mostraram maior número de acertos nas tarefas, independentemente do gênero de estímulo e valência emocional, criando ocasião para generalização da aprendizagem de reconhecimento e nomeação de emoções, além de consolidar a viabilidade de estratégias de ensino mediadas por recursos tecnológicos e aplicadas por familiares.(AU)


This study evaluated the recognition (imitation, identity, and identification) and naming of negative (anger and sadness) and positive (joy and surprise) emotional stimuli alongside the influence of the types of stimuli (social-female, social-male, family, and emoji) in children and young adults with autism and Down syndrome, via tasks applied by the family and mediated by technological resources, during the COVID-19 pandemic. Five children and two young adults with autism and one child and two young adults with Down syndrome participated. Identity, recognition, naming, and imitation tasks were planned and implemented using facial stimuli with evaluative (without differential consequence) and teaching (with differential consequence, tips, and learning criteria) functions, aiming at the emergence of emotional naming from the recognition teaching tasks. The baseline results showed that, for participants who had a shorter response time for the same gender, the response time difference was on average 57.28% lower. Regarding the emotional valence, 50% of the participants showed differences in the correct answers, depending on the positive and negative valence, and 66.66% showed differences in the response time depending on the emotional valence. After the teaching procedure, the participants showed a greater number of correct answers in the tasks, regardless of the stimulus type and emotional valence, creating an opportunity for generalizing learning of emotion recognition and naming, in addition to consolidating the feasibility of teaching strategies mediated by technological resources and applied by family members.(AU)


Este estudio evaluó el reconocimiento (imitación, identidad e identificación) y la denominación de estímulos emocionales negativos (enfado y tristeza) y positivos (alegría y sorpresa) y la influencia de los tipos de estímulos utilizados (social-femenino, social-masculino, familiar y emoji ) de niños y jóvenes con autismo o síndrome de Down, a través de tareas aplicadas por la familia, mediadas por recursos tecnológicos durante la pandemia de la covid-19. Participaron cinco niños y dos adultos jóvenes con autismo, y un niño y dos adultos jóvenes con síndrome de Down. Se planificaron e implementaron tareas de identidad, reconocimiento, nombramiento e imitación con estímulos faciales con función evaluativa (sin consecuencia diferencial) y enseñanza (con consecuencia diferencial, uso de ayudas y criterios de aprendizaje), buscando la emergencia del nombramiento emocional después de la enseñanza de tareas de reconocimiento. Los resultados de la línea de base identificaron que para los participantes que tenían un tiempo de respuesta más corto para el mismo género, la diferencia en el tiempo de respuesta fue un 57,28% menor. En cuanto a la valencia emocional, el 50% de los participantes mostraron diferencias en las respuestas correctas, en función de la valencia positiva y negativa, y el 66,66% tuvieron diferencias en el tiempo de respuesta, en función de la valencia emocional. Después del procedimiento de enseñanza, los participantes mostraron mayor número de aciertos en las tareas evaluadas, independientemente del tipo de estímulo o valencia emocional, lo que genera una oportunidad para la generalización del aprendizaje de reconocimiento y denominación de emociones, además de consolidar la viabilidad de estrategias de enseñanza mediadas por recursos tecnológicos y aplicadas por la familia.(AU)


Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Niño , Adolescente , Adulto , Adulto Joven , Trastorno Autístico , Familia , Síndrome de Down , Emoción Expresada , Emociones , Ansiedad , Relaciones Padres-Hijo , Padres , Percepción , Distorsión de la Percepción , Personalidad , Juego e Implementos de Juego , Prejuicio , Psiquiatría , Psicología , Psicología Social , Atención , Recursos Audiovisuales , Signos y Síntomas , Deseabilidad Social , Medio Social , Valores Sociales , Socialización , Estereotipo , Análisis y Desempeño de Tareas , Percepción Visual , Mujeres , Conducta , Imagen Corporal , Procesamiento de Imagen Asistido por Computador , Simbolismo , Actividades Cotidianas , Inteligencia Artificial , Adaptación Psicológica , Pesar , Actitud , Terapia Cognitivo-Conductual , Niño , Crianza del Niño , Cromosomas , Ensayo Clínico , Competencia Mental , Cuidadores , Cognición , Detección de Señal Psicológica , Comunicación , Conciencia , Intuición , Observación , Trastorno de Movimiento Estereotipado , Trastornos de los Cromosomas , Autonomía Personal , Hijos Adultos , Confianza , Comprensión , Delegación al Personal , Compresión de Datos , Educación , Educación de las Personas con Discapacidad Intelectual , Educación Especial , Ego , Empatía , Conducta Exploratoria , Cara , Expresión Facial , Competencia Cultural , Adulto Joven , Miedo , Retroalimentación , Inteligencia Emocional , Estigma Social , Pandemias , Habilidades Sociales , Normas Sociales , Ajuste Emocional , Optimismo , Metacognición , Reconocimiento Facial , Trastorno del Espectro Autista , Análisis Aplicado de la Conducta , Automanejo , Respeto , Regulación Emocional , Generalización Psicológica , Genética , Interacción Social , Reconocimiento de Identidad , COVID-19 , Gestos , Entrenamiento Cognitivo , Apoyo Familiar , Velocidad de Procesamiento , Manejo Psicológico , Imaginación , Relaciones Interpersonales , Lenguaje , Acontecimientos que Cambian la Vida , Memoria a Corto Plazo , Hombres , Trastornos Mentales , Procesos Mentales , Discapacidad Intelectual , Enfermedades del Sistema Nervioso , Manifestaciones Neurológicas , Neurología , Pruebas Neuropsicológicas , Comunicación no Verbal
12.
Conscious Cogn ; 113: 103532, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37295196

RESUMEN

Signal-detection theory (SDT) is one of the most popular frameworks for analyzing data from studies of human behavior - including investigations of confidence. SDT-based analyses of confidence deliver both standard estimates of sensitivity (d'), and a second estimate informed by high-confidence decisions - meta d'. The extent to which meta d' estimates fall short of d' estimates is regarded as a measure of metacognitive inefficiency, quantifying the contamination of confidence by additional noise. These analyses rely on a key but questionable assumption - that repeated exposures to an input will evoke a normally-shaped distribution of perceptual experiences (the normality assumption). Here we show, via analyses inspired by an experiment and modelling, that when distributions of experience do not conform with the normality assumption, meta d' can be systematically underestimated relative to d'. Our data highlight that SDT-based analyses of confidence do not provide a ground truth measure of human metacognitive inefficiency. We explain why deviance from the normality assumption is especially a problem for some popular SDT-based analyses of confidence, in contrast to other analyses inspired by the SDT framework, which are more robust to violations of the normality assumption.


Asunto(s)
Metacognición , Humanos , Detección de Señal Psicológica
13.
Sci Rep ; 13(1): 9739, 2023 06 16.
Artículo en Inglés | MEDLINE | ID: mdl-37328598

RESUMEN

Previous research indicates that irrational beliefs (Paranormal beliefs & conspiracy theory endorsement) are associated with the perception of patterns in noise, but the previous findings do not conclusively describe this relationship. This study aims to disentangle the underlying parameters of this association by applying a signal detection theory approach, thus allowing to distinguish illusory pattern perception (false alarms) from perceptual sensitivity and response tendencies-while also taking base rate information into account. Results from a large sample (N = 723) indicate that paranormal beliefs relate to a more liberal response bias and a lower perceptual sensitivity, and that this relationship is driven by illusory pattern perception. Such a clear pattern could not be observed for conspiracy beliefs, for which the increase in false alarm rates was moderated by the base rate. The associations between irrational beliefs and illusory pattern perception were however less substantial compared to other sources of variance. Implications are discussed.


Asunto(s)
Cultura , Ilusiones , Humanos , Detección de Señal Psicológica/fisiología , Ilusiones/fisiología
14.
PLoS One ; 18(4): e0284272, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37099529

RESUMEN

In an effort to inform interventions targeting littering behaviour, we estimate how much a change in trash-bag colour increases trash can visibility in Paris. To that end, we applied standard Signal Detection techniques to test how much changing trash-bag colour affects subjects' trash can detection rates. In three pre-registered studies, we found that changing trash bag colour from grey to either red, green or blue considerably increases the perception of bins in British (tourist) and Parisian (resident) samples. We found that changing the bag colour from grey to blue increased visibility the most.


Asunto(s)
Residuos de Alimentos , Detección de Señal Psicológica , Humanos , Paris , Percepción de Color
15.
Psychometrika ; 88(3): 1056-1086, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-36988755

RESUMEN

Signal detection theory (SDT; Tanner & Swets in Psychological Review 61:401-409, 1954) is a dominant modeling framework used for evaluating the accuracy of diagnostic systems that seek to distinguish signal from noise in psychology. Although the use of response time data in psychometric models has increased in recent years, the incorporation of response time data into SDT models remains a relatively underexplored approach to distinguishing signal from noise. Functional response time effects are hypothesized in SDT models, based on findings from other related psychometric models with response time data. In this study, an SDT model is extended to incorporate functional response time effects using smooth functions and to include all sources of variability in SDT model parameters across trials, participants, and items in the experimental data. The extended SDT model with smooth functions is formulated as a generalized linear mixed-effects model and implemented in the gamm4 R package. The extended model is illustrated using recognition memory data to understand how conversational language is remembered. Accuracy of parameter estimates and the importance of modeling variability in detecting the experimental condition effects and functional response time effects are shown in conditions similar to the empirical data set via a simulation study. In addition, the type 1 error rate of the test for a smooth function of response time is evaluated.


Asunto(s)
Reconocimiento en Psicología , Detección de Señal Psicológica , Humanos , Detección de Señal Psicológica/fisiología , Tiempo de Reacción , Psicometría , Simulación por Computador
16.
J Exp Psychol Learn Mem Cogn ; 49(2): 216-229, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36996188

RESUMEN

The recognition memory receiver operating characteristic (ROC) is typically asymmetric with a characteristic elevation of the left-hand portion. Whereas the unequal variance signal detection model (uvsd) assumes the asymmetry results because old item evidence is noisier than new item evidence, the dual process signal detection model (dpsd) assumes it results because old items convey more useful information than new items. To test these assumptions, the models were fit to old/new recognition data and their evidence parameters were used to predict performance on a novelty, three-alternative forced-choice (N3AFC) recognition task. Critically, under the uvsd model, increased old item variance (sigma) predicts poorer N3AFC performance, whereas under the dpsd model, increased recollection rates (Ro) predict better N3AFC performance. Hence, the asymmetry parameters of the two models make divergent predictions. In two experiments the dpsd model's predictions were supported, whereas the uvsd model yielded unpredicted (from that model's perspective) patterns. Through simulation it was also shown that the dpsd model predicted the uvsd model's mispredictions, which resulted because increases in old item noise markedly depress the upper portion of the ROC. Overall, the data demonstrate that increasing ROC asymmetry is not a function of increasingly noisier target evidence, but instead increasingly informative target evidence. These findings invalidate the uvsd model, which heretofore has been primarily supported by its post-hoc fitting ability, not its construct validity. (PsycInfo Database Record (c) 2023 APA, all rights reserved).


Asunto(s)
Reconocimiento en Psicología , Detección de Señal Psicológica , Humanos , Curva ROC , Modelos Psicológicos , Recuerdo Mental
17.
Ann Pharmacother ; 57(10): 1137-1146, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-36688283

RESUMEN

BACKGROUND: Colchicine has a narrow therapeutic index. Its toxicity can be increased due to concomitant exposure to drugs inhibiting its metabolic pathway; these are cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). OBJECTIVE: To examine clinical outcomes associated with colchicine drug interactions using the spontaneous reports of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). METHODS: We conducted a disproportionality analysis using FAERS data from January 2004 through June 2020. The reporting odds ratio (ROR) and observed-to-expected ratio (O/E) with shrinkage for adverse events related to colchicine's toxicity (ie, rhabdomyolysis/myopathy, agranulocytosis, hemorrhage, acute renal failure, hepatic failure, arrhythmias, torsade de pointes/QT prolongation, and cardiac failure) were compared between FAERS reports. RESULTS: A total of 787 reports included the combined mention of colchicine, an inhibitor of both CYP3A4 and P-gp drug, and an adverse event of interest. Among reports that indicated the severity, 61% mentioned hospitalization and 24% death. A total of 37 ROR and 34 O/E safety signals involving colchicine and a CYP3A4/P-gp inhibitor were identified. The strongest ROR signal was for colchicine + atazanavir and rhabdomyolysis/myopathy (ROR = 35.4, 95% CI: 12.8-97.6), and the strongest O/E signal was for colchicine + atazanavir and agranulocytosis (O/E = 3.79, 95% credibility interval: 3.44-4.03). CONCLUSION AND RELEVANCE: This study identifies numerous safety signals for colchicine and CYP3A4/P-gp inhibitor drugs. Avoiding the interaction or monitoring for toxicity in patients when co-prescribing colchicine and these agents is highly recommended.


Asunto(s)
Colchicina , Citocromo P-450 CYP3A , Humanos , Estados Unidos , Preparaciones Farmacéuticas , Colchicina/efectos adversos , Citocromo P-450 CYP3A/metabolismo , Miembro 1 de la Subfamilia B de Casetes de Unión a ATP , Sulfato de Atazanavir , Detección de Señal Psicológica , Subfamilia B de Transportador de Casetes de Unión a ATP , Sistemas de Registro de Reacción Adversa a Medicamentos , United States Food and Drug Administration
18.
Psychol Res ; 87(2): 509-518, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-35403969

RESUMEN

The sustained attention to response task (SART) is a popular measure in the psychology and neuroscience of attention. The underlying psychological cause for errors, in particular errors of commission, in the SART is actively disputed. Some researchers have suggested task-disengagement due to mind-wandering or mindlessness, and others have proposed strategic choices. In this study we explored an alternative perspective based on Signal Detection Theory, in which the high rate of commission errors in the SART reflects simply a shift in response bias (criterion) due to the high prevalence of Go-stimuli. We randomly assigned 406 participants to one of ten Go-stimuli prevalence rates (50%, 64%, 74%, 78%, 82%, 86%, 90%, 94%, 98% and 100%). As Go-stimuli prevalence increased reaction times to both Go and No-Go stimuli decreased, omission errors decreased and commission errors increased. These all were predicted from a hypothesized bias shift, but the findings were not compatible with some alternative theories of SART performance. These findings may have implications for similar tasks.


Asunto(s)
Desempeño Psicomotor , Detección de Señal Psicológica , Humanos , Desempeño Psicomotor/fisiología , Detección de Señal Psicológica/fisiología , Tiempo de Reacción/fisiología , Análisis y Desempeño de Tareas , Probabilidad
19.
Behav Res Methods ; 55(3): 1259-1274, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-35641680

RESUMEN

A police lineup is a procedure in which a suspect is surrounded by known-innocent persons (fillers) and presented to the witness for an identification attempt. The purpose of a lineup is to test the investigator's hypothesis that the suspect is the culprit, and the investigator uses the witness' identification decision and the associated confidence level to inform this hypothesis. Whereas suspect identifications provide evidence of guilt, filler identifications and rejections provide evidence of innocence. Despite the capacity of lineups to provide exculpatory information, past research has focused, almost exclusively, on inculpatory behaviors. We recently developed a method for incorporating all lineup outcomes in a single receiver operator characteristic (ROC) curve. The area under the full lineup ROC curve reflects the total capacity of a lineup procedure to discriminate guilty suspects from innocent suspects. Here, we introduce a Comprehensive R Archive Network (CRAN) package, fullROC, to support eyewitness researchers in using the full ROC approach to analyze lineup data. The fullROC package provides functions for adjusting identification rates, generating full ROC curves for lineup data, computing the area under the ROC curves (AUC), and statistically comparing the AUCs of different lineups. Using both simulated and empirical data, we illustrate the functionality of the fullROC CRAN package. In brief, the fullROC package provides a useful tool for eyewitness researchers to analyze lineup data using the full ROC method, which incorporates both the inculpatory and exculpatory information of eyewitness behaviors.


Asunto(s)
Recuerdo Mental , Reconocimiento en Psicología , Humanos , Curva ROC , Toma de Decisiones , Detección de Señal Psicológica , Crimen
20.
Mem Cognit ; 51(1): 160-174, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-35984624

RESUMEN

Recently, it has been suggested that the mnemonic information that underlies recognition decisions changes when participants are asked to indicate whether a test stimulus is new rather than old (Brainerd et al., 2021, Journal of Experimental Psychology: Learning Memory, and Cognition, advance online publication). However, some observations that have been interpreted as evidence for this assertion need not be due to mnemonic changes, but may instead be the result of conservative response strategies if the possibility of asymmetric receiver operating characteristics (ROCs) is taken into account. Conversely, recent findings in support of asymmetric ROCs rely on the assumption that the mnemonic information accessed by the decision-maker does not depend on whether an old or a new item is considered to be the target Kellen et al. (2021, Psychological Review 128[6], 1022-1050). Here, we aim to clarify whether there is such a difference in accessibility of mnemonic information by applying signal detection theory. To this end, we used two versions of a simultaneous detection and identification task in which we presented participants with two test stimuli at a time. In one version, the old item was the target; in the other, the new item was the target. This allowed us to assess differences in mnemonic information retrieved in the two tasks while taking possible ROC asymmetry into account. Results clearly indicate that there is indeed a difference in the accessibility of mnemonic information as postulated by (Brainerd et al., 2021, Journal of Experimental Psychology: Learning Memory, and Cognition, advance online publication).


Asunto(s)
Memoria , Detección de Señal Psicológica , Humanos , Reconocimiento en Psicología/fisiología , Cognición , Curva ROC
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