RESUMEN
BACKGROUND: In humans, vestibular epilepsy (VE) is described as focal seizures with transient signs of vestibular disease. In dogs, 2 cases of vestibular episodes, called vestibular paroxysmia, are reported. HYPOTHESIS/OBJECTIVES: The objective of this study was to define the clinical features, phenotypical manifestation, and outcome of suspected VE in dogs. ANIMALS: Ten dogs with recurrent vestibular episodes. METHODS: Retrospective study. Medical records between 2009 and 2023 were reviewed, and dogs with a normal neurological examination, a history of transient signs of vestibular disease, absence of abnormalities detected on blood exams and brain magnetic resonance imaging (MRI) or computed tomography (CT), besides a minimum 10-month follow-up were included. Clinical improvement was defined as a ≥50% reduction in frequency or the cessation of clinical signs after the onset of antiseizure medications (ASMs). RESULTS: Pugs were the most prevalent breed (5/10; 50%). In 2 cases, additional generalized tonic-clonic (GTC) seizures were reported. MRI exam was performed in most cases (9/10; 90%), whereas 1 dog underwent a CT scan (1/10; 10%). Electroencephalography (EEG) was carried out in 3 dogs that showed interictal spikes in the fronto-temporal and fronto-parietal areas. All cases received ASMs, with clinical improvement in 10/10 dogs (100%). CONCLUSION AND CLINICAL IMPORTANCE: The presence of GTC seizures, EEG interictal spikes, and responsiveness to ASMs supported the hypothesis of an epileptic origin of vestibular episodes and thus the existence of VE in these dogs, with a presumed idiopathic cause and apparent favorable outcome.
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Anticonvulsivantes , Enfermedades de los Perros , Animales , Perros , Enfermedades de los Perros/tratamiento farmacológico , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/diagnóstico , Estudios Retrospectivos , Femenino , Masculino , Anticonvulsivantes/uso terapéutico , Imagen por Resonancia Magnética/veterinaria , Enfermedades Vestibulares/veterinaria , Enfermedades Vestibulares/tratamiento farmacológico , Enfermedades Vestibulares/diagnóstico , Electroencefalografía/veterinaria , Tomografía Computarizada por Rayos X/veterinaria , Epilepsia/veterinaria , Epilepsia/tratamiento farmacológico , Epilepsia/diagnóstico por imagen , Epilepsia/diagnósticoRESUMEN
OBJECTIVES: Otitis media/interna (OMI) is the most common cause of peripheral vestibular disease in cats. The inner ear contains endolymph and perilymph, with perilymph being very similar in composition to cerebrospinal fluid (CSF). As a very-low-protein fluid, it would be expected that normal perilymph should suppress on fluid-attenuated inversion recovery (FLAIR) MRI sequences. Based on this, we hypothesized that MRI FLAIR sequences should provide a non-invasive way of diagnosing inflammatory/infectious diseases such as OMI in cats, something that has previously been demonstrated in humans and, more recently, in dogs. METHODS: This was a retrospective cohort study in which 41 cats met the inclusion criteria. They were placed into one of four groups, based on presenting complaint: clinical OMI (group A); inflammatory central nervous system (CNS) disease (group B); non-inflammatory structural disease (group C); and normal brain MRI (control group; group D). Transverse T2-weighted and FLAIR MRI sequences at the level of the inner ears bilaterally were compared in each group. The inner ear was selected as a region of interest using Horos, with a FLAIR suppression ratio calculated to account for variability in signal intensity between MRIs. This FLAIR suppression ratio was then compared between groups. Statistical analyses were performed by an experienced statistician, with a general linear model used to compare mean FLAIR suppression ratio, CSF nucleated cell count and CSF protein concentration between groups. RESULTS: The OMI group (group A) had significantly lower FLAIR suppression scores compared with all other groups. The CSF cell count was also significantly increased in the OMI (group A) and inflammatory CNS disease (group B) groups compared with the control group (group D). CONCLUSIONS AND RELEVANCE: This study demonstrates the utility of MRI FLAIR sequences in diagnosing presumptive OMI in cats, similarly to in humans and dogs. This study is relevant to practicing veterinary neurologists and radiologists in interpreting MRI findings in cats with suspected OMI.
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Enfermedades de los Gatos , Enfermedades de los Perros , Oído Interno , Enfermedades Vestibulares , Humanos , Gatos , Animales , Perros , Estudios Retrospectivos , Oído Interno/diagnóstico por imagen , Enfermedades Vestibulares/diagnóstico por imagen , Enfermedades Vestibulares/veterinaria , Imagen por Resonancia Magnética/veterinaria , Enfermedades de los Gatos/diagnóstico por imagenRESUMEN
BACKGROUND: Nausea and emesis can be, among other signs, common manifestations of acute vestibular system dysfunction in dogs. Currently, antiemetic drugs, such as maropitant and metoclopramide, are used commonly, but do not appear to control nausea. A non-placebo-controlled preliminary study suggested good efficacy of 5-HT3-receptor antagonists, such as ondansetron, against nausea in dogs with vestibular syndrome. OBJECTIVES: To assess and confirm the effect of ondansetron on behavior suggestive of nausea in dogs with vestibular syndrome. ANIMALS: Fourteen dogs with vestibular syndrome and clinical signs of nausea presented to a neurology service. METHODS: Placebo-controlled, double-blinded, crossover study. Behavioral assessment was performed hourly for 4 hours using an established numerical rating scale. The criteria salivation, lip licking, vocalization, restlessness, lethargy, and general nausea were scored. The occurrence of emesis was recorded. After scoring at T0 (pre-dose) and T2 (2 hours post-dose) either ondansetron (0.5 mg/kg) or placebo was injected IV. Two hours post-dose, treatments were switched. Blood samples were collected to measure serum arginine vasopressin (AVP) concentration, which previously has been shown to correlate with clinical signs of nausea. RESULTS: Clinical resolution of nausea was observed 1 hour after administration of ondansetron, whereas serum AVP concentration decreased 4 hours after ondansetron administration. CONCLUSION AND CLINICAL IMPORTANCE: Administration of ondansetron IV is beneficial for dogs with nausea secondary to acute vestibular syndrome. Ondansetron substantially and rapidly decreased clinical signs of nausea behavior and stopped emesis.
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Antieméticos , Enfermedades de los Perros , Enfermedades Vestibulares , Animales , Antieméticos/uso terapéutico , Arginina Vasopresina/uso terapéutico , Estudios Cruzados , Enfermedades de los Perros/tratamiento farmacológico , Perros , Método Doble Ciego , Metoclopramida , Náusea/tratamiento farmacológico , Náusea/veterinaria , Ondansetrón/uso terapéutico , Enfermedades Vestibulares/complicaciones , Enfermedades Vestibulares/tratamiento farmacológico , Enfermedades Vestibulares/veterinaria , Vómitos/tratamiento farmacológico , Vómitos/veterinariaRESUMEN
The vestibular system (VS) is the primary specialized sensory system responsible for maintaining balance (equilibrium) and orientation of the eyes, neck, trunk, and limbs during rest and movement. Two important reflexes are responsible for maintaining balance: vestibulo-ocular and vestibulospinal reflexes. These reflexes involve peripheral and central components of the VS. Whether central or peripheral disease, most of the disorders of the VS result in ipsilateral neurologic deficits. A few uncommon exceptions present with contralateral signs to the site of the lesion. This article provides a brief review of functional anatomy, vestibular disease, clinical signs, and examples of disorders affecting the VS.
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Enfermedades de los Caballos , Enfermedades Vestibulares , Animales , Caballos , Reflejo Vestibuloocular , Enfermedades Vestibulares/diagnóstico , Enfermedades Vestibulares/veterinariaRESUMEN
BACKGROUND: Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5-HT3 receptor antagonists to reduce nausea has been described for chemotherapy, but not for nausea secondary to vestibular disorders. METHODS: Sixteen dogs with vestibular syndrome-associated nausea were included in the open-label, multicentre study. The intensity of nausea-like behaviour was analysed before ondansetron administration (0.5 mg/kg i.v.) and 2 h afterwards, using a validated 5-point-scale. The occurrence and frequency of salivation, lip licking, restlessness, vocalisation, lethargy, and vomiting were assessed. RESULTS: All dogs initially showed signs of nausea, whereas only 31% showed vomitus. The intensity of nausea was significantly reduced in all dogs (p ≤ 0.0001) 2 h after ondansetron administration, including the clinical signs of nausea analysed in 11 dogs (salivation [p = 0.0078], lip licking [p = 0.0078], restlessness [p = 0.0039], and lethargy [p = 0.0078]) except for vocalisation (p > 0.9999). CONCLUSIONS: The results provide preliminary evidence of the potential benefit of ondansetron in the treatment of nausea, which was present in all examined dogs. Vomiting was only observed in 5 dogs indicating that nausea can occur separately and should not be perceived only as a preceding stimulation of the vomiting centre.
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Náusea/veterinaria , Ondansetrón/uso terapéutico , Enfermedades Vestibulares/veterinaria , Administración Intravenosa/veterinaria , Animales , Antieméticos/administración & dosificación , Antieméticos/uso terapéutico , Perros , Náusea/tratamiento farmacológico , Ondansetrón/administración & dosificación , Enfermedades Vestibulares/tratamiento farmacológico , Vómitos/tratamiento farmacológico , Vómitos/veterinariaRESUMEN
BACKGROUND: Although, vestibular syndrome is a common neurological presentation, little is known about the diagnostic value of cerebrospinal fluid (CSF) analysis in vestibular syndrome in dogs. METHODS: Medical records were retrospectively reviewed, and dogs with vestibular disease that had undergone magnetic resonance imaging of the head, CSF analysis and were diagnosed with central or peripheral vestibular syndrome were included. Disorders affecting the central vestibular system included meningoencephalitis of unknown origin (MUO), brain neoplasia, ischaemic infarct, intracranial empyema or metronidazole toxicity. Disorders affecting the peripheral vestibular system included idiopathic vestibular disease, otitis media/interna or neoplasia affecting the inner ear structures. Total nucleated cell concentration (TNCC), total protein concentration (TP) and cytologic assessment were recorded. RESULTS: A total of 102 dogs met the inclusion criteria. The sensitivity and specificity of increased CSF TNCC to differentiate central from peripheral vestibular syndrome was 49% and 90%, while the sensitivity and specificity of increased TP was 58% and 39%, respectively. The TNCC and TP in dogs with MUO were significantly higher than in dogs with idiopathic vestibular disease (p = 0.000 and p = 0.004). MUO was associated with lymphocytic pleocytosis, while idiopathic vestibular disease and ischaemic infarct were associated with the presence of activated macrophages or normal cytology (p = 0.000). CONCLUSION: Although consistent CSF abnormalities were observed in dogs with MUO, CSF analysis did not allow reliable differentiation between central and peripheral vestibular syndrome. CSF analysis is not reliable as the sole diagnostic technique in dogs with vestibular disease.
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Enfermedades de los Perros , Meningoencefalitis , Enfermedades Vestibulares , Animales , Enfermedades de los Perros/diagnóstico , Perros , Meningoencefalitis/veterinaria , Estudios Retrospectivos , Enfermedades Vestibulares/diagnóstico , Enfermedades Vestibulares/veterinaria , Sistema VestibularRESUMEN
BACKGROUND: Although the use of clinical reasoning has been evaluated for several neurological presentations, this approach has not yet been investigated for dogs with vestibular syndrome. METHODS: Two hundred and thirty-nine dogs presenting with vestibular syndrome were included in this retrospective study. Univariate analysis of variables (clinical history, signalment, clinical presentation and neurological examination findings) was performed. Variables with p < 0.3 were selected for logistic regression. RESULTS: Ninety-five percent of dogs were represented by eight conditions: idiopathic vestibular disease (n = 78 dogs), otitis media interna (n = 54), meningoencephalitis of unknown origin (n = 35), brain neoplasia (n = 26), ischaemic infarct (n = 25), intracranial empyema (n = 4), metronidazole toxicity (n = 3) and neoplasia affecting the middle ear (n = 3). Idiopathic vestibular disease was associated with higher age, higher bodyweight, improving clinical signs, pathological nystagmus, facial nerve paresis, absence of Horner's syndrome and a peripheral localisation. Otitis media interna was associated with younger age, male gender, Horner's syndrome, a peripheral localisation and a history of otitis externa. Ischaemic infarct was associated with older age, peracute onset of signs, absence of strabismus and a central localisation. CONCLUSIONS: Discrete clinical features can be used to identify the most likely diagnosis in dogs with vestibular syndrome.
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Razonamiento Clínico , Enfermedades de los Perros/diagnóstico , Enfermedades Vestibulares/veterinaria , Veterinarios/psicología , Animales , Perros , Femenino , Humanos , Masculino , Estudios Retrospectivos , Enfermedades Vestibulares/diagnósticoRESUMEN
BACKGROUND: Vestibular disease (VD), central or peripheral, can be a dramatic primary-care presentation. Current literature describes mostly dogs examined in referral centers. HYPOTHESIS/OBJECTIVES: Describe the prevalence, presentation, clinical management, and outcomes of VD in dogs under primary veterinary care at UK practices participating in VetCompass. ANIMALS: Seven hundred and fifty-nine vestibular cases identified out of 905 544 study dogs. METHODS: Retrospective cohort study. Potential VD cases clinically examined during 2016 were verified by reviewing clinical records for signalment, presenting clinical signs, treatments, and outcomes. Multivariable logistic regression was used to evaluate factors associated with VD. RESULTS: The overall prevalence of VD was 8 per 10 000 dogs (95% CI = 7-9). Median age at first diagnosis was 12.68 years (interquartile range [IQR], 11.28-14.64). Compared with crossbreeds, breeds with the highest odds of VD diagnosis included French Bulldogs (odds ratio [OR] = 9.25, 95% CI = 4.81-17.76, P < .001), Bulldogs (OR = 6.53, 95% CI = 2.66-16.15, P < .001), King Charles Spaniels (OR = 4.96, 95% CI = 2.52-9.78, P < .001), Cavalier King Charles Spaniels (OR = 3.56, 95% CI = 2.50-5.06, P < .001), and Springer Spaniels (OR = 3.37, 95% CI = 2.52-4.52, P < .001). The most common presenting signs were head tilt (69.8%), nystagmus (68.1%), and ataxia (64.5%). The most frequently used treatments were antiemetics (43.2%), systemic glucocorticoids (33.1%), antimicrobials (25%), and propentofylline (23.25%). There were 3.6% of cases referred. Improvement was recorded in 41.8% cases after a median of 4 days (IQR, 2-10.25). CONCLUSIONS: Our study identifies strong breed predispositions for VD. The low referral rates suggest that primary-care data sources offer more generalizable information for benchmarking to help clinicians review their own clinical activities.
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Enfermedades de los Perros , Enfermedades Vestibulares , Animales , Enfermedades de los Perros/diagnóstico , Enfermedades de los Perros/epidemiología , Enfermedades de los Perros/terapia , Perros , Prevalencia , Estudios Retrospectivos , Reino Unido/epidemiología , Enfermedades Vestibulares/diagnóstico , Enfermedades Vestibulares/epidemiología , Enfermedades Vestibulares/terapia , Enfermedades Vestibulares/veterinariaRESUMEN
Idiopathic vestibular syndrome (IVS) is the most common cause of acute unilateral peripheral vestibular dysfunction in older dogs. The purpose of this retrospective, cross-sectional study was to characterize morphological changes in the utricle of dogs affected by IVS, using MRI. To evaluate differences between affected and unaffected utricles, the ratio of the largest to the smallest utricle diameter was obtained, as measured on transverse T2-weighted images, and defined as the utricle asymmetricity ratio (UAR). Out of 137 patients diagnosed with IVS after excluding other vestibular diseases by MRI, 101 were eligible for inclusion. Additionally, 31 older dogs with no signs of vestibular disorders or other intracranial diseases were included as a control group. The disease group was divided into two subgroups in which the direction of head tilt and nystagmus symptoms versus the decreased utricle diameters were consistent or inconsistent. The medians of UARs of the IVS and control groups were 0.83 (range 0.37-1.00) and 0.98 (0.70-1.00), respectively. The medians of the UARs of the consistent and inconsistent IVS subgroups were 0.82 (0.37-0.99) and 0.90 (0.74-1.00), respectively. The UAR of the IVS group was significantly decreased than that of the control group and UAR of the consistent sub-group was significantly decreased than that of the inconsistent sub-group (P < .01). In conclusion, significant asymmetry of utricle diameter was identified in dogs with IVS versus unaffected dogs. We propose that canine IVS may possibly be correlated with structural atrophy of the vestibular system.
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Enfermedades de los Perros/diagnóstico por imagen , Imagen por Resonancia Magnética/veterinaria , Sáculo y Utrículo/patología , Enfermedades Vestibulares/veterinaria , Animales , Estudios Transversales , Enfermedades de los Perros/patología , Perros , Femenino , Masculino , Estudios Retrospectivos , Sáculo y Utrículo/diagnóstico por imagen , Enfermedades Vestibulares/diagnóstico por imagen , Enfermedades Vestibulares/patologíaRESUMEN
The inner ear contains endolymph and perilymph. The second is comparable and in continuity with the cerebrospinal fluid (CSF) so it is expected to suppress in fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) if normal. Even though inner ear FLAIR abnormalities have been extensively described in humans with inner ear disease, its diagnostic value in dogs is yet to be proven. The goal of this retrospective cohort study was to investigate the diagnostic utility of FLAIR MRI in dogs with vestibular disease. A review of medical records identified 101 dogs that had brain MRI performed because of vestibular signs. Based on the final diagnosis, patients were allocated to three groups: otitis media/interna, idiopathic vestibular disease, and central vestibular disease. Additionally, a control group (n = 73) included dogs with normal MRI and without vestibular signs. Inner ears were delineated using a region of interest, and signal intensity was measured in FLAIR and T2-weighted images. The percentages of suppression in FLAIR were calculated and compared between affected and unaffected sides of each individual and between groups using a general linear mixed model. Correlation between suppression and CSF cell count and protein concentration was assessed. Affected inner ears in dogs with otitis media/interna had decreased suppression in FLAIR compared to the unaffected side (P < .001), and all other groups (P < .01). No significant correlation was detected between CSF results and suppression. These results show the diagnostic value of FLAIR in otitis media/interna due to lack of suppression in the affected inner ear.
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Enfermedades de los Perros/diagnóstico por imagen , Oído Interno/diagnóstico por imagen , Imagen por Resonancia Magnética/veterinaria , Enfermedades Vestibulares/veterinaria , Animales , Enfermedades de los Perros/fisiopatología , Perros , Femenino , Masculino , Estudios Retrospectivos , Enfermedades Vestibulares/diagnóstico por imagen , Enfermedades Vestibulares/fisiopatologíaRESUMEN
An abrupt balance impairment, including leaning, falling, and rolling, occurred after IV administration of 0.2 mg/kg midazolam as a preanesthetic medication in two geriatric dogs with a history of nystagmus and head tilt. In the second case, leaning, falling, and rolling recurred after recovery from general anesthesia but gradually ceased after IV administration of 0.01 mg/kg flumazenil. These two cases suggest that the IV administration of midazolam was responsible for the balance impairment in dogs who were suspected to have idiopathic peripheral vestibular disease.
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Adyuvantes Anestésicos/efectos adversos , Enfermedades de los Perros/inducido químicamente , Midazolam/efectos adversos , Enfermedades Vestibulares/veterinaria , Envejecimiento , Animales , Perros , Femenino , Masculino , Enfermedades Vestibulares/inducido químicamenteRESUMEN
Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system associated with gene expression. In mammals there are six H3K4 methyltransferases related to yeast Set1 and fly Trithorax, including two orthologs of fly Trithorax-related: MLL3 and MLL4. Exome sequencing has documented high frequencies of MLL3 and MLL4 mutations in many types of human cancer. Despite this emerging importance, the requirements of these paralogs in mammalian development have only been incompletely reported. Here, we examined the null phenotypes to establish that MLL3 is first required for lung maturation, whereas MLL4 is first required for migration of the anterior visceral endoderm that initiates gastrulation in the mouse. This collective cell migration is preceded by a columnar-to-squamous transition in visceral endoderm cells that depends on MLL4. Furthermore, Mll4 mutants display incompletely penetrant, sex-distorted, embryonic haploinsufficiency and adult heterozygous mutants show aspects of Kabuki syndrome, indicating that MLL4 action, unlike MLL3, is dosage dependent. The highly specific and discordant functions of these paralogs in mouse development argues against their action as general enhancer factors.
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N-Metiltransferasa de Histona-Lisina/metabolismo , Anomalías Múltiples/genética , Anomalías Múltiples/patología , Anomalías Múltiples/veterinaria , Alelos , Animales , Embrión de Mamíferos/metabolismo , Desarrollo Embrionario , Cara/anomalías , Cara/patología , Femenino , Genotipo , Enfermedades Hematológicas/genética , Enfermedades Hematológicas/patología , Enfermedades Hematológicas/veterinaria , N-Metiltransferasa de Histona-Lisina/química , N-Metiltransferasa de Histona-Lisina/genética , Pulmón/crecimiento & desarrollo , Pulmón/metabolismo , Masculino , Ratones , Ratones Noqueados , Mutagénesis , Embarazo , Insuficiencia Respiratoria/etiología , Factores de Tiempo , Enfermedades Vestibulares/genética , Enfermedades Vestibulares/patología , Enfermedades Vestibulares/veterinariaRESUMEN
BACKGROUND: Vestibular dysfunction is relatively common in dogs, with a prevalence of 0.08% reported in primary veterinary care in the UK. There are several studies investigating how to differentiate between peripheral and central vestibular disease but only limited information regarding the possible underlying causes for peripheral vestibular dysfunction in dogs. This study therefore aimed to describe the clinical signs, magnetic resonance imaging findings (MRI), underlying causes and outcome in a large population of dogs diagnosed with peripheral vestibular disease. RESULTS: One hundred eighty-eight patients were included in the study with a median age of 6.9 years (range 3 months to 14.6 years). Neurological abnormalities included head tilt (n = 185), ataxia (n = 123), facial paralysis (n = 103), nystagmus (n = 97), positional strabismus (n = 93) and Horner syndrome (n = 7). The most prevalent diagnosis was idiopathic vestibular disease (n = 128), followed by otitis media and/or interna (n = 49), hypothyroidism (n = 7), suspected congenital vestibular disease (n = 2), neoplasia (n = 1) and cholesteatoma (n = 1). Long-term follow-up revealed persistence of head tilt (n = 50), facial paresis (n = 41) and ataxia (n = 6) in some cases. Recurrence of clinical signs was observed in 26 dogs. Increasing age was associated with a mild increased chance of diagnosis of idiopathic vestibular syndrome rather than otitis media and/or interna (P = 0.022, OR = 0.866; CI 0.765-0.980). History of previous vestibular episodes (P = 0.017, OR = 3.533; CI 1.251-9.981) was associated with an increased likelihood of resolution of the clinical signs whilst contrast enhancement of cranial nerves VII and/or VIII on MRI (P = 0.018, OR = 0.432; CI 0.251-0.868) was associated with a decreased chance of resolution of the clinical signs. CONCLUSIONS: Idiopathic vestibular disease is the most common cause of peripheral vestibular dysfunction in dogs and it is associated with advanced age. Incomplete recovery from peripheral vestibular disease is common, especially in dogs presenting with cranial nerve enhancement on MRI but less so if there is previous history of vestibular episodes.
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Enfermedades de los Perros/diagnóstico , Enfermedades Vestibulares/veterinaria , Factores de Edad , Animales , Nervios Craneales/diagnóstico por imagen , Nervios Craneales/patología , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/etiología , Perros , Femenino , Laberintitis/veterinaria , Imagen por Resonancia Magnética/veterinaria , Masculino , Otitis Media/veterinaria , Estudios Retrospectivos , Resultado del Tratamiento , Enfermedades Vestibulares/diagnóstico , Enfermedades Vestibulares/diagnóstico por imagen , Enfermedades Vestibulares/etiologíaRESUMEN
OBJECTIVES: To determine whether the neurological examination correctly distinguishes between central and peripheral vestibular lesions in dogs. MATERIALS AND METHODS: Retrospective study on dogs with vestibular disease presenting to two referral clinics in Germany. RESULTS: Ninety-three dogs were included; neurological examination suggested central vestibular disease in 62 and a peripheral lesion in 31. MRI diagnosis was central vestibular disease in 68 dogs and peripheral in 25. Of the 62 dogs with a lesion localisation diagnosed as central vestibular by neurological exam, 61 were correctly identified (98.4%). Twenty-four of the 31 dogs diagnosed with a peripheral lesion by neurological exam had a consistent lesion on MRI (77.4%). CLINICAL SIGNIFICANCE: The neurological examination is efficient at identifying lesions in the central vestibular system but less so for peripheral lesions. Therefore it is prudent to recommend imaging in dogs that show signs of peripheral vestibular syndrome but do not rapidly respond to treatment.
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Enfermedades Vestibulares/veterinaria , Animales , Perros , Alemania , Imagen por Resonancia Magnética , Examen Neurológico , Estudios RetrospectivosRESUMEN
Bilateral deafness with concurrent vestibular dysfunction was first reported in the Doberman pinscher in 1980. Here, we identify a coding mutation in the MYO7A gene that is perfectly associated with the disorder. The lack of visual deficits in affected dogs suggests that, like rodents but unlike humans, MYO7A is not required for retinal function. DNA testing of the mutation will enable dog breeders to manage the incidence of this genetic defect.
La surdité bilatérale avec dysfonctionnement vestibulaire concomitant a été rapporté pour la première fois chez le Doberman pinscher en 1980. Ici nous identifions une mutation codante dans le gène MYO7A qui est associée parfaitement avec cette condition. L'absence de défaut rétinien chez les chiens atteints suggère que, comme chez les rongeurs mais contrairement aux humains, MYO7A n'est pas requis pour la fonction rétinienne. Les tests d'ADN pour la mutation vont permettre aux éleveurs de chiens de gérer l'incidence de ce défaut génétique.(Traduit par Docteur Serge Messier).
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Sordera/veterinaria , Enfermedades de los Perros/genética , Predisposición Genética a la Enfermedad , Mutación Missense , Miosinas/genética , Enfermedades Vestibulares/veterinaria , Animales , Estudios de Casos y Controles , ADN/genética , Sordera/genética , Perros , Regulación de la Expresión Génica , Estudio de Asociación del Genoma Completo , Genotipo , Miosina VIIa , Miosinas/metabolismo , Enfermedades Vestibulares/genética , Secuenciación Completa del GenomaRESUMEN
OBJECTIVE To estimate reliability of interpretation of neurologic examination findings for localization of vestibular dysfunction in dogs. DESIGN Cross-sectional study. ANIMALS 496 dogs that underwent MRI of the head for diagnosis of a neurologic problem between September 2011 and September 2015. PROCEDURES Medical records were reviewed and data collected regarding signalment and neurologic examination, MRI, and CSF findings. Independent observers interpreted the findings, and agreement was assessed for a subset of dogs. Distributions of variables were compared between dogs with and without a neurologic findings-based interpretation of vestibular disease. RESULTS 37% (185/496) of dogs had signs of vestibular dysfunction, of which 82% (151/185) had MRI abnormalities. In 73% (110/151) of dogs with MRI abnormalities, lesions involved central vestibular structures, and in 19% (29/151), lesions involved peripheral vestibular structures. On the basis of neurologic findings interpretation, 86% (160/185) of dogs were classified as having central vestibular dysfunction, and 61% (98/160) of these had an MRI-identified central vestibular lesion. Agreement among 3 independent observers was good (κ = 0.72) regarding use of neurologic examination findings to diagnose central versus peripheral vestibular dysfunction and very good (κ = 0.85) regarding use of MRI to diagnose peripheral vestibular lesions. Despite this agreement, only 29% (7/24) of dogs with a consensus clinical interpretation of peripheral vestibular dysfunction had MRI-identified peripheral lesions. CONCLUSIONS AND CLINICAL RELEVANCE Although interobserver agreement was good for distinguishing central from peripheral vestibular dysfunction in dogs through interpretation of neurologic examination findings, this interpretation did not agree with the MRI-based diagnosis.
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Enfermedades de los Perros/diagnóstico , Enfermedades Vestibulares/veterinaria , Animales , Estudios Transversales , Enfermedades de los Perros/líquido cefalorraquídeo , Perros , Femenino , Imagen por Resonancia Magnética/veterinaria , Masculino , Examen Neurológico/veterinaria , Registros/veterinaria , Reproducibilidad de los Resultados , Texas , Universidades , Enfermedades Vestibulares/diagnósticoRESUMEN
BACKGROUND: A congenital syndrome of hearing loss and vestibular dysfunction affects Doberman Pinschers. Its inheritance pattern is suspected to be autosomal recessive and it potentially represents a spontaneous animal model of an autosomal recessive syndromic hearing loss. HYPOTHESIS/OBJECTIVES: The objectives of this study were to use whole genome sequencing (WGS) to identify deleterious genetic variants in candidate genes associated with the syndrome and to study the prevalence of candidate variants among a population of unaffected Doberman Pinschers. ANIMALS: One affected Doberman Pinscher and 202 unaffected Doberman Pinschers. METHODS: WGS of the affected dog with filtering of variants against a database of 154 unaffected dogs of diverse breeds was performed. Confirmation of candidate variants was achieved by Sanger sequencing followed by genotyping of the control population of unaffected Doberman Pinschers. RESULTS: WGS and variant filtering identified an alteration in a gene associated with both deafness and vestibular disease in humans: protein tyrosine phosphatase, receptor type Q (PTPRQ). There was a homozygous A insertion at CFA15: 22 989 894, causing a frameshift mutation in exon 39 of the gene. This insertion is predicted to cause a protein truncation with a premature stop codon occurring after position 2054 of the protein sequence that causes 279 C-terminal amino acids to be eliminated. Prevalence of the variant was 1.5% in a cohort of 202 unaffected Doberman Pinschers; all unaffected Doberman Pinschers were heterozygous or heterozygous for the reference allele. CONCLUSION AND CLINICAL IMPORTANCE: We report the identification of a genetic alteration on the PTPRQ gene that is associated with congenital hearing and vestibular disorder in a young Doberman Pinscher dog.
Asunto(s)
Enfermedades de los Perros/genética , Pérdida Auditiva/veterinaria , Proteínas Tirosina Fosfatasas Clase 3 Similares a Receptores/genética , Enfermedades Vestibulares/veterinaria , Animales , Perros , Femenino , Mutación del Sistema de Lectura , Pérdida Auditiva/genética , Enfermedades Vestibulares/genética , Secuenciación Completa del GenomaRESUMEN
The occurrence of vestibular disease in a cat following a wellness/vaccination visit which included routine ear cleaning is described. The cat recovered in 10 days following supportive therapy. The cause of vestibular disease was not identified but sensitivity to an ear cleaning solution or subclinical ear disease may have played a role.
Maladie vestibulaire périphérique inhabituelle chez un chat après un nettoyage d'oreilles. Le présent rapport de cas décrit l'occurrence d'une maladie vestibulaire chez un chat après une visite pour examen de santé et vaccination qui incluait le nettoyage routinier des oreilles. Le chat s'est rétabli dans un délai de 10 jours après une thérapie de soutien. La cause de la maladie vestibulaire n'a pas été identifiée, mais la sensibilité à une solution de nettoyage des oreilles ou une maladie subclinique de l'oreille peut avoir joué un rôle.(Traduit par Isabelle Vallières).
Asunto(s)
Enfermedades de los Gatos/etiología , Enfermedades Vestibulares/veterinaria , Animales , Gatos , Oído Externo , Masculino , Vacunación/veterinaria , Enfermedades Vestibulares/etiologíaRESUMEN
A dog from western Newfoundland was presented with paradoxical vestibular syndrome. First-stage larvae of Angiostrongylus vasorum were detected on fecal examination. Treatment with milbemycin oxime resulted in resolution of signs. This is the first report of the spread of this parasite to western Newfoundland and of paradoxical vestibular syndrome in a dog infected with A. vasorum.
Syndrome vestibulaire paradoxal chez un chien de l'ouest de Terre-Neuve infecté par des vers du cÅur(Angiostrongylus vasorum). Un chien de l'ouest de Terre-Neuve a été présenté avec un syndrome vestibulaire paradoxal. Des larves de premier stade d'Angiostrongylus vasorum ont été détectées à l'examen fécal. Le traitement à l'aide d'oxime de milbémycine a produit une disparition des symptômes. Il s'agit du premier rapport de la propagation de ce parasite dans l'ouest de Terre-Neuve et du syndrome vestibulaire paradoxal chez un chien infecté par A. vasorum.(Traduit par Isabelle Vallières).